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Select item 108282691.

In-vivo screening implicates endoribonuclease Regnase-1 in modulating senescence-associated lysosomal changes

Richard Venz, Anita Goyala, Abel Soto-Gamez, Tugce Yenice, Marco Demaria, Collin Y. Ewald

GeroScience. 2024 Apr; 46(2): 1499–1514. Published online 2023 Aug 29. doi: 10.1007/s11357-023-00909-z

PMCID:: PMC10828269

Abstract Article PDF–3.0M

Select item 106176262.

SIN-3 acts in distinct complexes to regulate the germline transcriptional program in Caenorhabditis elegans

Valerie J. Robert, Matthieu Caron, Loic Gely, Annie Adrait, Victoria Pakulska, Yohann Couté, Manon Chevalier, Christian G. Riedel, Cecile Bedet, Francesca Palladino

Development. 2023 Nov 1; 150(21): dev201755. Published online 2023 Oct 17. doi: 10.1242/dev.201755

PMCID:: PMC10617626

Abstract Article

Select item 104418033.

Rege-1 promotes C. elegans survival by modulating IIS and TOR pathways

Yi-Ting Tsai, Chen-Hsi Chang, Hsin-Yue Tsai

PLoS Genet. 2023 Aug; 19(8): e1010869. Published online 2023 Aug 9. doi: 10.1371/journal.pgen.1010869

PMCID:: PMC10441803

Abstract Article PDF–3.9M

Select item 101779294.

AI-Predicted mTOR Inhibitor Reduces Cancer Cell Proliferation and Extends the Lifespan of C. elegans

Tinka Vidovic, Alexander Dakhovnik, Oleksii Hrabovskyi, Michael R. MacArthur, Collin Y. Ewald

Int J Mol Sci. 2023 May; 24(9): 7850. Published online 2023 Apr 25. doi: 10.3390/ijms24097850

PMCID:: PMC10177929

Abstract Article PDF–3.0M

Select item 98206705.

Isocitrate Dehydrogenase Alpha-1 Modulates Lifespan and Oxidative Stress Tolerance in Caenorhabditis elegans

Zhi-Han Lin, Shun-Ya Chang, Wen-Chi Shen, Yen-Hung Lin, Chiu-Lun Shen, Sin-Bo Liao, Yu-Chun Liu, Chang-Shi Chen, Tsui-Ting Ching, Horng-Dar Wang

Int J Mol Sci. 2023 Jan; 24(1): 612. Published online 2022 Dec 29. doi: 10.3390/ijms24010612

PMCID:: PMC9820670

Abstract Article PDF–2.9M

Select item 97108736.

Stimulation of RAS-dependent ROS signaling extends longevity by modulating a developmental program of global gene expression

Robyn Branicky, Ying Wang, Arman Khaki, Ju-Ling Liu, Maximilian Kramer-Drauberg, Siegfried Hekimi

Sci Adv. 2022 Dec; 8(48): eadc9851. Published online 2022 Nov 30. doi: 10.1126/sciadv.adc9851

PMCID:: PMC9710873

Abstract Article PDF–2.2M

Select item 96587097.

Quetiapine Shortens the Lifespan of Caenorhabditis elegans through DOP-2, DAF-2 and RSKS-1

Yizhou Jiang, Uma Gaur, Zhibai Cao, Sheng-Tao Hou, Wenhua Zheng

Int J Mol Sci. 2022 Nov; 23(21): 12927. Published online 2022 Oct 26. doi: 10.3390/ijms232112927

PMCID:: PMC9658709

Abstract Article PDF–1.5M

Select item 95148498.

H3K9me1/2 methylation limits the lifespan of daf-2 mutants in C. elegans

Meng Huang, Minjie Hong, Xinhao Hou, Chengming Zhu, Di Chen, Xiangyang Chen, Shouhong Guang, Xuezhu Feng

eLife. 2022; 11: e74812. Published online 2022 Sep 20. doi: 10.7554/eLife.74812

PMCID:: PMC9514849

Abstract Article PDF–2.1M

Select item 94955979.

Deregulation of Mitochondrial Calcium Handling Due to Presenilin Loss Disrupts Redox Homeostasis and Promotes Neuronal Dysfunction

Kerry C. Ryan, Jocelyn T. Laboy, Kenneth R. Norman

Antioxidants (Basel) 2022 Sep; 11(9): 1642. Published online 2022 Aug 24. doi: 10.3390/antiox11091642

PMCID:: PMC9495597

Abstract Article PDF–2.2M

Select item 948099010.

Nutrient sensing pathways regulating adult reproductive diapause in C. elegans

Moriah Eustice, Daniel Konzman, Jeff M. Reece, Salil Ghosh, Jhullian Alston, Tyler Hansen, Andy Golden, Michelle R. Bond, Lara K. Abramowitz, John A. Hanover

PLoS One. 2022; 17(9): e0274076. Published online 2022 Sep 16. doi: 10.1371/journal.pone.0274076

PMCID:: PMC9480990

Abstract Article PDF–2.1M

Select item 944864511.

Lysosome Inhibition Reduces Basal and Nutrient-Induced Fat Accumulation in Caenorhabditis elegans

Rui Lu, Juan Chen, Fangbin Wang, Lu Wang, Jian Liu, Yan Lin

Mol Cells. 2022 Sep 30; 45(9): 649–659. Published online 2022 Aug 29. doi: 10.14348/molcells.2022.0073

PMCID:: PMC9448645

Abstract Article PDF–2.5M

Select item 943784812.

Depletion of endogenously biotinylated carboxylases enhances the sensitivity of TurboID-mediated proximity labeling in Caenorhabditis elegans

Murat Artan, Markus Hartl, Weiqiang Chen, Mario de Bono

J Biol Chem. 2022 Sep; 298(9): 102343. Published online 2022 Aug 3. doi: 10.1016/j.jbc.2022.102343

PMCID:: PMC9437848

Abstract Article PDF–2.0M

Select item 917078313.

SGPL1 stimulates VPS39 recruitment to the mitochondria in MICU1 deficient cells

Joshua Jackson, Lena Wischhof, Enzo Scifo, Anna Pellizzer, Yiru Wang, Antonia Piazzesi, Debora Gentile, Sana Siddig, Miriam Stork, Chris E. Hopkins, Kristian Händler, Joachim Weis, Andreas Roos, Joachim L. Schultze, Pierluigi Nicotera, Dan Ehninger, Daniele Bano

Mol Metab. 2022 Jul; 61: 101503. Published online 2022 Apr 19. doi: 10.1016/j.molmet.2022.101503

PMCID:: PMC9170783

Abstract Article PDF–3.7M

Select item 903611814.

The TORC1 phosphoproteome in C. elegans reveals roles in transcription and autophagy

Aileen K. Sewell, Zachary C. Poss, Christopher C. Ebmeier, Jeremy R. Jacobsen, William M. Old, Min Han

iScience. 2022 May 20; 25(5): 104186. Published online 2022 Mar 31. doi: 10.1016/j.isci.2022.104186

PMCID:: PMC9036118

Abstract Article PDF–2.4M

Select item 852166415.

Context-specific regulation of lysosomal lipolysis through network-level diverting of transcription factor interactions

Vinod K. Mony, Anna Drangowska-Way, Reka Albert, Emma Harrison, Abbas Ghaddar, Mary Kate Horak, Wenfan Ke, Eyleen J. O’Rourke

Proc Natl Acad Sci U S A. 2021 Oct 12; 118(41): e2104832118. Published online 2021 Oct 4. doi: 10.1073/pnas.2104832118

PMCID:: PMC8521664

Abstract Article PDF–1.6M

Select item 852071316.

Increased mitochondrial calcium uptake and concomitant mitochondrial activity by presenilin loss promotes mTORC1 signaling to drive neurodegeneration

Kerry C. Ryan, Zahra Ashkavand, Shaarika Sarasija, Jocelyn T. Laboy, Rohan Samarakoon, Kenneth R. Norman

Aging Cell. 2021 Oct; 20(10): e13472. Published online 2021 Sep 9. doi: 10.1111/acel.13472

PMCID:: PMC8520713

Abstract Article PDF–1.6M

Select item 848782817.

Trigonelline Extends the Lifespan of C. Elegans and Delays the Progression of Age-Related Diseases by Activating AMPK, DAF-16, and HSF-1

Wen-Yu Zeng, Lin Tan, Cong Han, Zhuo-Ya Zheng, Gui-Sheng Wu, Huai-Rong Luo, Su-Lian Li

Oxid Med Cell Longev. 2021; 2021: 7656834. Published online 2021 Sep 25. doi: 10.1155/2021/7656834

PMCID:: PMC8487828

Abstract Article PDF–2.4M

Select item 846353918.

A PTEN variant uncouples longevity from impaired fitness in Caenorhabditis elegans with reduced insulin/IGF-1 signaling

Hae-Eun H. Park, Wooseon Hwang, Seokjin Ham, Eunah Kim, Ozlem Altintas, Sangsoon Park, Heehwa G. Son, Yujin Lee, Dongyeop Lee, Won Do Heo, Seung-Jae V. Lee

Nat Commun. 2021; 12: 5631. Published online 2021 Sep 24. doi: 10.1038/s41467-021-25920-w