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Select item 114472561.

Cell fixation improves performance of in situ crosslinking mass spectrometry while preserving cellular ultrastructure

Andrew R. M. Michael, Bruno C. Amaral, Kallie L. Ball, Kristen H. Eiriksson, David C. Schriemer

Nat Commun. 2024; 15: 8537. Published online 2024 Oct 2. doi: 10.1038/s41467-024-52844-y

PMCID:: PMC11447256

Abstract Article PDF–2.8M

Select item 113646432.

A sophisticated mechanism governs Pol ζ activity in response to replication stress

Chun Li, Shuchen Fan, Pan Li, Yuzhen Bai, Ye Wang, Yueyun Cui, Mengdi Li, Ruru Wang, Yuan Shao, Yingying Wang, Shuo Zheng, Rong Wang, Lijun Gao, Miaomiao Li, Yuanyuan Zheng, Fengting Wang, Sihang Gao, Shiguo Feng, Jianing Wang, Xinqi Qu, Xialu Li

Nat Commun. 2024; 15: 7562. Published online 2024 Aug 31. doi: 10.1038/s41467-024-52112-z

PMCID:: PMC11364643

Abstract Article PDF–3.4M

Select item 112969143.

DSBSO-Based XL-MS Analysis of Breast Cancer PDX Tissues to Delineate Protein Interaction Network in Clinical Samples

Fenglong Jiao, Clinton Yu, Andrew Wheat, Lijun Chen, Tung-Shing Mamie Lih, Hui Zhang, Lan Huang

J Proteome Res. Author manuscript; available in PMC 2024 Aug 3.

Published in final edited form as: J Proteome Res. 2024 Aug 2; 23(8): 3269–3279. Published online 2024 Feb 9. doi: 10.1021/acs.jproteome.3c00832

PMCID:: PMC11296914

Abstract Article PDF–1.7M

Select item 102431164.

Comprehensive Interactome Mapping of the DNA Repair Scaffold SLX4 Using Proximity Labeling and Affinity Purification

Camila M. Aprosoff, Boris J.A. Dyakov, Vivian H.W. Cheung, Cassandra J. Wong, Mikaela Palandra, Anne-Claude Gingras, Haley D.M. Wyatt

J Proteome Res. 2023 Jun 2; 22(6): 1660–1681. Published online 2023 Apr 18. doi: 10.1021/acs.jproteome.2c00706

PMCID:: PMC10243116

Abstract Article PDF–13M

Select item 101516155.

Cross-linking mass spectrometry discovers, evaluates, and corroborates structures and protein–protein interactions in the human cell

Tara K. Bartolec, Xabier Vázquez-Campos, Alexander Norman, Clement Luong, Marcus Johnson, Richard J. Payne, Marc R. Wilkins, Joel P. Mackay, Jason K. K. Low

Proc Natl Acad Sci U S A. 2023 Apr 25; 120(17): e2219418120. Published online 2023 Apr 18. doi: 10.1073/pnas.2219418120

PMCID:: PMC10151615

Abstract Article PDF–2.9M

Select item 93485766.

Chr21 protein–protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer’s disease

Julia Viard, Yann Loe-Mie, Rachel Daudin, Malik Khelfaoui, Christine Plancon, Anne Boland, Francisco Tejedor, Richard L Huganir, Eunjoon Kim, Makoto Kinoshita, Guofa Liu, Volker Haucke, Thomas Moncion, Eugene Yu, Valérie Hindie, Henri Bléhaut, Clotilde Mircher, Yann Herault, Jean-François Deleuze, Jean-Christophe Rain, Michel Simonneau, Aude-Marie Lepagnol-Bestel

Life Sci Alliance. 2022 Dec; 5(12): e202101205. Published online 2022 Aug 1. doi: 10.26508/lsa.202101205

PMCID:: PMC9348576

Abstract Article PDF–3.0M

Select item 92626147.

A dual-activity topoisomerase complex regulates mRNA translation and turnover

Shuaikun Su, Yutong Xue, Alexei Sharov, Yongqing Zhang, Seung Kyu Lee, Jennifer L Martindale, Wen Li, Wai Lim Ku, Keji Zhao, Supriyo De, Weiping Shen, Payel Sen, Myriam Gorospe, Dongyi Xu, Weidong Wang

Nucleic Acids Res. 2022 Jul 8; 50(12): 7013–7033. Published online 2022 Jun 24. doi: 10.1093/nar/gkac538

PMCID:: PMC9262614

Abstract Article PDF–3.6M

Select item 85889998.

The Protexin complex counters resection on stalled forks to promote homologous recombination and crosslink repair

Richard O. Adeyemi, Nicholas A. Willis, Andrew E.H. Elia, Connor Clairmont, Shibo Li, Xiaohua Wu, Alan D. D’Andrea, Ralph Scully, Stephen J. Elledge

Mol Cell. Author manuscript; available in PMC 2022 Nov 4.

Published in final edited form as: Mol Cell. 2021 Nov 4; 81(21): 4440–4456.e7. Published online 2021 Sep 30. doi: 10.1016/j.molcel.2021.09.008

PMCID:: PMC8588999

Abstract Article PDF–2.2M

Select item 85616399.

DNA polymerase zeta contributes to heterochromatin replication to prevent genome instability

Barbara Ben Yamin, Sana Ahmed‐Seghir, Junya Tomida, Emmanuelle Despras, Caroline Pouvelle, Andrey Yurchenko, Jordane Goulas, Raphael Corre, Quentin Delacour, Nathalie Droin, Philippe Dessen, Didier Goidin, Sabine S Lange, Sarita Bhetawal, Maria Teresa Mitjavila‐Garcia, Giuseppe Baldacci, Sergey Nikolaev, Jean Charles Cadoret, Richard D Wood, Patricia L Kannouche

EMBO J. 2021 Nov 2; 40(21): e104543. Published online 2021 Sep 17. doi: 10.15252/embj.2020104543

PMCID:: PMC8561639

Abstract Article PDF–4.4M

Select item 850094910.

REV1-Polζ maintains the viability of homologous recombination-deficient cancer cells through mutagenic repair of PRIMPOL-dependent ssDNA gaps

Angelo Taglialatela, Giuseppe Leuzzi, Vincenzo Sannino, Raquel Cuella-Martin, Jen-Wei Huang, Foon Wu-Baer, Richard Baer, Vincenzo Costanzo, Alberto Ciccia

Mol Cell. Author manuscript; available in PMC 2022 Oct 7.

Published in final edited form as: Mol Cell. 2021 Oct 7; 81(19): 4008–4025.e7. Published online 2021 Sep 10. doi: 10.1016/j.molcel.2021.08.016

PMCID:: PMC8500949

Abstract Article PDF–3.1M

Select item 836418111.

Protein interaction landscapes revealed by advanced in vivo cross-linking–mass spectrometry

Andrew Wheat, Clinton Yu, Xiaorong Wang, Anthony M. Burke, Ilan E. Chemmama, Robyn M. Kaake, Peter Baker, Scott D. Rychnovsky, Jing Yang, Lan Huang

Proc Natl Acad Sci U S A. 2021 Aug 10; 118(32): e2023360118. Published online 2021 Aug 4. doi: 10.1073/pnas.2023360118

PMCID:: PMC8364181

Abstract Article PDF–3.0M

Select item 830719412.

Cullin 1 (CUL1) Promotes Primary Ciliogenesis through the Induction of Ubiquitin-Proteasome-Dependent Dvl2 Degradation

Sun-Ok Kim, Kyoung Sang Cho, Bo Yeon Kim, Kyung Ho Lee

Int J Mol Sci. 2021 Jul; 22(14): 7572. Published online 2021 Jul 15. doi: 10.3390/ijms22147572

PMCID:: PMC8307194

Abstract Article PDF–2.8M

Select item 816503013.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 799002414.

Disruption of DNA polymerase ζ engages an innate immune response

Sara K. Martin, Junya Tomida, Richard D. Wood

Cell Rep. Author manuscript; available in PMC 2021 Mar 24.

Published in final edited form as: Cell Rep. 2021 Feb 23; 34(8): 108775. doi: 10.1016/j.celrep.2021.108775

PMCID:: PMC7990024

Abstract Article PDF–1.2M

Select item 766962815.

Translesion synthesis of 6-nitrochrysene-derived 2ʹ-deoxyadenosine adduct in human cells

Brent V. Powell, Jan Henric T. Bacurio, Ashis K. Basu

DNA Repair (Amst) Author manuscript; available in PMC 2021 Nov 1.

Published in final edited form as: DNA Repair (Amst). 2020 Nov; 95: 102935. Published online 2020 Jul 18. doi: 10.1016/j.dnarep.2020.102935

PMCID:: PMC7669628

Abstract Article PDF–925K

Select item 744605716.

Mutant POLQ and POLZ/REV3L DNA polymerases may contribute to the favorable survival of patients with tumors with POLE mutations outside the exonuclease domain

Fangjin Huang, Hisashi Tanaka, Beatrice S. Knudsen, Joanne K. Rutgers

BMC Med Genet. 2020; 21: 167. Published online 2020 Aug 24. doi: 10.1186/s12881-020-01089-9

PMCID:: PMC7446057

Abstract Article PDF–1.5M

Select item 718169717.

Molecular basis for assembly of the shieldin complex and its implications for NHEJ

Ling Liang, Jiawen Feng, Peng Zuo, Juan Yang, Yishuo Lu, Yuxin Yin

Nat Commun. 2020; 11: 1972. Published online 2020 Apr 24. doi: 10.1038/s41467-020-15879-5

PMCID:: PMC7181697

Abstract Article PDF–6.5M

Select item 714494818.

Site-specific proteolytic cleavage prevents ubiquitination and degradation of human REV3L, the catalytic subunit of DNA polymerase ζ

Fengting Wang, Pan Li, Yuan Shao, Yanyan Li, Kai Zhang, Miaomiao Li, Rong Wang, Shuo Zheng, Yingying Wang, Sen Song, Shiguo Feng, Fei Liu, Wei Xiao, Xialu Li

Nucleic Acids Res. 2020 Apr 17; 48(7): 3619–3637. Published online 2020 Feb 17. doi: 10.1093/nar/gkaa096

PMCID:: PMC7144948

Abstract Article PDF–10M

Select item 694204419.

Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity

Jae Jin Kim, Seo Yun Lee, Fade Gong, Anna M. Battenhouse, Daniel R. Boutz, Aarti Bashyal, Samantha T. Refvik, Cheng-Ming Chiang, Blerta Xhemalce, Tanya T. Paull, Jennifer S. Brodbelt, Edward M. Marcotte, Kyle M. Miller

Genes Dev. 2019 Dec 1; 33(23-24): 1751–1774. doi: 10.1101/gad.331231.119

PMCID:: PMC6942044

Abstract Article PDF–10M

Select item 689527820.

DNA polymerase ζ in DNA replication and repair

Sara K Martin, Richard D Wood

Nucleic Acids Res. 2019 Sep 19; 47(16): 8348–8361. Published online 2019 Aug 14. doi: 10.1093/nar/gkz705

PMCID:: PMC6895278

Abstract Article PDF–3.1M

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