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Items: 1 to 20 of 671

1.
A p62-dependent rheostat dictates micronuclei catastrophe and chromosome rearrangements
Sara Martin, Simone Scorzoni, Sara Cordone, Alice Mazzagatti, Galina V. Beznoussenko, Amanda L. Gunn, Melody Di Bona, Yonatan Eliezer, Gil Leor, Tal Ben-Yishay, Alessia Loffreda, Valeria Cancila, Maria Chiara Rainone, Marica Rosaria Ippolito, Valentino Martis, Fabio Bedin, Massimiliano Garrè, Laura Pontano Vaites, Paolo Vasapolli, Simona Polo, Dario Parazzoli, Claudio Tripodo, Alexander A. Mironov, Alessandro Cuomo, Uri Ben-David, Samuel F. Bakhoum, Emily M. Hatch, Peter Ly, Stefano Santaguida
Science. Author manuscript; available in PMC 2024 Dec 23.
Published in final edited form as: Science. 2024 Aug 30; 385(6712): eadj7446. Published online 2024 Aug 30. doi: 10.1126/science.adj7446
PMCID:
PMC11664475
AbstractArticlePDF–4.0M
2.
Cell fixation improves performance of in situ crosslinking mass spectrometry while preserving cellular ultrastructure
Andrew R. M. Michael, Bruno C. Amaral, Kallie L. Ball, Kristen H. Eiriksson, David C. Schriemer
Nat Commun. 2024; 15: 8537. Published online 2024 Oct 2. doi: 10.1038/s41467-024-52844-y
PMCID:
PMC11447256
AbstractArticlePDF–2.8M
3.
The Autophagy Receptor SQSTM1/p62 Is a Restriction Factor of HCMV Infection
Nadine Krämer, Uxía Gestal Mato, Steffi Krauter, Nicole Büscher, Ahmad Afifi, Lina Herhaus, Luise Florin, Bodo Plachter, Christine Zimmermann
Viruses. 2024 Sep; 16(9): 1440. Published online 2024 Sep 10. doi: 10.3390/v16091440
PMCID:
PMC11436200
AbstractArticlePDF–3.7M
4.
Proximity labeling reveals dynamic changes in the SQSTM1 protein network
Alejandro N. Rondón-Ortiz, Lushuang Zhang, Peter E.A. Ash, Avik Basu, Sambhavi Puri, Sophie J.F. van der Spek, Zihan Wang, Luke Dorrian, Andrew Emili, Benjamin Wolozin
J Biol Chem. 2024 Sep; 300(9): 107621. Published online 2024 Aug 3. doi: 10.1016/j.jbc.2024.107621
PMCID:
PMC11401034
AbstractArticlePDF–5.4M
5.
Proteome-scale characterisation of motif-based interactome rewiring by disease mutations
Johanna Kliche, Leandro Simonetti, Izabella Krystkowiak, Hanna Kuss, Marcel Diallo, Emma Rask, Jakob Nilsson, Norman E Davey, Ylva Ivarsson
Mol Syst Biol. 2024 Sep; 20(9): 1025–1048. Published online 2024 Jul 15. doi: 10.1038/s44320-024-00055-4
PMCID:
PMC11369174
AbstractArticlePDF–2.7M
6.
TRIM44 enhances autophagy via SQSTM1 oligomerization in response to oxidative stress
Yuqin Wang, Lin Lyu, Trung Vu, Nami McCarty
Sci Rep. 2024; 14: 18974. Published online 2024 Aug 16. doi: 10.1038/s41598-024-67832-x
PMCID:
PMC11329658
AbstractArticlePDF–2.8M
7.
Antagonistic roles of canonical and alternative-RPA in disease-associated tandem CAG repeat instability
Terence Gall-Duncan, Jennifer Luo, Carla-Marie Jurkovic, Laura A. Fischer, Kyota Fujita, Amit L. Deshmukh, Rachel J. Harding, Stephanie Tran, Mustafa Mehkary, Vanessa Li, David E. Leib, Ran Chen, Hikari Tanaka, Amanda G. Mason, Dominique Lévesque, Mahreen Khan, Mortezaali Razzaghi, Tanya Prasolava, Stella Lanni, Nozomu Sato, Marie-Christine Caron, Gagan B. Panigrahi, Peixiang Wang, Rachel Lau, Arturo López Castel, Jean-Yves Masson, Lynette Tippett, Clinton Turner, Maria Spies, Albert R. La Spada, Eric I. Campos, Maurice A. Curtis, François-Michel Boisvert, Richard L.M. Faull, Beverly L. Davidson, Masayuki Nakamori, Hitoshi Okazawa, Marc S. Wold, Christopher E. Pearson
Cell. Author manuscript; available in PMC 2024 Oct 26.
Published in final edited form as: Cell. 2023 Oct 26; 186(22): 4898–4919.e25. Published online 2023 Oct 11. doi: 10.1016/j.cell.2023.09.008
PMCID:
PMC11209935
AbstractArticlePDF–3.0M
8.
Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability
YiQing Lü, Tiffany Cho, Saptaparna Mukherjee, Carmen Florencia Suarez, Nicolas S Gonzalez-Foutel, Ahmad Malik, Sebastien Martinez, Dzana Dervovic, Robin Hyunseo Oh, Ellen Langille, Khalid N Al-Zahrani, Lisa Hoeg, Zhen Yuan Lin, Ricky Tsai, Geraldine Mbamalu, Varda Rotter, Patricia Ashton-Prolla, Jason Moffat, Lucia Beatriz Chemes, Anne-Claude Gingras, Moshe Oren, Daniel Durocher, Daniel Schramek
Mol Syst Biol. 2024 Jun; 20(6): 719–740. Published online 2024 Apr 5. doi: 10.1038/s44320-024-00032-x
PMCID:
PMC11148184
AbstractArticlePDF–8.1M
9.
K48- and K63-linked ubiquitin chain interactome reveals branch- and length-specific ubiquitin interactors
Anita Waltho, Oliver Popp, Christopher Lenz, Lukas Pluska, Mahil Lambert, Volker Dötsch, Philipp Mertins, Thomas Sommer
Life Sci Alliance. 2024 Aug; 7(8): e202402740. Published online 2024 May 21. doi: 10.26508/lsa.202402740
PMCID:
PMC11109483
AbstractArticlePDF–2.9M
10.
Pathogenic mutation in the ALS/FTD gene, CCNF, causes elevated Lys48-linked ubiquitylation and defective autophagy
Albert Lee, Stephanie L. Rayner, Serene S. L. Gwee, Alana De Luca, Hamideh Shahheydari, Vinod Sundaramoorthy, Audrey Ragagnin, Marco Morsch, Rowan Radford, Jasmin Galper, Sarah Freckleton, Bingyang Shi, Adam K. Walker, Emily K. Don, Nicholas J. Cole, Shu Yang, Kelly L. Williams, Justin J. Yerbury, Ian P. Blair, Julie D. Atkin, Mark P. Molloy, Roger S. Chung
Cell Mol Life Sci. 2018 Jan; 75(2): 335–354. Published online 2017 Aug 29. doi: 10.1007/s00018-017-2632-8
PMCID:
PMC11105586
AbstractArticlePDF–1.8M
11.
Vaccinia virus subverts xenophagy through phosphorylation and nuclear targeting of p62
Melanie Krause, Jerzy Samolej, Artur Yakimovich, Janos Kriston-Vizi, Moona Huttunen, Samuel Lara-Reyna, Eva-Maria Frickel, Jason Mercer
J Cell Biol. 2024 Jun 3; 223(6): e202104129. Published online 2024 May 6. doi: 10.1083/jcb.202104129
PMCID:
PMC11076808
AbstractArticlePDF–5.0M
12.
Dual-specificity kinase DYRK3 phosphorylates p62 at the Thr-269 residue and promotes melanoma progression
Ye Hyung Lee, A-Rum Yoon, Chae-Ok Yun, Kwang Chul Chung
J Biol Chem. 2024 Apr; 300(4): 107206. Published online 2024 Mar 20. doi: 10.1016/j.jbc.2024.107206
PMCID:
PMC11021969
AbstractArticlePDF–4.5M
13.
circRNA_SLC8A1 promotes the survival of mycobacterium tuberculosis in macrophages by upregulating expression of autophagy-related protein SQSTM1/p62 to activate the NF-κB pathway
Zhenyun Li, Yuan Gao, Bianfang Zhang, Wei Dong, Yuling Xi, Yan Li, Junwei Cui
Sci Rep. 2024; 14: 5233. Published online 2024 Mar 4. doi: 10.1038/s41598-024-55493-9
Correction in:
Sci Rep. 2024; 14: 8860.
PMCID:
PMC10909944
AbstractArticlePDF–4.3M
14.
Endothelium-specific deletion of p62 causes organ fibrosis and cardiac dysfunction
Jing Feng, Yan Li, Yu Zhang, Shengnan Sun, Jian Sun, Quanlin Xu, Xingzhao Ji, Yi Liu, Qiang Wan
J Transl Med. 2024; 22: 161. Published online 2024 Feb 16. doi: 10.1186/s12967-024-04946-w
PMCID:
PMC10870664
AbstractArticlePDF–8.1M
15.
Cancer-associated fibroblasts-derived CXCL12 enhances immune escape of bladder cancer through inhibiting P62-mediated autophagic degradation of PDL1
Zhao Zhang, Yongbo Yu, Zhilei Zhang, Dan Li, Zhijuan Liang, Liping Wang, Yuanbin Chen, Ye Liang, Haitao Niu
J Exp Clin Cancer Res. 2023; 42: 316. Published online 2023 Nov 25. doi: 10.1186/s13046-023-02900-0
PMCID:
PMC10675892
AbstractArticlePDF–12M
16.
SQSTM1/p62 and Hepatic Mallory-Denk Body Formation in Alcohol-Associated Liver Disease
Hui Qian, Wen-Xing Ding
Am J Pathol. 2023 Oct; 193(10): 1415–1426. doi: 10.1016/j.ajpath.2023.02.015
PMCID:
PMC10642158
AbstractArticlePDF–965K
17.
Pulse-SILAC and Interactomics Reveal Distinct DDB1-CUL4–Associated Factors, Cellular Functions, and Protein Substrates
Jennifer Raisch, Marie-Line Dubois, Marika Groleau, Dominique Lévesque, Thomas Burger, Carla-Marie Jurkovic, Romain Brailly, Gwendoline Marbach, Alyson McKenna, Catherine Barrette, Pierre-Étienne Jacques, François-Michel Boisvert
Mol Cell Proteomics. 2023 Oct; 22(10): 100644. Published online 2023 Sep 7. doi: 10.1016/j.mcpro.2023.100644
PMCID:
PMC10565876
AbstractArticlePDF–3.7M
18.
S-acylation of p62 promotes p62 droplet recruitment into autophagosomes in mammalian autophagy
Xue Huang, Jia Yao, Lu Liu, Jing Chen, Ligang Mei, Jingjing Huangfu, Dong Luo, Xinyi Wang, Changhai Lin, Xiaorong Chen, Yi Yang, Sheng Ouyang, Fujing Wei, Zhuolin Wang, Shaolin Zhang, Tingxiu Xiang, Dante Neculai, Qiming Sun, Eryan Kong, Edward W. Tate, Aimin Yang
Mol Cell. 2023 Oct 5; 83(19): 3485–3501.e11. doi: 10.1016/j.molcel.2023.09.004
PMCID:
PMC10552648
AbstractArticlePDF–6.9M
19.
The transcription factor NRF1 (NFE2L1) activates aggrephagy by inducing p62 and GABARAPL1 after proteasome inhibition to maintain proteostasis
Atsushi Hatanaka, Sota Nakada, Gen Matsumoto, Katsuya Satoh, Iori Aketa, Akira Watanabe, Tomoaki Hirakawa, Tadayuki Tsujita, Tsuyoshi Waku, Akira Kobayashi
Sci Rep. 2023; 13: 14405. Published online 2023 Sep 1. doi: 10.1038/s41598-023-41492-9
PMCID:
PMC10474156
AbstractArticlePDF–2.8M
20.
The E3 Ubiquitin Ligase SCF Cyclin F Promotes Sequestosome-1/p62 Insolubility and Foci Formation and is Dysregulated in ALS and FTD Pathogenesis
Jennilee M. Davidson, Sharlynn S. L. Wu, Stephanie L. Rayner, Flora Cheng, Kimberley Duncan, Carlo Russo, Michelle Newbery, Kunjie Ding, Natalie M. Scherer, Rachelle Balez, Alberto García-Redondo, Alberto Rábano, Livia Rosa-Fernandes, Lezanne Ooi, Kelly L. Williams, Marco Morsch, Ian P. Blair, Antonio Di Ieva, Shu Yang, Roger S. Chung, Albert Lee
Mol Neurobiol. 2023; 60(9): 5034–5054. Published online 2023 May 27. doi: 10.1007/s12035-023-03355-2
PMCID:
PMC10415446
AbstractArticlePDF–4.2M

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