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Select item 111695661.

Human gastric cancer progression and stabilization of ATG2B through RNF5 binding facilitated by autophagy-associated CircDHX8

Guanxin Wei, Xiang Chen, Tuo Ruan, Xianxiong Ma, Xiuxian Zhu, Wenhao Wen, Danzeng He, Kaixiong Tao, Chuanqing Wu

Cell Death Dis. 2024 Jun; 15(6): 410. Published online 2024 Jun 12. doi: 10.1038/s41419-024-06782-8

PMCID:: PMC11169566

Abstract Article PDF–9.3M

Select item 105649272.

Downregulation of EphA2 stability by RNF5 limits its tumor-suppressive function in HER2-negative breast cancers

Xiaojuan Li, Fan Wang, Lu Huang, Mengtian Yang, Ersheng Kuang

Cell Death Dis. 2023 Oct; 14(10): 662. Published online 2023 Oct 10. doi: 10.1038/s41419-023-06188-y

PMCID:: PMC10564927

Abstract Article PDF–5.5M

Select item 98971593.

The E3 ligase RNF5 restricts SARS-CoV-2 replication by targeting its envelope protein for degradation

Zhaolong Li, Pengfei Hao, Zhilei Zhao, Wenying Gao, Chen Huan, Letian Li, Xiang Chen, Hong Wang, Ningyi Jin, Zhao-Qing Luo, Chang Li, Wenyan Zhang

Signal Transduct Target Ther. 2023; 8: 53. Published online 2023 Feb 3. doi: 10.1038/s41392-023-01335-5

Correction in:: Signal Transduct Target Ther. 2023; 8: 85.

PMCID:: PMC9897159

Abstract Article PDF–3.7M

Select item 98886814.

Suppression of KSHV lytic replication and primary effusion lymphoma by selective RNF5 inhibition

Xiaojuan Li, Fan Wang, Xiaolin Zhang, Qinqin Sun, Ersheng Kuang

PLoS Pathog. 2023 Jan; 19(1): e1011103. Published online 2023 Jan 19. doi: 10.1371/journal.ppat.1011103

PMCID:: PMC9888681

Abstract Article PDF–5.6M

Select item 96349775.

A small-molecule inhibitor and degrader of the RNF5 ubiquitin ligase

Jingjing Ruan, Dongdong Liang, Wenjing Yan, Yongwang Zhong, Daniel C. Talley, Ganesha Rai, Dingyin Tao, Christopher A. LeClair, Anton Simeonov, Yinghua Zhang, Feihu Chen, Nancy L. Quinney, Susan E. Boyles, Deborah M. Cholon, Martina Gentzsch, Mark J. Henderson, Fengtian Xue, Shengyun Fang

Mol Biol Cell. 2022 Nov 1; 33(13): ar120. Published online 2022 Nov 1. doi: 10.1091/mbc.E22-06-0233

PMCID:: PMC9634977

Abstract Article PDF–5.8M

Select item 94819336.

ALS-linked loss of Cyclin-F function affects HSP90

Alexander Siebert, Vanessa Gattringer, Jochen H Weishaupt, Christian Behrends

Life Sci Alliance. 2022 Dec; 5(12): e202101359. Published online 2022 Sep 16. doi: 10.26508/lsa.202101359

PMCID:: PMC9481933

Abstract Article PDF–3.5M

Select item 94087027.

Differential CFTR-Interactome Proximity Labeling Procedures Identify Enrichment in Multiple SLC Transporters

Benoît Chevalier, Nesrine Baatallah, Matthieu Najm, Solène Castanier, Vincent Jung, Iwona Pranke, Anita Golec, Véronique Stoven, Stefano Marullo, Fabrice Antigny, Ida Chiara Guerrera, Isabelle Sermet-Gaudelus, Aleksander Edelman, Alexandre Hinzpeter

Int J Mol Sci. 2022 Aug; 23(16): 8937. Published online 2022 Aug 11. doi: 10.3390/ijms23168937

PMCID:: PMC9408702

Abstract Article PDF–3.5M

Select item 93037468.

E3 ubiquitin ligase ring finger protein 5 protects against hepatic ischemia reperfusion injury by mediating phosphoglycerate mutase family member 5 ubiquitination

Ming‐Jie Ding, Hao‐Ran Fang, Jia‐Kai Zhang, Ji‐Hua Shi, Xiao Yu, Pei‐Hao Wen, Zhi‐Hui Wang, Sheng‐Li Cao, Yi Zhang, Xiao‐Yi Shi, Hua‐Peng Zhang, Yu‐Ting He, Bing Yan, Hong‐Wei Tang, Dan‐Feng Guo, Jie Gao, Zhen Liu, Li Zhang, Shui‐Jun Zhang, Xiao‐Jing Zhang, Wen‐Zhi Guo

Hepatology. 2022 Jul; 76(1): 94–111. Published online 2022 Jan 23. doi: 10.1002/hep.32226

PMCID:: PMC9303746

Abstract Article PDF–12M

Select item 91197369.

OpenCell: proteome-scale endogenous tagging enables the cartography of human cellular organization

Nathan H. Cho, Keith C. Cheveralls, Andreas-David Brunner, Kibeom Kim, André C. Michaelis, Preethi Raghavan, Hirofumi Kobayashi, Laura Savy, Jason Y. Li, Hera Canaj, James Y.S. Kim, Edna M. Stewart, Christian Gnann, Frank McCarthy, Joana P. Cabrera, Rachel M. Brunetti, Bryant B. Chhun, Greg Dingle, Marco Y. Hein, Bo Huang, Shalin B. Mehta, Jonathan S. Weissman, Rafael Gómez-Sjöberg, Daniel N. Itzhak, Loic A. Royer, Matthias Mann, Manuel D. Leonetti

Science. Author manuscript; available in PMC 2022 Sep 11.

Published in final edited form as: Science. 2022 Mar 11; 375(6585): eabi6983. Published online 2022 Mar 11. doi: 10.1126/science.abi6983

PMCID:: PMC9119736

Abstract Article PDF–3.3M

Select item 894193310.

The Role of REC8 in the Innate Immune Response to Viral Infection

Shengwen Chen, Qian Liu, Lini Zhang, Jiahuan Ma, Binbin Xue, Huiyi Li, Rilin Deng, Mengmeng Guo, Yan Xu, Renyun Tian, Jingjing Wang, Wenyan Cao, Qiong Yang, Luolin Wang, Xinran Li, Shun Liu, Di Yang, Haizhen Zhu

J Virol. 2022 Mar; 96(6): e02175-21. Prepublished online 2022 Feb 2. Published online 2022 Mar 23. doi: 10.1128/jvi.02175-21

PMCID:: PMC8941933

Abstract Article PDF–7.8M

Select item 890518911.

Metformin Combining PD-1 Inhibitor Enhanced Anti-Tumor Efficacy in STK11 Mutant Lung Cancer Through AXIN-1-Dependent Inhibition of STING Ubiquitination

Zhiguo Wang, Conghua Lu, Kejun Zhang, Caiyu Lin, Fang Wu, Xiaolin Tang, Di Wu, Yuanyao Dou, Rui Han, Yubo Wang, Chao Hou, Qin Ouyang, Mingxia Feng, Yong He, Li Li

Front Mol Biosci. 2022; 9: 780200. Published online 2022 Feb 23. doi: 10.3389/fmolb.2022.780200

PMCID:: PMC8905189

Abstract Article PDF–4.8M

Select item 880502712.

The E3 Ubiquitin Ligase RNF5 Facilitates SARS-CoV-2 Membrane Protein-Mediated Virion Release

Zhen Yuan, Bing Hu, Hurong Xiao, Xuan Tan, Yan Li, Ke Tang, Yonghui Zhang, Kun Cai, Binbin Ding

mBio. 2022 Jan-Feb; 13(1): e03168-21. Published online 2022 Feb 1. doi: 10.1128/mbio.03168-21

PMCID:: PMC8805027

Abstract Article PDF–4.4M

Select item 855290713.

SARS‐CoV‐2–host proteome interactions for antiviral drug discovery

Xiaonan Liu, Sini Huuskonen, Tuomo Laitinen, Taras Redchuk, Mariia Bogacheva, Kari Salokas, Ina Pöhner, Tiina Öhman, Arun Kumar Tonduru, Antti Hassinen, Lisa Gawriyski, Salla Keskitalo, Maria K Vartiainen, Vilja Pietiäinen, Antti Poso, Markku Varjosalo

Mol Syst Biol. 2021 Nov; 17(11): e10396. Published online 2021 Oct 28. doi: 10.15252/msb.202110396

PMCID:: PMC8552907

Abstract Article PDF–3.9M

Select item 848772114.

Identification of Smurf2 as a HIF-1α degrading E3 ubiquitin ligase

Shuai Zhao, Wafik S. El-Deiry

Oncotarget. 2021 Sep 28; 12(20): 1970–1979. Published online 2021 Sep 28. doi: 10.18632/oncotarget.28081

PMCID:: PMC8487721

Abstract Article PDF–3.1M

Select item 843797915.

The ubiquitin ligase RNF5 determines acute myeloid leukemia growth and susceptibility to histone deacetylase inhibitors

Ali Khateb, Anagha Deshpande, Yongmei Feng, Darren Finlay, Joo Sang Lee, Ikrame Lazar, Bertrand Fabre, Yan Li, Yu Fujita, Tongwu Zhang, Jun Yin, Ian Pass, Ido Livneh, Irmela Jeremias, Carol Burian, James R. Mason, Ronit Almog, Nurit Horesh, Yishai Ofran, Kevin Brown, Kristiina Vuori, Michael Jackson, Eytan Ruppin, Aniruddha J. Deshpande, Ze’ev A. Ronai

Nat Commun. 2021; 12: 5397. Published online 2021 Sep 13. doi: 10.1038/s41467-021-25664-7

PMCID:: PMC8437979

Abstract Article PDF–4.3M

Select item 823607816.

Comparative Host Interactomes of the SARS-CoV-2 Nonstructural Protein 3 and Human Coronavirus Homologs

Katherine M. Almasy, Jonathan P. Davies, Lars Plate

Mol Cell Proteomics. 2021; 20: 100120. Published online 2021 Jun 27. doi: 10.1016/j.mcpro.2021.100120

PMCID:: PMC8236078

Abstract Article PDF–4.6M

Select item 816503017.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 797189018.

JMJD6 negatively regulates cytosolic RNA induced antiviral signaling by recruiting RNF5 to promote activated IRF3 K48 ubiquitination

Wei Zhang, Qi Wang, Fan Yang, Zixiang Zhu, Yueyue Duan, Yang Yang, Weijun Cao, Keshan Zhang, Junwu Ma, Xiangtao Liu, Haixue Zheng

PLoS Pathog. 2021 Mar; 17(3): e1009366. Published online 2021 Mar 8. doi: 10.1371/journal.ppat.1009366

PMCID:: PMC7971890

Abstract Article PDF–3.3M

Select item 788043819.

The PB1 protein of influenza A virus inhibits the innate immune response by targeting MAVS for NBR1-mediated selective autophagic degradation

Yan Zeng, Shuai Xu, Yanli Wei, Xuegang Zhang, Qian Wang, Yane Jia, Wanbing Wang, Lu Han, Zhaoshan Chen, Zhengxiang Wang, Bo Zhang, Hualan Chen, Cao-Qi Lei, Qiyun Zhu

PLoS Pathog. 2021 Feb; 17(2): e1009300. Published online 2021 Feb 12. doi: 10.1371/journal.ppat.1009300

PMCID:: PMC7880438

Abstract Article PDF–5.2M

Select item 772476020.

Comparative multiplexed interactomics of SARS-CoV-2 and homologous coronavirus non-structural proteins identifies unique and shared host-cell dependencies

Jonathan P. Davies, Katherine M. Almasy, Eli F. McDonald, Lars Plate

ACS Infect Dis. Author manuscript; available in PMC 2024 Mar 5.

Published in final edited form as: ACS Infect Dis. 2020 Dec 11; 6(12): 3174–3189. Published online 2020 Dec 2. doi: 10.1021/acsinfecdis.0c00500

PMCID:: PMC7724760

Abstract Article PDF–2.1M

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