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Select item 108973041.

Lactylation-driven FTO targets CDK2 to aggravate microvascular anomalies in diabetic retinopathy

Xue Chen, Ying Wang, Jia-Nan Wang, Yi-Chen Zhang, Ye-Ran Zhang, Ru-Xu Sun, Bing Qin, Yuan-Xin Dai, Hong-Jing Zhu, Jin-Xiang Zhao, Wei-Wei Zhang, Jiang-Dong Ji, Song-Tao Yuan, Qun-Dong Shen, Qing-Huai Liu

EMBO Mol Med. 2024 Feb; 16(2): 294–318. Published online 2024 Jan 31. doi: 10.1038/s44321-024-00025-1

PMCID:: PMC10897304

Abstract Article PDF–6.8M

Select item 104498042.

Expression of Cyclin E1 in hepatic stellate cells is critical for the induction and progression of liver fibrosis and hepatocellular carcinoma in mice

Julia Otto, Anna Verwaayen, Christian Penners, Jana Hundertmark, Cheng Lin, Carina Kallen, Daniela Paffen, Tobias Otto, Hilmar Berger, Frank Tacke, Ralf Weiskirchen, Yulia A. Nevzorova, Matthias Bartneck, Christian Trautwein, Roland Sonntag, Christian Liedtke

Cell Death Dis. 2023 Aug; 14(8): 549. Published online 2023 Aug 24. doi: 10.1038/s41419-023-06077-4

PMCID:: PMC10449804

Abstract Article PDF–12M

Select item 100358763.

Identification PMS1 and PMS2 as potential meiotic substrates of CDK2 activity

Nathan Palmer, S. Zakiah A. Talib, Christine M. F. Goh, Kajal Biswas, Shyam K. Sharan, Philipp Kaldis

PLoS One. 2023; 18(3): e0283590. Published online 2023 Mar 23. doi: 10.1371/journal.pone.0283590

PMCID:: PMC10035876

Abstract Article PDF–3.3M

Select item 95539514.

Neonatal ketone body elevation regulates postnatal heart development by promoting cardiomyocyte mitochondrial maturation and metabolic reprogramming

Danyang Chong, Yayun Gu, Tongyu Zhang, Yu Xu, Dandan Bu, Zhong Chen, Na Xu, Liangkui Li, Xiyu Zhu, Haiquan Wang, Yangqing Li, Feng Zheng, Dongjin Wang, Peng Li, Li Xu, Zhibin Hu, Chaojun Li

Cell Discov. 2022; 8: 106. Published online 2022 Oct 11. doi: 10.1038/s41421-022-00447-6

PMCID:: PMC9553951

Abstract Article PDF–3.8M

Select item 94995405.

A kinase-independent function of cyclin-dependent kinase 6 promotes outer radial glia expansion and neocortical folding

Lei Wang, Jun Young Park, Fengming Liu, Kris M. Olesen, Shirui Hou, Jamy C. Peng, Jordan Infield, Anna C. Levesque, Yong-Dong Wang, Hongjian Jin, Yiping Fan, Patrick J. Connelly, Shondra M. Pruett-Miller, Miaofen G. Hu, Philip W. Hinds, Young-Goo Han

Proc Natl Acad Sci U S A. 2022 Sep 20; 119(38): e2206147119. Published online 2022 Sep 12. doi: 10.1073/pnas.2206147119

PMCID:: PMC9499540

Abstract Article PDF–3.4M

Select item 94819336.

ALS-linked loss of Cyclin-F function affects HSP90

Alexander Siebert, Vanessa Gattringer, Jochen H Weishaupt, Christian Behrends

Life Sci Alliance. 2022 Dec; 5(12): e202101359. Published online 2022 Sep 16. doi: 10.26508/lsa.202101359

PMCID:: PMC9481933

Abstract Article PDF–3.5M

Select item 91190077.

Cdk2 suppresses IL‐23 expression and the onset of severe acute pancreatitis

Yanpeng Ma, Longlong Liu, Bin Li, Wenyao Wang, Tingting Zhao

Immun Inflamm Dis. 2022 Jun; 10(6): e631. Published online 2022 May 19. doi: 10.1002/iid3.631

PMCID:: PMC9119007

Abstract Article PDF–1.0M

Select item 87264908.

HES1 is a novel downstream modifier of the SHH-GLI3 Axis in the development of preaxial polydactyly

Deepika Sharma, Anthony J. Mirando, Abigail Leinroth, Jason T. Long, Courtney M. Karner, Matthew J. Hilton

PLoS Genet. 2021 Dec; 17(12): e1009982. Published online 2021 Dec 20. doi: 10.1371/journal.pgen.1009982

PMCID:: PMC8726490

Abstract Article PDF–3.4M

Select item 86354469.

Heart neurons use clock genes to control myocyte proliferation

Emmanouil Tampakakis, Harshi Gangrade, Stephanie Glavaris, Myo Htet, Sean Murphy, Brian Leei Lin, Ting Liu, Amir Saberi, Matthew Miyamoto, William Kowalski, Yoh-Suke Mukouyama, Gabsang Lee, Liliana Minichiello, Chulan Kwon

Sci Adv. 2021 Dec; 7(49): eabh4181. Published online 2021 Dec 1. doi: 10.1126/sciadv.abh4181

PMCID:: PMC8635446

Abstract Article PDF–6.2M

Select item 858411210.

Regulation of p27 and Cdk2 Expression in Different Adipose Tissue Depots in Aging and Obesity

Ignacio Colón-Mesa, Marta Fernández-Galilea, Neira Sáinz, Marta Lopez-Yus, Jose M. Artigas, José Miguel Arbonés-Mainar, Elisa Félix-Soriano, Xavier Escoté, María Jesús Moreno-Aliaga

Int J Mol Sci. 2021 Nov; 22(21): 11745. Published online 2021 Oct 29. doi: 10.3390/ijms222111745

PMCID:: PMC8584112

Abstract Article PDF–9.3M

Select item 856411711.

Alternative Functions of Cell Cycle-Related and DNA Repair Proteins in Post-mitotic Neurons

Remi Akagawa, Yo-ichi Nabeshima, Takeshi Kawauchi

Front Cell Dev Biol. 2021; 9: 753175. Published online 2021 Oct 20. doi: 10.3389/fcell.2021.753175

PMCID:: PMC8564117

Abstract Article PDF–2.2M

Select item 790202712.

Maternal UHRF1 Is Essential for Transcription Landscapes and Repression of Repetitive Elements During the Maternal-to-Zygotic Transition

Yanqing Wu, Juan Dong, Shenglei Feng, Qiang Zhao, Peng Duan, Mengneng Xiong, Yujiao Wen, Chunyu Lv, Xiaoli Wang, Shuiqiao Yuan

Front Cell Dev Biol. 2020; 8: 610773. Published online 2021 Feb 9. doi: 10.3389/fcell.2020.610773

PMCID:: PMC7902027

Abstract Article PDF–3.9M

Select item 788206613.

CDK2 limits the highly energetic secretory program of mature β cells by restricting PEP cycle-dependent K_ATP channel closure

Sophia M. Sdao, Thuong Ho, Chetan Poudel, Hannah R. Foster, Elizabeth R. De Leon, Melissa T. Adams, Ji-Hyeon Lee, Barak Blum, Sushil G. Rane, Matthew J. Merrins

Cell Rep. Author manuscript; available in PMC 2021 Feb 14.

Published in final edited form as: Cell Rep. 2021 Jan 26; 34(4): 108690. doi: 10.1016/j.celrep.2021.108690

PMCID:: PMC7882066

Abstract Article PDF–1.5M

Select item 768431914.

STRAP regulates alternative splicing fidelity during lineage commitment of mouse embryonic stem cells

Lin Jin, Yunjia Chen, David K. Crossman, Arunima Datta, Trung Vu, James A. Mobley, Malay Kumar Basu, Mariangela Scarduzio, Hengbin Wang, Chenbei Chang, Pran K. Datta

Nat Commun. 2020; 11: 5941. Published online 2020 Nov 23. doi: 10.1038/s41467-020-19698-6

PMCID:: PMC7684319

Abstract Article PDF–3.4M

Select item 764135815.

Loss of hepatocyte cell division leads to liver inflammation and fibrosis

Matthew R. Dewhurst, Jin Rong Ow, Gözde Zafer, Noémi K. M. van Hul, Heike Wollmann, Xavier Bisteau, David Brough, Hyungwon Choi, Philipp Kaldis

PLoS Genet. 2020 Nov; 16(11): e1009084. Published online 2020 Nov 4. doi: 10.1371/journal.pgen.1009084

PMCID:: PMC7641358

Abstract Article PDF–5.9M

Select item 759564016.

A novel function for CDK2 activity at meiotic crossover sites

Nathan Palmer, S. Zakiah A. Talib, Priti Singh, Christine M. F. Goh, Kui Liu, John C. Schimenti, Philipp Kaldis

PLoS Biol. 2020 Oct; 18(10): e3000903. Published online 2020 Oct 19. doi: 10.1371/journal.pbio.3000903

PMCID:: PMC7595640

Abstract Article PDF–3.4M

Select item 749826717.

A missense in HSF2BP causing primary ovarian insufficiency affects meiotic recombination by its novel interactor C19ORF57/BRME1

Natalia Felipe-Medina, Sandrine Caburet, Fernando Sánchez-Sáez, Yazmine B Condezo, Dirk G de Rooij, Laura Gómez-H, Rodrigo Garcia-Valiente, Anne Laure Todeschini, Paloma Duque, Manuel Adolfo Sánchez-Martin, Stavit A Shalev, Elena Llano, Reiner A Veitia, Alberto M Pendás

eLife. 2020; 9: e56996. Published online 2020 Aug 26. doi: 10.7554/eLife.56996