PMC Links for GEO Profiles (Select 109231921) - PMC

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 106417524.

TMEM106B reduction does not rescue GRN deficiency in iPSC-derived human microglia and mouse models

Sara L. Dominguez, Benjamin I. Laufer, Arundhati Sengupta Ghosh, Qingling Li, Gaia Ruggeri, Maheswara Reddy Emani, Lilian Phu, Brad A. Friedman, Wendy Sandoval, Christopher M. Rose, Hai Ngu, Oded Foreman, Mike Reichelt, Yves Juste, Guita Lalehzadeh, Dennis Hansen, Helle Nymark, Denia Mellal, Helene Gylling, Łukasz J. Kiełpiński, Ben Chih, Baris Bingol, Casper C. Hoogenraad, William J. Meilandt, Amy Easton

iScience. 2023 Nov 17; 26(11): 108362. Published online 2023 Oct 29. doi: 10.1016/j.isci.2023.108362

PMCID:: PMC10641752

Abstract Article PDF–6.1M

Select item 106032975.

The TMEM106B T186S coding variant increases neurite arborization and synaptic density in primary hippocampal neurons

Quynh Nguyen, Caleb A. Wood, Peter J. Kim, Joanna L. Jankowsky

Front Neurosci. 2023; 17: 1275959. Published online 2023 Oct 13. doi: 10.3389/fnins.2023.1275959

PMCID:: PMC10603297

Abstract Article PDF–1.3M

Select item 104094966.

TMEM106B is a receptor mediating ACE2-independent SARS-CoV-2 cell entry

Jim Baggen, Maarten Jacquemyn, Leentje Persoons, Els Vanstreels, Valerie E. Pye, Antoni G. Wrobel, Valeria Calvaresi, Stephen R. Martin, Chloë Roustan, Nora B. Cronin, Eamonn Reading, Hendrik Jan Thibaut, Thomas Vercruysse, Piet Maes, Frederik De Smet, Angie Yee, Toey Nivitchanyong, Marina Roell, Natalia Franco-Hernandez, Herve Rhinn, Alusha Andre Mamchak, Maxime Ah Young-Chapon, Eric Brown, Peter Cherepanov, Dirk Daelemans

Cell. 2023 Aug 3; 186(16): 3427–3442.e22. doi: 10.1016/j.cell.2023.06.005

PMCID:: PMC10409496

Abstract Article PDF–13M

Select item 103718297.

AAV-GRN partially corrects motor deficits and ALS/FTLD-related pathology in Tmem106b^−/−Grn^−/− mice

Tuancheng Feng, Gregory Minevich, Pengan Liu, Henry Xin Qin, Glenn Wozniak, Jenny Pham, Khanh Pham, Akshata Korgaonkar, Michael Kurnellas, Nadine A. Defranoux, Hua Long, Ananya Mitra, Fenghua Hu

iScience. 2023 Jul 21; 26(7): 107247. Published online 2023 Jun 28. doi: 10.1016/j.isci.2023.107247

PMCID:: PMC10371829

Abstract Article PDF–6.9M

Select item 103401768.

TMEM106B Puncta Is Increased in Multiple Sclerosis Plaques, and Reduced Protein in Mice Results in Delayed Lipid Clearance Following CNS Injury

Bridget Shafit-Zagardo, Simone Sidoli, James E. Goldman, Juwen C. DuBois, John R. Corboy, Stephen M. Strittmatter, Hillary Guzik, Ukuemi Edema, Anita G. Arackal, Yair M. Botbol, Emilio Merheb, Rashed M. Nagra, Sarah Graff

Cells. 2023 Jul; 12(13): 1734. Published online 2023 Jun 27. doi: 10.3390/cells12131734

PMCID:: PMC10340176

Abstract Article PDF–19M

Select item 101626779.

TMEM106B regulates microglial proliferation and survival in response to demyelination

Tingting Zhang, Weilun Pang, Tuancheng Feng, Jennifer Guo, Kenton Wu, Mariela Nunez Santos, Akshayakeerthi Arthanarisami, Alissa L. Nana, Quynh Nguyen, Peter J. Kim, Joanna L. Jankowsky, William W. Seeley, Fenghua Hu

Sci Adv. 2023 May; 9(18): eadd2676. Published online 2023 May 5. doi: 10.1126/sciadv.add2676

PMCID:: PMC10162677

Abstract Article PDF–2.9M

Select item 988126810.

Lack of a protective effect of the Tmem106b “protective SNP” in the Grn knockout mouse model for frontotemporal lobar degeneration

Anne-Sophie Cabron, Uwe Borgmeyer, Julia Richter, Helga Peisker, Katharina Gutbrod, Peter Dörmann, Anja Capell, Markus Damme

Acta Neuropathol Commun. 2023; 11: 21. Published online 2023 Jan 27. doi: 10.1186/s40478-023-01510-3

PMCID:: PMC9881268

Abstract Article PDF–4.5M

Select item 891960111.

TMEM106B deficiency impairs cerebellar myelination and synaptic integrity with Purkinje cell loss

Tuancheng Feng, Lin Luan, Isabel Iscol Katz, Mohammed Ullah, Vivianna M. Van Deerlin, John Q. Trojanowski, Edward B. Lee, Fenghua Hu

Acta Neuropathol Commun. 2022; 10: 33. Published online 2022 Mar 14. doi: 10.1186/s40478-022-01334-7

PMCID:: PMC8919601

Abstract Article PDF–3.5M

Select item 847719312.

Spreading of Alzheimer tau seeds is enhanced by aging and template matching with limited impact of amyloid-β

Sarah Helena Nies, Hideyuki Takahashi, Charlotte S. Herber, Anita Huttner, Alison Chase, Stephen M. Strittmatter

J Biol Chem. 2021 Oct; 297(4): 101159. Published online 2021 Sep 2. doi: 10.1016/j.jbc.2021.101159

PMCID:: PMC8477193

Abstract Article PDF–6.8M

Select item 841208413.

Loss of Tmem106b leads to cerebellum Purkinje cell death and motor deficits

Rosa Rademakers, Alexandra M. Nicholson, Yingxue Ren, Shunsuke Koga, Hung Phuoc Nguyen, Mieu Brooks, Wenhui Qiao, Zachary S. Quicksall, Billie Matchett, Ralph B. Perkerson, Aishe Kurti, Monica Castanedes‐Casey, Virginia Phillips, Ariston L Librero, Cristhoper H. Fernandez De Castro, Matthew C. Baker, Shanu F. Roemer, Melissa E. Murray, Yan Asmann, John D. Fryer, Guojun Bu, Dennis W. Dickson, Xiaolai Zhou

Brain Pathol. 2021 May; 31(3): e12945. Published online 2021 Mar 11. doi: 10.1111/bpa.12945

PMCID:: PMC8412084

Abstract Article PDF–1.0M

Select item 801811914.

Aged Tmem106b knockout mice display gait deficits in coincidence with Purkinje cell loss and only limited signs of non‐motor dysfunction

Stijn Stroobants, Rudi D’Hooge, Markus Damme

Brain Pathol. 2021 Mar; 31(2): 223–238. Published online 2020 Nov 1. doi: 10.1111/bpa.12903

PMCID:: PMC8018119

Abstract Article PDF–1.4M

Select item 799011815.

Fronto-temporal dementia risk gene TMEM106B has opposing effects in different lysosomal storage disorders

Azucena Perez-Canamas, Hideyuki Takahashi, Jane A Lindborg, Stephen M Strittmatter

Brain Commun. 2021; 3(1): fcaa200. Published online 2020 Nov 16. doi: 10.1093/braincomms/fcaa200

PMCID:: PMC7990118

Abstract Article PDF–1.7M

Select item 753463816.

Loss of Tmem106b exacerbates FTLD pathologies and causes motor deficits in progranulin‐deficient mice

Xiaolai Zhou, Mieu Brooks, Peizhou Jiang, Shunsuke Koga, Aamir R Zuberi, Matthew C Baker, Tammee M Parsons, Monica Castanedes‐Casey, Virginia Phillips, Ariston L Librero, Aishe Kurti, John D Fryer, Guojun Bu, Cathleen Lutz, Dennis W Dickson, Rosa Rademakers

EMBO Rep. 2020 Oct 5; 21(10): e50197. Published online 2020 Aug 5. doi: 10.15252/embr.202050197

PMCID:: PMC7534638

Abstract Article PDF–6.3M

Select item 753463617.

Loss of TMEM106B and PGRN leads to severe lysosomal abnormalities and neurodegeneration in mice

Tuancheng Feng, Shuyi Mai, Jenn Marie Roscoe, Rory R Sheng, Mohammed Ullah, Junke Zhang, Isabel Iscol Katz, Haiyuan Yu, Wenjun Xiong, Fenghua Hu

EMBO Rep. 2020 Oct 5; 21(10): e50219. Published online 2020 Aug 10. doi: 10.15252/embr.202050219

PMCID:: PMC7534636

Abstract Article PDF–11M

Select item 753463518.

Progranulin and TMEM106B: when two become wan

Emma L Clayton, Adrian M Isaacs

EMBO Rep. 2020 Oct 5; 21(10): e51668. Published online 2020 Sep 28. doi: 10.15252/embr.202051668

PMCID:: PMC7534635

Abstract Article PDF–562K

Select item 753463319.

Loss of TMEM106B potentiates lysosomal and FTLD‐like pathology in progranulin‐deficient mice

Georg Werner, Markus Damme, Martin Schludi, Johannes Gnörich, Karin Wind, Katrin Fellerer, Benedikt Wefers, Wolfgang Wurst, Dieter Edbauer, Matthias Brendel, Christian Haass, Anja Capell

EMBO Rep. 2020 Oct 5; 21(10): e50241. Published online 2020 Sep 14. doi: 10.15252/embr.202050241

PMCID:: PMC7534633

Abstract Article PDF–4.5M

Select item 736349120.

A role of the frontotemporal lobar degeneration risk factor TMEM106B in myelination

Tuancheng Feng, Rory R Sheng, Santiago Solé-Domènech, Mohammed Ullah, Xiaolai Zhou, Christina S Mendoza, Laura Camila Martinez Enriquez, Isabel Iscol Katz, Daniel H Paushter, Peter M Sullivan, Xiaochun Wu, Frederick R Maxfield, Fenghua Hu

Brain. 2020 Jul; 143(7): 2255–2271. Published online 2020 Jun 23. doi: 10.1093/brain/awaa154

PMCID:: PMC7363491

Abstract Article PDF–1.5M

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