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Select item 107862821.

A TLR4/TRAF6-dependent signaling pathway mediates NCoR coactivator complex formation for inflammatory gene activation

Yohei Abe, Eric R. Kofman, Zhengyu Ouyang, Grisel Cruz-Becerra, Nathanael J. Spann, Jason S. Seidman, Ty D. Troutman, Joshua D. Stender, Havilah Taylor, Weiwei Fan, Verena M. Link, Zeyang Shen, Juro Sakai, Michael Downes, Ronald M. Evans, James T. Kadonaga, Michael G. Rosenfeld, Christopher K. Glass

Proc Natl Acad Sci U S A. 2024 Jan 9; 121(2): e2316104121. Published online 2024 Jan 2. doi: 10.1073/pnas.2316104121

PMCID:: PMC10786282

Abstract Article PDF–1.6M

Select item 107222912.

The thyroid hormone enhances mouse embryonic fibroblasts reprogramming to pluripotent stem cells: role of the nuclear receptor corepressor 1

Constanza Contreras-Jurado, Ana Montero-Pedrazuela, Raúl F. Pérez, Susana Alemany, Mario F. Fraga, Ana Aranda

Front Endocrinol (Lausanne) 2023; 14: 1235614. Published online 2023 Dec 1. doi: 10.3389/fendo.2023.1235614

PMCID:: PMC10722291

Abstract Article PDF–7.6M

Select item 105140853.

The NCOR-HDAC3 co-repressive complex modulates the leukemogenic potential of the transcription factor ERG

Eitan Kugler, Shreyas Madiwale, Darren Yong, Julie A. I. Thoms, Yehudit Birger, David B. Sykes, Johannes Schmoellerl, Aneta Drakul, Valdemar Priebe, Muhammad Yassin, Nasma Aqaqe, Avigail Rein, Hila Fishman, Ifat Geron, Chun-Wei Chen, Brian Raught, Qiao Liu, Heather Ogana, Elisabeth Liedke, Jean-Pierre Bourquin, Johannes Zuber, Michael Milyavsky, John Pimanda, Gilbert G. Privé, Shai Izraeli

Nat Commun. 2023; 14: 5871. Published online 2023 Sep 21. doi: 10.1038/s41467-023-41067-2

PMCID:: PMC10514085

Abstract Article PDF–17M

Select item 104650064.

NCoR1 controls Mycobacterium tuberculosis growth in myeloid cells by regulating the AMPK-mTOR-TFEB axis

Viplov Kumar Biswas, Kaushik Sen, Abdul Ahad, Arup Ghosh, Surbhi Verma, Rashmirekha Pati, Subhasish Prusty, Sourya Prakash Nayak, Sreeparna Podder, Dhiraj Kumar, Bhawna Gupta, Sunil Kumar Raghav

PLoS Biol. 2023 Aug; 21(8): e3002231. Published online 2023 Aug 17. doi: 10.1371/journal.pbio.3002231

PMCID:: PMC10465006

Abstract Article PDF–3.7M

Select item 104481985.

Chaperone-mediated autophagy dysregulation during aging impairs hepatic fatty acid oxidation via accumulation of NCoR1

You-Jin Choi, Sung Ho Yun, Jihyeon Yu, Yewon Mun, Wonseok Lee, Cheon Jun Park, Byung Woo Han, Byung-Hoon Lee

Mol Metab. 2023 Oct; 76: 101784. Published online 2023 Jul 29. doi: 10.1016/j.molmet.2023.101784

PMCID:: PMC10448198

Abstract Article PDF–3.2M

Select item 104355196.

p21-activated kinase 4 suppresses fatty acid β-oxidation and ketogenesis by phosphorylating NCoR1

Min Yan Shi, Hwang Chan Yu, Chang Yeob Han, In Hyuk Bang, Ho Sung Park, Kyu Yun Jang, Sangkyu Lee, Jeong Bum Son, Nam Doo Kim, Byung-Hyun Park, Eun Ju Bae

Nat Commun. 2023; 14: 4987. Published online 2023 Aug 17. doi: 10.1038/s41467-023-40597-z

Correction in:: Nat Commun. 2023; 14: 7007.

PMCID:: PMC10435519

Abstract Article PDF–3.6M

Select item 102037457.

Interaction between poly(A)–binding protein PABPC4 and nuclear receptor corepressor NCoR1 modulates a metabolic stress response

A.G. Oliveira, L.D. Oliveira, M.V. Cruz, D.S.P.S.F. Guimarães, T.I. Lima, B.C. Santos-Fávero, A.D. Luchessi, B.A. Pauletti, A.P. Leme, M.C. Bajgelman, J. Afonso, L.C.A. Regitano, H.F. Carvalho, E.M. Carneiro, J. Kobarg, V. Perissi, J. Auwerx, L.R. Silveira

J Biol Chem. 2023 Jun; 299(6): 104702. Published online 2023 Apr 12. doi: 10.1016/j.jbc.2023.104702

PMCID:: PMC10203745

Abstract Article PDF–2.9M

Select item 98042508.

NCoR1 controls immune tolerance in conventional dendritic cells by fine-tuning glycolysis and fatty acid oxidation

Kaushik Sen, Rashmirekha Pati, Atimukta Jha, Gyan Prakash Mishra, Subhasish Prusty, Shweta Chaudhary, Swati Swetalika, Sreeparna Podder, Aishwarya Sen, Mamuni Swain, Ranjan Kumar Nanda, Sunil K. Raghav

Redox Biol. 2023 Feb; 59: 102575. Published online 2022 Dec 16. doi: 10.1016/j.redox.2022.102575

PMCID:: PMC9804250

Abstract Article PDF–14M

Select item 97720929.

Nuclear corepressors NCOR1/NCOR2 regulate B cell development, maintain genomic integrity, and prevent transformation

Robin D. Lee, Todd P. Knutson, Sarah A. Munro, Jeffrey T. Miller, Lynn M. Heltemes-Harris, Charles G. Mullighan, Kristen Jepsen, Michael A. Farrar

Nat Immunol. Author manuscript; available in PMC 2023 Jun 1.

Published in final edited form as: Nat Immunol. 2022 Dec; 23(12): 1763–1776. Published online 2022 Oct 31. doi: 10.1038/s41590-022-01343-7

PMCID:: PMC9772092

Abstract Article PDF–6.3M

Select item 955296010.

SMRT and NCoR1 fine-tune inflammatory versus tolerogenic balance in dendritic cells by differentially regulating STAT3 signaling

Atimukta Jha, Abdul Ahad, Gyan Prakash Mishra, Kaushik Sen, Shuchi Smita, Aliva Prity Minz, Viplov Kumar Biswas, Archana Tripathy, Shantibhushan Senapati, Bhawna Gupta, Hans Acha-Orbea, Sunil Kumar Raghav

Front Immunol. 2022; 13: 910705. Published online 2022 Sep 27. doi: 10.3389/fimmu.2022.910705

PMCID:: PMC9552960

Abstract Article PDF–11M

Select item 876331711.

Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1–CoREST interactome during embryonic stem cell differentiation

Claire E. Barnes, David M. English, Megan Broderick, Mark O. Collins, Shaun M. Cowley

Mol Omics. 2022 Jan 17; 18(1): 31–44. Published online 2021 Oct 14. doi: 10.1039/d1mo00236h

PMCID:: PMC8763317

Abstract Article

Select item 863999012.

Spatiotemporal dynamics of SETD5-containing NCoR–HDAC3 complex determines enhancer activation for adipogenesis

Yoshihiro Matsumura, Ryo Ito, Ayumu Yajima, Rei Yamaguchi, Toshiya Tanaka, Takeshi Kawamura, Kenta Magoori, Yohei Abe, Aoi Uchida, Takeshi Yoneshiro, Hiroyuki Hirakawa, Ji Zhang, Makoto Arai, Chaoran Yang, Ge Yang, Hiroki Takahashi, Hitomi Fujihashi, Ryo Nakaki, Shogo Yamamoto, Satoshi Ota, Shuichi Tsutsumi, Shin-ichi Inoue, Hiroshi Kimura, Youichiro Wada, Tatsuhiko Kodama, Takeshi Inagaki, Timothy F. Osborne, Hiroyuki Aburatani, Koichi Node, Juro Sakai

Nat Commun. 2021; 12: 7045. Published online 2021 Dec 2. doi: 10.1038/s41467-021-27321-5

PMCID:: PMC8639990

Abstract Article PDF–4.9M

Select item 842996513.

Nuclear Receptor CoRepressors, NCOR1 and SMRT, are required for maintaining systemic metabolic homeostasis

Megan J. Ritter, Izuki Amano, Norihiro Imai, Lorraine Soares De Oliveira, Kristen R. Vella, Anthony N. Hollenberg

Mol Metab. 2021 Nov; 53: 101315. Published online 2021 Aug 12. doi: 10.1016/j.molmet.2021.101315

PMCID:: PMC8429965

Abstract Article PDF–3.5M

Select item 793877014.

BraInMap elucidates the macromolecular connectivity landscape of mammalian brain

Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili

Cell Syst. Author manuscript; available in PMC 2021 Apr 22.

Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003

Correction in:: Cell Syst. 2020 Aug 26; 11(2): 208.

PMCID:: PMC7938770

Abstract Article PDF–2.0M

Select item 779226615.

Macrophage NCOR1 Deficiency Ameliorates Myocardial Infarction and Neointimal Hyperplasia in Mice

Lin‐Juan Du, Jian‐Yong Sun, Wu‐Chang Zhang, Yong‐Li Wang, Hong Zhu, Ting Liu, Ming‐Zhu Gao, Chen Zheng, Yu‐Yao Zhang, Yuan Liu, Yan Liu, Shuai Shao, Xue‐Qing Zhang, Qibin Leng, Johan Auwerx, Sheng‐Zhong Duan

J Am Heart Assoc. 2020 Aug 4; 9(15): e015862. Published online 2020 Jul 28. doi: 10.1161/JAHA.120.015862

PMCID:: PMC7792266

Abstract Article PDF–3.3M

Select item 772528016.

Dichotomous Engagement of HDAC3 Activity Governs Inflammatory Responses

Hoang C. B. Nguyen, Marine Adlanmerini, Amy K. Hauck, Mitchell A. Lazar

Nature. Author manuscript; available in PMC 2021 Feb 5.

Published in final edited form as: Nature. 2020 Aug; 584(7820): 286–290. Published online 2020 Aug 5. doi: 10.1038/s41586-020-2576-2

PMCID:: PMC7725280

Abstract Article PDF–4.5M

Select item 761716917.

DeSUMOylase SENP7-Mediated Epithelial Signaling Triggers Intestinal Inflammation via Expansion of Gamma-Delta T Cells

Aamir Suhail, Zaigham Abbas Rizvi, Prabhakar Mujagond, Syed Azmal Ali, Preksha Gaur, Mukesh Singh, Vineet Ahuja, Amit Awasthi, Chittur Venkateshwaran Srikanth

Cell Rep. Author manuscript; available in PMC 2024 Dec 9.

Published in final edited form as: Cell Rep. 2019 Dec 10; 29(11): 3522–3538.e7. doi: 10.1016/j.celrep.2019.11.028

PMCID:: PMC7617169

Abstract Article PDF–2.9M

Select item 758806918.

Specific ablation of the NCoR corepressor δ splice variant reveals alternative RNA splicing as a key regulator of hepatic metabolism

Michael L. Goodson, Trina A. Knotts, Elsie L. Campbell, Chelsea A. Snyder, Briana M. Young, Martin L. Privalsky

PLoS One. 2020; 15(10): e0241238. Published online 2020 Oct 26. doi: 10.1371/journal.pone.0241238

PMCID:: PMC7588069

Abstract Article PDF–3.3M

Select item 736883319.

A cell type-specific expression map of NCoR1 and SMRT transcriptional co-repressors in the mouse brain

Attilio Iemolo, Patricia Montilla-Perez, I-Chi Lai, Yinuo Meng, Syreeta Nolan, Junneng Wen, Iulia Rusu, Davide Dulcis, Francesca Telese

J Comp Neurol. Author manuscript; available in PMC 2021 Sep 1.

Published in final edited form as: J Comp Neurol. 2020 Sep 1; 528(13): 2218–2238. Published online 2020 Feb 24. doi: 10.1002/cne.24886

PMCID:: PMC7368833

Abstract Article PDF–7.4M

Select item 732851320.

HDAC3 ensures stepwise epidermal stratification via NCoR/SMRT-reliant mechanisms independent of its histone deacetylase activity

Katherine M. Szigety, Fang Liu, Chase Y. Yuan, Deborah J. Moran, Jeremy Horrell, Heather R. Gochnauer, Ronald N. Cohen, Jonathan P. Katz, Klaus H. Kaestner, John T. Seykora, John W. Tobias, Mitchell A. Lazar, Mingang Xu, Sarah E. Millar

Genes Dev. 2020 Jul 1; 34(13-14): 973–988. doi: 10.1101/gad.333674.119

PMCID:: PMC7328513

Abstract Article PDF–22M

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