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Items: 1 to 20 of 112

1.
Autoinhibition of ubiquitin-specific protease 8: Insights into domain interactions and mechanisms of regulation
Cody Caba, Megan Black, Yujue Liu, Ashley A. DaDalt, Josh Mallare, Lixin Fan, Rachel J. Harding, Yun-Xing Wang, Panayiotis O. Vacratsis, Rui Huang, Zhihao Zhuang, Yufeng Tong
J Biol Chem. 2024 Oct; 300(10): 107727. Published online 2024 Aug 28. doi: 10.1016/j.jbc.2024.107727
PMCID:
PMC11467669
AbstractArticlePDF–2.3M
2.
DSBSO-Based XL-MS Analysis of Breast Cancer PDX Tissues to Delineate Protein Interaction Network in Clinical Samples
Fenglong Jiao, Clinton Yu, Andrew Wheat, Lijun Chen, Tung-Shing Mamie Lih, Hui Zhang, Lan Huang
J Proteome Res. Author manuscript; available in PMC 2024 Aug 3.
Published in final edited form as: J Proteome Res. 2024 Aug 2; 23(8): 3269–3279. Published online 2024 Feb 9. doi: 10.1021/acs.jproteome.3c00832
PMCID:
PMC11296914
AbstractArticlePDF–1.7M
3.
Antagonistic roles of canonical and alternative-RPA in disease-associated tandem CAG repeat instability
Terence Gall-Duncan, Jennifer Luo, Carla-Marie Jurkovic, Laura A. Fischer, Kyota Fujita, Amit L. Deshmukh, Rachel J. Harding, Stephanie Tran, Mustafa Mehkary, Vanessa Li, David E. Leib, Ran Chen, Hikari Tanaka, Amanda G. Mason, Dominique Lévesque, Mahreen Khan, Mortezaali Razzaghi, Tanya Prasolava, Stella Lanni, Nozomu Sato, Marie-Christine Caron, Gagan B. Panigrahi, Peixiang Wang, Rachel Lau, Arturo López Castel, Jean-Yves Masson, Lynette Tippett, Clinton Turner, Maria Spies, Albert R. La Spada, Eric I. Campos, Maurice A. Curtis, François-Michel Boisvert, Richard L.M. Faull, Beverly L. Davidson, Masayuki Nakamori, Hitoshi Okazawa, Marc S. Wold, Christopher E. Pearson
Cell. Author manuscript; available in PMC 2024 Oct 26.
Published in final edited form as: Cell. 2023 Oct 26; 186(22): 4898–4919.e25. Published online 2023 Oct 11. doi: 10.1016/j.cell.2023.09.008
PMCID:
PMC11209935
AbstractArticlePDF–3.0M
4.
K48- and K63-linked ubiquitin chain interactome reveals branch- and length-specific ubiquitin interactors
Anita Waltho, Oliver Popp, Christopher Lenz, Lukas Pluska, Mahil Lambert, Volker Dötsch, Philipp Mertins, Thomas Sommer
Life Sci Alliance. 2024 Aug; 7(8): e202402740. Published online 2024 May 21. doi: 10.26508/lsa.202402740
PMCID:
PMC11109483
AbstractArticlePDF–2.9M
5.
Polymorphic USP8 allele promotes Parkinson’s disease by inducing the accumulation of α-synuclein through deubiquitination
Shouhai Wu, Tongxiang Lin, Yang Xu
Cell Mol Life Sci. 2023 Dec; 80(12): 363. Published online 2023 Nov 19. doi: 10.1007/s00018-023-05006-0
PMCID:
PMC11072815
AbstractArticlePDF–11M
6.
USP8 prevents aberrant NF-κB and Nrf2 activation by counteracting ubiquitin signals from endosomes
Akinori Endo, Toshiaki Fukushima, Chikage Takahashi, Hikaru Tsuchiya, Fumiaki Ohtake, Sayaka Ono, Tony Ly, Yukiko Yoshida, Keiji Tanaka, Yasushi Saeki, Masayuki Komada
J Cell Biol. 2024 Mar 4; 223(3): e202306013. Published online 2024 Jan 5. doi: 10.1083/jcb.202306013
PMCID:
PMC10783432
AbstractArticlePDF–6.4M
7.
A Multipronged Unbiased Strategy Guides the Development of an Anti-EGFR/EPHA2–Bispecific Antibody for Combination Cancer Therapy
Amr El Zawily, Frederick S. Vizeacoumar, Renuka Dahiya, Sara L. Banerjee, Kalpana K. Bhanumathy, Hussain Elhasasna, Glinton Hanover, Jessica C. Sharpe, Malkon G. Sanchez, Paul Greidanus, R. Greg Stacey, Kyung-Mee Moon, Ilya Alexandrov, Juha P. Himanen, Dimitar B. Nikolov, Humphrey Fonge, Aaron P. White, Leonard J. Foster, Bingcheng Wang, Behzad M. Toosi, Nicolas Bisson, Tajib A. Mirzabekov, Franco J. Vizeacoumar, Andrew Freywald
Clin Cancer Res. 2023 Jul 14; 29(14): 2686–2701. Published online 2023 Mar 28. doi: 10.1158/1078-0432.CCR-22-2535
PMCID:
PMC10345963
AbstractArticlePDF–13M
8.
piRNA-1742 promotes renal cell carcinoma malignancy by regulating USP8 stability through binding to hnRNPU and thereby inhibiting MUC12 ubiquitination
Wentao Zhang, Zongtai Zheng, Keyi Wang, Weipu Mao, Xue Li, Guangchun Wang, Yuanyuan Zhang, Jianhua Huang, Ning Zhang, Pengfei Wu, Ji Liu, Haimin Zhang, Jianping Che, Bo Peng, Junhua Zheng, Wei Li, Xudong Yao
Exp Mol Med. 2023 Jun; 55(6): 1258–1271. Published online 2023 Jun 19. doi: 10.1038/s12276-023-01010-3
PMCID:
PMC10318070
AbstractArticlePDF–8.1M
9.
USP8 positively regulates hepatocellular carcinoma tumorigenesis and confers ferroptosis resistance through β-catenin stabilization
Jianing Tang, Guo Long, Liang Xiao, Ledu Zhou
Cell Death Dis. 2023 Jun; 14(6): 360. Published online 2023 Jun 13. doi: 10.1038/s41419-023-05747-7
PMCID:
PMC10264414
AbstractArticlePDF–5.4M
10.
TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing
Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan
Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233
PMCID:
PMC10237422
AbstractArticlePDF–23M
11.
Inhibition of the intracellular domain of Notch1 results in vascular endothelial cell dysfunction in sepsis
Tingyan Liu, Caiyan Zhang, Jiayun Ying, Yaodong Wang, Gangfeng Yan, Yufeng Zhou, Guoping Lu
Front Immunol. 2023; 14: 1134556. Published online 2023 May 2. doi: 10.3389/fimmu.2023.1134556
PMCID:
PMC10185824
AbstractArticlePDF–27M
12.
USP8 Down-Regulation Promotes Parkin-Independent Mitophagy in the Drosophila Brain and in Human Neurons
Sofia Mauri, Greta Bernardo, Aitor Martinez, Mariavittoria Favaro, Marta Trevisan, Gael Cobraiville, Marianne Fillet, Federico Caicci, Alexander J. Whitworth, Elena Ziviani
Cells. 2023 Apr; 12(8): 1143. Published online 2023 Apr 13. doi: 10.3390/cells12081143
PMCID:
PMC10136645
AbstractArticlePDF–4.7M
13.
Reciprocal regulatory balance within the CLEC16A–RNF41 mitophagy complex depends on an intrinsically disordered protein region
Morgan A. Gingerich, Jie Zhu, Biaoxin Chai, Michael P. Vincent, Nuli Xie, Vaibhav Sidarala, Nicholas A. Kotov, Debashish Sahu, Daniel J. Klionsky, Santiago Schnell, Scott A. Soleimanpour
J Biol Chem. 2023 Apr; 299(4): 103057. Published online 2023 Feb 22. doi: 10.1016/j.jbc.2023.103057
PMCID:
PMC10066562
AbstractArticlePDF–1.8M
14.
Targeting ubiquitin-specific protease 8 sensitizes anti-programmed death-ligand 1 immunotherapy of pancreatic cancer
Hanshen Yang, Xiaozhen Zhang, Mengyi Lao, Kang Sun, Lihong He, Jian Xu, Yi Duan, Yan Chen, Honggang Ying, Muchun Li, Chengxiang Guo, Qingsong Lu, Sicheng Wang, Wei Su, Tingbo Liang, Xueli Bai
Cell Death Differ. 2023 Feb; 30(2): 560–575. Published online 2022 Dec 20. doi: 10.1038/s41418-022-01102-z
PMCID:
PMC9950432
AbstractArticlePDF–13M
15.
ALS-linked loss of Cyclin-F function affects HSP90
Alexander Siebert, Vanessa Gattringer, Jochen H Weishaupt, Christian Behrends
Life Sci Alliance. 2022 Dec; 5(12): e202101359. Published online 2022 Sep 16. doi: 10.26508/lsa.202101359
PMCID:
PMC9481933
AbstractArticlePDF–3.5M
16.
Identification and validation of Selective Deubiquitinase Inhibitors
Anthony C. Varca, Dominick Casalena, Wai Cheung Chan, Bin Hu, Robert S. Magin, Rebekka M. Roberts, Xiaoxi Liu, He Zhu, Hyuk-Soo Seo, Sirano Dhe-Paganon, Jarrod A. Marto, Douglas Auld, Sara J. Buhrlage
Cell Chem Biol. Author manuscript; available in PMC 2022 Dec 16.
Published in final edited form as: Cell Chem Biol. 2021 Dec 16; 28(12): 1758–1771.e13. Published online 2021 Jun 14. doi: 10.1016/j.chembiol.2021.05.012
PMCID:
PMC9473745
AbstractArticlePDF–2.3M
17.
USP8 promotes cancer progression and extracellular vesicle‐mediated CD8+ T cell exhaustion by deubiquitinating the TGF‐β receptor TβRII
Feng Xie, Xiaoxue Zhou, Heyu Li, Peng Su, Sijia Liu, Ran Li, Jing Zou, Xiang Wei, Chen Pan, Zhengkui Zhang, Min Zheng, Zhuang Liu, Xuli Meng, Huib Ovaa, Peter ten Dijke, Fangfang Zhou, Long Zhang
EMBO J. 2022 Aug; 41(16): e108791. Published online 2022 Jul 11. doi: 10.15252/embj.2021108791
PMCID:
PMC9379553
AbstractArticlePDF–5.6M
18.
Chr21 protein–protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer’s disease
Julia Viard, Yann Loe-Mie, Rachel Daudin, Malik Khelfaoui, Christine Plancon, Anne Boland, Francisco Tejedor, Richard L Huganir, Eunjoon Kim, Makoto Kinoshita, Guofa Liu, Volker Haucke, Thomas Moncion, Eugene Yu, Valérie Hindie, Henri Bléhaut, Clotilde Mircher, Yann Herault, Jean-François Deleuze, Jean-Christophe Rain, Michel Simonneau, Aude-Marie Lepagnol-Bestel
Life Sci Alliance. 2022 Dec; 5(12): e202101205. Published online 2022 Aug 1. doi: 10.26508/lsa.202101205
PMCID:
PMC9348576
AbstractArticlePDF–3.0M
19.
HSF1 phosphorylation establishes an active chromatin state via the TRRAP–TIP60 complex and promotes tumorigenesis
Mitsuaki Fujimoto, Ryosuke Takii, Masaki Matsumoto, Mariko Okada, Keiich I. Nakayama, Ryuichiro Nakato, Katsunori Fujiki, Katsuhiko Shirahige, Akira Nakai
Nat Commun. 2022; 13: 4355. Published online 2022 Jul 29. doi: 10.1038/s41467-022-32034-4
PMCID:
PMC9338313
AbstractArticlePDF–2.8M
20.
Scalable multiplex co-fractionation/mass spectrometry platform for accelerated protein interactome discovery
Pierre C. Havugimana, Raghuveera Kumar Goel, Sadhna Phanse, Ahmed Youssef, Dzmitry Padhorny, Sergei Kotelnikov, Dima Kozakov, Andrew Emili
Nat Commun. 2022; 13: 4043. Published online 2022 Jul 13. doi: 10.1038/s41467-022-31809-z
PMCID:
PMC9279285
AbstractArticlePDF–2.5M

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