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Items: 1 to 20 of 142

1.
SETting up the genome: KMT2D and KDM6A genomic function in the Kabuki syndrome craniofacial developmental disorder
Karl B. Shpargel, Gabrielle Quickstad
Birth Defects Res. 2023 Dec 1; 115(20): 1885–1898. Published online 2023 Oct 6. doi: 10.1002/bdr2.2253
PMCID:
PMC11190966
AbstractArticlePDF–2.3M
2.
Interaction network of human early embryonic transcription factors
Lisa Gawriyski, Zenglai Tan, Xiaonan Liu, Iftekhar Chowdhury, Dicle Malaymar Pinar, Qin Zhang, Jere Weltner, Eeva-Mari Jouhilahti, Gong-Hong Wei, Juha Kere, Markku Varjosalo
EMBO Rep. 2024 Mar; 25(3): 1589–1622. Published online 2024 Jan 31. doi: 10.1038/s44319-024-00074-0
PMCID:
PMC10933267
AbstractArticlePDF–2.9M
3.
Epigenetic-focused CRISPR/Cas9 screen identifies (absent, small, or homeotic)2-like protein (ASH2L) as a regulator of glioblastoma cell survival
Ezgi Ozyerli-Goknar, Ezgi Yagmur Kala, Ali Cenk Aksu, Ipek Bulut, Ahmet Cingöz, Sheikh Nizamuddin, Martin Biniossek, Fidan Seker-Polat, Tunc Morova, Can Aztekin, Sonia H. Y. Kung, Hamzah Syed, Nurcan Tuncbag, Mehmet Gönen, Martin Philpott, Adam P. Cribbs, Ceyda Acilan, Nathan A. Lack, Tamer T. Onder, H. T. Marc Timmers, Tugba Bagci-Onder
Cell Commun Signal. 2023; 21: 328. Published online 2023 Nov 16. doi: 10.1186/s12964-023-01335-6
PMCID:
PMC10652464
AbstractArticlePDF–8.0M
4.
The KDM6A-KMT2D-p300 axis regulates susceptibility to diverse coronaviruses by mediating viral receptor expression
Jin Wei, Mia Madel Alfajaro, Wesley L. Cai, Vincent R. Graziano, Madison S. Strine, Renata B. Filler, Scott B. Biering, Sylvia A. Sarnik, Sonam Patel, Bridget L. Menasche, Susan R. Compton, Silvana Konermann, Patrick D. Hsu, Robert C. Orchard, Qin Yan, Craig B. Wilen
PLoS Pathog. 2023 Jul; 19(7): e1011351. Published online 2023 Jul 6. doi: 10.1371/journal.ppat.1011351
PMCID:
PMC10325096
AbstractArticlePDF–2.9M
5.
Catalytic domain-dependent and -independent transcriptional activities of the tumour suppressor histone H3K27 demethylase UTX/KDM6A in specific cancer types
Wendi Sun, Kian Leong Lee, Lorenz Poellinger, Hisao Masai, Hiroyuki Kato
Epigenetics. 2023; 18(1): 2222245. Published online 2023 Jun 10. doi: 10.1080/15592294.2023.2222245
PMCID:
PMC10259304
AbstractArticlePDF–1.8M
6.
TRIM28 represses renal cell carcinoma cell proliferation by inhibiting TFE3/KDM6A-regulated autophagy
Tanjing Song, Suli Lv, Xianyun Ma, Xuefeng Zhao, Li Fan, Qingli Zou, Neng Li, Yingying Yan, Wen Zhang, Lidong Sun
J Biol Chem. 2023 May; 299(5): 104621. Published online 2023 Mar 18. doi: 10.1016/j.jbc.2023.104621
PMCID:
PMC10141522
AbstractArticlePDF–2.5M
7.
Homeobox A3 and KDM6A cooperate in transcriptional control of aerobic glycolysis and glioblastoma progression
Rui Yang, Guanghui Zhang, Zhen Dong, Shanshan Wang, Yanping Li, Fuming Lian, Xiaoran Liu, Haibin Li, Xiaonan Wei, Hongjuan Cui
Neuro Oncol. 2023 Apr; 25(4): 635–647. Published online 2022 Oct 10. doi: 10.1093/neuonc/noac231
PMCID:
PMC10076951
AbstractArticlePDF–9.1M
8.
Differential Occupancy and Regulatory Interactions of KDM6A in Bladder Cell Lines
Gülden Özden-Yılmaz, Busra Savas, Ahmet Bursalı, Aleyna Eray, Alirıza Arıbaş, Serif Senturk, Ezgi Karaca, Gökhan Karakülah, Serap Erkek-Ozhan
Cells. 2023 Mar; 12(6): 836. Published online 2023 Mar 8. doi: 10.3390/cells12060836
PMCID:
PMC10047809
AbstractArticlePDF–4.1M
9.
KDM6A depletion in breast epithelial cells leads to reduced sensitivity to anticancer agents and increased TGF-β activity
Jin-Fen Xiao, Ley-Fang Kua, Ling-Wen Ding, Qiao-Yang Sun, Khine Nyein Myint, Xiu-Rong Chia, Nachiyappan Venkatachalam, Xinyi Loh, Jason E. Duex, Vanessa Neang, Siqin Zhou, Ying Li, Henry Yang, H. Phillip Koeffler, Dan Theodorescu
Mol Cancer Res. Author manuscript; available in PMC 2023 Mar 21.
Published in final edited form as: Mol Cancer Res. 2022 Apr 1; 20(4): 637–649. doi: 10.1158/1541-7786.MCR-21-0402
PMCID:
PMC10030164
AbstractArticlePDF–2.7M
10.
KDM6A Loss Triggers an Epigenetic Switch That Disrupts Urothelial Differentiation and Drives Cell Proliferation in Bladder Cancer
Hong Qiu, Vladimir Makarov, Jennifer K. Bolzenius, Angela Halstead, Yvonne Parker, Allen Wang, Gopakumar V. Iyer, Hannah Wise, Daniel Kim, Varna Thayaparan, Daniel J. Lindner, Georges-Pascal Haber, Angela H. Ting, Bing Ren, Timothy A. Chan, Vivek Arora, David B. Solit, Byron H. Lee
Cancer Res. 2023 Mar 15; 83(6): 814–829. Published online 2023 Jan 13. doi: 10.1158/0008-5472.CAN-22-1444
PMCID:
PMC10015223
AbstractArticlePDF–12M
11.
A whole genome CRISPR screen identifies AHR loss as a mechanism of resistance to a PARP7 inhibitor
Huadong Chen, Morgan E. Diolaiti, Patrick C. O’Leary, Ajda Rojc, Nevan J. Krogan, Minkyu Kim, Alan Ashworth
Mol Cancer Ther. Author manuscript; available in PMC 2023 Jan 5.
Published in final edited form as: Mol Cancer Ther. 2022 Jul 5; 21(7): 1076–1089. doi: 10.1158/1535-7163.MCT-21-0841
PMCID:
PMC9769698
AbstractArticlePDF–2.7M
12.
The SCF–FBXW7 E3 ubiquitin ligase triggers degradation of histone 3 lysine 4 methyltransferase complex component WDR5 to prevent mitotic slippage
Simon Hänle-Kreidler, Kai T. Richter, Ingrid Hoffmann
J Biol Chem. 2022 Dec; 298(12): 102703. Published online 2022 Nov 14. doi: 10.1016/j.jbc.2022.102703
PMCID:
PMC9764181
AbstractArticlePDF–2.1M
13.
KDM6A loss recruits tumor-associated neutrophils and promotes neutrophil extracellular trap formation in pancreatic cancer
Jing Yang, Lin Jin, Hong Sun Kim, Feng Tian, Zhujun Yi, Karan Bedi, Mats Ljungman, Marina Pasca di Magliano, Howard Crawford, Jiaqi Shi
Cancer Res. Author manuscript; available in PMC 2023 May 15.
Published in final edited form as: Cancer Res. 2022 Nov 15; 82(22): 4247–4260. doi: 10.1158/0008-5472.CAN-22-0968
PMCID:
PMC9669233
AbstractArticlePDF–4.0M
14.
CircNFIX regulates chondrogenesis and cartilage homeostasis by targeting the miR758‐3p/KDM6A axis
Hongyi Liao, Qingqiang Tu, Yunze Kang, Guping Mao, Zhiwen Li, Shu Hu, Puyi Sheng, Xudong Wang, Yiyang Xu, Dianbo Long, Yuanyuan Xu, Yan Kang, Ziji Zhang
Cell Prolif. 2022 Nov; 55(11): e13302. Published online 2022 Jul 5. doi: 10.1111/cpr.13302
PMCID:
PMC9628241
AbstractArticlePDF–17M
15.
Chr21 protein–protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer’s disease
Julia Viard, Yann Loe-Mie, Rachel Daudin, Malik Khelfaoui, Christine Plancon, Anne Boland, Francisco Tejedor, Richard L Huganir, Eunjoon Kim, Makoto Kinoshita, Guofa Liu, Volker Haucke, Thomas Moncion, Eugene Yu, Valérie Hindie, Henri Bléhaut, Clotilde Mircher, Yann Herault, Jean-François Deleuze, Jean-Christophe Rain, Michel Simonneau, Aude-Marie Lepagnol-Bestel
Life Sci Alliance. 2022 Dec; 5(12): e202101205. Published online 2022 Aug 1. doi: 10.26508/lsa.202101205
PMCID:
PMC9348576
AbstractArticlePDF–3.0M
16.
TRIM33 drives prostate tumor growth by stabilizing androgen receptor from Skp2‐mediated degradation
Mi Chen, Shreyas Lingadahalli, Nitin Narwade, Kate Man Kei Lei, Shanshan Liu, Zuxianglan Zhao, Yimin Zheng, Qian Lu, Alexander Hin Ning Tang, Terence Chuen Wai Poon, Edwin Cheung
EMBO Rep. 2022 Aug; 23(8): e53468. Published online 2022 Jul 4. doi: 10.15252/embr.202153468
PMCID:
PMC9346471
AbstractArticlePDF–5.2M
17.
Renal UTX-PHGDH-serine axis regulates metabolic disorders in the kidney and liver
Hong Chen, Chong Liu, Qian Wang, Mingrui Xiong, Xia Zeng, Dong Yang, Yunhao Xie, Hua Su, Yu Zhang, Yixue Huang, Yuchen Chen, Junqiu Yue, Chengyu Liu, Shun Wang, Kun Huang, Ling Zheng
Nat Commun. 2022; 13: 3835. Published online 2022 Jul 4. doi: 10.1038/s41467-022-31476-0
PMCID:
PMC9253056
AbstractArticlePDF–17M
18.
Histone H3K27 demethylase UTX compromises articular chondrocyte anabolism and aggravates osteoarthritic degeneration
Wei-Shiung Lian, Re-Wen Wu, Jih-Yang Ko, Yu-Shan Chen, Shao-Yu Wang, Chun-Ping Yu, Holger Jahr, Feng-Sheng Wang
Cell Death Dis. 2022 Jun; 13(6): 538. Published online 2022 Jun 8. doi: 10.1038/s41419-022-04985-5
PMCID:
PMC9178009
AbstractArticlePDF–4.9M
19.
Cullin 3 Exon 9 Deletion in Familial Hyperkalemic Hypertension Impairs Cullin3-Ring-E3 Ligase (CRL3) Dynamic Regulation and Cycling
Ilektra Kouranti, Waed Abdel Khalek, Stephani Mazurkiewicz, Irmine Loisel-Ferreira, Alexis M. Gautreau, Lionel Pintard, Xavier Jeunemaitre, Eric Clauser
Int J Mol Sci. 2022 May; 23(9): 5151. Published online 2022 May 5. doi: 10.3390/ijms23095151
PMCID:
PMC9105235
AbstractArticlePDF–5.8M
20.
The KDM6A-SPARCL1 axis blocks metastasis and regulates the tumour microenvironment of gastrointestinal stromal tumours by inhibiting the nuclear translocation of p65
Chaoyong Shen, Luyin Han, Baike Liu, Guixiang Zhang, Zhaolun Cai, Xiaonan Yin, Yuan Yin, Zhixin Chen, Bo Zhang
Br J Cancer. 2022 Jun 1; 126(10): 1457–1469. Published online 2022 Feb 8. doi: 10.1038/s41416-022-01728-3
PMCID:
PMC9090789
AbstractArticlePDF–2.7M

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