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Items: 1 to 20 of 197

1.
Loss of Lymphatic IKKα Disrupts Lung Immune Homeostasis, Drives BALT Formation, and Protects against Influenza
Michelle D. Cully, Julianne E. Nolte, Athena Patel, Andrew E. Vaughan, Michael J. May
Immunohorizons. 2024 Jul; 8(7): 478–491. Published online 2024 Jul 15. doi: 10.4049/immunohorizons.2400047
PMCID:
PMC11294277
AbstractArticlePDF–2.5M
2.
Genetic determinants of micronucleus formation in vivo
D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus
Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0
PMCID:
PMC10917660
AbstractArticlePDF–4.8M
3.
IKK1 aggravates ischemia–reperfusion kidney injury by promoting the differentiation of effector T cells
Ning Song, Yang Xu, Hans-Joachim Paust, Ulf Panzer, Maria Mercedes de las Noriega, Linlin Guo, Thomas Renné, Jiabin Huang, Xianglin Meng, Mingyan Zhao, Friedrich Thaiss
Cell Mol Life Sci. 2023 May; 80(5): 125. Published online 2023 Apr 19. doi: 10.1007/s00018-023-04763-2
PMCID:
PMC10115737
AbstractArticlePDF–5.3M
4.
Exercise-activated hepatic autophagy via the FN1-α5β1 integrin pathway drives metabolic benefits of exercise
Kenta Kuramoto, Huijia Liang, Jung-Hwa Hong, Congcong He
Cell Metab. Author manuscript; available in PMC 2024 Apr 4.
Published in final edited form as: Cell Metab. 2023 Apr 4; 35(4): 620–632.e5. Published online 2023 Feb 21. doi: 10.1016/j.cmet.2023.01.011
PMCID:
PMC10079584
AbstractArticlePDF–2.5M
5.
Non-Oncogene Addiction of KRAS-Mutant Cancers to IL-1β via Versican and Mononuclear IKKβ
Magda Spella, Giannoula Ntaliarda, Georgios Skiadas, Anne-Sophie Lamort, Malamati Vreka, Antonia Marazioti, Ioannis Lilis, Eleni Bouloukou, Georgia A. Giotopoulou, Mario A. A. Pepe, Stefanie A. I. Weiss, Agnese Petrera, Stefanie M. Hauck, Ina Koch, Michael Lindner, Rudolph A. Hatz, Juergen Behr, Kristina A. M. Arendt, Ioanna Giopanou, David Brunn, Rajkumar Savai, Dieter E. Jenne, Maarten de Château, Fiona E. Yull, Timothy S. Blackwell, Georgios T. Stathopoulos
Cancers (Basel) 2023 Mar; 15(6): 1866. Published online 2023 Mar 20. doi: 10.3390/cancers15061866
PMCID:
PMC10047096
AbstractArticlePDF–6.8M
6.
A TNFR1–UBCH10 axis drives lung squamous cell carcinoma dedifferentiation and metastasis through a cell-autonomous signaling loop
Zuoxiang Xiao, Gongping Shi, Sichuan Xi, Amit Kumar Singh, Jami Willette-Brown, Xin Li, Feng Zhu, Ling Su, Xiaolin Wu, David S. Schrump, Yinling Hu
Cell Death Dis. 2022 Oct; 13(10): 885. Published online 2022 Oct 21. doi: 10.1038/s41419-022-05308-4
PMCID:
PMC9587052
AbstractArticlePDF–5.9M
7.
A STUB1 ubiquitin ligase/CHIC2 protein complex negatively regulates the IL-3, IL-5, and GM-CSF cytokine receptor common β chain (CSF2RB) protein stability
Sebastian H.J. Koochaki, Mikołaj Słabicki, Ryan Lumpkin, Charles Zou, Roger Belizaire, Eric S. Fischer, Benjamin L. Ebert
J Biol Chem. 2022 Oct; 298(10): 102484. Published online 2022 Sep 13. doi: 10.1016/j.jbc.2022.102484
PMCID:
PMC9574515
AbstractArticlePDF–1.8M
8.
Biliary NIK promotes ductular reaction and liver injury and fibrosis in mice
Zhiguo Zhang, Xiao Zhong, Hong Shen, Liang Sheng, Suthat Liangpunsakul, Anna S. Lok, M. Bishr Omary, Shaomeng Wang, Liangyou Rui
Nat Commun. 2022; 13: 5111. Published online 2022 Aug 30. doi: 10.1038/s41467-022-32575-8
PMCID:
PMC9427946
AbstractArticlePDF–4.5M
9.
p62 Promotes Survival and Hepatocarcinogenesis in Mice with Liver-Specific NEMO Ablation
Vangelis Kondylis, Farina Schneider, Fabian Schorn, Nikos Oikonomou, Beate Katharina Straub, Sabine Werner, Philip Rosenstiel, Manolis Pasparakis
Cancers (Basel) 2022 May; 14(10): 2436. Published online 2022 May 15. doi: 10.3390/cancers14102436
PMCID:
PMC9139637
AbstractArticlePDF–8.6M
10.
Functional genomic landscape of cancer-intrinsic evasion of killing by T cells
Keith A. Lawson, Cristovão M. Sousa, Xiaoyu Zhang, Eiru Kim, Rummy Akthar, Joseph J. Caumanns, Yuxi Yao, Nicholas Mikolajewicz, Catherine Ross, Kevin R. Brown, Abdelrahman Abou Zid, Zi Peng Fan, Shirley Hui, Jordan A. Krall, Donald M. Simons, Chloe J. Slater, Victor De Jesus, Lujia Tang, Richa Singh, Joshua E. Goldford, Sarah Martin, Qian Huang, Elizabeth A. Francis, Andrea Habsid, Ryan Climie, David Tieu, Jiarun Wei, Ren Li, Amy Hin Yan Tong, Michael Aregger, Katherine S. Chan, Hong Han, Xiaowei Wang, Patricia Mero, John H. Brumell, Antonio Finelli, Laurie Ailles, Gary Bader, Gromoslaw A. Smolen, Gillian A. Kingsbury, Traver Hart, Charles Kung, Jason Moffat
Nature. Author manuscript; available in PMC 2022 Apr 18.
Published in final edited form as: Nature. 2020 Oct; 586(7827): 120–126. Published online 2020 Sep 23. doi: 10.1038/s41586-020-2746-2
PMCID:
PMC9014559
AbstractArticlePDF–6.6M
11.
Conditional loss of IKKα in Osterix + cells has no effect on bone but leads to age-related loss of peripheral fat
Jennifer L. Davis, Nitin Kumar Pokhrel, Linda Cox, Nidhi Rohatgi, Roberta Faccio, Deborah J. Veis
Sci Rep. 2022; 12: 4915. Published online 2022 Mar 22. doi: 10.1038/s41598-022-08914-6
PMCID:
PMC8940989
AbstractArticlePDF–5.0M
12.
IKKα-deficient lung adenocarcinomas generate an immunosuppressive microenvironment by overproducing Treg-inducing cytokines
Na-Young Song, Xin Li, Buyong Ma, Jami Willette-Brown, Feng Zhu, Chengfei Jiang, Ling Su, Jyoti Shetty, Yongmei Zhao, Gongping Shi, Sayantan Banerjee, Xiaolin Wu, Bao Tran, Ruth Nussinov, Michael Karin, Yinling Hu
Proc Natl Acad Sci U S A. 2022 Feb 8; 119(6): e2120956119. Published online 2022 Feb 4. doi: 10.1073/pnas.2120956119
PMCID:
PMC8833198
AbstractArticlePDF–2.6M
13.
Deficiency of IKKα in Macrophages Mitigates Fibrosis Progression in the Kidney after Renal Ischemia-Reperfusion Injury
Feng Zhang, Li Fan, Hao Zhang, Wen-juan Huang, Dong Sun, Bin-bin Pan, Xin Wan, Chang-Chun Cao
J Immunol Res. 2021; 2021: 5521051. Published online 2021 Dec 7. doi: 10.1155/2021/5521051
PMCID:
PMC8670970
AbstractArticlePDF–2.6M
14.
The ubiquitin ligase HOIL-1L regulates immune responses by interacting with linear ubiquitin chains
Carlos Gomez-Diaz, Gustav Jonsson, Katrin Schodl, Luiza Deszcz, Annika Bestehorn, Kevin Eislmayr, Jorge Almagro, Anoop Kavirayani, Mayu Seida, Lilian M. Fennell, Astrid Hagelkruys, Pavel Kovarik, Josef M. Penninger, Fumiyo Ikeda
iScience. 2021 Nov 19; 24(11): 103241. Published online 2021 Oct 8. doi: 10.1016/j.isci.2021.103241
PMCID:
PMC8561004
AbstractArticlePDF–4.4M
15.
Lung Epithelial Signaling Mediates Early Vaccine-Induced CD4+ T Cell Activation and Mycobacterium tuberculosis Control
Shibali Das, Nancy D. Marin, Ekaterina Esaulova, Mushtaq Ahmed, Amanda Swain, Bruce A. Rosa, Makedonka Mitreva, Javier Rangel-Moreno, Mihai G. Netea, Luis B. Barreiro, Maziar Divangahi, Maxim N. Artyomov, Deepak Kaushal, Shabaana A. Khader
mBio. 2021 Jul-Aug; 12(4): e01468-21. Published online 2021 Jul 13. doi: 10.1128/mBio.01468-21
PMCID:
PMC8406195
AbstractArticlePDF–4.7M
16.
Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development
Francesco Bedogni, Robert F. Hevner
Front Mol Neurosci. 2021; 14: 686034. Published online 2021 Jul 12. doi: 10.3389/fnmol.2021.686034
PMCID:
PMC8313239
AbstractArticlePDF–1.6M
17.
IKKα deficiency disrupts the development of marginal zone and follicular B cells
Mumtaz Y. Balkhi, Jami Willette-Brown, Gabor Wittmann, Yinling Hu
Genes Immun. Author manuscript; available in PMC 2021 Jun 10.
Published in final edited form as: Genes Immun. 2019 Mar; 20(3): 224–233. Published online 2018 May 8. doi: 10.1038/s41435-018-0025-0
PMCID:
PMC8191388
AbstractArticlePDF–1.0M
18.
BraInMap elucidates the macromolecular connectivity landscape of mammalian brain
Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili
Cell Syst. Author manuscript; available in PMC 2021 Apr 22.
Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003
Correction in:
Cell Syst. 2020 Aug 26; 11(2): 208.
PMCID:
PMC7938770
AbstractArticlePDF–2.0M
19.
Annexin-A1 SUMOylation regulates microglial polarization after cerebral ischemia by modulating IKKα stability via selective autophagy
Xing Li, Qian Xia, Meng Mao, Huijuan Zhou, Lu Zheng, Yi Wang, Zhen Zeng, Lulu Yan, Yin Zhao, Jing Shi
Sci Adv. 2021 Jan; 7(4): eabc5539. Published online 2021 Jan 20. doi: 10.1126/sciadv.abc5539
PMCID:
PMC7817101
AbstractArticlePDF–2.8M
20.
Deletion of IKK2 in haematopoietic cells of adult mice leads to elevated interleukin-6, neutrophilia and fatal gastrointestinal inflammation
Karla C. Fischer, Carmel P. Daunt, Cédric S. Tremblay, Sheila Dias, James E. Vince, Anissa M. Jabbour
Cell Death Dis. 2021 Jan; 12(1): 28. Published online 2021 Jan 4. doi: 10.1038/s41419-020-03298-9
PMCID:
PMC7791118
AbstractArticlePDF–3.1M

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