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Items: 1 to 20 of 61

1.
Antagonistic roles of canonical and alternative-RPA in disease-associated tandem CAG repeat instability
Terence Gall-Duncan, Jennifer Luo, Carla-Marie Jurkovic, Laura A. Fischer, Kyota Fujita, Amit L. Deshmukh, Rachel J. Harding, Stephanie Tran, Mustafa Mehkary, Vanessa Li, David E. Leib, Ran Chen, Hikari Tanaka, Amanda G. Mason, Dominique Lévesque, Mahreen Khan, Mortezaali Razzaghi, Tanya Prasolava, Stella Lanni, Nozomu Sato, Marie-Christine Caron, Gagan B. Panigrahi, Peixiang Wang, Rachel Lau, Arturo López Castel, Jean-Yves Masson, Lynette Tippett, Clinton Turner, Maria Spies, Albert R. La Spada, Eric I. Campos, Maurice A. Curtis, François-Michel Boisvert, Richard L.M. Faull, Beverly L. Davidson, Masayuki Nakamori, Hitoshi Okazawa, Marc S. Wold, Christopher E. Pearson
Cell. Author manuscript; available in PMC 2024 Oct 26.
Published in final edited form as: Cell. 2023 Oct 26; 186(22): 4898–4919.e25. Published online 2023 Oct 11. doi: 10.1016/j.cell.2023.09.008
PMCID:
PMC11209935
AbstractArticlePDF–3.0M
2.
K48- and K63-linked ubiquitin chain interactome reveals branch- and length-specific ubiquitin interactors
Anita Waltho, Oliver Popp, Christopher Lenz, Lukas Pluska, Mahil Lambert, Volker Dötsch, Philipp Mertins, Thomas Sommer
Life Sci Alliance. 2024 Aug; 7(8): e202402740. Published online 2024 May 21. doi: 10.26508/lsa.202402740
PMCID:
PMC11109483
AbstractArticlePDF–2.9M
3.
TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing
Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan
Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233
PMCID:
PMC10237422
AbstractArticlePDF–23M
4.
FBXO42 facilitates Notch signaling activation and global chromatin relaxation by promoting K63-linked polyubiquitination of RBPJ
Hua Jiang, Weixiang Bian, Yue Sui, Huanle Li, Han Zhao, Wenqi Wang, Xu Li
Sci Adv. 2022 Sep; 8(38): eabq4831. Published online 2022 Sep 21. doi: 10.1126/sciadv.abq4831
PMCID:
PMC9491713
AbstractArticlePDF–12M
5.
OpenCell: proteome-scale endogenous tagging enables the cartography of human cellular organization
Nathan H. Cho, Keith C. Cheveralls, Andreas-David Brunner, Kibeom Kim, André C. Michaelis, Preethi Raghavan, Hirofumi Kobayashi, Laura Savy, Jason Y. Li, Hera Canaj, James Y.S. Kim, Edna M. Stewart, Christian Gnann, Frank McCarthy, Joana P. Cabrera, Rachel M. Brunetti, Bryant B. Chhun, Greg Dingle, Marco Y. Hein, Bo Huang, Shalin B. Mehta, Jonathan S. Weissman, Rafael Gómez-Sjöberg, Daniel N. Itzhak, Loic A. Royer, Matthias Mann, Manuel D. Leonetti
Science. Author manuscript; available in PMC 2022 Sep 11.
Published in final edited form as: Science. 2022 Mar 11; 375(6585): eabi6983. Published online 2022 Mar 11. doi: 10.1126/science.abi6983
PMCID:
PMC9119736
AbstractArticlePDF–3.3M
6.
Human TDP1, APE1 and TREX1 repair 3′-DNA–peptide/protein cross-links arising from abasic sites in vitro
Xiaoying Wei, Zhishuo Wang, Caroline Hinson, Kun Yang
Nucleic Acids Res. 2022 Apr 22; 50(7): 3638–3657. Published online 2022 Mar 29. doi: 10.1093/nar/gkac185
PMCID:
PMC9023300
AbstractArticlePDF–4.6M
7.
SARS‐CoV‐2–host proteome interactions for antiviral drug discovery
Xiaonan Liu, Sini Huuskonen, Tuomo Laitinen, Taras Redchuk, Mariia Bogacheva, Kari Salokas, Ina Pöhner, Tiina Öhman, Arun Kumar Tonduru, Antti Hassinen, Lisa Gawriyski, Salla Keskitalo, Maria K Vartiainen, Vilja Pietiäinen, Antti Poso, Markku Varjosalo
Mol Syst Biol. 2021 Nov; 17(11): e10396. Published online 2021 Oct 28. doi: 10.15252/msb.202110396
PMCID:
PMC8552907
AbstractArticlePDF–3.9M
8.
Direct interaction of DNA repair protein tyrosyl DNA phosphodiesterase 1 and the DNA ligase III catalytic domain is regulated by phosphorylation of its flexible N-terminus
Ishtiaque Rashid, Michal Hammel, Aleksandr Sverzhinsky, Miaw-Sheue Tsai, John M. Pascal, John A. Tainer, Alan E. Tomkinson
J Biol Chem. 2021 Aug; 297(2): 100921. Published online 2021 Jun 25. doi: 10.1016/j.jbc.2021.100921
PMCID:
PMC8318918
AbstractArticlePDF–3.5M
9.
New Hybrid Compounds Combining Fragments of Usnic Acid and Monoterpenoids for Effective Tyrosyl-DNA Phosphodiesterase 1 Inhibition
Nadezhda S. Dyrkheeva, Aleksandr S. Filimonov, Olga A. Luzina, Alexandra L. Zakharenko, Ekaterina S. Ilina, Anastasia A. Malakhova, Sergey P. Medvedev, Jóhannes Reynisson, Konstantin P. Volcho, Suren M. Zakian, Nariman F. Salakhutdinov, Olga I. Lavrik
Biomolecules. 2021 Jul; 11(7): 973. Published online 2021 Jul 1. doi: 10.3390/biom11070973
PMCID:
PMC8301776
AbstractArticlePDF–3.1M
10.
Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome
Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi
Cell. Author manuscript; available in PMC 2022 May 27.
Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011
PMCID:
PMC8165030
AbstractArticlePDF–2.2M
11.
Probing the evolutionary conserved residues Y204, F259, S400 and W590 that shape the catalytic groove of human TDP1 for 3′- and 5′-phosphodiester-DNA bond cleavage
Evgeny Kiselev, Thomas S. Dexheimer, Christophe Marchand, Shar-yin Naomi Huang, Yves Pommier
DNA Repair (Amst) Author manuscript; available in PMC 2021 Apr 20.
Published in final edited form as: DNA Repair (Amst). 2018 Jun-Jul; 66-67: 64–71. Published online 2018 May 2. doi: 10.1016/j.dnarep.2018.05.001
PMCID:
PMC8057126
AbstractArticlePDF–1.1M
12.
SCAN1-TDP1 trapping on mitochondrial DNA promotes mitochondrial dysfunction and mitophagy
Arijit Ghosh, Sangheeta Bhattacharjee, Srijita Paul Chowdhuri, Abhik Mallick, Ishita Rehman, Sudipta Basu, Benu Brata Das
Sci Adv. 2019 Nov; 5(11): eaax9778. Published online 2019 Nov 6. doi: 10.1126/sciadv.aax9778
PMCID:
PMC6834389
AbstractArticlePDF–5.5M
13.
Identification of a ligand binding hot spot and structural motifs replicating aspects of tyrosyl-DNA phosphodiesterase I (TDP1) phosphoryl recognition by crystallographic fragment cocktail screening
George T Lountos, Xue Zhi Zhao, Evgeny Kiselev, Joseph E Tropea, Danielle Needle, Yves Pommier, Terrence R Burke, Jr, David S Waugh
Nucleic Acids Res. 2019 Nov 4; 47(19): 10134–10150. Published online 2019 Jun 14. doi: 10.1093/nar/gkz515
PMCID:
PMC6821334
AbstractArticlePDF–10M
14.
Association of Tyrosyl‐DNA Phosphodiesterase 1 Polymorphism With Tourette Syndrome in Taiwanese Patients
Bor‐Tsang Wu, Wei‐Yong Lin, I‐Ching Chou, Hsin‐Ping Liu, Cheng‐Chun Lee, Yuhsin Tsai, Wan‐Chen Wu, Fuu‐Jen Tsai
J Clin Lab Anal. 2013 Jul; 27(4): 323–327. Published online 2013 Jul 12. doi: 10.1002/jcla.21606
PMCID:
PMC6807418
AbstractArticlePDF–81K
15.
Mammalian Tyrosyl-DNA Phosphodiesterases in the Context of Mitochondrial DNA Repair
Shar-yin Naomi Huang, Yves Pommier
Int J Mol Sci. 2019 Jun; 20(12): 3015. Published online 2019 Jun 20. doi: 10.3390/ijms20123015
PMCID:
PMC6628236
AbstractArticlePDF–1.0M
16.
Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei
Domenico Fasci, Hugo van Ingen, Richard A. Scheltema, Albert J. R. Heck
Mol Cell Proteomics. 2018 Oct; 17(10): 2018–2033. Published online 2018 Jul 18. doi: 10.1074/mcp.RA118.000924
PMCID:
PMC6166682
AbstractArticlePDF–3.8M
17.
TDP1 suppresses mis-joining of radiomimetic DNA double-strand breaks and cooperates with Artemis to promote optimal nonhomologous end joining
Ajinkya S Kawale, Konstantin Akopiants, Kristoffer Valerie, Brian Ruis, Eric A Hendrickson, Shar-yin N Huang, Yves Pommier, Lawrence F Povirk
Nucleic Acids Res. 2018 Sep 28; 46(17): 8926–8939. Published online 2018 Aug 3. doi: 10.1093/nar/gky694
PMCID:
PMC6158748
AbstractArticlePDF–3.2M
18.
Estrogen-regulated feedback loop limits the efficacy of estrogen receptor–targeted breast cancer therapy
Tengfei Xiao, Wei Li, Xiaoqing Wang, Han Xu, Jixin Yang, Qiu Wu, Ying Huang, Joseph Geradts, Peng Jiang, Teng Fei, David Chi, Chongzhi Zang, Qi Liao, Jonathan Rennhack, Eran Andrechek, Nanlin Li, Simone Detre, Mitchell Dowsett, Rinath M. Jeselsohn, X. Shirley Liu, Myles Brown
Proc Natl Acad Sci U S A. 2018 Jul 31; 115(31): 7869–7878. Published online 2018 Jul 9. doi: 10.1073/pnas.1722617115
PMCID:
PMC6077722
AbstractArticlePDF–2.4M
19.
PRMT5-mediated arginine methylation of TDP1 for the repair of topoisomerase I covalent complexes
Ishita Rehman, Suparna M Basu, Subhendu K Das, Sangheeta Bhattacharjee, Arijit Ghosh, Yves Pommier, Benu Brata Das
Nucleic Acids Res. 2018 Jun 20; 46(11): 5601–5617. Published online 2018 Apr 30. doi: 10.1093/nar/gky291
PMCID:
PMC6009676
AbstractArticlePDF–7.5M
20.
TDP1 is critical for the repair of DNA breaks induced by sapacitabine, a nucleoside also targeting ATM- and BRCA-deficient tumors
Muthana Al Abo, Hiroyuki Sasanuma, Xiaojun Liu, Vinodh N Rajapakse, Shar-Yin Huang, Evgeny Kiselev, Shunichi Takeda, William Plunkett, Yves Pommier
Mol Cancer Ther. Author manuscript; available in PMC 2018 Nov 1.
Published in final edited form as: Mol Cancer Ther. 2017 Nov; 16(11): 2543–2551. Published online 2017 Aug 11. doi: 10.1158/1535-7163.MCT-17-0110
PMCID:
PMC5971110
AbstractArticlePDF–2.4M

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