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Items: 1 to 20 of 49

1.
DLK signaling in axotomized neurons triggers complement activation and loss of upstream synapses
Elham Asghari Adib, Jennifer L. Shadrach, Lauren Reilly-Jankowiak, Manish K. Dwivedi, Abigail E. Rogers, Shameena Shahzad, Ryan Passino, Roman J. Giger, Brian A. Pierchala, Catherine A. Collins
Cell Rep. Author manuscript; available in PMC 2024 May 11.
Published in final edited form as: Cell Rep. 2024 Feb 27; 43(2): 113801. Published online 2024 Feb 14. doi: 10.1016/j.celrep.2024.113801
PMCID:
PMC11088462
AbstractArticlePDF–3.9M
2.
Genetic determinants of micronucleus formation in vivo
D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus
Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0
PMCID:
PMC10917660
AbstractArticlePDF–4.8M
3.
Deficiency of the bZIP transcription factors Mafg and Mafk causes misexpression of genes in distinct pathways and results in lens embryonic developmental defects
Shaili D. Patel, Deepti Anand, Hozumi Motohashi, Fumiki Katsuoka, Masayuki Yamamoto, Salil A. Lachke
Front Cell Dev Biol. 2022; 10: 981893. Published online 2022 Aug 26. doi: 10.3389/fcell.2022.981893
PMCID:
PMC9459095
AbstractArticlePDF–5.1M
4.
MiR-191-5p alleviates microglial cell injury by targeting Map3k12 (mitogen-activated protein kinase kinase kinase 12) to inhibit the MAPK (mitogen-activated protein kinase) signaling pathway in Alzheimer’s disease
Wenjun Wan, Ganzhe Liu, Xia Li, Yu Liu, Ying Wang, Haisong Pan, Jun Hu
Bioengineered. 2021; 12(2): 12678–12690. Published online 2021 Dec 22. doi: 10.1080/21655979.2021.2008638
PMCID:
PMC8810200
AbstractArticlePDF–2.1M
5.
A Phase 1 study of GDC‐0134, a dual leucine zipper kinase inhibitor, in ALS
Jonathan S. Katz, Jeffrey D. Rothstein, Merit E. Cudkowicz, Angela Genge, Björn Oskarsson, Avis B. Hains, Chen Chen, Joshua Galanter, Braydon L. Burgess, William Cho, Geoffrey A. Kerchner, Felix L. Yeh, Arundhati Sengupta Ghosh, Sravanthi Cheeti, Logan Brooks, Lee Honigberg, Jessica A. Couch, Michael E. Rothenberg, Flavia Brunstein, Khema R. Sharma, Leonard van den Berg, James D. Berry, Jonathan D. Glass
Ann Clin Transl Neurol. 2022 Jan; 9(1): 50–66. Published online 2022 Jan 10. doi: 10.1002/acn3.51491
PMCID:
PMC8791798
AbstractArticlePDF–291K
6.
Activation of MAP3K DLK and LZK in Purkinje cells causes rapid and slow degeneration depending on signaling strength
Yunbo Li, Erin M Ritchie, Christopher L Steinke, Cai Qi, Lizhen Chen, Binhai Zheng, Yishi Jin
eLife. 2021; 10: e63509. Published online 2021 Jan 21. doi: 10.7554/eLife.63509
Correction in:
eLife. 2023; 12: e86472.
PMCID:
PMC7870138
AbstractArticlePDF–8.1M
7.
Dual Leucine Zipper Kinase Is Constitutively Active in the Adult Mouse Brain and Has Both Stress-Induced and Homeostatic Functions
Sunil Goodwani, Celia Fernandez, Paul J. Acton, Virginie Buggia-Prevot, Morgan L. McReynolds, Jiacheng Ma, Cheng Hui Hu, Mary E. Hamby, Yongying Jiang, Kang Le, Michael J. Soth, Philip Jones, William J. Ray
Int J Mol Sci. 2020 Jul; 21(14): 4849. Published online 2020 Jul 9. doi: 10.3390/ijms21144849
PMCID:
PMC7402291
AbstractArticlePDF–4.2M
8.
The c-Jun N-Terminal Kinase Activator Dual Leucine Zipper Kinase Regulates Axon Growth and Neuronal Migration in the Developing Cerebral Cortex
Syu-ichi Hirai, De Feng Cui, Takaki Miyata, Masaharu Ogawa, Hiroshi Kiyonari, Yoko Suda, Shinichi Aizawa, Yumi Banba, Shigeo Ohno
J Neurosci. 2006 Nov 15; 26(46): 11992–12002. doi: 10.1523/JNEUROSCI.2272-06.2006
PMCID:
PMC6674859
AbstractArticlePDF–759K
9.
Axon Formation in Neocortical Neurons Depends on Stage-Specific Regulation of Microtubule Stability by the Dual Leucine Zipper Kinase–c-Jun N-Terminal Kinase Pathway
Syu-ichi Hirai, Yumi Banba, Tomoko Satake, Shigeo Ohno
J Neurosci. 2011 Apr 27; 31(17): 6468–6480. doi: 10.1523/JNEUROSCI.5038-10.2011
PMCID:
PMC6622676
AbstractArticlePDF–5.6M
10.
DLK regulates a distinctive transcriptional regeneration program after peripheral nerve injury
Jung Eun Shin, Hongseok Ha, Yoon Ki Kim, Yongcheol Cho, Aaron DiAntonio
Neurobiol Dis. Author manuscript; available in PMC 2020 Jul 1.
Published in final edited form as: Neurobiol Dis. 2019 Jul; 127: 178–192. Published online 2019 Feb 5. doi: 10.1016/j.nbd.2019.02.001
PMCID:
PMC6588443
AbstractArticlePDF–2.1M
11.
High-throughput microscopy exposes a pharmacological window in which dual leucine zipper kinase inhibition preserves neuronal network connectivity
Marlies Verschuuren, Peter Verstraelen, Gerardo García-Díaz Barriga, Ines Cilissen, Emma Coninx, Mieke Verslegers, Peter H. Larsen, Rony Nuydens, Winnok H. De Vos
Acta Neuropathol Commun. 2019; 7: 6. Published online 2019 Jun 4. doi: 10.1186/s40478-019-0741-3
Correction in:
Acta Neuropathol Commun. 2019; 7: 131.
PMCID:
PMC6549294
AbstractArticlePDF–5.6M
12.
Dual leucine zipper kinase is required for mechanical allodynia and microgliosis after nerve injury
Josette J Wlaschin, Jacob M Gluski, Eileen Nguyen, Hanna Silberberg, James H Thompson, Alexander T Chesler, Claire E Le Pichon
eLife. 2018; 7: e33910. Published online 2018 Jul 3. doi: 10.7554/eLife.33910
PMCID:
PMC6029846
AbstractArticlePDF–4.7M
13.
Enhanced functional genomic screening identifies novel mediators of dual leucine zipper kinase-dependent injury signaling in neurons
Derek S. Welsbie, Katherine L. Mitchell, Vinod Ranganathan, Valentin M. Sluch, Zhiyong Yang, Jessica Kim, Eugen Buehler, Amit Patel, Scott E. Martin, Ping-Wu Zhang, Yan Ge, Yukan Duan, John Fuller, Byung-Jin Kim, Eman Hamed, Xitiz Chamling, Lei Lei, Iain D.C. Fraser, Ze’ev A. Ronai, Cynthia A. Berlinicke, Donald J. Zack
Neuron. Author manuscript; available in PMC 2018 Jun 21.
Published in final edited form as: Neuron. 2017 Jun 21; 94(6): 1142–1154.e6. doi: 10.1016/j.neuron.2017.06.008
PMCID:
PMC5553555
AbstractArticlePDF–959K
14.
Dual leucine zipper kinase-dependent PERK activation contributes to neuronal degeneration following insult
Martin Larhammar, Sarah Huntwork-Rodriguez, Zhiyu Jiang, Hilda Solanoy, Arundhati Sengupta Ghosh, Bei Wang, Joshua S Kaminker, Kevin Huang, Jeffrey Eastham-Anderson, Michael Siu, Zora Modrusan, Madeline M Farley, Marc Tessier-Lavigne, Joseph W Lewcock, Trent A Watkins
eLife. 2017; 6: e20725. Published online 2017 Apr 25. doi: 10.7554/eLife.20725
PMCID:
PMC5404924
AbstractArticlePDF–5.7M
15.
Leucine Zipper-bearing Kinase promotes axon growth in mammalian central nervous system neurons
Meifan Chen, Cédric G. Geoffroy, Hetty N. Wong, Oliver Tress, Mallorie T. Nguyen, Lawrence B. Holzman, Yishi Jin, Binhai Zheng
Sci Rep. 2016; 6: 31482. Published online 2016 Aug 11. doi: 10.1038/srep31482
PMCID:
PMC4980599
AbstractArticlePDF–2.3M
16.
Dual leucine zipper kinase regulates expression of axon guidance genes in mouse neuronal cells
Andréanne Blondeau, Jean-François Lucier, Dominick Matteau, Lauralyne Dumont, Sébastien Rodrigue, Pierre-Étienne Jacques, Richard Blouin
Neural Dev. 2016; 11: 13. Published online 2016 Jul 28. doi: 10.1186/s13064-016-0068-8
PMCID:
PMC4965899
AbstractArticlePDF–2.1M
17.
An evolutionarily conserved mechanism for cAMP elicited axonal regeneration involves direct activation of the dual leucine zipper kinase DLK
Yan Hao, Erin Frey, Choya Yoon, Hetty Wong, Douglas Nestorovski, Lawrence B Holzman, Roman J Giger, Aaron DiAntonio, Catherine Collins
eLife. 2016; 5: e14048. Published online 2016 Jun 7. doi: 10.7554/eLife.14048
PMCID:
PMC4896747
AbstractArticlePDF–3.0M
18.
Activating injury-responsive genes with hypoxia enhances axon regeneration through neuronal HIF-1α
Yongcheol Cho, Jung Eun Shin, Eric Edward Ewan, Young Mi Oh, Wolfgang Pita-Thomas, Valeria Cavalli
Neuron. Author manuscript; available in PMC 2016 Nov 18.
Published in final edited form as: Neuron. 2015 Nov 18; 88(4): 720–734. Published online 2015 Oct 29. doi: 10.1016/j.neuron.2015.09.050
PMCID:
PMC4655162
AbstractArticlePDF–4.0M
19.
Cytoskeletal disruption activates the DLK/JNK pathway, which promotes axonal regeneration and mimics a preconditioning injury
Vera Valakh, Erin Frey, Elisabetta Babetto, Lauren J Walker, Aaron DiAntonio
Neurobiol Dis. Author manuscript; available in PMC 2016 May 1.
Published in final edited form as: Neurobiol Dis. 2015 May; 77: 13–25. Published online 2015 Feb 26. doi: 10.1016/j.nbd.2015.02.014
PMCID:
PMC4402261
AbstractArticlePDF–1.7M
20.
An In Vitro Assay to Study Induction of the Regenerative State in Sensory Neurons
E. Frey, V. Valakh, S. Karney-Grobe, Y. Shi, J. Milbrandt, A. DiAntonio
Exp Neurol. Author manuscript; available in PMC 2016 Jan 1.
Published in final edited form as: Exp Neurol. 2015 Jan; 263: 350–363. Published online 2014 Nov 4. doi: 10.1016/j.expneurol.2014.10.012
PMCID:
PMC4266464
AbstractArticlePDF–2.3M

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