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Items: 1 to 20 of 57

1.
IRAK3-mediated suppression of pro-inflammatory MyD88/IRAK signaling affects disease severity in acute pancreatitis
Franziska G. Thiel, Saeedeh Asgarbeik, Juliane Glaubitz, Anika Wilden, Markus M. Lerch, Frank Ulrich Weiss, Matthias Sendler
Sci Rep. 2023; 13: 10833. Published online 2023 Jul 4. doi: 10.1038/s41598-023-37930-3
PMCID:
PMC10319718
AbstractArticlePDF–11M
2.
IL-1 receptor–associated kinase-3 acts as an immune checkpoint in myeloid cells to limit cancer immunotherapy
Gürcan Tunalı, Marta Rúbies Bedós, Divya Nagarajan, Patrik Fridh, Irineos Papakyriacou, Yumeng Mao
J Clin Invest. 2023 Apr 3; 133(7): e161084. Published online 2023 Apr 3. doi: 10.1172/JCI161084
PMCID:
PMC10065081
AbstractArticlePDF–10M
3.
IRAK-M suppresses the activation of microglial NLRP3 inflammasome and GSDMD-mediated pyroptosis through inhibiting IRAK1 phosphorylation during experimental autoimmune encephalomyelitis
Yuanyuan Wang, Shanshan Pei, Zhuhe Liu, Yuewen Ding, Tinglin Qian, Haixia Wen, Ssu-Wei Hsu, Zheyi Zhou, Jun Zhang, Honghao Wang
Cell Death Dis. 2023 Feb; 14(2): 103. Published online 2023 Feb 10. doi: 10.1038/s41419-023-05621-6
PMCID:
PMC9918485
AbstractArticlePDF–4.4M
4.
TRAM-Related TLR4 Pathway Antagonized by IRAK-M Mediates the Expression of Adhesion/Coactivating Molecules on Low-Grade Inflammatory Monocytes
Kisha Pradhan, Shuo Geng, Yao Zhang, Rui-Ci Lin, Liwu Li
J Immunol. 2021 Jun 15; 206(12): 2980–2988. Published online 2021 Jun 15. doi: 10.4049/jimmunol.2000978
PMCID:
PMC8278277
AbstractArticlePDF–1.7M
5.
BraInMap elucidates the macromolecular connectivity landscape of mammalian brain
Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili
Cell Syst. Author manuscript; available in PMC 2021 Apr 22.
Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003
Correction in:
Cell Syst. 2020 Aug 26; 11(2): 208.
PMCID:
PMC7938770
AbstractArticlePDF–2.0M
6.
Macrophage HIF-1α mediates obesity-related adipose tissue dysfunction via interleukin-1 receptor-associated kinase M
Josept Mari S. Poblete, Megan N. Ballinger, Shengying Bao, Miriam Alghothani, Jose B. Nevado, Jr., Timothy D. Eubank, John W. Christman, Ulysses J. Magalang
Am J Physiol Endocrinol Metab. 2020 May 1; 318(5): E689–E700. Published online 2020 Mar 10. doi: 10.1152/ajpendo.00174.2019
PMCID:
PMC7717118
AbstractArticle
7.
IRAK-M regulates monocyte trafficking to the lungs in response to bleomycin challenge.
Brenda F. Reader, Shruthi Sethurman, Bryan R. Hay, Rose Viguna Thomas Becket, Manjula Karpurapu, Sangwoon Chung, Yong Gyu Lee, John W. Christman, Megan N. Ballinger
J Immunol. Author manuscript; available in PMC 2020 Nov 15.
Published in final edited form as: J Immunol. 2020 May 15; 204(10): 2661–2670. Published online 2020 Apr 6. doi: 10.4049/jimmunol.1900466
PMCID:
PMC7356730
AbstractArticlePDF–1.8M
8.
Neutrophils Deficient in Innate Suppressor IRAK-M Enhances Anti-tumor Immune Responses
Yao Zhang, Na Diao, Christina K. Lee, Hong Wei Chu, Lan Bai, Liwu Li
Mol Ther. 2020 Jan 8; 28(1): 89–99. Published online 2019 Sep 23. doi: 10.1016/j.ymthe.2019.09.019
PMCID:
PMC6953792
AbstractArticlePDF–2.9M
9.
Critical Role of IRAK-M in Regulating Antigen-Induced Airway Inflammation
Mingqiang Zhang, Wei Chen, Weixun Zhou, Yan Bai, Jinming Gao
Am J Respir Cell Mol Biol. 2017 Nov; 57(5): 547–559. doi: 10.1165/rcmb.2016-0370OC
PMCID:
PMC6943878
AbstractArticlePDF–2.2M
10.
IRAK-M associates with susceptibility to adult-onset asthma and promotes chronic airway inflammation
Yi Liu, Mingqiang Zhang, Lili Lou, Lun Li, Youming Zhang, Wei Chen, Weixun Zhou, Yan Bai, Jinming Gao
J Immunol. Author manuscript; available in PMC 2020 Feb 1.
Published in final edited form as: J Immunol. 2019 Feb 1; 202(3): 899–911. Published online 2019 Jan 7. doi: 10.4049/jimmunol.1800712
PMCID:
PMC6344301
AbstractArticlePDF–2.0M
11.
IRAK-M Deficiency Exacerbates Ischemic Neurovascular Injuries in Experimental Stroke Mice
Chenfei Lyu, Yongfang Zhang, Minhua Gu, Yusheng Huang, Guanghui Liu, Chen Wang, Miaodan Li, Shumin Chen, Suyue Pan, Yong Gu
Front Cell Neurosci. 2018; 12: 504. Published online 2018 Dec 21. doi: 10.3389/fncel.2018.00504
PMCID:
PMC6308305
AbstractArticlePDF–5.9M
12.
TLR-stimulated IRAKM activates caspase-8 inflammasome in microglia and promotes neuroinflammation
Cun-Jin Zhang, Meiling Jiang, Hao Zhou, Weiwei Liu, Chenhui Wang, Zizhen Kang, Bing Han, Quanri Zhang, Xing Chen, Jianxin Xiao, Amanda Fisher, William J. Kaiser, Masanori A. Murayama, Yoichiro Iwakura, Ji Gao, Julie Carman, Ashok Dongre, George Dubyak, Derek W. Abbott, Fu-Dong Shi, Richard M. Ransohoff, Xiaoxia Li
J Clin Invest. 2018 Dec 3; 128(12): 5399–5412. Published online 2018 Oct 29. doi: 10.1172/JCI121901
PMCID:
PMC6264724
AbstractArticlePDF–13M
13.
Blimp-1-Mediated Pathway Promotes Type I IFN Production in Plasmacytoid Dendritic Cells by Targeting to Interleukin-1 Receptor-Associated Kinase M
Yi-An Ko, Yueh-Hsuan Chan, Chin-Hsiu Liu, Jian-Jong Liang, Tsung-Hsien Chuang, Yi-Ping Hsueh, Yi-Ling Lin, Kuo-I Lin
Front Immunol. 2018; 9: 1828. Published online 2018 Aug 7. doi: 10.3389/fimmu.2018.01828
PMCID:
PMC6091234
AbstractArticlePDF–6.5M
14.
TLR4, TRIF, and MyD88 are essential for myelopoiesis and CD11c+ adipose tissue macrophage production in obese mice
Cameron Griffin, Leila Eter, Nico Lanzetta, Simin Abrishami, Mita Varghese, Kaitlin McKernan, Lindsey Muir, Jamie Lane, Carey N. Lumeng, Kanakadurga Singer
J Biol Chem. 2018 Jun 8; 293(23): 8775–8786. Published online 2018 Apr 10. doi: 10.1074/jbc.RA117.001526
PMCID:
PMC5995515
AbstractArticlePDF–2.9M
15.
The IL-33-PIN1-IRAK-M axis is critical for type 2 immunity in IL-33-induced allergic airway inflammation
Morris Nechama, Jeahoo Kwon, Shuo Wei, Adrian Tun-Kyi, Robert S. Welner, Iddo Z. Ben-Dov, Mohamed S. Arredouani, John M. Asara, Chun-Hau Chen, Cheng-Yu Tsai, Kyle F. Nelson, Koichi S Kobayashi, Elliot Israel, Xiao Zhen Zhou, Linda K. Nicholson, Kun Ping Lu
Nat Commun. 2018; 9: 1603. Published online 2018 Apr 23. doi: 10.1038/s41467-018-03886-6
Correction in:
Nat Commun. 2023; 14: 3622.
PMCID:
PMC5913134
AbstractArticlePDF–3.9M
16.
A novel mouse model of conditional IRAK-M deficiency in myeloid cells: application in lung Pseudomonas aeruginosa infection
Di Jiang, Jennifer Matsuda, Reena Berman, Niccolette Schaefer, Connor Stevenson, James Gross, Bicheng Zhang, Amelia Sanchez, Liwu Li, Hong Wei Chu
Innate Immun. Author manuscript; available in PMC 2018 Feb 1.
Published in final edited form as: Innate Immun. 2017 Feb; 23(2): 206–215. Published online 2016 Dec 18. doi: 10.1177/1753425916684202
PMCID:
PMC5612436
AbstractArticlePDF–1.3M
17.
Enhanced Mucosal Defense and Reduced Tumor Burden in Mice with the Compromised Negative Regulator IRAK-M
Daniel E. Rothschild, Yao Zhang, Na Diao, Christina K. Lee, Keqiang Chen, Clayton C. Caswell, Daniel J. Slade, Richard F. Helm, Tanya LeRoith, Liwu Li, Irving C. Allen
EBioMedicine. 2017 Feb; 15: 36–47. Published online 2016 Dec 3. doi: 10.1016/j.ebiom.2016.11.039
PMCID:
PMC5233813
AbstractArticlePDF–1.8M
18.
The persistence of low-grade inflammatory monocytes contributes to aggravated atherosclerosis
Shuo Geng, Keqiang Chen, Ruoxi Yuan, Liang Peng, Urmila Maitra, Na Diao, Chun Chen, Yao Zhang, Yuan Hu, Chen-Feng Qi, Susan Pierce, Wenhua Ling, Huabao Xiong, Liwu Li
Nat Commun. 2016; 7: 13436. Published online 2016 Nov 8. doi: 10.1038/ncomms13436
PMCID:
PMC5105176
AbstractArticlePDF–2.4M
19.
The role of Interleukin Receptor Associated Kinase (IRAK)-M in regulation of myofibroblast phenotype in vitro, and in an experimental model of non-reperfused myocardial infarction
Amit Saxena, Arti V Shinde, Zaffar Haque, Yi-Jin Wu, Wei Chen, Ya Su, Nikolaos G Frangogiannis
J Mol Cell Cardiol. Author manuscript; available in PMC 2016 Dec 1.
Published in final edited form as: J Mol Cell Cardiol. 2015 Dec; 89(0 0): 223–231. Published online 2015 Nov 2. doi: 10.1016/j.yjmcc.2015.11.001
PMCID:
PMC4689654
AbstractArticlePDF–1.7M
20.
Tolerance and Cross-Tolerance following Toll-Like Receptor (TLR)-4 and -9 Activation Are Mediated by IRAK-M and Modulated by IL-7 in Murine Splenocytes
Mark W. Julian, Heather R. Strange, Megan N. Ballinger, Richard S. Hotchkiss, Tracey L. Papenfuss, Elliott D. Crouser
PLoS One. 2015; 10(7): e0132921. Published online 2015 Jul 28. doi: 10.1371/journal.pone.0132921
PMCID:
PMC4517781
AbstractArticlePDF–3.1M

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