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Select item 111580931.

Cytosolic acetyl‐CoA synthetase affected tumor cell survival under hypoxia: the possible function in tumor acetyl‐CoA/acetate metabolism

Yukie Yoshii, Takako Furukawa, Hiroshi Yoshii, Tetsuya Mori, Yasushi Kiyono, Atsuo Waki, Masato Kobayashi, Tetsuya Tsujikawa, Takashi Kudo, Hidehiko Okazawa, Yoshiharu Yonekura, Yasuhisa Fujibayashi

Cancer Sci. 2009 May; 100(5): 821–827. Published online 2009 Feb 17. doi: 10.1111/j.1349-7006.2009.01099.x

PMCID:: PMC11158093

Abstract Article PDF–240K

Select item 109588322.

Acetyl-CoA synthetase 2 induces pyroptosis and inflammation of renal epithelial tubular cells in sepsis-induced acute kidney injury by upregulating the KLF5/NF-κB pathway

Jian Lu, Ya Hou, Si-Xiu Liu, Bo Jin, Jing Liu, Nan Li, Yan Zhu, Qing-Yan Zhang, Cheng Wan, Yuan Feng, Jun Xie, Chun-Ming Jiang

Cell Commun Signal. 2024; 22: 187. Published online 2024 Mar 21. doi: 10.1186/s12964-024-01556-3

PMCID:: PMC10958832

Abstract Article PDF–3.8M

Select item 108538943.

Gut microbiota regulates hepatic ischemia–reperfusion injury‐induced cognitive dysfunction via the HDAC2‐ACSS2 axis in mice

Yanbo Liu, Zhen Li, Tianning Sun, Zhixiao Li, Anne Manyande, Hongbing Xiang, Zhigang He

CNS Neurosci Ther. 2024 Feb; 30(2): e14610. Published online 2024 Feb 9. doi: 10.1111/cns.14610

PMCID:: PMC10853894

Abstract Article PDF–6.2M

Select item 105297014.

Acetate controls endothelial-to-mesenchymal transition

Xiaolong Zhu, Yunyun Wang, Ioana Soaita, Heon-Woo Lee, Hosung Bae, Nabil Boutagy, Anna Bostwick, Rong-Mo Zhang, Caitlyn Bowman, Yanying Xu, Sophie Trefely, Yu Chen, Lingfeng Qin, William Sessa, George Tellides, Cholsoon Jang, Nathaniel W. Snyder, Luyang Yu, Zoltan Arany, Michael Simons

Cell Metab. Author manuscript; available in PMC 2024 Jul 11.

Published in final edited form as: Cell Metab. 2023 Jul 11; 35(7): 1163–1178.e10. Published online 2023 Jun 15. doi: 10.1016/j.cmet.2023.05.010

PMCID:: PMC10529701

Abstract Article PDF–3.5M

Select item 103395675.

ACSS2-dependent histone acetylation improves cognition in mouse model of Alzheimer’s disease

Yingbin Lin, Anlan Lin, Lili Cai, Weibin Huang, Shanzhi Yan, Yuanxiang Wei, Xinglin Ruan, Wenting Fang, Xiaoman Dai, Jinbo Cheng, Jie Zhang, Wanjin Chen, Qinyong Ye, Xiaochun Chen, Jing Zhang

Mol Neurodegener. 2023; 18: 47. Published online 2023 Jul 12. doi: 10.1186/s13024-023-00625-4

PMCID:: PMC10339567

Abstract Article PDF–3.0M

Select item 99647126.

Acss2 Deletion Reveals Functional Versatility via Tissue-Specific Roles in Transcriptional Regulation

Narayanan Puthillathu Vasudevan, Dharmendra K. Soni, John R. Moffett, Jishnu K. S. Krishnan, Abhilash P. Appu, Sarani Ghoshal, Peethambaran Arun, John M. Denu, Thomas P. Flagg, Roopa Biswas, Aryan M. Namboodiri

Int J Mol Sci. 2023 Feb; 24(4): 3673. Published online 2023 Feb 12. doi: 10.3390/ijms24043673

PMCID:: PMC9964712

Abstract Article PDF–16M

Select item 98958417.

Folate-deficiency induced acyl-CoA synthetase short-chain family member 2 increases lysine crotonylome involved in neural tube defects

Shan Wang, Yubing Zeng, Xuejia He, Fan Liu, Pei Pei, Ting Zhang

Front Mol Neurosci. 2022; 15: 1064509. Published online 2023 Jan 20. doi: 10.3389/fnmol.2022.1064509

PMCID:: PMC9895841

Abstract Article PDF–3.7M

Select item 93716798.

Targeting acetyl-CoA metabolism attenuates the formation of fear memories through reduced activity-dependent histone acetylation

Desi C. Alexander, Tanya Corman, Mariel Mendoza, Andrew Glass, Tal Belity, Ranran Wu, Rianne R. Campbell, Joseph Han, Ashley A. Keiser, Jeffrey Winkler, Marcelo A. Wood, Thomas Kim, Benjamin A. Garcia, Hagit Cohen, Philipp Mews, Gabor Egervari, Shelley L. Berger

Proc Natl Acad Sci U S A. 2022 Aug 9; 119(32): e2114758119. Published online 2022 Aug 3. doi: 10.1073/pnas.2114758119

PMCID:: PMC9371679

Abstract Article PDF–5.1M

Select item 84976069.

ATP-citrate lyase promotes axonal transport across species

Aviel Even, Giovanni Morelli, Silvia Turchetto, Michal Shilian, Romain Le Bail, Sophie Laguesse, Nathalie Krusy, Ariel Brisker, Alexander Brandis, Shani Inbar, Alain Chariot, Frédéric Saudou, Paula Dietrich, Ioannis Dragatsis, Bert Brone, Loïc Broix, Jean-Michel Rigo, Miguel Weil, Laurent Nguyen

Nat Commun. 2021; 12: 5878. Published online 2021 Oct 7. doi: 10.1038/s41467-021-25786-y

Correction in:: Nat Commun. 2021; 12: 6678.

PMCID:: PMC8497606

Abstract Article PDF–5.3M

Select item 840593210.

Mammalian acetate-dependent acetyl CoA synthetase 2 contains multiple protein destabilization and masking elements

Jason S. Nagati, Philippe H. Kobeissy, Minh Q. Nguyen, Min Xu, Trent Garcia, Sarah A. Comerford, Robert E. Hammer, Joseph A. Garcia

J Biol Chem. 2021 Sep; 297(3): 101037. Published online 2021 Jul 31. doi: 10.1016/j.jbc.2021.101037

PMCID:: PMC8405932

Abstract Article PDF–5.4M

Select item 802671911.

Histone crotonylation promotes mesoendodermal commitment of human embryonic stem cells

Yi Fang, Xiaojiang Xu, Jun Ding, Lu Yang, Mary T. Doan, Peer W.F. Karmaus, Nathaniel W. Snyder, Yingming Zhao, Jian-Liang Li, Xiaoling Li

Cell Stem Cell. Author manuscript; available in PMC 2022 Apr 1.

Published in final edited form as: Cell Stem Cell. 2021 Apr 1; 28(4): 748–763.e7. Published online 2021 Jan 14. doi: 10.1016/j.stem.2020.12.009

PMCID:: PMC8026719

Abstract Article PDF–4.3M

Select item 793877012.

BraInMap elucidates the macromolecular connectivity landscape of mammalian brain

Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili

Cell Syst. Author manuscript; available in PMC 2021 Apr 22.

Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003

Correction in:: Cell Syst. 2020 Aug 26; 11(2): 208.

PMCID:: PMC7938770

Abstract Article PDF–2.0M

Select item 779939013.

Acetyl-CoA synthetase 2: a critical linkage in obesity-induced tumorigenesis in myeloma

Zongwei Li, Huan Liu, Jin He, Zhiqiang Wang, Zheng Yin, Gichun You, Zhiming Wang, Richard E. Davis, Pei Lin, P. Leif Bergsagel, Elisabet E. Manasanch, Stephen T.C. Wong, Nestor F. Esnaola, Jenny C. Chang, Robert Z. Orlowski, Qing Yi, Jing Yang

Cell Metab. Author manuscript; available in PMC 2022 Jan 5.

Published in final edited form as: Cell Metab. 2021 Jan 5; 33(1): 78–93.e7. doi: 10.1016/j.cmet.2020.12.011

PMCID:: PMC7799390

Abstract Article PDF–3.8M

Select item 722984914.

Transcription factor Tcf4 is the preferred heterodimerization partner for Olig2 in oligodendrocytes and required for differentiation

Miriam Wedel, Franziska Fröb, Olga Elsesser, Marie-Theres Wittmann, D Chichung Lie, André Reis, Michael Wegner

Nucleic Acids Res. 2020 May 21; 48(9): 4839–4857. Published online 2020 Apr 8. doi: 10.1093/nar/gkaa218

PMCID:: PMC7229849

Abstract Article PDF–36M

Select item 685542015.

A substitution mutation in a conserved domain of mammalian acetate-dependent acetyl CoA synthetase 2 results in destabilized protein and impaired HIF-2 signaling

Jason S. Nagati, Min Xu, Trent Garcia, Sarah A. Comerford, Robert E. Hammer, Joseph A. Garcia

PLoS One. 2019; 14(11): e0225105. Published online 2019 Nov 14. doi: 10.1371/journal.pone.0225105

PMCID:: PMC6855420

Abstract Article PDF–3.8M

Select item 672200916.

Different effects of knockouts in ALDH2 and ACSS2 on embryonic stem cell differentiation

Ryan N Serio, Changyuan Lu, Steven S Gross, Lorraine J Gudas

Alcohol Clin Exp Res. Author manuscript; available in PMC 2020 Sep 1.

Published in final edited form as: Alcohol Clin Exp Res. 2019 Sep; 43(9): 1859–1871. Published online 2019 Aug 5. doi: 10.1111/acer.14146

PMCID:: PMC6722009

Abstract Article PDF–1.6M

Select item 617656617.

ACSS2 promotes systemic fat storage and utilization through selective regulation of genes involved in lipid metabolism

Zhiguang Huang, Menglu Zhang, Abigail A. Plec, Sandi Jo Estill, Ling Cai, Joyce J. Repa, Steven L. McKnight, Benjamin P. Tu

Proc Natl Acad Sci U S A. 2018 Oct 2; 115(40): E9499–E9506. Published online 2018 Sep 18. doi: 10.1073/pnas.1806635115

PMCID:: PMC6176566

Abstract Article PDF–1.9M

Select item 600407118.

Maf links Neuregulin1 signaling to cholesterol synthesis in myelinating Schwann cells

Minchul Kim, Hagen Wende, Jan Walcher, Johannes Kühnemund, Cyril Cheret, Stefan Kempa, Erik McShane, Matthias Selbach, Gary R. Lewin, Carmen Birchmeier

Genes Dev. 2018 May 1; 32(9-10): 645–657. doi: 10.1101/gad.310490.117

Correction in:: Genes Dev. 2018 Aug 1; 32(15-16): 1101.

PMCID:: PMC6004071

Abstract Article PDF–9.0M

Select item 552121319.

Nucleus-translocated ACSS2 promotes the gene transcription for lysosomal biogenesis and autophagy

Xinjian Li, Willie Yu, Xu Qian, Yan Xia, Yanhua Zheng, Jong-Ho Lee, Wei Li, Jianxin Lyu, Ganesh Rao, Xiaochun Zhang, Chao-Nan Qian, Steven G Rozen, Tao Jiang, Zhimin Lu

Mol Cell. Author manuscript; available in PMC 2018 Jun 1.

Published in final edited form as: Mol Cell. 2017 Jun 1; 66(5): 684–697.e9. Published online 2017 May 25. doi: 10.1016/j.molcel.2017.04.026

PMCID:: PMC5521213

Abstract Article PDF–1.4M

Select item 550551420.

ACETYL-COA SYNTHETASE REGULATES HISTONE ACETYLATION AND HIPPOCAMPAL MEMORY

Philipp Mews, Greg Donahue, Adam M. Drake, Vincent Luczak, Ted Abel, Shelley L. Berger

Nature. Author manuscript; available in PMC 2017 Nov 30.

Published in final edited form as: Nature. 2017 Jun 15; 546(7658): 381–386. Published online 2017 May 31. doi: 10.1038/nature22405

PMCID:: PMC5505514

Abstract Article PDF–4.3M

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