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Select item 101774051.

A Non-Canonical Role for the Glycosyltransferase Enzyme UGT2B17 as a Novel Constituent of the B Cell Receptor Signalosome

Antoine Wagner, Michèle Rouleau, Lyne Villeneuve, Trang Le, Cheryl Peltier, Éric P. Allain, Caroline Beaudoin, Sophie Tremblay, Fréderic Courtier, Flora Nguyen Van Long, Isabelle Laverdière, Éric Lévesque, Versha Banerji, Katrina Vanura, Chantal Guillemette

Cells. 2023 May; 12(9): 1295. Published online 2023 May 2. doi: 10.3390/cells12091295

PMCID:: PMC10177405

Abstract Article PDF–5.4M

Select item 99503602.

Distilling functional variations for human UGT2B4 upstream region based on selection signals and implications for phenotypes of Neanderthal and Denisovan

Pin-Yi Wang, Yuan Yang, Xiao-Qian Shi, Ying Chen, Shao-Dong Liu, Hong-Yan Wang, Tao Peng, Qiang Shi, Wei Zhang, Chang Sun

Sci Rep. 2023; 13: 3134. Published online 2023 Feb 23. doi: 10.1038/s41598-023-29682-x

PMCID:: PMC9950360

Abstract Article PDF–1.3M

Select item 99026213.

Extensive metabolic consequences of human glycosyltransferase gene knockouts in prostate cancer

Michèle Rouleau, Flora Nguyen Van Long, Véronique Turcotte, Patrick Caron, Louis Lacombe, Armen Aprikian, Fred Saad, Michel Carmel, Simone Chevalier, Eric Lévesque, Chantal Guillemette

Br J Cancer. 2023 Jan 19; 128(2): 285–296. Published online 2022 Nov 8. doi: 10.1038/s41416-022-02040-w

PMCID:: PMC9902621

Abstract Article PDF–1.0M

Select item 94778194.

Pangenomic analysis of Chinese gastric cancer

Yingyan Yu, Zhen Zhang, Xiaorui Dong, Ruixin Yang, Zhongqu Duan, Zhen Xiang, Jun Li, Guichao Li, Fazhe Yan, Hongzhang Xue, Du Jiao, Jinyuan Lu, Huimin Lu, Wenmin Zhang, Yangzhen Wei, Shiyu Fan, Jing Li, Jingya Jia, Jun Zhang, Jun Ji, Pixu Liu, Hui Lu, Hongyu Zhao, Saijuan Chen, Chaochun Wei, Hongzhuan Chen, Zhenggang Zhu

Nat Commun. 2022; 13: 5412. Published online 2022 Sep 15. doi: 10.1038/s41467-022-33073-7

PMCID:: PMC9477819

Abstract Article PDF–3.8M

Select item 93673405.

Uridine Diphosphate Glucuronosyl Transferase 2B28 (UGT2B28) Promotes Tumor Progression and Is Elevated in African American Prostate Cancer Patients

Anindita Ravindran, Kimiko L. Krieger, Akash K. Kaushik, Hélène Hovington, Sadia Mehdi, Danthasinghe Waduge Badrajee Piyarathna, Vasanta Putluri, Paul Basil, Uttam Rasaily, Franklin Gu, Truong Dang, Jong Min Choi, Rajni Sonavane, Sung Yun Jung, Lisha Wang, Rohit Mehra, Nancy L. Weigel, Nagireddy Putluri, David R. Rowley, Ganesh S. Palapattu, Chantal Guillemette, Louis Lacombe, Éric Lévesque, Arun Sreekumar

Cells. 2022 Aug; 11(15): 2329. Published online 2022 Jul 29. doi: 10.3390/cells11152329

PMCID:: PMC9367340

Abstract Article PDF–3.2M

Select item 87489586.

EZH2 depletion potentiates MYC degradation inhibiting neuroblastoma and small cell carcinoma tumor formation

Liyuan Wang, Chan Chen, Zemin Song, Honghong Wang, Minghui Ye, Donghai Wang, Wenqian Kang, Hudan Liu, Guoliang Qing

Nat Commun. 2022; 13: 12. Published online 2022 Jan 10. doi: 10.1038/s41467-021-27609-6

PMCID:: PMC8748958

Abstract Article PDF–3.0M

Select item 83485627.

Potential Assessment of UGT2B17 Inhibition by Salicylic Acid in Human Supersomes In Vitro

Hassan Salhab, Declan P. Naughton, James Barker

Molecules. 2021 Aug; 26(15): 4410. Published online 2021 Jul 21. doi: 10.3390/molecules26154410

PMCID:: PMC8348562

Abstract Article PDF–774K

Select item 81650308.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 79402089.

Association between sex hormones regulation‐related SNP rs12233719 and lung cancer risk among never‐smoking Chinese women

Ying Qian, Li Xie, Lei Li, Tienan Feng, Tengteng Zhu, Ruoyang Wang, Yuqing Yang, Baosen Zhou, Herbert Yu, Biyun Qian

Cancer Med. 2021 Mar; 10(5): 1880–1888. Published online 2021 Feb 17. doi: 10.1002/cam4.3772

PMCID:: PMC7940208

Abstract Article PDF–984K

Select item 790154310.

Expression of UDP Glucuronosyltransferases 2B15 and 2B17 is associated with methylation status in prostate cancer cells

Farideh Shafiee-Kermani, Skyla T. Carney, Dereje Jima, Utibe C. Utin, LaNeisha B. Farrar, Melvin O. Oputa, Marcono R. Hines, Jr. H. Karimi Kinyamu, Kevin W. Trotter, Trevor K. Archer, Cathrine Hoyo, Beverly H. Koller, Stephen J. Freedland, Delores J. Grant

Epigenetics. 2021; 16(3): 289–299. Published online 2020 Jul 27. doi: 10.1080/15592294.2020.1795601

PMCID:: PMC7901543

Abstract Article PDF–1.0M

Select item 743833611.

Histone methyltransferase DOT1L coordinates AR and MYC stability in prostate cancer

R. Vatapalli, V. Sagar, Y. Rodriguez, J. C. Zhao, K. Unno, S. Pamarthy, B. Lysy, J. Anker, H. Han, Y. A. Yoo, M. Truica, Z. R. Chalmers, F. Giles, J. Yu, D. Chakravarti, B. Carneiro, S. A. Abdulkadir

Nat Commun. 2020; 11: 4153. Published online 2020 Aug 19. doi: 10.1038/s41467-020-18013-7

PMCID:: PMC7438336

Abstract Article PDF–2.4M

Select item 741571012.

UGT2B10 genotype influences serum cotinine levels and is a primary determinant of higher cotinine in African American smokers

Christopher J. Sipe, Joseph S. Koopmeiners, Eric C. Donny, Dorothy K. Hatsukami, Sharon E. Murphy

Cancer Epidemiol Biomarkers Prev. Author manuscript; available in PMC 2021 Feb 1.

Published in final edited form as: Cancer Epidemiol Biomarkers Prev. 2020 Aug; 29(8): 1673–1678. Published online 2020 Jun 12. doi: 10.1158/1055-9965.EPI-20-0203

PMCID:: PMC7415710

Abstract Article PDF–342K

Select item 737409713.

UGT2B17 modifies drug response in chronic lymphocytic leukaemia

Eric P. Allain, Michèle Rouleau, Katrina Vanura, Sophie Tremblay, Joanie Vaillancourt, Vincent Bat, Patrick Caron, Lyne Villeneuve, Adrien Labriet, Véronique Turcotte, Trang Le, Medhat Shehata, Susanne Schnabl, Dita Demirtas, Rainer Hubmann, Charles Joly-Beauparlant, Arnaud Droit, Ulrich Jäger, Philipp B. Staber, Eric Lévesque, Chantal Guillemette

Br J Cancer. 2020 Jul 21; 123(2): 240–251. Published online 2020 May 18. doi: 10.1038/s41416-020-0887-6

PMCID:: PMC7374097

Abstract Article PDF–1.0M

Select item 724505714.

Influences of UGT2B7 rs7439366 and rs12233719 Polymorphisms on Fentanyl Sensitivity in Chinese Gynecologic Patients

Zhenling Yang, Qingfeng Yin, Xiaodong Li

Med Sci Monit. 2020; 26: e924153-1–e924153-5. Prepublished online 2020 May 6. Published online 2020 May 13. doi: 10.12659/MSM.924153

PMCID:: PMC7245057

Abstract Article PDF–202K

Select item 722008915.

The correlation between UDP-glucuronosyltransferase polymorphisms and environmental endocrine disruptors levels in polycystic ovary syndrome patients

Yunyao Luo, Ying Nie, Lu Tang, Charles C. Xu, Liangzhi Xu

Medicine (Baltimore) 2020 Mar; 99(11): e19444. Published online 2020 Mar 13. doi: 10.1097/MD.0000000000019444

PMCID:: PMC7220089

Abstract Article PDF–318K

Select item 716998316.

A reference map of the human binary protein interactome

Katja Luck, Dae-Kyum Kim, Luke Lambourne, Kerstin Spirohn, Bridget E. Begg, Wenting Bian, Ruth Brignall, Tiziana Cafarelli, Francisco J. Campos-Laborie, Benoit Charloteaux, Dongsic Choi, Atina G. Coté, Meaghan Daley, Steven Deimling, Alice Desbuleux, Amélie Dricot, Marinella Gebbia, Madeleine F. Hardy, Nishka Kishore, Jennifer J. Knapp, István A. Kovács, Irma Lemmens, Miles W. Mee, Joseph C. Mellor, Carl Pollis, Carles Pons, Aaron D. Richardson, Sadie Schlabach, Bridget Teeking, Anupama Yadav, Mariana Babor, Dawit Balcha, Omer Basha, Christian Bowman-Colin, Suet-Feung Chin, Soon Gang Choi, Claudia Colabella, Georges Coppin, Cassandra D’Amata, David De Ridder, Steffi De Rouck, Miquel Duran-Frigola, Hanane Ennajdaoui, Florian Goebels, Liana Goehring, Anjali Gopal, Ghazal Haddad, Elodie Hatchi, Mohamed Helmy, Yves Jacob, Yoseph Kassa, Serena Landini, Roujia Li, Natascha van Lieshout, Andrew MacWilliams, Dylan Markey, Joseph N. Paulson, Sudharshan Rangarajan, John Rasla, Ashyad Rayhan, Thomas Rolland, Adriana San-Miguel, Yun Shen, Dayag Sheykhkarimli, Gloria M. Sheynkman, Eyal Simonovsky, Murat Taşan, Alexander Tejeda, Vincent Tropepe, Jean-Claude Twizere, Yang Wang, Robert J. Weatheritt, Jochen Weile, Yu Xia, Xinping Yang, Esti Yeger-Lotem, Quan Zhong, Patrick Aloy, Gary D. Bader, Javier De Las Rivas, Suzanne Gaudet, Tong Hao, Janusz Rak, Jan Tavernier, David E. Hill, Marc Vidal, Frederick P. Roth, Michael A. Calderwood

Nature. Author manuscript; available in PMC 2020 Oct 8.

Published in final edited form as: Nature. 2020 Apr; 580(7803): 402–408. Published online 2020 Apr 8. doi: 10.1038/s41586-020-2188-x

PMCID:: PMC7169983

Abstract Article PDF–5.4M

Select item 710910017.

Alternative promoters control UGT2B17-dependent androgen catabolism in prostate cancer and its influence on progression

Eric Lévesque, Adrien Labriet, Hélène Hovington, Éric P. Allain, Luciana Melo-Garcia, Michèle Rouleau, Hervé Brisson, Véronique Turcotte, Patrick Caron, Lyne Villeneuve, Mickaël Leclercq, Arnaud Droit, Etienne Audet-Walsh, David Simonyan, Yves Fradet, Louis Lacombe, Chantal Guillemette

Br J Cancer. 2020 Mar 31; 122(7): 1068–1076. Published online 2020 Feb 12. doi: 10.1038/s41416-020-0749-2

PMCID:: PMC7109100

Abstract Article PDF–1.6M

Select item 706318618.

Association of SCN1A, SCN2A, and UGT2B7 Polymorphisms with Responsiveness to Valproic Acid in the Treatment of Epilepsy

Yuan Lu, Quanping Su, Ming Li, Alimu Dayimu, Xiaoyu Dai, Zhiheng Wang, Fengyuan Che, Fuzhong Xue

Biomed Res Int. 2020; 2020: 8096235. Published online 2020 Feb 25. doi: 10.1155/2020/8096235

PMCID:: PMC7063186

Abstract Article PDF–609K

Select item 703176419.

The Human UGT2B7 Nanodisc

Ian Cook, Anna B. Asenjo, Hernando Sosa, Thomas S. Leyh

Drug Metab Dispos. 2020 Mar; 48(3): 198–204. Published online 2020 Mar. doi: 10.1124/dmd.119.089946

PMCID:: PMC7031764

Abstract Article PDF–453K

Select item 689649520.

Ages of hepatocellular carcinoma occurrence and life expectancy are associated with a UGT2B28 genomic variation

Puo-Hsien Le, Chia-Jung Kuo, Yi-Chung Hsieh, Tsung-Hsing Chen, Chih-Lang Lin, Chau-Ting Yeh, Kung-Hao Liang

BMC Cancer. 2019; 19: 1190. Published online 2019 Dec 5. doi: 10.1186/s12885-019-6409-3

PMCID:: PMC6896495

Abstract Article PDF–1.3M

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