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Items: 1 to 20 of 270

1.
Mast cell regranulation requires a metabolic switch involving mTORC1 and a glucose-6-phosphate transporter
Jason A Iskarpatyoti, Jianling Shi, Mathew A Abraham, Abhay P S Rathore, Yuxuan Miao, Soman N Abraham
Cell Rep. Author manuscript; available in PMC 2024 Jul 2.
Published in final edited form as: Cell Rep. 2022 Sep 27; 40(13): 111346. doi: 10.1016/j.celrep.2022.111346
PMCID:
PMC11218746
AbstractArticlePDF–1.8M
2.
The level of protein in the maternal murine diet modulates the facial appearance of the offspring via mTORC1 signaling
Meng Xie, Markéta Kaiser, Yaakov Gershtein, Daniela Schnyder, Ruslan Deviatiiarov, Guzel Gazizova, Elena Shagimardanova, Tomáš Zikmund, Greet Kerckhofs, Evgeny Ivashkin, Dominyka Batkovskyte, Phillip T. Newton, Olov Andersson, Kaj Fried, Oleg Gusev, Hugo Zeberg, Jozef Kaiser, Igor Adameyko, Andrei S. Chagin
Nat Commun. 2024; 15: 2367. Published online 2024 Mar 26. doi: 10.1038/s41467-024-46030-3
PMCID:
PMC10965948
AbstractArticlePDF–9.9M
3.
Genetic determinants of micronucleus formation in vivo
D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus
Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0
PMCID:
PMC10917660
AbstractArticlePDF–4.8M
4.
Reprogramming tumour-associated macrophages to outcompete cancer cells
Xian Zhang, Shun Li, Isha Malik, Mytrang H. Do, Liangliang Ji, Chun Chou, Wei Shi, Kristelle J. Capistrano, Jing Zhang, Ting-Wei Hsu, Briana G. Nixon, Ke Xu, Xinxin Wang, Andrea Ballabio, Laura S. Schmidt, W. Marston Linehan, Ming O. Li
Nature. Author manuscript; available in PMC 2023 Dec 14.
Published in final edited form as: Nature. 2023 Jul; 619(7970): 616–623. Published online 2023 Jun 28. doi: 10.1038/s41586-023-06256-5
PMCID:
PMC10719927
AbstractArticlePDF–5.6M
5.
Glucagon-like peptide-1 receptor activation stimulates PKA-mediated phosphorylation of Raptor and this contributes to the weight loss effect of liraglutide
Thao DV Le, Dianxin Liu, Gai-Linn K Besing, Ritika Raghavan, Blair J Ellis, Ryan P Ceddia, Sheila Collins, Julio E Ayala
eLife. 2023; 12: e80944. Published online 2023 Nov 6. doi: 10.7554/eLife.80944
PMCID:
PMC10691799
AbstractArticlePDF–1.7M
6.
mTORC1-selective activation of translation elongation promotes disease progression in chronic lymphocytic leukemia
Natasha Malik, Jodie Hay, Hassan N. B. Almuhanna, Karen M. Dunn, Jamie Lees, Jennifer Cassels, Jiatian Li, Rinako Nakagawa, Owen J. Sansom, Alison M. Michie
Leukemia. 2023; 37(12): 2414–2425. Published online 2023 Sep 29. doi: 10.1038/s41375-023-02043-3
PMCID:
PMC10681897
AbstractArticlePDF–4.8M
7.
Uptake of tumor-derived microparticles induces metabolic reprogramming of macrophages in the early metastatic lung
Kelly Kersten, Ran You, Sophia Liang, Kevin M. Tharp, Joshua Pollack, Valerie M. Weaver, Matthew F. Krummel, Mark B. Headley
Cell Rep. Author manuscript; available in PMC 2023 Oct 23.
Published in final edited form as: Cell Rep. 2023 Jun 27; 42(6): 112582. Published online 2023 May 31. doi: 10.1016/j.celrep.2023.112582
PMCID:
PMC10592447
AbstractArticlePDF–1.1M
8.
Steroidogenic factor 1 (SF-1; Nr5a1) regulates the formation of the ovarian reserve
Camilla H. K. Hughes, Olivia E. Smith, Marie-Charlotte Meinsohn, Mylène Brunelle, Nicolas Gévry, Bruce D. Murphy
Proc Natl Acad Sci U S A. 2023 Aug 8; 120(32): e2220849120. Published online 2023 Jul 26. doi: 10.1073/pnas.2220849120
PMCID:
PMC10410717
AbstractArticlePDF–3.9M
9.
Architecture of androgen receptor pathways amplifying glucagon-like peptide-1 insulinotropic action in male pancreatic β cells
Weiwei Xu, M.M. Fahd Qadir, Daniela Nasteska, Paula Mota de Sa, Caroline M. Gorvin, Manuel Blandino-Rosano, Charles R. Evans, Thuong Ho, Evgeniy Potapenko, Rajakrishnan Veluthakal, Fiona B. Ashford, Stavroula Bitsi, Jia Fan, Manika Bhondeley, Kejing Song, Venkata N. Sure, Siva S.V.P. Sakamuri, Lina Schiffer, Wandy Beatty, Rachael Wyatt, Daniel E. Frigo, Xiaowen Liu, Prasad V. Katakam, Wiebke Arlt, Jochen Buck, Lonny R. Levin, Tony Hu, Jay Kolls, Charles F. Burant, Alejandra Tomas, Matthew J. Merrins, Debbie C. Thurmond, Ernesto Bernal-Mizrachi, David J. Hodson, Franck Mauvais-Jarvis
Cell Rep. Author manuscript; available in PMC 2023 Jun 30.
Published in final edited form as: Cell Rep. 2023 May 30; 42(5): 112529. Published online 2023 May 17. doi: 10.1016/j.celrep.2023.112529
PMCID:
PMC10312392
AbstractArticlePDF–3.8M
10.
Maternal hyperglycemia inhibits pulmonary vasculogenesis during mouse fetal lung development by promoting GβL Ubiquitination-dependent mammalian target of Rapamycin assembly
Qingqing Luo, Xinqun Chai, Xiaoyan Xin, Weixiang Ouyang, Feitao Deng
Diabetol Metab Syndr. 2023; 15: 49. Published online 2023 Mar 17. doi: 10.1186/s13098-022-00974-y
PMCID:
PMC10021989
AbstractArticlePDF–1.5M
11.
Cell-type-specific translational control of spatial working memory by the cap-binding protein 4EHP
Shane Wiebe, Ziying Huang, Reese Jalal Ladak, Agnieszka Skalecka, Roberta Cagnetta, Jean-Claude Lacaille, Argel Aguilar-Valles, Nahum Sonenberg
Mol Brain. 2023; 16: 9. Published online 2023 Jan 18. doi: 10.1186/s13041-023-00995-2
PMCID:
PMC9847188
AbstractArticlePDF–1.9M
12.
Mechanism of cystogenesis by Cd79a-driven, conditional mTOR activation in developing mouse nephrons
Linh Tran Nguyen Truc, Satoshi Matsuda, Akiko Takenouchi, Quynh Tran Thuy Huong, Yui Kotani, Tatsuhiko Miyazaki, Hiroaki Kanda, Katsuhiko Yoshizawa, Hiroyasu Tsukaguchi
Sci Rep. 2023; 13: 508. Published online 2023 Jan 10. doi: 10.1038/s41598-023-27766-2
PMCID:
PMC9832032
AbstractArticlePDF–17M
13.
Inhibition of nonalcoholic fatty liver disease in mice by selective inhibition of mTORC1
Bridget S. Gosis, Shogo Wada, Chelsea Thorsheim, Kristina Li, Sunhee Jung, Joshua H. Rhoades, Yifan Yang, Jeffrey Brandimarto, Li Li, Kahealani Uehara, Cholsoon Jang, Matthew Lanza, Nathan B. Sanford, Marc R. Bornstein, Sunhye Jeong, Paul M. Titchenell, Sudha B. Biddinger, Zoltan Arany
Science. Author manuscript; available in PMC 2023 Apr 15.
Published in final edited form as: Science. 2022 Apr 15; 376(6590): eabf8271. Published online 2022 Apr 15. doi: 10.1126/science.abf8271
PMCID:
PMC9811404
AbstractArticlePDF–2.3M
14.
Object location learning in mice requires hippocampal somatostatin interneuron activity and is facilitated by mTORC1-mediated long-term potentiation of their excitatory synapses
Eve Honoré, Jean-Claude Lacaille
Mol Brain. 2022; 15: 101. Published online 2022 Dec 21. doi: 10.1186/s13041-022-00988-7
PMCID:
PMC9769025
AbstractArticlePDF–3.9M
15.
Disruption of mTORC1 rescues neuronal overgrowth and synapse function dysregulated by Pten loss
Kamran Tariq, Erin Cullen, Stephanie A. Getz, Andie K.S. Conching, Andrew R. Goyette, Mackenzi L. Prina, Wei Wang, Meijie Li, Matthew C. Weston, Bryan W. Luikart
Cell Rep. Author manuscript; available in PMC 2022 Dec 12.
Published in final edited form as: Cell Rep. 2022 Nov 1; 41(5): 111574. doi: 10.1016/j.celrep.2022.111574
PMCID:
PMC9743803
AbstractArticlePDF–2.8M
16.
mTORC1 signaling facilitates differential stem cell differentiation to shape the developing murine lung and is associated with mitochondrial capacity
Kuan Zhang, Erica Yao, Ethan Chuang, Biao Chen, Evelyn Y. Chuang, Pao-Tien Chuang
Nat Commun. 2022; 13: 7252. Published online 2022 Nov 25. doi: 10.1038/s41467-022-34763-y
PMCID:
PMC9700781
AbstractArticlePDF–11M
17.
SZT2 maintains hematopoietic stem cell homeostasis via nutrient-mediated mTORC1 regulation
Na Yin, Gang Jin, Yuying Ma, Hanfei Zhao, Guangyue Zhang, Ming O. Li, Min Peng
J Clin Invest. 2022 Oct 17; 132(20): e146272. Published online 2022 Oct 17. doi: 10.1172/JCI146272
PMCID:
PMC9566891
AbstractArticlePDF–4.5M
18.
Loss of Raptor induces Sertoli cells into an undifferentiated state in mice
Minyu Xie, Xiao Hu, Lei Li, Zhi Xiong, Hanbin Zhang, Yuge Zhuang, Zicong Huang, Jinsheng Liu, Jingyao Lian, Chuyu Huang, Qiang Xie, Xiangjin Kang, Yong Fan, Xiaochun Bai, Zhenguo Chen
Biol Reprod. 2022 Oct; 107(4): 1125–1138. Published online 2022 May 19. doi: 10.1093/biolre/ioac104
Correction in:
Biol Reprod. 2023 Feb; 108(2): 353.
PMCID:
PMC9562113
AbstractArticlePDF–3.2M
19.
PPARγ-induced upregulation of subcutaneous fat adiponectin secretion, glyceroneogenesis and BCAA oxidation requires mTORC1 activity
Maynara L. Andrade, Gustavo R. Gilio, Luiz A. Perandini, Albert S. Peixoto, Mayara F. Moreno, Érique Castro, Tiago E. Oliveira, Thayna S. Vieira, Milene Ortiz-Silva, Caroline A. Thomazelli, Adriano B. Chaves-Filho, Thiago Belchior, Patricia Chimin, Juliana Magdalon, Rachael Ivison, Deepti Pant, Linus Tsai, Marcos Y. Yoshinaga, Sayuri Miyamoto, William T. Festuccia
Biochim Biophys Acta Mol Cell Biol Lipids. Author manuscript; available in PMC 2022 Aug 19.
Published in final edited form as: Biochim Biophys Acta Mol Cell Biol Lipids. 2021 Aug; 1866(8): 158967. Published online 2021 May 15. doi: 10.1016/j.bbalip.2021.158967
PMCID:
PMC9391032
AbstractArticlePDF–1.7M
20.
Raptor downregulation rescues neuronal phenotypes in mouse models of Tuberous Sclerosis Complex
Vasiliki Karalis, Franklin Caval-Holme, Helen S. Bateup
Nat Commun. 2022; 13: 4665. Published online 2022 Aug 9. doi: 10.1038/s41467-022-31961-6
PMCID:
PMC9363483
AbstractArticlePDF–9.8M

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