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Select item 98867071.

Recapitulation of anti-aging phenotypes by global, but not by muscle-specific, deletion of PAPP-A in mice

Xinna Li, Mary Hager, Madaline McPherson, Michael Lee, Riha Hagalwadi, Mary E. Skinner, David Lombard, Richard A. Miller

GeroScience. 2023 Apr; 45(2): 931–948. Published online 2022 Dec 21. doi: 10.1007/s11357-022-00692-3

PMCID:: PMC9886707

Abstract Article PDF–4.5M

Select item 97968142.

Endothelial PlexinD1 signaling instructs spinal cord vascularization and motor neuron development

José Ricardo Vieira, Bhavin Shah, Sebastian Dupraz, Isidora Paredes, Patricia Himmels, Géza Schermann, Heike Adler, Alessia Motta, Lea Gärtner, Ariadna Navarro-Aragall, Elena Ioannou, Elena Dyukova, Remy Bonnavion, Andreas Fischer, Dario Bonanomi, Frank Bradke, Christiana Ruhrberg, Carmen Ruiz de Almodóvar

Neuron. 2022 Dec 21; 110(24): 4074–4089.e6. doi: 10.1016/j.neuron.2022.12.005

PMCID:: PMC9796814

Abstract Article

Select item 89561343.

A functional cellular framework for sex and estrous cycle-dependent gene expression and behavior

Joseph R. Knoedler, Sayaka Inoue, Daniel W. Bayless, Taehong Yang, Adarsh Tantry, Chung-ha Davis, Nicole Y. Leung, Srinivas Parthasarathy, Grace Wang, Maricruz Alvarado, Abbas H. Rizvi, Lief E. Fenno, Charu Ramakrishnan, Karl Deisseroth, Nirao M. Shah

Cell. Author manuscript; available in PMC 2023 Feb 17.

Published in final edited form as: Cell. 2022 Feb 17; 185(4): 654–671.e22. Published online 2022 Jan 21. doi: 10.1016/j.cell.2021.12.031

Correction in:: Cell. 2024 Jul 11; 187(14): 3781.

PMCID:: PMC8956134

Abstract Article PDF–4.6M

Select item 89401774.

Control of spinal motor neuron terminal differentiation through sustained Hoxc8 gene activity

Catarina Catela, Yihan Chen, Yifei Weng, Kailong Wen, Paschalis Kratsios

eLife. 2022; 11: e70766. Published online 2022 Mar 22. doi: 10.7554/eLife.70766

PMCID:: PMC8940177

Abstract Article PDF–6.0M

Select item 88623085.

Germline saturation mutagenesis induces skeletal phenotypes in mice

Jonathan J Rios, Kristin Denton, Jamie Russell, Julia Kozlitina, Carlos R Ferreira, Amy F Lewanda, Joshua E Mayfield, Eva Moresco, Sara Ludwig, Miao Tang, Xiaohong Li, Stephen Lyon, Anas Khanshour, Nandina Paria, Aysha Khalid, Yang Li, Xudong Xie, Jian Q Feng, Qian Xu, Yongbo Lu, Robert E Hammer, Carol A Wise, Bruce Beutler

J Bone Miner Res. Author manuscript; available in PMC 2022 Aug 1.

Published in final edited form as: J Bone Miner Res. 2021 Aug; 36(8): 1548–1565. Published online 2021 May 10. doi: 10.1002/jbmr.4323

PMCID:: PMC8862308

Abstract Article PDF–2.5M

Select item 84940126.

Brain-specific PAPP-A Knock-out Mice?

Laurie K. Bale, Sally A. West, Cheryl A. Conover

Exp Gerontol. Author manuscript; available in PMC 2022 Oct 15.

Published in final edited form as: Exp Gerontol. 2021 Oct 15; 154: 111548. Published online 2021 Sep 9. doi: 10.1016/j.exger.2021.111548

PMCID:: PMC8494012

Abstract Article PDF–285K

Select item 83752437.

PAPPA-mediated adipose tissue remodeling mitigates insulin resistance and protects against gestational diabetes in mice and humans

Raziel Rojas-Rodriguez, Rachel Ziegler, Tiffany DeSouza, Sana Majid, Aylin S. Madore, Nili Amir, Veronica A. Pace, Daniel Nachreiner, David Alfego, Jomol Mathew, Katherine Leung, Tiffany A. Moore Simas, Silvia Corvera

Sci Transl Med. Author manuscript; available in PMC 2021 Aug 19.

Published in final edited form as: Sci Transl Med. 2020 Nov 25; 12(571): eaay4145. doi: 10.1126/scitranslmed.aay4145

PMCID:: PMC8375243

Abstract Article PDF–1.2M

Select item 79633328.

Inhibition of longevity regulator PAPP‐A modulates tissue homeostasis via restraint of mesenchymal stromal cells

Mary Mohrin, Justin Liu, Jose Zavala‐Solorio, Sakshi Bhargava, John Maxwell Trumble, Alyssa Brito, Dorothy Hu, Daniel Brooks, Georgios Koukos, Lama Alabdulaaly, Jonathan S. Paw, Kayley Hake, Ganesh Kolumam, Mary L. Bouxsein, Roland Baron, Yuliya Kutskova, Adam Freund

Aging Cell. 2021 Mar; 20(3): e13313. Published online 2021 Feb 9. doi: 10.1111/acel.13313

PMCID:: PMC7963332

Abstract Article PDF–2.2M

Select item 79387709.

BraInMap elucidates the macromolecular connectivity landscape of mammalian brain

Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili

Cell Syst. Author manuscript; available in PMC 2021 Apr 22.

Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003

Correction in:: Cell Syst. 2020 Aug 26; 11(2): 208.

PMCID:: PMC7938770

Abstract Article PDF–2.0M

Select item 752855610.

Genetic and Pharmacological Inhibition of PAPP-A Protects Against Visceral Obesity in Mice

Akhila Ramakrishna, Laurie K Bale, Sally A West, Cheryl A Conover

Endocrinology. 2020 Oct; 161(10): bqaa160. Published online 2020 Sep 5. doi: 10.1210/endocr/bqaa160

PMCID:: PMC7528556

Abstract Article

Select item 717855311.

Host Cathelicidin Exacerbates Group B Streptococcus Urinary Tract Infection

Kathryn A. Patras, Alison Coady, Priyanka Babu, Samuel R. Shing, Albert D. Ha, Emma Rooholfada, Stephanie L. Brandt, Matthew Geriak, Richard L. Gallo, Victor Nizet

mSphere. 2020 Mar-Apr; 5(2): e00932-19. Published online 2020 Apr 22. doi: 10.1128/mSphere.00932-19

PMCID:: PMC7178553

Abstract Article PDF–1.7M

Select item 710114812.

Metalloproteinase PAPP-A regulation of IGF-1 contributes to polycystic kidney disease pathogenesis

Sonu Kashyap, Kyaw Zaw Hein, Claudia C.S. Chini, Jorgo Lika, Gina M. Warner, Laurie K. Bale, Vicente E. Torres, Peter C. Harris, Claus Oxvig, Cheryl A. Conover, Eduardo N. Chini

JCI Insight. 2020 Feb 27; 5(4): e135700. Published online 2020 Feb 27. doi: 10.1172/jci.insight.135700

PMCID:: PMC7101148

Abstract Article PDF–10M

Select item 674881313.

Pregnancy-Associated Plasma Protein-A (PAPP-A) in Ewing Sarcoma: Role in Tumor Growth and Immune Evasion

Sabine Heitzeneder, Elena Sotillo, Jack F Shern, Sivasish Sindiri, Peng Xu, Robert Jones, Michael Pollak, Pernille R Noer, Julie Lorette, Ladan Fazli, Anya Alag, Paul Meltzer, Ching Lau, Cheryl A Conover, Claus Oxvig, Poul H Sorensen, John M Maris, Javed Khan, Crystal L Mackall

J Natl Cancer Inst. 2019 Sep; 111(9): 970–982. Published online 2019 Jan 30. doi: 10.1093/jnci/djy209