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Select item 66718501.

Neuroaxonal Dystrophy Caused by Group VIA Phospholipase A₂ Deficiency in Mice: A Model of Human Neurodegenerative Disease

Koei Shinzawa, Hisae Sumi, Masahito Ikawa, Yosuke Matsuoka, Masaru Okabe, Saburo Sakoda, Yoshihide Tsujimoto

J Neurosci. 2008 Feb 27; 28(9): 2212–2220. doi: 10.1523/JNEUROSCI.4354-07.2008

PMCID:: PMC6671850

Abstract Article PDF–893K

Select item 51878642.

PEDF Inhibits the Activation of NLRP3 Inflammasome in Hypoxia Cardiomyocytes through PEDF Receptor/Phospholipase A2

Zhongxin Zhou, Zhu Wang, Qiuhua Guan, Fan Qiu, Yufeng Li, Zhiwei Liu, Hao Zhang, Hongyan Dong, Zhongming Zhang

Int J Mol Sci. 2016 Dec; 17(12): 2064. Published online 2016 Dec 12. doi: 10.3390/ijms17122064

PMCID:: PMC5187864

Abstract Article PDF–2.0M

Select item 46239893.

H₂O₂-Activated Mitochondrial Phospholipase iPLA₂γ Prevents Lipotoxic Oxidative Stress in Synergy with UCP2, Amplifies Signaling via G-Protein–Coupled Receptor GPR40, and Regulates Insulin Secretion in Pancreatic β-Cells

Jan Ježek, Andrea Dlasková, Jaroslav Zelenka, Martin Jabůrek, Petr Ježek

Antioxid Redox Signal. 2015 Oct 20; 23(12): 958–972. doi: 10.1089/ars.2014.6195

PMCID:: PMC4623989

Abstract Article PDF–1.4M

Select item 43640034.

iPLA₂• Knockout Mouse, a Genetic Model for Progressive Human Motor Disorders, Develops Age-Related Neuropathology

Helene Blanchard, Ameer Y. Taha, Yewon Cheon, Hyung-Wook Kim, John Turk, Stanley I. Rapoport

Neurochem Res. Author manuscript; available in PMC 2015 Aug 1.

Published in final edited form as: Neurochem Res. 2014 Aug; 39(8): 1522–1532. Published online 2014 Jun 12. doi: 10.1007/s11064-014-1342-y

PMCID:: PMC4364003

Abstract Article PDF–1.2M

Select item 40228865.

Group VIA Phospholipase A₂ Mitigates Palmitate-induced β-Cell Mitochondrial Injury and Apoptosis

Haowei Song, Mary Wohltmann, Min Tan, Jack H. Ladenson, John Turk

J Biol Chem. 2014 May 16; 289(20): 14194–14210. Published online 2014 Mar 19. doi: 10.1074/jbc.M114.561910

PMCID:: PMC4022886

Abstract Article PDF–2.1M

Select item 39954616.

Regulation of the Ca-independent phospholipase A₂ in liver mitochondria by changes in the energetic state

Adam J. Rauckhorst, Kimberly M. Broekemeier, Douglas R. Pfeiffer

J Lipid Res. 2014 May; 55(5): 826–836. doi: 10.1194/jlr.M043307

PMCID:: PMC3995461

Abstract Article PDF–645K

Select item 37169127.

Group VIA Phospholipase A₂ Forms a Signaling Complex with the Calcium/Calmodulin-dependent Protein Kinase IIβ Expressed in Pancreatic Islet β-Cells

Zhepeng Wang, Sasanka Ramanadham, Zhongmin Alex Ma, Shunzhong Bao, David J. Mancuso, Richard W. Gross, John Turk

J Biol Chem. Author manuscript; available in PMC 2013 Jul 19.

Published in final edited form as: J Biol Chem. 2005 Feb 25; 280(8): 6840–6849. Published online 2004 Dec 2. doi: 10.1074/jbc.M405287200

PMCID:: PMC3716912

Abstract Article PDF–1.6M

Select item 36063428.

Assessing Phospholipase A₂ Activity toward Cardiolipin by Mass Spectrometry

Yuan-Hao Hsu, Darren S. Dumlao, Jian Cao, Edward A. Dennis

PLoS One. 2013; 8(3): e59267. Published online 2013 Mar 22. doi: 10.1371/journal.pone.0059267

Correction in:: PLoS One. 2013; 8(6): 10.1371/annotation/47607b18-ed69-4a08-8619-60c39bd83a13.

PMCID:: PMC3606342

Abstract Article PDF–1002K

Select item 33633309.

Severe disturbance in the Ca²⁺ signaling in astrocytes from mouse models of human infantile neuroaxonal dystrophy with mutated Pla2g6

Mikhail Strokin, Kevin L. Seburn, Gregory A. Cox, Kimberly A. Martens, Georg Reiser

Hum Mol Genet. 2012 Jun 15; 21(12): 2807–2814. Published online 2012 Mar 22. doi: 10.1093/hmg/dds108

PMCID:: PMC3363330

Abstract Article PDF–248K

Select item 324795010.

Identification of a cAMP-response Element in the Regulator of G-protein Signaling-2 (RGS2) Promoter as a Key Cis-regulatory Element for RGS2 Transcriptional Regulation by Angiotensin II in Cultured Vascular Smooth Muscles

Zhongwen Xie, Dexiang Liu, Shu Liu, Lindsay Calderon, Guogang Zhao, John Turk, Zhenheng Guo

J Biol Chem. 2011 Dec 30; 286(52): 44646–44658. Published online 2011 Nov 4. doi: 10.1074/jbc.M111.265462

PMCID:: PMC3247950

Abstract Article PDF–2.3M

Select item 323663211.

Phospholipase A₂ superfamily members play divergent roles after spinal cord injury

Rubèn López-Vales, Nader Ghasemlou, Adriana Redensek, Bradley J. Kerr, Efrosini Barbayianni, Georgia Antonopoulou, Constantinos Baskakis, Khizr I. Rathore, Violetta Constantinou-Kokotou, Daren Stephens, Takao Shimizu, Edward A. Dennis, George Kokotos, Samuel David

FASEB J. 2011 Dec; 25(12): 4240–4252. doi: 10.1096/fj.11-183186

PMCID:: PMC3236632

Abstract Article

Select item 317805912.

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas

Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042

PMCID:: PMC3178059

Abstract Article PDF–1.0M

Select item 296248413.

Effects of Endoplasmic Reticulum Stress on Group VIA Phospholipase A₂ in Beta Cells Include Tyrosine Phosphorylation and Increased Association with Calnexin

Haowei Song, Henry Rohrs, Min Tan, Mary Wohltmann, Jack H. Ladenson, John Turk

J Biol Chem. 2010 Oct 29; 285(44): 33843–33857. Published online 2010 Aug 23. doi: 10.1074/jbc.M110.153197

PMCID:: PMC2962484

Abstract Article PDF–3.9M

Select item 294482014.

Catalytic Function of PLA2G6 Is Impaired by Mutations Associated with Infantile Neuroaxonal Dystrophy but Not Dystonia-Parkinsonism

Laura A. Engel, Zheng Jing, Daniel E. O'Brien, Mengyang Sun, Paul T. Kotzbauer

PLoS One. 2010; 5(9): e12897. Published online 2010 Sep 23. doi: 10.1371/journal.pone.0012897

PMCID:: PMC2944820

Abstract Article PDF–340K

Select item 286738515.

Dexamethasone stimulates store-operated calcium entry and protein degradation in cultured L6 myotubes through a phospholipase A₂-dependent mechanism

Kiyoshi Itagaki, Michael Menconi, Bozena Antoniu, Qin Zhang, Patricia Gonnella, David Soybel, Carl Hauser, Per-Olof Hasselgren

Am J Physiol Cell Physiol. 2010 May; 298(5): C1127–C1139. Published online 2010 Jan 27. doi: 10.1152/ajpcell.00309.2009

PMCID:: PMC2867385

Abstract Article

Select item 286070616.

Intracellular phospholipase A₂ group IVA and group VIA play important roles in Wallerian degeneration and axon regeneration after peripheral nerve injury

Rubèn López-Vales, Xavier Navarro, Takao Shimizu, Constantinos Baskakis, George Kokotos, Violetta Constantinou-Kokotou, Daren Stephens, Edward A. Dennis, Samuel David

Brain. 2008 Oct; 131(10): 2620–2631. Published online 2008 Aug 21. doi: 10.1093/brain/awn188

Correction in:: Brain. 2010 Nov; 133(11): 3485.

PMCID:: PMC2860706

Abstract Article PDF–1.3M

Select item 284806917.

Evidence for Proteolytic Processing and Stimulated Organelle Redistribution of iPLA₂β

Haowei Song, Shunzhong Bao, Xiaoyong Lei, Chun Jin, Sheng Zhang, John Turk, Sasanka Ramanadham

Biochim Biophys Acta. Author manuscript; available in PMC 2011 May 1.

Published in final edited form as: Biochim Biophys Acta. 2010 May; 1801(5): 547–558. Published online 2010 Feb 2. doi: 10.1016/j.bbalip.2010.01.006

PMCID:: PMC2848069

Abstract Article PDF–2.3M

Select item 281758218.

The role of calcium-independent phospholipase A₂ in cardiolipin remodeling in the spontaneously hypertensive heart failure rat heart

Derek K. Zachman, Adam J. Chicco, Sylvia A. McCune, Robert C. Murphy, Russell L. Moore, Genevieve C. Sparagna

J Lipid Res. 2010 Mar; 51(3): 525–534. doi: 10.1194/jlr.M000646

PMCID:: PMC2817582

Abstract Article PDF–876K

Select item 278963419.

Establishment of an Improved Mouse Model for Infantile Neuroaxonal Dystrophy That Shows Early Disease Onset and Bears a Point Mutation in Pla2g6

Haruka Wada, Takuwa Yasuda, Ikuo Miura, Kazuhiko Watabe, Chika Sawa, Hajime Kamijuku, Satoshi Kojo, Masaru Taniguchi, Ichizo Nishino, Shigeharu Wakana, Hisahiro Yoshida, Ken-ichiro Seino

Am J Pathol. 2009 Dec; 175(6): 2257–2263. doi: 10.2353/ajpath.2009.090343