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Select item 105166291.

Pot1b^−/− tumors activate G-quadruplex-induced DNA damage to promote telomere hyper-elongation

Taylor Takasugi, Peili Gu, Fengshan Liang, Isabelle Staco, Sandy Chang

Nucleic Acids Res. 2023 Sep 22; 51(17): 9227–9247. Published online 2023 Aug 10. doi: 10.1093/nar/gkad648

PMCID:: PMC10516629

Abstract Article PDF–4.5M

Select item 92121512.

A mouse model for Li-Fraumeni-Like Syndrome with cardiac angiosarcomas associated to POT1 mutations

Paula Martínez, Raúl Sánchez-Vázquez, Iole Ferrara-Romeo, Rosa Serrano, Juana M. Flores, Maria A. Blasco

PLoS Genet. 2022 Jun; 18(6): e1010260. Published online 2022 Jun 21. doi: 10.1371/journal.pgen.1010260

PMCID:: PMC9212151

Abstract Article PDF–3.4M

Select item 91610093.

TRF2-mediated telomere protection is dispensable in pluripotent stem cells

Marta Markiewicz-Potoczny, Anastasia Lobanova, Anisha M. Loeb, Oktay Kirak, Teresa Olbrich, Sergio Ruiz, Eros Lazzerini Denchi

Nature. Author manuscript; available in PMC 2022 Jun 2.

Published in final edited form as: Nature. 2021 Jan; 589(7840): 110–115. Published online 2020 Nov 25. doi: 10.1038/s41586-020-2959-4

PMCID:: PMC9161009

Abstract Article PDF–5.8M

Select item 84487354.

Distinct functions of POT1 proteins contribute to the regulation of telomerase recruitment to telomeres

Peili Gu, Shuting Jia, Taylor Takasugi, Valerie M. Tesmer, Jayakrishnan Nandakumar, Yong Chen, Sandy Chang

Nat Commun. 2021; 12: 5514. Published online 2021 Sep 17. doi: 10.1038/s41467-021-25799-7

PMCID:: PMC8448735

Abstract Article PDF–8.7M

Select item 61395655.

Protection of telomeres 1 proteins POT1a and POT1b can repress ATR signaling by RPA exclusion, but binding to CST limits ATR repression by POT1b

Katja Kratz, Titia de Lange

J Biol Chem. 2018 Sep 14; 293(37): 14384–14392. Published online 2018 Aug 6. doi: 10.1074/jbc.RA118.004598

PMCID:: PMC6139565

Abstract Article PDF–2.5M

Select item 60725596.

53BP1/Rif1/Shieldin counteract DSB resection through CST/Polα-dependent fill-in

Zachary Mirman, Francisca Lottersberger, Hiroyuki Takai, Tatsuya Kibe, Yi Gong, Kaori Takai, Alessandro Bianchi, Michal Zimmermann, Daniel Durocher, Titia de Lange

Nature. Author manuscript; available in PMC 2019 Jan 18.

Published in final edited form as: Nature. 2018 Aug; 560(7716): 112–116. Published online 2018 Jul 18. doi: 10.1038/s41586-018-0324-7

PMCID:: PMC6072559

Abstract Article PDF–1.8M

Select item 54251237.

The differential spatiotemporal expression pattern of shelterin genes throughout lifespan

Kay-Dietrich Wagner, Yilin Ying, Waiian Leong, Jie Jiang, Xuefei Hu, Yi Chen, Jean-François Michiels, Yiming Lu, Eric Gilson, Nicole Wagner, Jing Ye

Aging (Albany NY) 2017 Apr; 9(4): 1219–1228. Published online 2017 Apr 17. doi: 10.18632/aging.101223

PMCID:: PMC5425123

Abstract Article PDF–4.4M

Select item 52871128.

PHF11 promotes DSB resection, ATR signaling, and HR

Yi Gong, Naofumi Handa, Stephen C. Kowalczykowski, Titia de Lange

Genes Dev. 2017 Jan 1; 31(1): 46–58. doi: 10.1101/gad.291807.116

PMCID:: PMC5287112

Abstract Article PDF–664K

Select item 49336659.

Dysfunctional telomeres induce p53‐dependent and independent apoptosis to compromise cellular proliferation and inhibit tumor formation

Yang Wang, Xinwei Wang, Elsa R. Flores, Jian Yu, Sandy Chang

Aging Cell. 2016 Aug; 15(4): 646–660. Published online 2016 Apr 26. doi: 10.1111/acel.12476

PMCID:: PMC4933665

Abstract Article PDF–2.0M

Select item 414884910.

Binding of TPP1 Protein to TIN2 Protein Is Required for POT1a,b Protein-mediated Telomere Protection

David Frescas, Titia de Lange

J Biol Chem. 2014 Aug 29; 289(35): 24180–24187. Published online 2014 Jul 23. doi: 10.1074/jbc.M114.592592

PMCID:: PMC4148849

Abstract Article PDF–2.5M

Select item 406287311.

Super-resolution fluorescence imaging of telomeres reveals TRF2-dependent t-loop formation

Ylli Doksani, John Y. Wu, Titia de Lange, Xiaowei Zhuang

Cell. Author manuscript; available in PMC 2014 Oct 10.

Published in final edited form as: Cell. 2013 Oct 10; 155(2): 345–356. doi: 10.1016/j.cell.2013.09.048

PMCID:: PMC4062873

Abstract Article PDF–438K

Select item 399356012.

TRF2-Tethered TIN2 Can Mediate Telomere Protection by TPP1/POT1

David Frescas, Titia de Lange

Mol Cell Biol. 2014 Apr; 34(7): 1349–1362. doi: 10.1128/MCB.01052-13

PMCID:: PMC3993560

Abstract Article PDF–5.2M

Select item 378454313.

p16^INK4a protects against dysfunctional telomere–induced ATR-dependent DNA damage responses

Yang Wang, Norman Sharpless, Sandy Chang

J Clin Invest. 2013 Oct 1; 123(10): 4489–4501. Published online 2013 Sep 16. doi: 10.1172/JCI69574

PMCID:: PMC3784543

Abstract Article PDF–4.4M

Select item 368073214.

HOT1 is a mammalian direct telomere repeat-binding protein contributing to telomerase recruitment

Dennis Kappei, Falk Butter, Christian Benda, Marion Scheibe, Irena Draškovič, Michelle Stevense, Clara Lopes Novo, Claire Basquin, Masatake Araki, Kimi Araki, Dragomir Blazhev Krastev, Ralf Kittler, Rolf Jessberger, J Arturo Londoño-Vallejo, Matthias Mann, Frank Buchholz

EMBO J. 2013 Jun 12; 32(12): 1681–1701. Published online 2013 May 17. doi: 10.1038/emboj.2013.105

PMCID:: PMC3680732

Abstract Article PDF–1.6M

Select item 357241015.

A conditional knockout resource for the genome–wide study of mouse gene function

William C. Skarnes, Barry Rosen, Anthony P. West, Manousos Koutsourakis, Wendy Bushell, Vivek Iyer, Alejandro O. Mujica, Mark Thomas, Jennifer Harrow, Tony Cox, David Jackson, Jessica Severin, Patrick Biggs, Jun Fu, Michael Nefedov, Pieter J. de Jong, A. Francis Stewart, Allan Bradley

Nature. Author manuscript; available in PMC 2013 Feb 14.

Published in final edited form as: Nature. 2011 Jun 15; 474(7351): 337–342. Published online 2011 Jun 15. doi: 10.1038/nature10163