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Select item 113196501.

Protective effect of PDE4B subtype-specific inhibition in an App knock-in mouse model for Alzheimer’s disease

Paul Armstrong, Hüseyin Güngör, Pariya Anongjanya, Clare Tweedy, Edward Parkin, Jamie Johnston, Ian M. Carr, Neil Dawson, Steven J. Clapcote

Neuropsychopharmacology. 2024 Sep; 49(10): 1559–1568. Published online 2024 Mar 23. doi: 10.1038/s41386-024-01852-z

PMCID:: PMC11319650

Abstract Article PDF–3.1M

Select item 112019792.

Early Inhibition of Phosphodiesterase 4B (PDE4B) Instills Cognitive Resilience in APPswe/PS1dE9 Mice

Ben Rombaut, Melissa Schepers, Assia Tiane, Femke Mussen, Lisa Koole, Sofie Kessels, Chloë Trippaers, Ruben Jacobs, Kristiaan Wouters, Emily Willems, Lieve van Veggel, Philippos Koulousakis, Dorien Deluyker, Virginie Bito, Jos Prickaerts, Inez Wens, Bert Brône, Daniel L. A. van den Hove, Tim Vanmierlo

Cells. 2024 Jun; 13(12): 1000. Published online 2024 Jun 8. doi: 10.3390/cells13121000

PMCID:: PMC11201979

Abstract Article PDF–2.6M

Select item 93610423.

LncRNA GAS5 Knockdown Mitigates Hepatic Lipid Accumulation via Regulating MiR-26a-5p/PDE4B to Activate cAMP/CREB Pathway

Shizan Xu, Yajie Wang, Zhengyang Li, Qian Hua, Miao Jiang, Xiaoming Fan

Front Endocrinol (Lausanne) 2022; 13: 889858. Published online 2022 Jul 26. doi: 10.3389/fendo.2022.889858

PMCID:: PMC9361042

Abstract Article PDF–13M

Select item 86982904.

Assessment of PDE4 Inhibitor-Induced Hypothermia as a Correlate of Nausea in Mice

Abigail Boyd, Ileana V. Aragon, Justin Rich, Will McDonough, Marianna Oditt, Daniel Irelan, Edward Fiedler, Lina Abou Saleh, Wito Richter

Biology (Basel) 2021 Dec; 10(12): 1355. Published online 2021 Dec 20. doi: 10.3390/biology10121355

PMCID:: PMC8698290

Abstract Article PDF–2.5M

Select item 85603975.

Evidence for reprogramming of monocytes into reparative alveolar macrophages in vivo by targeting PDE4b

Ian Rochford, Jagdish Chandra Joshi, Sheikh Rayees, Mumtaz Anwar, Md Zahid Akhter, Lakshmi Yalagala, Somenath Banerjee, Dolly Mehta

Am J Physiol Lung Cell Mol Physiol. 2021 Oct 1; 321(4): L686–L702. Published online 2021 Jul 28. doi: 10.1152/ajplung.00145.2021

PMCID:: PMC8560397

Abstract Article

Select item 84248726.

Ablation of PDE4B protects from Pseudomonas aeruginosa-induced acute lung injury in mice by ameliorating the cytostorm and associated hypothermia

Lina Abou Saleh, Abigail Boyd, Ileana V. Aragon, Anna Koloteva, Domenico Spadafora, Wadad Mneimneh, Robert A. Barrington, Wito Richter

FASEB J. Author manuscript; available in PMC 2022 Sep 1.

Published in final edited form as: FASEB J. 2021 Sep; 35(9): e21797. doi: 10.1096/fj.202100495R

PMCID:: PMC8424872

Abstract Article PDF–2.0M

Select item 83723777.

circPDE4B prevents articular cartilage degeneration and promotes repair by acting as a scaffold for RIC8A and MID1

Shuying Shen, Yute Yang, Panyang Shen, Jun Ma, Bin Fang, Qingxin Wang, Kefan Wang, Peihua Shi, Shunwu Fan, Xiangqian Fang

Ann Rheum Dis. 2021 Sep; 80(9): 1209–1219. Published online 2021 May 26. doi: 10.1136/annrheumdis-2021-219969

PMCID:: PMC8372377

Abstract Article PDF–7.8M

Select item 83479368.

A Positive Regulatory Feedback Loop between EKLF/KLF1 and TAL1/SCL Sustaining the Erythropoiesis

Chun-Hao Hung, Tung-Liang Lee, Anna Yu-Szu Huang, Kang-Chung Yang, Yu-Chiau Shyu, Shau-Ching Wen, Mu-Jie Lu, Shinsheng Yuan, Che-Kun James Shen

Int J Mol Sci. 2021 Aug; 22(15): 8024. Published online 2021 Jul 27. doi: 10.3390/ijms22158024

PMCID:: PMC8347936

Abstract Article PDF–4.4M

Select item 83132399.

Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development

Francesco Bedogni, Robert F. Hevner

Front Mol Neurosci. 2021; 14: 686034. Published online 2021 Jul 12. doi: 10.3389/fnmol.2021.686034

PMCID:: PMC8313239

Abstract Article PDF–1.6M

Select item 821888910.

The cAMP-phosphodiesterase 4 (PDE4) controls β-adrenoceptor- and CFTR-dependent saliva secretion in mice.

Abigail Boyd, Ileana V. Aragon, Lina Abou Saleh, Dylan Southers, Wito Richter

Biochem J. Author manuscript; available in PMC 2022 May 28.

Published in final edited form as: Biochem J. 2021 May 28; 478(10): 1891–1906. doi: 10.1042/BCJ20210212

PMCID:: PMC8218889

Abstract Article PDF–2.0M

Select item 819675711.

Selective Inhibition of PDE4B Reduces Binge Drinking in Two C57BL/6 Substrains

C. Leonardo Jimenez Chavez, Camron D. Bryant, Melissa A. Munn-Chernoff, Karen K. Szumlinski

Int J Mol Sci. 2021 Jun; 22(11): 5443. Published online 2021 May 21. doi: 10.3390/ijms22115443

PMCID:: PMC8196757

Abstract Article PDF–2.7M

Select item 818747812.

Regulation of PD-L1 expression is a novel facet of cyclic-AMP-mediated immunosuppression

Binu Sasi, Purushoth Ethiraj, Jamie Myers, An-Ping Lin, Shoulei Jiang, Zhijun Qiu, Kenneth N. Holder, Ricardo C. T. Aguiar

Leukemia. Author manuscript; available in PMC 2021 Jul 8.

Published in final edited form as: Leukemia. 2021 Jul; 35(7): 1990–2001. Published online 2020 Dec 9. doi: 10.1038/s41375-020-01105-0

PMCID:: PMC8187478

Abstract Article PDF–1.8M

Select item 805228613.

Inhibition of cAMP-phosphodiesterase 4 (PDE4) potentiates the anesthetic effects of Isoflurane in mice

Ileana V. Aragon, Abigail Boyd, Lina Abou Saleh, Justin Rich, Will McDonough, Anna Koloteva, Wito Richter

Biochem Pharmacol. Author manuscript; available in PMC 2022 Apr 1.

Published in final edited form as: Biochem Pharmacol. 2021 Apr; 186: 114477. Published online 2021 Feb 18. doi: 10.1016/j.bcp.2021.114477

PMCID:: PMC8052286

Abstract Article PDF–1.7M

Select item 795451314.

PAN-selective inhibition of cAMP-phosphodiesterase 4 (PDE4) induces gastroparesis in mice

Will McDonough, Ileana V. Aragon, Justin Rich, James M. Murphy, Lina Abou Saleh, Abigail Boyd, Anna Koloteva, Wito Richter

FASEB J. Author manuscript; available in PMC 2021 Sep 1.

Published in final edited form as: FASEB J. 2020 Sep; 34(9): 12533–12548. Published online 2020 Aug 1. doi: 10.1096/fj.202001016RR

PMCID:: PMC7954513

Abstract Article PDF–852K

Select item 675835615.

Congenic Mapping of Alcohol and Pentobarbital Withdrawal Liability Loci to a <1 Centimorgan Interval of Murine Chromosome 4: Identification of Mpdz as a Candidate Gene

Christoph Fehr, Renee L. Shirley, John K. Belknap, John C. Crabbe, Kari J. Buck

J Neurosci. 2002 May 1; 22(9): 3730–3738. doi: 10.1523/JNEUROSCI.22-09-03730.2002

PMCID:: PMC6758356

Abstract Article PDF–458K

Select item 644538816.

Following spinal cord injury, PDE4B drives an acute, local inflammatory response and a chronic, systemic response exacerbated by gut dysbiosis and endotoxemia

Scott A. Myers, Leila Gobejishvili, Sujata Saraswat Ohri, C. Garrett Wilson, Kariena R. Andres, Amberly S. Riegler, Hridgandh Donde, Swati Joshi-Barve, Shirish Barve, Scott R. Whittemore

Neurobiol Dis. Author manuscript; available in PMC 2019 Apr 2.

Published in final edited form as: Neurobiol Dis. 2019 Apr; 124: 353–363. Published online 2018 Dec 14. doi: 10.1016/j.nbd.2018.12.008

PMCID:: PMC6445388

Abstract Article PDF–2.2M

Select item 614327017.

The conserved protective cyclic AMP-phosphodiesterase function PDE4B is expressed in the adenoma and adjacent normal colonic epithelium of mammals and silenced in colorectal cancer

Jennifer K. Pleiman, Amy A. Irving, Zhishi Wang, Erik Toraason, Linda Clipson, William F. Dove, Dustin A. Deming, Michael A. Newton

PLoS Genet. 2018 Sep; 14(9): e1007611. Published online 2018 Sep 6. doi: 10.1371/journal.pgen.1007611

PMCID:: PMC6143270

Abstract Article PDF–8.4M

Select item 579742718.

Phosphodiesterase 4b expression plays a major role in alcohol-induced neuro-inflammation

Diana V Avila, Scott A Myers, JingWen Zhang, Giorgi Kharebava, Craig J McClain, Hee-Yong Kim, Scott R Whittemore, Leila Gobejishvili, Shirish Barve

Neuropharmacology. Author manuscript; available in PMC 2018 Oct 1.

Published in final edited form as: Neuropharmacology. 2017 Oct; 125: 376–385. Published online 2017 Aug 12. doi: 10.1016/j.neuropharm.2017.08.011

PMCID:: PMC5797427

Abstract Article PDF–1.4M

Select item 571214219.

Altered phosphorylation, electrophysiology, and behavior on attenuation of PDE4B action in hippocampus

Susan L. Campbell, Thomas van Groen, Inga Kadish, Lisa High Mitchell Smoot, Graeme B. Bolger

BMC Neurosci. 2017; 18: 77. Published online 2017 Dec 2. doi: 10.1186/s12868-017-0396-6

PMCID:: PMC5712142

Abstract Article PDF–1.7M

Select item 568019020.

Atropine augments cardiac contractility by inhibiting cAMP-specific phosphodiesterase type 4

Ruwan K. Perera, Thomas H. Fischer, Michael Wagner, Matthias Dewenter, Christiane Vettel, Nadja I. Bork, Lars S. Maier, Marco Conti, Juergen Wess, Ali El-Armouche, Gerd Hasenfuß, Viacheslav O. Nikolaev

Sci Rep. 2017; 7: 15222. Published online 2017 Nov 9. doi: 10.1038/s41598-017-15632-x