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Items: 1 to 20 of 64

1.
Genetic determinants of micronucleus formation in vivo
D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus
Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0
PMCID:
PMC10917660
AbstractArticlePDF–4.8M
2.
Furin Regulates the Alveolarization of Neonatal Lungs in a Mouse Model of Hyperoxic Lung Injury
Shin Kato, Osuke Iwata, Hiroyuki Kato, Satoko Fukaya, Yukari Imai, Shinji Saitoh
Biomolecules. 2023 Nov; 13(11): 1656. Published online 2023 Nov 16. doi: 10.3390/biom13111656
PMCID:
PMC10669361
AbstractArticlePDF–3.0M
3.
Loss of hypothalamic Furin affects POMC to proACTH cleavage and feeding behavior in high-fat diet-fed mice
Ilaria Coppola, Bas Brouwers, Leanne Walker, Ceyhun Alar, Sandra Meulemans, Anne White, Bruno Ramos-Molina, John W.M. Creemers
Mol Metab. 2022 Dec; 66: 101627. Published online 2022 Oct 29. doi: 10.1016/j.molmet.2022.101627
PMCID:
PMC9664468
AbstractArticlePDF–1.4M
4.
Neuropilin-1 Facilitates Pseudorabies Virus Replication and Viral Glycoprotein B Promotes Its Degradation in a Furin-Dependent Manner
Meng Chen, Meng-Hang Wang, Xue-Gang Shen, Hao Liu, Yu-Yuan Zhang, Jin-Mei Peng, Fandan Meng, Tong-Yun Wang, Yuan-Zhe Bai, Ming-Xia Sun, Zhi-Jun Tian, Xin Yin, Xue-Hui Cai, Yan-Dong Tang
J Virol. 2022 Oct; 96(20): e01318-22. Published online 2022 Sep 29. doi: 10.1128/jvi.01318-22
PMCID:
PMC9599266
AbstractArticlePDF–3.3M
5.
The proprotein convertase furin regulates the development of thymic epithelial cells to ensure central immune tolerance
Zhanfeng Liang, Zhaoqi Zhang, Qian Zhang, Xue Dong, Xiaofeng Yang, Jiayu Zhang, Tong Lei, John W.M. Creemers, Baojun Zhang, Yong Zhao
iScience. 2022 Oct 21; 25(10): 105233. Published online 2022 Sep 28. doi: 10.1016/j.isci.2022.105233
PMCID:
PMC9579486
AbstractArticlePDF–5.8M
6.
Differential Effects of Furin Deficiency on Insulin Receptor Processing and Glucose Control in Liver and Pancreatic β Cells of Mice
Ilaria Coppola, Bas Brouwers, Sandra Meulemans, Bruno Ramos-Molina, John W. M. Creemers
Int J Mol Sci. 2021 Jun; 22(12): 6344. Published online 2021 Jun 14. doi: 10.3390/ijms22126344
PMCID:
PMC8231939
AbstractArticlePDF–2.0M
7.
In Vivo Analysis of the Contribution of Proprotein Convertases to the Processing of FGF23
Omar Al Rifai, Delia Susan-Resiga, Rachid Essalmani, John W. M. Creemers, Nabil G. Seidah, Mathieu Ferron
Front Endocrinol (Lausanne) 2021; 12: 690681. Published online 2021 Jun 4. doi: 10.3389/fendo.2021.690681
PMCID:
PMC8213403
AbstractArticlePDF–6.4M
8.
BraInMap elucidates the macromolecular connectivity landscape of mammalian brain
Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili
Cell Syst. Author manuscript; available in PMC 2021 Apr 22.
Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003
Correction in:
Cell Syst. 2020 Aug 26; 11(2): 208.
PMCID:
PMC7938770
AbstractArticlePDF–2.0M
9.
Identification of Novel Genetic Regulatory Region for Proprotein Convertase FURIN and Interferon Gamma in T Cells
Zsuzsanna Ortutay, Anna Grönholm, Melina Laitinen, Melinda Keresztes-Andrei, Ismail Hermelo, Marko Pesu
Front Immunol. 2021; 12: 630389. Published online 2021 Feb 18. doi: 10.3389/fimmu.2021.630389
PMCID:
PMC7930619
AbstractArticlePDF–2.1M
10.
The half-life of the bone-derived hormone osteocalcin is regulated through O-glycosylation in mice, but not in humans
Omar Al Rifai, Catherine Julien, Julie Lacombe, Denis Faubert, Erandi Lira-Navarrete, Yoshiki Narimatsu, Henrik Clausen, Mathieu Ferron
eLife. 2020; 9: e61174. Published online 2020 Dec 7. doi: 10.7554/eLife.61174
PMCID:
PMC7822592
AbstractArticlePDF–2.6M
11.
Furin, a transcriptional target of NKX2-5, has an essential role in heart development and function
Laurent Dupays, Norma Towers, Sophie Wood, Anna David, Daniel J. Stuckey, Timothy Mohun
PLoS One. 2019; 14(3): e0212992. Published online 2019 Mar 6. doi: 10.1371/journal.pone.0212992
PMCID:
PMC6402701
AbstractArticlePDF–4.3M
12.
FURIN inhibition reduces vascular remodeling and atherosclerotic lesion progression in mice
Gopala K. Yakala, Hector A. Cabrera-Fuentes, Gustavo E. Crespo-Avilan, Chutima Rattanasopa, Alexandrina Burlacu, Benjamin L. George, Kaviya Anand, David Castano Mayan, Maria Corliano, Sauri Hernández-Reséndiz, Zihao Wu, Anne M.K. Schwerk, Amberlyn L.J. Tan, Laia Trigueros-Motos, Raphael Chevre, Tricia Chua, Robert Kleemann, Elisa A. Liehn, Derek J. Hausenloy, Sujoy Ghosh, Roshni R. Singaraja
Arterioscler Thromb Vasc Biol. Author manuscript; available in PMC 2020 Mar 1.
Published in final edited form as: Arterioscler Thromb Vasc Biol. 2019 Mar; 39(3): 387–401. doi: 10.1161/ATVBAHA.118.311903
PMCID:
PMC6393193
AbstractArticlePDF–2.8M
13.
Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors
Hyeonwoo Kim, Christiane D. Wrann, Mark Jedrychowski, Sara Vidoni, Yukiko Kitase, Kenichi Nagano, Chenhe Zhou, Joshua Chou, Virginia-Jeni A. Parkman, Scott J. Novick, Timothy S. Strutzenberg, Bruce D. Pascal, Phuong T. Le, Daniel J. Brooks, Alexander M. Roche, Kaitlyn K. Gerber, Laura Mattheis, Wenjing Chen, Hua Tu, Mary L. Bouxsein, Patrick R. Griffin, Roland Baron, Clifford J. Rosen, Lynda F. Bonewald, Bruce M. Spiegelman
Cell. Author manuscript; available in PMC 2019 Dec 13.
Published in final edited form as: Cell. 2018 Dec 13; 175(7): 1756–1768.e17. doi: 10.1016/j.cell.2018.10.025
Correction in:
Cell. 2019 Jul 11; 178(2): 507–508.
PMCID:
PMC6298040
AbstractArticlePDF–1.2M
14.
STAT6 and Furin Are Successive Triggers for the Production of TGFβ by T Cells
Yue Li, Weiren Liu, Xiaqun Guan, Jamie Truscott, John W. Creemers, Hung-Lin Chen, Marko Pesu, Rami G. El Abiad, Bahri Karacay, Joseph F. Urban, Jr, David E. Elliott, Mark H. Kaplan, Bruce R. Blazar, M. Nedim Ince
J Immunol. Author manuscript; available in PMC 2019 Nov 1.
Published in final edited form as: J Immunol. 2018 Nov 1; 201(9): 2612–2623. Published online 2018 Sep 28. doi: 10.4049/jimmunol.1700808
PMCID:
PMC6200631
AbstractArticlePDF–2.1M
15.
Influence of a Coronary Artery Disease–Associated Genetic Variant on FURIN Expression and Effect of Furin on Macrophage Behavior
Guojun Zhao, Wei Yang, Jingchun Wu, Bairu Chen, Xu Yang, Junhui Chen, David G. McVey, Catherine Andreadi, Peng Gong, Tom R. Webb, Nilesh J. Samani, Shu Ye
Arterioscler Thromb Vasc Biol. 2018 Aug; 38(8): 1837–1844. Published online 2018 Jul 5. doi: 10.1161/ATVBAHA.118.311030
PMCID:
PMC6092112
AbstractArticlePDF–1.0M
16.
Cleavage activates Dispatched for Sonic Hedgehog ligand release
Daniel P Stewart, Suresh Marada, William J Bodeen, Ashley Truong, Sadie Miki Sakurada, Tanushree Pandit, Shondra M Pruett-Miller, Stacey K Ogden
eLife. 2018; 7: e31678. Published online 2018 Jan 23. doi: 10.7554/eLife.31678
PMCID:
PMC5811216
AbstractArticlePDF–2.8M
17.
Proprotein convertase furin regulates osteocalcin and bone endocrine function
Omar Al Rifai, Jacqueline Chow, Julie Lacombe, Catherine Julien, Denis Faubert, Delia Susan-Resiga, Rachid Essalmani, John W.M. Creemers, Nabil G. Seidah, Mathieu Ferron
J Clin Invest. 2017 Nov 1; 127(11): 4104–4117. Published online 2017 Oct 3. doi: 10.1172/JCI93437
PMCID:
PMC5663350
AbstractArticlePDF–5.4M
18.
Oocyte-specific deletion of furin leads to female infertility by causing early secondary follicle arrest in mice
Tie-Gang Meng, Meng-Wen Hu, Xue-Shan Ma, Lin Huang, Qiu-Xia Liang, Yue Yuan, Yi Hou, Hongmei Wang, Heide Schatten, Zhen-Bo Wang, Qing-Yuan Sun
Cell Death Dis. 2017 Jun; 8(6): e2846. Published online 2017 Jun 1. doi: 10.1038/cddis.2017.231
PMCID:
PMC5520891
AbstractArticlePDF–7.1M
19.
Thrombin activation of protein C requires prior processing by a liver proprotein convertase
Rachid Essalmani, Delia Susan-Resiga, Johann Guillemot, Woojin Kim, Vatsal Sachan, Zuhier Awan, Ann Chamberland, Marie-Claude Asselin, Kévin Ly, Roxane Desjardins, Robert Day, Annik Prat, Nabil G. Seidah
J Biol Chem. 2017 Jun 23; 292(25): 10564–10573. Published online 2017 May 3. doi: 10.1074/jbc.M116.770040
Correction in:
J Biol Chem. 2017 Aug 18; 292(33): 13565.
PMCID:
PMC5481563
AbstractArticlePDF–1.1M
20.
Myeloid cell expressed proprotein convertase FURIN attenuates inflammation
Zuzet Martinez Cordova, Anna Grönholm, Ville Kytölä, Valentina Taverniti, Sanna Hämäläinen, Saara Aittomäki, Wilhelmiina Niininen, Ilkka Junttila, Antti Ylipää, Matti Nykter, Marko Pesu
Oncotarget. 2016 Aug 23; 7(34): 54392–54404. Published online 2016 Aug 5. doi: 10.18632/oncotarget.11106
PMCID:
PMC5342350
AbstractArticlePDF–2.9M

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