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Select item 111391961.

Detailed molecular comparison between the inhibition mode of A/B-type carboxypeptidases in the zymogen state and by the endogenous inhibitor latexin

R. García-Castellanos, R. Bonet-Figueredo, I. Pallarés, S. Ventura, F. X. Avilés, J. Vendrell, F. X. Gomis-Rütha

Cell Mol Life Sci. 2005 Sep; 62(17): 1996–2014. Published online 2005 Aug 9. doi: 10.1007/s00018-005-5174-4

PMCID:: PMC11139196

Abstract Article PDF–7.3M

Select item 109957152.

CircCPA4 induces ASCT2 expression to promote tumor property of non‐small cell lung cancer cells in a miR‐145‐5p‐dependent manner

Zhenhua Zhang, Weiliang Liu, Tao Huang, Junyan Li, Hui Hu, Xinyu Xu, Zhigang Fan

Thorac Cancer. 2024 Apr; 15(10): 764–777. Published online 2024 Feb 24. doi: 10.1111/1759-7714.15257

PMCID:: PMC10995715

Abstract Article PDF–4.3M

Select item 108261573.

circCPA4 induces malignant behaviors of prostate cancer via miR-491-5p/SHOC2 feedback loop

Wenqing Xu, Zhihong Zhong, Long Gu, Yiming Xiao, BinShen Chen, Weilie Hu

Clinics (Sao Paulo) 2024 Jan-Dec; 79: 100314. Published online 2024 Jan 13. doi: 10.1016/j.clinsp.2023.100314

PMCID:: PMC10826157

Abstract Article PDF–3.8M

Select item 102374224.

TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing

Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan

Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233

PMCID:: PMC10237422

Abstract Article PDF–23M

Select item 92792855.

Scalable multiplex co-fractionation/mass spectrometry platform for accelerated protein interactome discovery

Pierre C. Havugimana, Raghuveera Kumar Goel, Sadhna Phanse, Ahmed Youssef, Dzmitry Padhorny, Sergei Kotelnikov, Dima Kozakov, Andrew Emili

Nat Commun. 2022; 13: 4043. Published online 2022 Jul 13. doi: 10.1038/s41467-022-31809-z

PMCID:: PMC9279285

Abstract Article PDF–2.5M

Select item 92778536.

A functional reference map of the RNF8 interactome in cancer

Chuanyang Liu, Jingyu Kuang, Yuxuan Wang, Ting Duan, Lu Min, Chenyu Lu, Tianyi Zhang, Ruifen Chen, Ying Wu, Lingyun Zhu

Biol Direct. 2022; 17: 17. Published online 2022 Jul 13. doi: 10.1186/s13062-022-00331-z

PMCID:: PMC9277853

Abstract Article PDF–5.9M

Select item 81650307.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 79765938.

Carboxypeptidase A4 negatively correlates with p53 expression and regulates the stemness of breast cancer cells

Yipeng Wang, Yibin Xie, Yanan Niu, Peng Song, Ye Liu, Joseph Burnett, Zhihua Yang, Duxin Sun, Yuliang Ran, Yang Li, Lichao Sun

Int J Med Sci. 2021; 18(8): 1753–1759. Published online 2021 Feb 18. doi: 10.7150/ijms.54954

PMCID:: PMC7976593

Abstract Article PDF–1.1M

Select item 72143959.

Carboxypeptidase A4 promotes cardiomyocyte hypertrophy through activating PI3K-AKT-mTOR signaling

Weinian Gao, Na Guo, Shuguang Zhao, Ziying Chen, Wenli Zhang, Fang Yan, Hongjuan Liao, Kui Chi

Biosci Rep. 2020 May 29; 40(5): BSR20200669. Published online 2020 May 11. doi: 10.1042/BSR20200669

PMCID:: PMC7214395

Abstract Article PDF–1.0M

Select item 685188410.

Downregulation of CPA4 inhibits non small–cell lung cancer growth by suppressing the AKT/c‐MYC pathway

Yangyang Fu, Lihuang Su, Mengsi Cai, Boyang Yao, Sisi Xiao, Qinlian He, Le Xu, Lehe Yang, Chengguang Zhao, Tingting Wan, Lianyou Shao, Liangxing Wang, Xiaoying Huang

Mol Carcinog. 2019 Nov; 58(11): 2026–2039. Published online 2019 Aug 9. doi: 10.1002/mc.23095

PMCID:: PMC6851884

Abstract Article PDF–11M

Select item 678687311.

A Genome-Wide Knockout Screen in Human Macrophages Identified Host Factors Modulating Salmonella Infection

Amy T. Y. Yeung, Yoon Ha Choi, Amy H. Y. Lee, Christine Hale, Hannes Ponstingl, Derek Pickard, David Goulding, Mark Thomas, Erin Gill, Jong Kyoung Kim, Allan Bradley, Robert E. W. Hancock, Gordon Dougan

mBio. 2019 Sep-Oct; 10(5): e02169-19. Published online 2019 Oct 8. doi: 10.1128/mBio.02169-19

PMCID:: PMC6786873

Abstract Article PDF–2.2M

Select item 676327112.

Mast cell peptidases (carboxypeptidase A and chymase)-mediated hydrolysis of human angiotensin-(1–12) substrate

Sarfaraz Ahmad, Kendra N. Wright, Xuming Sun, Leanne Groban, Carlos M. Ferrario

Biochem Biophys Res Commun. Author manuscript; available in PMC 2019 Oct 22.

Published in final edited form as: Biochem Biophys Res Commun. 2019 Oct 22; 518(4): 651–656. Published online 2019 Aug 26. doi: 10.1016/j.bbrc.2019.08.098

PMCID:: PMC6763271

Abstract Article PDF–558K

Select item 589141713.

Proteomic profiling of VCP substrates links VCP to K6‐linked ubiquitylation and c‐Myc function

Jan B Heidelberger, Andrea Voigt, Marina E Borisova, Giuseppe Petrosino, Stefanie Ruf, Sebastian A Wagner, Petra Beli

EMBO Rep. 2018 Apr; 19(4): e44754. Published online 2018 Feb 21. doi: 10.15252/embr.201744754

PMCID:: PMC5891417

Abstract Article PDF–1.0M

Select item 567858114.

RNA-binding activity of TRIM25 is mediated by its PRY/SPRY domain and is required for ubiquitination

Nila Roy Choudhury, Gregory Heikel, Maryia Trubitsyna, Peter Kubik, Jakub Stanislaw Nowak, Shaun Webb, Sander Granneman, Christos Spanos, Juri Rappsilber, Alfredo Castello, Gracjan Michlewski

BMC Biol. 2017; 15: 105. Published online 2017 Nov 8. doi: 10.1186/s12915-017-0444-9

PMCID:: PMC5678581

Abstract Article PDF–3.2M

Select item 553161115.

Architecture of the human interactome defines protein communities and disease networks

Edward L. Huttlin, Raphael J. Bruckner, Joao A. Paulo, Joe R. Cannon, Lily Ting, Kurt Baltier, Greg Colby, Fana Gebreab, Melanie P. Gygi, Hannah Parzen, John Szpyt, Stanley Tam, Gabriela Zarraga, Laura Pontano-Vaites, Sharan Swarup, Anne E. White, Devin K. Schweppe, Ramin Rad, Brian K. Erickson, Robert A. Obar, K.G. Guruharsha, Kejie Li, Spyros Artavanis-Tsakonas, Steven P. Gygi, J. Wade Harper

Nature. Author manuscript; available in PMC 2017 Nov 17.

Published in final edited form as: Nature. 2017 May 25; 545(7655): 505–509. Published online 2017 May 17. doi: 10.1038/nature22366

PMCID:: PMC5531611

Abstract Article PDF–2.7M

Select item 534667016.

Serum carboxypeptidaseA4 levels predict liver metastasis in colorectal carcinoma

Lichao Sun, Chunguang Guo, Joseph Burnett, Zhihua Yang, Yuliang Ran, Duxin Sun

Oncotarget. 2016 Nov 29; 7(48): 78688–78697. Published online 2016 Oct 21. doi: 10.18632/oncotarget.12798

PMCID:: PMC5346670

Abstract Article PDF–5.1M

Select item 503155817.

SPATA2 Links CYLD to LUBAC, Activates CYLD, and Controls LUBAC Signaling

Paul R. Elliott, Derek Leske, Matous Hrdinka, Katrin Bagola, Berthe K. Fiil, Stephen H. McLaughlin, Jane Wagstaff, Norbert Volkmar, John C. Christianson, Benedikt M. Kessler, Stefan M.V. Freund, David Komander, Mads Gyrd-Hansen

Mol Cell. 2016 Sep 15; 63(6): 990–1005. doi: 10.1016/j.molcel.2016.08.001

PMCID:: PMC5031558

Abstract Article PDF–5.9M

Select item 464794118.

hORFeome v3.1: A resource of human open reading frames representing over 10,000 human genes

Philippe Lamesch, Ning Li, Stuart Milstein, Changyu Fan, Tong Hao, Gabor Szabo, Zhenjun Hu, Kavitha Venkatesan, Graeme Bethel, Paul Martin, Jane Rogers, Stephanie Lawlor, Stuart McLaren, Amélie Dricot, Heather Borick, Michael E. Cusick, Jean Vandenhaute, Ian Dunham, David E. Hill, Marc Vidal

Genomics. 2007 Mar; 89(3): 307–315. doi: 10.1016/j.ygeno.2006.11.012

PMCID:: PMC4647941

Abstract Article

Select item 461721119.

The BioPlex Network: A Systematic Exploration of the Human Interactome

Edward L. Huttlin, Lily Ting, Raphael J. Bruckner, Fana Gebreab, Melanie P. Gygi, John Szpyt, Stanley Tam, Gabriela Zarraga, Greg Colby, Kurt Baltier, Rui Dong, Virginia Guarani, Laura Pontano Vaites, Alban Ordureau, Ramin Rad, Brian K. Erickson, Martin Wühr, Joel Chick, Bo Zhai, Deepak Kolippakkam, Julian Mintseris, Robert A. Obar, Tim Harris, Spyros Artavanis-Tsakonas, Mathew E. Sowa, Pietro DeCamilli, Joao A. Paulo, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2016 Jul 16.

Published in final edited form as: Cell. 2015 Jul 16; 162(2): 425–440. doi: 10.1016/j.cell.2015.06.043

PMCID:: PMC4617211

Abstract Article PDF–2.2M

Select item 330880120.

Crystal Structure of Novel Metallocarboxypeptidase Inhibitor from Marine Mollusk Nerita versicolor in Complex with Human Carboxypeptidase A4

Giovanni Covaleda, Maday Alonso del Rivero, María A. Chávez, Francesc X. Avilés, David Reverter

J Biol Chem. 2012 Mar 16; 287(12): 9250–9258. Published online 2012 Jan 31. doi: 10.1074/jbc.M111.330100

PMCID:: PMC3308801

Abstract Article PDF–1.8M

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