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Select item 110174361.

Truncated Dyrk1A aggravates neuronal apoptosis by inhibiting ASF‐mediated Bcl‐x exon 2b inclusion

Shuqiang Zhang, Junjie Zhong, Lian Xu, Yue Wu, Jie Xu, Jianhua Shi, Zhikai Gu, Xiaoyu Li, Nana Jin

CNS Neurosci Ther. 2024 Apr; 30(4): e14493. Published online 2023 Oct 21. doi: 10.1111/cns.14493

PMCID:: PMC11017436

Abstract Article PDF–12M

Select item 109902892.

An in vitro neurogenetics platform for precision disease modeling in the mouse

Daniel E. Cortes, Mélanie Escudero, Austin C. Korgan, Arojit Mitra, Alyssa Edwards, Selcan C. Aydin, Steven C. Munger, Kevin Charland, Zhong-Wei Zhang, Kristen M. S. O'Connell, Laura G. Reinholdt, Martin F. Pera

Sci Adv. 2024 Apr 5; 10(14): eadj9305. Published online 2024 Apr 3. doi: 10.1126/sciadv.adj9305

PMCID:: PMC10990289

Abstract Article PDF–7.4M

Select item 109248443.

MicroRNA-221-3p inhibits the inflammatory response of keratinocytes by regulating the DYRK1A/STAT3 signaling pathway to promote wound healing in diabetes

Keyan Hu, Lei Liu, Songtao Tang, Xin Zhang, Hongfeng Chang, Wenyang Chen, Taotao Fan, Lesha Zhang, Bing Shen, Qiu Zhang

Commun Biol. 2024; 7: 300. Published online 2024 Mar 9. doi: 10.1038/s42003-024-05986-0

PMCID:: PMC10924844

Abstract Article PDF–18M

Select item 108438014.

Sex-specific developmental alterations in DYRK1A expression in the brain of a Down syndrome mouse model

Laura E. Hawley, Megan Stringer, Abigail J. Deal, Andrew Folz, Charles R. Goodlett, Randall J. Roper

Neurobiol Dis. Author manuscript; available in PMC 2024 Feb 5.

Published in final edited form as: Neurobiol Dis. 2024 Jan; 190: 106359. Published online 2023 Nov 20. doi: 10.1016/j.nbd.2023.106359

PMCID:: PMC10843801

Abstract Article PDF–1.2M

Select item 107935735.

Deficits in neuronal architecture but not over-inhibition are main determinants of reduced neuronal network activity in a mouse model of overexpression of Dyrk1A

Linus Manubens-Gil, Meritxell Pons-Espinal, Thomas Gener, Inmaculada Ballesteros-Yañez, María Martínez de Lagrán, Mara Dierssen

Cereb Cortex. 2024 Jan; 34(1): bhad431. Published online 2023 Nov 23. doi: 10.1093/cercor/bhad431

PMCID:: PMC10793573

Abstract Article PDF–4.2M

Select item 107325246.

Haploid-genetic screening of trophectoderm specification identifies Dyrk1a as a repressor of totipotent-like status

Wenhao Zhang, Shengyi Sun, Qing Wang, Xu Li, Mei Xu, Qian Li, Yiding Zhao, Keli Peng, Chunmeng Yao, Yuna Wang, Ying Chang, Yan Liu, Xudong Wu, Qian Gao, Ling Shuai

Sci Adv. 2023 Dec 22; 9(51): eadi5683. Published online 2023 Dec 20. doi: 10.1126/sciadv.adi5683

PMCID:: PMC10732524

Abstract Article PDF–1.6M

Select item 103995367.

Over‐expression of Dyrk1A affects bleeding by modulating plasma fibronectin and fibrinogen level in mice

Guillaume Postic, Jean Solarz, Cécile Loubière, Janany Kandiah, Jaysen Sawmynaden, Frederic Adam, Marie Vilaire, Thibaut Léger, Jean‐Michel Camadro, Daniella Balduino Victorino, Marie‐Claude Potier, Eric Bun, Gautier Moroy, Alexandre Kauskot, Olivier Christophe, Nathalie Janel

J Cell Mol Med. 2023 Aug; 27(15): 2228–2238. Published online 2023 Jul 6. doi: 10.1111/jcmm.17817

PMCID:: PMC10399536

Abstract Article PDF–1.3M

Select item 102633568.

DYRK1A promotes viral entry of highly pathogenic human coronaviruses in a kinase-independent manner

Madison S. Strine, Wesley L. Cai, Jin Wei, Mia Madel Alfajaro, Renata B. Filler, Scott B. Biering, Sylvia Sarnik, Ryan D. Chow, Ajinkya Patil, Kasey S. Cervantes, Clayton K. Collings, Peter C. DeWeirdt, Ruth E. Hanna, Kevin Schofield, Christopher Hulme, Silvana Konermann, John G. Doench, Patrick D. Hsu, Cigall Kadoch, Qin Yan, Craig B. Wilen

PLoS Biol. 2023 Jun; 21(6): e3002097. Published online 2023 Jun 13. doi: 10.1371/journal.pbio.3002097

PMCID:: PMC10263356

Abstract Article PDF–2.6M

Select item 101633499.

Craniofacial dysmorphology in Down syndrome is caused by increased dosage of Dyrk1a and at least three other genes

Yushi Redhead, Dorota Gibbins, Eva Lana-Elola, Sheona Watson-Scales, Lisa Dobson, Matthias Krause, Karen J. Liu, Elizabeth M. C. Fisher, Jeremy B. A. Green, Victor L. J. Tybulewicz

Development. 2023 Apr 15; 150(8): dev201077. Published online 2023 Apr 26. doi: 10.1242/dev.201077

PMCID:: PMC10163349

Abstract Article

Select item 977548910.

Large-Scale Functional Assessment of Genes Involved in Rare Diseases with Intellectual Disabilities Unravels Unique Developmental and Behaviour Profiles in Mouse Models

Hamid Meziane, Marie-Christine Birling, Olivia Wendling, Sophie Leblanc, Aline Dubos, Mohammed Selloum, Guillaume Pavlovic, Tania Sorg, Vera M. Kalscheuer, Pierre Billuart, Frédéric Laumonnier, Jamel Chelly, Hans van Bokhoven, Yann Herault

Biomedicines. 2022 Dec; 10(12): 3148. Published online 2022 Dec 6. doi: 10.3390/biomedicines10123148

PMCID:: PMC9775489

Abstract Article PDF–2.8M

Select item 967585411.

Impaired macroglial development and axonal conductivity contributes to the neuropathology of DYRK1A-related intellectual disability syndrome

Isabel Pijuan, Elisa Balducci, Cristina Soto-Sánchez, Eduardo Fernández, María José Barallobre, Maria L. Arbonés

Sci Rep. 2022; 12: 19912. Published online 2022 Nov 19. doi: 10.1038/s41598-022-24284-5

PMCID:: PMC9675854

Abstract Article PDF–4.8M

Select item 952511812.

Relieving DYRK1A repression of MKL1 confers an adult-like phenotype to human infantile megakaryocytes

Kamaleldin E. Elagib, Ashton Brock, Cara M. Clementelli, Goar Mosoyan, Lorrie L. Delehanty, Ranjit K. Sahu, Alexandra Pacheco-Benichou, Corinne Fruit, Thierry Besson, Stephan W. Morris, Koji Eto, Chintan Jobaliya, Deborah L. French, Paul Gadue, Sandeep Singh, Xinrui Shi, Fujun Qin, Robert Cornelison, Hui Li, Camelia Iancu-Rubin, Adam N. Goldfarb

J Clin Invest. 2022 Oct 3; 132(19): e154839. Published online 2022 Oct 3. doi: 10.1172/JCI154839

PMCID:: PMC9525118

Abstract Article PDF–7.2M

Select item 934857613.

Chr21 protein–protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer’s disease

Julia Viard, Yann Loe-Mie, Rachel Daudin, Malik Khelfaoui, Christine Plancon, Anne Boland, Francisco Tejedor, Richard L Huganir, Eunjoon Kim, Makoto Kinoshita, Guofa Liu, Volker Haucke, Thomas Moncion, Eugene Yu, Valérie Hindie, Henri Bléhaut, Clotilde Mircher, Yann Herault, Jean-François Deleuze, Jean-Christophe Rain, Michel Simonneau, Aude-Marie Lepagnol-Bestel

Life Sci Alliance. 2022 Dec; 5(12): e202101205. Published online 2022 Aug 1. doi: 10.26508/lsa.202101205

PMCID:: PMC9348576

Abstract Article PDF–3.0M

Select item 927807714.

Inhibition of DYRK1A, via histone modification, promotes cardiomyocyte cell cycle activation and cardiac repair after myocardial infarction

Cong Lan, Caiyu Chen, Shuang Qu, Nian Cao, Hao Luo, Cheng Yu, Na Wang, Yuanzheng Xue, Xuewei Xia, Chao Fan, Hongmei Ren, Yongjian Yang, Pedro A. Jose, Zaicheng Xu, Gengze Wu, Chunyu Zeng

eBioMedicine. 2022 Aug; 82: 104139. Published online 2022 Jul 8. doi: 10.1016/j.ebiom.2022.104139

PMCID:: PMC9278077

Abstract Article PDF–4.8M

Select item 883246115.

DYRK1a mediates BAFF-induced noncanonical NF-κB activation to promote autoimmunity and B-cell leukemogenesis

Yanchuan Li, Xiaoping Xie, Zuliang Jie, Lele Zhu, Jin-Young Yang, Chun-Jung Ko, Tianxiao Gao, Antrix Jain, Sung Yun Jung, Natalia Baran, Marina Y. Konopleva, Xuhong Cheng, Shao-Cong Sun

Blood. 2021 Dec 9; 138(23): 2360–2371. doi: 10.1182/blood.2021011247

PMCID:: PMC8832461

Abstract Article

Select item 878782216.

Dyrk1a mutations cause undergrowth of cortical pyramidal neurons via dysregulated growth factor signaling

Jenna A. Levy, Christy W. LaFlamme, George Tsaprailis, Gogce Crynen, Damon T. Page

Biol Psychiatry. Author manuscript; available in PMC 2022 Sep 1.

Published in final edited form as: Biol Psychiatry. 2021 Sep 1; 90(5): 295–306. Published online 2021 Apr 8. doi: 10.1016/j.biopsych.2021.01.012

PMCID:: PMC8787822

Abstract Article PDF–3.0M

Select item 874425717.

The interactome of CLUH reveals its association to SPAG5 and its co-translational proximity to mitochondrial proteins

Mickaële Hémono, Alexandre Haller, Johana Chicher, Anne-Marie Duchêne, Richard Patryk Ngondo

BMC Biol. 2022; 20: 13. Published online 2022 Jan 10. doi: 10.1186/s12915-021-01213-y

PMCID:: PMC8744257

Abstract Article PDF–6.0M

Select item 862498318.

Skeletal Deficits in Male and Female down Syndrome Model Mice Arise Independent of Normalized Dyrk1a Expression in Osteoblasts

Jared R. Thomas, Kourtney Sloan, Kelsey Cave, Joseph M. Wallace, Randall J. Roper

Genes (Basel) 2021 Nov; 12(11): 1729. Published online 2021 Oct 28. doi: 10.3390/genes12111729

PMCID:: PMC8624983

Abstract Article PDF–2.7M

Select item 862127219.

DYRK1A Overexpression in Mice Downregulates the Gonadotropic Axis and Disturbs Early Stages of Spermatogenesis

Rodolphe Dard, Manon Moreau, Estelle Parizot, Farah Ghieh, Leslie Brehier, Nadim Kassis, Valérie Serazin, Antonin Lamaziere, Chrystèle Racine, Nathalie di Clemente, François Vialard, Nathalie Janel

Genes (Basel) 2021 Nov; 12(11): 1800. Published online 2021 Nov 16. doi: 10.3390/genes12111800

PMCID:: PMC8621272

Abstract Article PDF–2.5M

Select item 852881920.

Mice lacking DYRK2 exhibit congenital malformations with lung hypoplasia and altered Foxf1 expression gradient

Satomi Yogosawa, Makiko Ohkido, Takuro Horii, Yasumasa Okazaki, Jun Nakayama, Saishu Yoshida, Shinya Toyokuni, Izuho Hatada, Mitsuru Morimoto, Kiyotsugu Yoshida

Commun Biol. 2021; 4: 1204. Published online 2021 Oct 20. doi: 10.1038/s42003-021-02734-6

PMCID:: PMC8528819

Abstract Article PDF–3.6M

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