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Select item 104618411.

Role of hepcidin upregulation and proteolytic cleavage of ferroportin 1 in hepatitis C virus-induced iron accumulation

Kazuyoshi Ohta, Masahiko Ito, Takeshi Chida, Kenji Nakashima, Satoshi Sakai, Yumi Kanegae, Hideya Kawasaki, Takuya Aoshima, Shuji Takabayashi, Hirotaka Takahashi, Kazuhito Kawata, Ikuo Shoji, Tatsuya Sawasaki, Takafumi Suda, Tetsuro Suzuki

PLoS Pathog. 2023 Aug; 19(8): e1011591. Published online 2023 Aug 16. doi: 10.1371/journal.ppat.1011591

PMCID:: PMC10461841

Abstract Article PDF–2.6M

Select item 98830142.

Mechanism of Ca²⁺ transport by ferroportin

Jiemin Shen, Azaan Saalim Wilbon, Ming Zhou, Yaping Pan

eLife. 2023; 12: e82947. Published online 2023 Jan 17. doi: 10.7554/eLife.82947

PMCID:: PMC9883014

Abstract Article PDF–3.5M

Select item 91991463.

Assessment of iron overload in a cohort of Sri Lankan patients with transfusion dependent beta thalassaemia and its correlation with pathogenic variants in HBB, HFE, SLC40A1, and TFR2 genes

Ruwangi Dissanayake, Nayana Samarasinghe, Samantha Waidyanatha, Sajeewani Pathirana, Nilaksha Neththikumara, Vajira H. W. Dissanayake, Kalum Wetthasinghe, Lallindra Gooneratne, Pujitha Wickramasinghe

BMC Pediatr. 2022; 22: 344. Published online 2022 Jun 15. doi: 10.1186/s12887-022-03191-8

PMCID:: PMC9199146

Abstract Article PDF–977K

Select item 91355544.

MicroRNA-4735-3p Facilitates Ferroptosis in Clear Cell Renal Cell Carcinoma by Targeting SLC40A1

Cairong Zhu, Zhiquan Song, Zhen Chen, Tianqi Lin, Haili Lin, Zhenqiang Xu, Fen Ai, Shijiao Zheng

Anal Cell Pathol (Amst) 2022; 2022: 4213401. Published online 2022 May 19. doi: 10.1155/2022/4213401

PMCID:: PMC9135554

Abstract Article PDF–1.0M

Select item 88347925.

Interplay of Ferritin Accumulation and Ferroportin Loss in Ageing Brain: Implication for Protein Aggregation in Down Syndrome Dementia, Alzheimer’s, and Parkinson’s Diseases

Animesh Alexander Raha, Anwesha Biswas, James Henderson, Subhojit Chakraborty, Anthony Holland, Robert P. Friedland, Elizabeta Mukaetova-Ladinska, Shahid Zaman, Ruma Raha-Chowdhury

Int J Mol Sci. 2022 Feb; 23(3): 1060. Published online 2022 Jan 19. doi: 10.3390/ijms23031060

PMCID:: PMC8834792

Abstract Article PDF–5.1M

Select item 88116276.

ENTREP/FAM189A2 encodes a new ITCH ubiquitin ligase activator that is downregulated in breast cancer

Takumi Tsunoda, Miho Riku, Norika Yamada, Hikaru Tsuchiya, Takuya Tomita, Minako Suzuki, Mari Kizuki, Akihito Inoko, Hideaki Ito, Kenta Murotani, Hideki Murakami, Yasushi Saeki, Kenji Kasai

EMBO Rep. 2022 Feb 3; 23(2): e51182. Published online 2021 Dec 20. doi: 10.15252/embr.202051182

PMCID:: PMC8811627

Abstract Article PDF–3.8M

Select item 88045827.

UBA6 and NDFIP1 regulate the degradation of ferroportin

Lisa Traeger, Steffen B. Wiegand, Andrew J. Sauer, Benjamin H.P. Corman, Kathryn M. Peneyra, Florian Wunderer, Anna Fischbach, Aranya Bagchi, Rajeev Malhotra, Warren M. Zapol, Donald B. Bloch

Haematologica. 2022 Feb 1; 107(2): 478–488. Published online 2021 Jul 29. doi: 10.3324/haematol.2021.278530

PMCID:: PMC8804582

Abstract Article PDF–1.1M

Select item 85240068.

Ferroportin and FBXL5 as Prognostic Markers in Advanced Stage Clear Cell Renal Cell Carcinoma

Cheol Keun Park, Jayoon Heo, Won Sik Ham, Young-Deuk Choi, Sang Joon Shin, Nam Hoon Cho

Cancer Res Treat. 2021 Oct; 53(4): 1174–1183. Published online 2021 Mar 17. doi: 10.4143/crt.2021.031

PMCID:: PMC8524006

Abstract Article PDF–3.5M

Select item 84238589.

Gene interfered-ferroptosis therapy for cancers

Jinliang Gao, Tao Luo, Jinke Wang

Nat Commun. 2021; 12: 5311. Published online 2021 Sep 7. doi: 10.1038/s41467-021-25632-1

PMCID:: PMC8423858

Abstract Article PDF–6.9M

Select item 839490410.

RNF217 regulates iron homeostasis through its E3 ubiquitin ligase activity by modulating ferroportin degradation

Li Jiang, Jiaming Wang, Kai Wang, Hao Wang, Qian Wu, Cong Yang, Yingying Yu, Pu Ni, Yueyang Zhong, Zijun Song, Enjun Xie, Ronggui Hu, Junxia Min, Fudi Wang

Blood. 2021 Aug 26; 138(8): 689–705. Prepublished online 2021 Apr 25. doi: 10.1182/blood.2020008986

PMCID:: PMC8394904

Abstract Article

Select item 834918711.

Erythrocytic ferroportin reduces intracellular iron accumulation, hemolysis, and malaria risk

De-Liang Zhang, Jian Wu, Binal N. Shah, Katja C. Greutélaers, Manik C. Ghosh, Hayden Ollivierre, Xin-zhuan Su, Philip E. Thuma, George Bedu-Addo, Frank P. Mockenhaupt, Victor R. Gordeuk, Tracey A. Rouault

Science. Author manuscript; available in PMC 2021 Aug 7.

Published in final edited form as: Science. 2018 Mar 30; 359(6383): 1520–1523. doi: 10.1126/science.aal2022

PMCID:: PMC8349187

Abstract Article PDF–1.0M

Select item 823902212.

Decreased ferroportin in hepatocytes promotes macrophages polarize towards an M2-like phenotype and liver fibrosis

Chengyuan Cai, Danning Zeng, Qing Gao, Lei Ma, Bohang Zeng, Yi Zhou, He Wang

Sci Rep. 2021; 11: 13386. Published online 2021 Jun 28. doi: 10.1038/s41598-021-92839-z

PMCID:: PMC8239022

Abstract Article PDF–11M

Select item 823278513.

Insights into the Role of the Discontinuous TM7 Helix of Human Ferroportin through the Prism of the Asp325 Residue

Marlène Le Tertre, Ahmad Elbahnsi, Chandran Ka, Isabelle Callebaut, Gérald Le Gac

Int J Mol Sci. 2021 Jun; 22(12): 6412. Published online 2021 Jun 15. doi: 10.3390/ijms22126412

PMCID:: PMC8232785

Abstract Article PDF–5.6M

Select item 803490114.

Downregulation of FPN1 acts as a prognostic biomarker associated with immune infiltration in lung cancer

Bing Liu, Zhiyuan Song, Yumei Fan, Guangyu Zhang, Pengxiu Cao, Danyu Li, Xiaopeng Liu, Yanzhong Chang, Ke Tan

Aging (Albany NY) 2021 Mar 31; 13(6): 8737–8761. Published online 2021 Mar 10. doi: 10.18632/aging.202685

PMCID:: PMC8034901

Abstract Article PDF–4.5M

Select item 799935715.

Iron Availability in Tissue Microenvironment: The Key Role of Ferroportin

Elena Gammella, Margherita Correnti, Gaetano Cairo, Stefania Recalcati

Int J Mol Sci. 2021 Mar; 22(6): 2986. Published online 2021 Mar 15. doi: 10.3390/ijms22062986

PMCID:: PMC7999357

Abstract Article PDF–881K

Select item 793317916.

Knocking out alpha-synuclein in melanoma cells dysregulates cellular iron metabolism and suppresses tumor growth

Sahar Shekoohi, Santhanasabapathy Rajasekaran, Dhaval Patel, Shu Yang, Wang Liu, Shile Huang, Xiuping Yu, Stephan N. Witt

Sci Rep. 2021; 11: 5267. Published online 2021 Mar 4. doi: 10.1038/s41598-021-84443-y

PMCID:: PMC7933179

Abstract Article PDF–5.4M

Select item 790603617.

Structure of hepcidin-bound ferroportin reveals iron homeostatic mechanisms

Christian B. Billesbølle, Caleigh M. Azumaya, Rachael C. Kretsch, Alexander S. Powers, Shane Gonen, Simon Schneider, Tara Arvedson, Ron O. Dror, Yifan Cheng, Aashish Manglik

Nature. Author manuscript; available in PMC 2021 Feb 25.

Published in final edited form as: Nature. 2020 Oct; 586(7831): 807–811. Published online 2020 Aug 19. doi: 10.1038/s41586-020-2668-z

PMCID:: PMC7906036

Abstract Article PDF–5.3M

Select item 788933418.

Ferroportin-Dependent Iron Homeostasis Protects against Oxidative Stress-Induced Nucleus Pulposus Cell Ferroptosis and Ameliorates Intervertebral Disc Degeneration In Vivo

Saideng Lu, Yu Song, Rongjin Luo, Shuai Li, Gaocai Li, Kun Wang, Zhiwei Liao, Bingjin Wang, Wencan Ke, Qian Xiang, Chao Chen, Xinghuo Wu, Yukun Zhang, Li Ling, Cao Yang

Oxid Med Cell Longev. 2021; 2021: 6670497. Published online 2021 Feb 10. doi: 10.1155/2021/6670497