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Select item 110353811.

TREM2 alleviates white matter injury after traumatic brain injury in mice might be mediated by regulation of DHCR24/LXR pathway in microglia

Zhao Li, Shenghui Yu, Lin Li, Chao Zhou, Lin Wang, Shuang Tang, Nina Gu, Zhaosi Zhang, Zhijian Huang, Hong Chen, Wei Tang, Yingwen Wang, Xiaomin Yang, Xiaochuan Sun, Jin Yan

Clin Transl Med. 2024 Apr; 14(4): e1665. Published online 2024 Apr 22. doi: 10.1002/ctm2.1665

PMCID:: PMC11035381

Abstract Article PDF–16M

Select item 109176602.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 107344643.

3β-hydroxysteroid-Δ24 reductase dampens anti-viral innate immune responses by targeting K27 ubiquitination of MAVS and STING

Qian Liu, Shengwen Chen, Renyun Tian, Binbin Xue, Huiyi Li, Mengmeng Guo, Shun Liu, Ming Yan, Ruina You, Luoling Wang, Di Yang, Mengyu Wan, Haizhen Zhu

J Virol. 2023 Dec; 97(12): e01513-23. Published online 2023 Nov 30. doi: 10.1128/jvi.01513-23

PMCID:: PMC10734464

Abstract Article PDF–4.9M

Select item 102865074.

DHCR24 reverses Alzheimer’s disease-related pathology and cognitive impairment via increasing hippocampal cholesterol levels in 5xFAD mice

Wen-bin Zhang, Yue Huang, Xiao-rou Guo, Meng-qi Zhang, Xiang-shan Yuan, Heng-bing Zu

Acta Neuropathol Commun. 2023; 11: 102. Published online 2023 Jun 21. doi: 10.1186/s40478-023-01593-y

PMCID:: PMC10286507

Abstract Article PDF–13M

Select item 98673145.

DHCR24, a Key Enzyme of Cholesterol Synthesis, Serves as a Marker Gene of the Mouse Adrenal Gland Inner Cortex

Huifei Sophia Zheng, Yuan Kang, Qiongxia Lyu, Kristina Junghans, Courtney Cleary, Olivia Reid, Greer Cauthen, Karly Laprocina, Chen-Che Jeff Huang

Int J Mol Sci. 2023 Jan; 24(2): 933. Published online 2023 Jan 4. doi: 10.3390/ijms24020933

PMCID:: PMC9867314

Abstract Article PDF–10M

Select item 93955006.

DHCR24 Knockdown Induces Tau Hyperphosphorylation at Thr181, Ser199, Ser262, and Ser396 Sites via Activation of the Lipid Raft-Dependent Ras/MEK/ERK Signaling Pathway in C8D1A Astrocytes

Meiting Mai, Xiaorou Guo, Yue Huang, Wenbin Zhang, Yixuan Xu, Ying Zhang, Xiaojing Bai, Junfeng Wu, Hengbing Zu

Mol Neurobiol. 2022; 59(9): 5856–5873. Published online 2022 Jul 8. doi: 10.1007/s12035-022-02945-w

PMCID:: PMC9395500

Abstract Article PDF–7.3M

Select item 79387707.

BraInMap elucidates the macromolecular connectivity landscape of mammalian brain

Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili

Cell Syst. Author manuscript; available in PMC 2021 Apr 22.

Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003

Correction in:: Cell Syst. 2020 Aug 26; 11(2): 208.

PMCID:: PMC7938770

Abstract Article PDF–2.0M

Select item 79337908.

Generation and validation of a conditional knockout mouse model for desmosterolosis

Babunageswararao Kanuri, Vincent Fong, Sithara Raju Ponny, Ranjuna Weerasekera, Kirthi Pulakanti, Kriya S. Patel, Roman Tyshynsky, Shailendra B. Patel

J Lipid Res. 2021; 62: 100028. Published online 2021 Jan 30. doi: 10.1016/j.jlr.2021.100028

PMCID:: PMC7933790

Abstract Article PDF–2.3M

Select item 73827469.

3β-Hydroxysteroid-Δ24 Reductase (DHCR24) Protects Pancreatic β Cells from Endoplasmic Reticulum Stress-Induced Apoptosis by Scavenging Excessive Intracellular Reactive Oxygen Species

Yang Li, Xude Wang, Baoyu Yang, Haozhen Wang, Zhenzhong Ma, Ziyin Lu, Xiuli Lu, Bing Gao

J Diabetes Res. 2020; 2020: 3426902. Published online 2020 Jul 16. doi: 10.1155/2020/3426902

PMCID:: PMC7382746

Abstract Article PDF–3.1M

Select item 673918910.

Desmosterolosis and desmosterol homeostasis in the developing mouse brain

Luke B. Allen, Thiago C. Genaro-Mattos, Ned A. Porter, Károly Mirnics, Zeljka Korade

J Inherit Metab Dis. Author manuscript; available in PMC 2020 Sep 1.

Published in final edited form as: J Inherit Metab Dis. 2019 Sep; 42(5): 934–943. Published online 2019 Apr 8. doi: 10.1002/jimd.12088

PMCID:: PMC6739189

Abstract Article PDF–556K

Select item 645951011.

Mouse screen reveals multiple new genes underlying mouse and human hearing loss

Neil J. Ingham, Selina A. Pearson, Valerie E. Vancollie, Victoria Rook, Morag A. Lewis, Jing Chen, Annalisa Buniello, Elisa Martelletti, Lorenzo Preite, Chi Chung Lam, Felix D. Weiss, Zӧe Powis, Pim Suwannarat, Christopher J. Lelliott, Sally J. Dawson, Jacqueline K. White, Karen P. Steel

PLoS Biol. 2019 Apr; 17(4): e3000194. Published online 2019 Apr 11. doi: 10.1371/journal.pbio.3000194

PMCID:: PMC6459510

Abstract Article PDF–5.1M

Select item 538122612.

Fancd2 in vivo interaction network reveals a non-canonical role in mitochondrial function

Tingting Zhang, Wei Du, Andrew F. Wilson, Satoshi H. Namekawa, Paul R. Andreassen, Amom Ruhikanta Meetei, Qishen Pang

Sci Rep. 2017; 7: 45626. Published online 2017 Apr 5. doi: 10.1038/srep45626

PMCID:: PMC5381226

Abstract Article PDF–1.4M

Select item 504520013.

Mtu1-Mediated Thiouridine Formation of Mitochondrial tRNAs Is Required for Mitochondrial Translation and Is Involved in Reversible Infantile Liver Injury

Yong Wu, Fan-Yan Wei, Layla Kawarada, Takeo Suzuki, Kimi Araki, Yoshihiro Komohara, Atsushi Fujimura, Taku Kaitsuka, Motohiro Takeya, Yuichi Oike, Tsutomu Suzuki, Kazuhito Tomizawa

PLoS Genet. 2016 Sep; 12(9): e1006355. Published online 2016 Sep 30. doi: 10.1371/journal.pgen.1006355

PMCID:: PMC5045200

Abstract Article PDF–2.9M

Select item 451399614.

A compendium of expression patterns of cholesterol biosynthetic enzymes in the mouse embryo

Melda Şişecioğlu, Harun Budak, Lars Geffers, Murat Çankaya, Mehmet Çiftci, Christina Thaller, Gregor Eichele, Ömer İrfan Küfrevioğlu, Hasan Özdemir

J Lipid Res. 2015 Aug; 56(8): 1551–1559. doi: 10.1194/jlr.M059634

PMCID:: PMC4513996

Abstract Article PDF–3.4M

Select item 410690315.

Desmosterol in brain is elevated because DHCR24 needs REST for robust expression but REST is poorly expressed

G.S. Tint, Luxing Pan, Quan Shang, Laura J. Sharpe, Andrew J. Brown, Man Li, Hongwei Yu

Dev Neurosci. Author manuscript; available in PMC 2015 May 24.

Published in final edited form as: Dev Neurosci. 2014; 36: 132–142. Published online 2014 May 24. doi: 10.1159/000362363

PMCID:: PMC4106903

Abstract Article PDF–5.5M

Select item 357241016.

A conditional knockout resource for the genome–wide study of mouse gene function

William C. Skarnes, Barry Rosen, Anthony P. West, Manousos Koutsourakis, Wendy Bushell, Vivek Iyer, Alejandro O. Mujica, Mark Thomas, Jennifer Harrow, Tony Cox, David Jackson, Jessica Severin, Patrick Biggs, Jun Fu, Michael Nefedov, Pieter J. de Jong, A. Francis Stewart, Allan Bradley

Nature. Author manuscript; available in PMC 2013 Feb 14.

Published in final edited form as: Nature. 2011 Jun 15; 474(7351): 337–342. Published online 2011 Jun 15. doi: 10.1038/nature10163