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Select item 114472561.

Cell fixation improves performance of in situ crosslinking mass spectrometry while preserving cellular ultrastructure

Andrew R. M. Michael, Bruno C. Amaral, Kallie L. Ball, Kristen H. Eiriksson, David C. Schriemer

Nat Commun. 2024; 15: 8537. Published online 2024 Oct 2. doi: 10.1038/s41467-024-52844-y

PMCID:: PMC11447256

Abstract Article PDF–2.8M

Select item 110053652.

Single-genome analysis reveals a heterogeneous association of the herpes simplex virus genome with H3K27me2 and the reader PHF20L1 following infection of human fibroblasts

Alison K. Francois, Ali Rohani, Matt Loftus, Sara Dochnal, Joel Hrit, Steven McFarlane, Abigail Whitford, Anna Lewis, Patryk Krakowiak, Chris Boutell, Scott B. Rothbart, David Kashatus, Anna R. Cliffe

mBio. 2024 Apr; 15(4): e03278-23. Published online 2024 Feb 27. doi: 10.1128/mbio.03278-23

PMCID:: PMC11005365

Abstract Article PDF–4.1M

Select item 105658763.

Pulse-SILAC and Interactomics Reveal Distinct DDB1-CUL4–Associated Factors, Cellular Functions, and Protein Substrates

Jennifer Raisch, Marie-Line Dubois, Marika Groleau, Dominique Lévesque, Thomas Burger, Carla-Marie Jurkovic, Romain Brailly, Gwendoline Marbach, Alyson McKenna, Catherine Barrette, Pierre-Étienne Jacques, François-Michel Boisvert

Mol Cell Proteomics. 2023 Oct; 22(10): 100644. Published online 2023 Sep 7. doi: 10.1016/j.mcpro.2023.100644

PMCID:: PMC10565876

Abstract Article PDF–3.7M

Select item 95403454.

The in vivo Interaction Landscape of Histones H3.1 and H3.3

Robert Siddaway, Scott Milos, Étienne Coyaud, Hwa Young Yun, Shahir M. Morcos, Sanja Pajovic, Eric I. Campos, Brian Raught, Cynthia Hawkins

Mol Cell Proteomics. 2022 Oct; 21(10): 100411. Published online 2022 Sep 9. doi: 10.1016/j.mcpro.2022.100411

PMCID:: PMC9540345

Abstract Article PDF–3.9M

Select item 83641815.

Protein interaction landscapes revealed by advanced in vivo cross-linking–mass spectrometry

Andrew Wheat, Clinton Yu, Xiaorong Wang, Anthony M. Burke, Ilan E. Chemmama, Robyn M. Kaake, Peter Baker, Scott D. Rychnovsky, Jing Yang, Lan Huang

Proc Natl Acad Sci U S A. 2021 Aug 10; 118(32): e2023360118. Published online 2021 Aug 4. doi: 10.1073/pnas.2023360118

PMCID:: PMC8364181

Abstract Article PDF–3.0M

Select item 81650306.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 71599107.

PHF20L1 as a H3K27me2 reader coordinates with transcriptional repressors to promote breast tumorigenesis

Yongqiang Hou, Wei Liu, Xianfu Yi, Yang Yang, Dongxue Su, Wei Huang, Hefen Yu, Xu Teng, Ying Yang, Wei Feng, Tao Zhang, Jie Gao, Kai Zhang, Rongfang Qiu, Yan Wang

Sci Adv. 2020 Apr; 6(16): eaaz0356. Published online 2020 Apr 15. doi: 10.1126/sciadv.aaz0356

PMCID:: PMC7159910

Abstract Article PDF–4.3M

Select item 63338838.

Proteolysis of methylated SOX2 protein is regulated by L3MBTL3 and CRL4^DCAF5 ubiquitin ligase

Chunxiao Zhang, Feng Leng, Lovely Saxena, Nam Hoang, Jiekai Yu, Salvador Alejo, Logan Lee, Dandan Qi, Fei Lu, Hong Sun, Hui Zhang

J Biol Chem. 2019 Jan 11; 294(2): 476–489. Published online 2018 Nov 15. doi: 10.1074/jbc.RA118.005336

PMCID:: PMC6333883

Abstract Article PDF–3.1M

Select item 60777229.

Estrogen-regulated feedback loop limits the efficacy of estrogen receptor–targeted breast cancer therapy

Tengfei Xiao, Wei Li, Xiaoqing Wang, Han Xu, Jixin Yang, Qiu Wu, Ying Huang, Joseph Geradts, Peng Jiang, Teng Fei, David Chi, Chongzhi Zang, Qi Liao, Jonathan Rennhack, Eran Andrechek, Nanlin Li, Simone Detre, Mitchell Dowsett, Rinath M. Jeselsohn, X. Shirley Liu, Myles Brown

Proc Natl Acad Sci U S A. 2018 Jul 31; 115(31): 7869–7878. Published online 2018 Jul 9. doi: 10.1073/pnas.1722617115

PMCID:: PMC6077722

Abstract Article PDF–2.4M

Select item 599210410.

Comparative Protein Interaction Network Analysis Identifies Shared and Distinct Functions for the Human ROCO Proteins

James E. Tomkins, Sybille Dihanich, Alexandra Beilina, Raffaele Ferrari, Nicolò Ilacqua, Mark R. Cookson, Patrick A. Lewis, Claudia Manzoni

Proteomics. 2018 May; 18(10): 1700444. Published online 2018 Apr 17. doi: 10.1002/pmic.201700444

PMCID:: PMC5992104

Abstract Article PDF–1.2M

Select item 591560011.

Methylated DNMT1 and E2F1 are targeted for proteolysis by L3MBTL3 and CRL4^DCAF5 ubiquitin ligase

Feng Leng, Jiekai Yu, Chunxiao Zhang, Salvador Alejo, Nam Hoang, Hong Sun, Fei Lu, Hui Zhang

Nat Commun. 2018; 9: 1641. Published online 2018 Apr 24. doi: 10.1038/s41467-018-04019-9

PMCID:: PMC5915600

Abstract Article PDF–2.0M

Select item 584613412.

LSD1 demethylase and the methyl-binding protein PHF20L1 prevent SET7 methyltransferase–dependent proteolysis of the stem-cell protein SOX2

Chunxiao Zhang, Nam Hoang, Feng Leng, Lovely Saxena, Logan Lee, Salvador Alejo, Dandan Qi, Anthony Khal, Hong Sun, Fei Lu, Hui Zhang

J Biol Chem. 2018 Mar 9; 293(10): 3663–3674. Published online 2018 Jan 22. doi: 10.1074/jbc.RA117.000342

PMCID:: PMC5846134

Abstract Article PDF–2.2M

Select item 568635113.

Tudor-domain protein PHF20L1 reads lysine methylated retinoblastoma tumour suppressor protein

Simon M Carr, Shonagh Munro, Cari A Sagum, Oleg Fedorov, Mark T Bedford, Nicholas B La Thangue

Cell Death Differ. 2017 Dec; 24(12): 2139–2149. Published online 2017 Aug 25. doi: 10.1038/cdd.2017.135

PMCID:: PMC5686351

Abstract Article PDF–1.6M

Select item 553161114.

Architecture of the human interactome defines protein communities and disease networks

Edward L. Huttlin, Raphael J. Bruckner, Joao A. Paulo, Joe R. Cannon, Lily Ting, Kurt Baltier, Greg Colby, Fana Gebreab, Melanie P. Gygi, Hannah Parzen, John Szpyt, Stanley Tam, Gabriela Zarraga, Laura Pontano-Vaites, Sharan Swarup, Anne E. White, Devin K. Schweppe, Ramin Rad, Brian K. Erickson, Robert A. Obar, K.G. Guruharsha, Kejie Li, Spyros Artavanis-Tsakonas, Steven P. Gygi, J. Wade Harper

Nature. Author manuscript; available in PMC 2017 Nov 17.

Published in final edited form as: Nature. 2017 May 25; 545(7655): 505–509. Published online 2017 May 17. doi: 10.1038/nature22366

PMCID:: PMC5531611

Abstract Article PDF–2.7M

Select item 535872315.

ZMYM3 regulates BRCA1 localization at damaged chromatin to promote DNA repair

Justin W.C. Leung, Nodar Makharashvili, Poonam Agarwal, Li-Ya Chiu, Renaud Pourpre, Michael B. Cammarata, Joe R. Cannon, Alana Sherker, Daniel Durocher, Jennifer S. Brodbelt, Tanya T. Paull, Kyle M. Miller

Genes Dev. 2017 Feb 1; 31(3): 260–274. doi: 10.1101/gad.292516.116

PMCID:: PMC5358723

Abstract Article PDF–1.8M

Select item 474024416.

An integrated genomic analysis of Tudor domain–containing proteins identifies PHD finger protein 20‐like 1 (PHF20L1) as a candidate oncogene in breast cancer

Yuanyuan Jiang, Lanxin Liu, Wenqi Shan, Zeng-Quan Yang

Mol Oncol. 2016 Feb; 10(2): 292–302. Published online 2015 Oct 28. doi: 10.1016/j.molonc.2015.10.013

PMCID:: PMC4740244

Abstract Article PDF–1.6M

Select item 464965817.

Dependence of Human Colorectal Cells Lacking the FBW7 Tumor Suppressor on the Spindle Assembly Checkpoint

Melanie L. Bailey, Tejomayee Singh, Patricia Mero, Jason Moffat, Philip Hieter

Genetics. 2015 Nov; 201(3): 885–895. Published online 2015 Sep 8. doi: 10.1534/genetics.115.180653

PMCID:: PMC4649658

Abstract Article PDF–1.8M

Select item 461721118.

The BioPlex Network: A Systematic Exploration of the Human Interactome

Edward L. Huttlin, Lily Ting, Raphael J. Bruckner, Fana Gebreab, Melanie P. Gygi, John Szpyt, Stanley Tam, Gabriela Zarraga, Greg Colby, Kurt Baltier, Rui Dong, Virginia Guarani, Laura Pontano Vaites, Alban Ordureau, Ramin Rad, Brian K. Erickson, Martin Wühr, Joel Chick, Bo Zhai, Deepak Kolippakkam, Julian Mintseris, Robert A. Obar, Tim Harris, Spyros Artavanis-Tsakonas, Mathew E. Sowa, Pietro DeCamilli, Joao A. Paulo, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2016 Jul 16.

Published in final edited form as: Cell. 2015 Jul 16; 162(2): 425–440. doi: 10.1016/j.cell.2015.06.043

PMCID:: PMC4617211

Abstract Article PDF–2.2M

Select item 433215019.

Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes

Xu Li, Wenqi Wang, Jiadong Wang, Anna Malovannaya, Yuanxin Xi, Wei Li, Rudy Guerra, David H Hawke, Jun Qin, Junjie Chen

Mol Syst Biol. 2015 Jan; 11(1): 775. Published online 2015 Jan 21. doi: 10.15252/msb.20145504

PMCID:: PMC4332150

Abstract Article PDF–2.8M

Select item 429813820.

Screen identifies bromodomain protein ZMYND8 in chromatin recognition of transcription-associated DNA damage that promotes homologous recombination

Fade Gong, Li-Ya Chiu, Ben Cox, François Aymard, Thomas Clouaire, Justin W. Leung, Michael Cammarata, Mercedes Perez, Poonam Agarwal, Jennifer S. Brodbelt, Gaëlle Legube, Kyle M. Miller

Genes Dev. 2015 Jan 15; 29(2): 197–211. doi: 10.1101/gad.252189.114

PMCID:: PMC4298138

Abstract Article PDF–2.5M

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