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Select item 103126741.

AI-guided pipeline for protein-protein interaction drug discovery identifies a SARS-CoV-2 inhibitor

Philipp Trepte, Christopher Secker, Simona Kostova, Sibusiso B. Maseko, Soon Gang Choi, Jeremy Blavier, Igor Minia, Eduardo Silva Ramos, Patricia Cassonnet, Sabrina Golusik, Martina Zenkner, Stephanie Beetz, Mara J. Liebich, Nadine Scharek, Anja Schütz, Marcel Sperling, Michael Lisurek, Yang Wang, Kerstin Spirohn, Tong Hao, Michael A. Calderwood, David E. Hill, Markus Landthaler, Julien Olivet, Jean-Claude Twizere, Marc Vidal, Erich E. Wanker

Version 1. bioRxiv. Preprint. 2023 Jun 14. doi: 10.1101/2023.06.14.544560

Published in:: Mol Syst Biol. 2024 Apr; 20(4): 428–457.

PMCID:: PMC10312674

Abstract Article PDF–9.6M

Select item 99224682.

FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia

Xiao-Na Zhu, Yu-Sheng Wei, Qian Yang, Hao-Ran Liu, Zhe Zhi, Di Zhu, Li Xia, Deng-Li Hong, Yun Yu, Guo-Qiang Chen

J Hematol Oncol. 2023; 16: 9. Published online 2023 Feb 11. doi: 10.1186/s13045-023-01400-0

PMCID:: PMC9922468

Abstract Article PDF–4.9M

Select item 86494473.

Lymphocyte cytosolic protein 2 is a novel prognostic marker in lung adenocarcinoma

Yishan Huo, Kainan Zhang, Songtao Han, Yangchun Feng, Yongxing Bao

J Int Med Res. 2021 Nov; 49(11): 03000605211059681. Published online 2021 Nov 24. doi: 10.1177/03000605211059681

PMCID:: PMC8649447

Abstract Article PDF–1.0M

Select item 81941454.

STAT1 epigenetically regulates LCP2 and TNFAIP2 by recruiting EP300 to contribute to the pathogenesis of inflammatory bowel disease

Ya-Li Yu, Meng Chen, Hua Zhu, Ming-Xing Zhuo, Ping Chen, Yu-Juan Mao, Lian-Yun Li, Qiu Zhao, Min Wu, Mei Ye

Clin Epigenetics. 2021; 13: 127. Published online 2021 Jun 10. doi: 10.1186/s13148-021-01101-w

PMCID:: PMC8194145

Abstract Article PDF–1.9M

Select item 80807225.

A novel prognostic biomarker LCP2 correlates with metastatic melanoma-infiltrating CD8⁺ T cells

Zijun Wang, Mou Peng

Sci Rep. 2021; 11: 9164. Published online 2021 Apr 28. doi: 10.1038/s41598-021-88676-9

PMCID:: PMC8080722

Abstract Article PDF–7.4M

Select item 78042036.

Targeting adaptor protein SLP76 of RAGE as a therapeutic approach for lethal sepsis

Zhengzheng Yan, Haihua Luo, Bingyao Xie, Tian Tian, Shan Li, Zhixia Chen, Jinghua Liu, Xuwen Zhao, Liyong Zhang, Yongqiang Deng, Timothy R. Billiar, Yong Jiang

Nat Commun. 2021; 12: 308. Published online 2021 Jan 12. doi: 10.1038/s41467-020-20577-3

PMCID:: PMC7804203

Abstract Article PDF–4.7M

Select item 71699837.

A reference map of the human binary protein interactome

Katja Luck, Dae-Kyum Kim, Luke Lambourne, Kerstin Spirohn, Bridget E. Begg, Wenting Bian, Ruth Brignall, Tiziana Cafarelli, Francisco J. Campos-Laborie, Benoit Charloteaux, Dongsic Choi, Atina G. Coté, Meaghan Daley, Steven Deimling, Alice Desbuleux, Amélie Dricot, Marinella Gebbia, Madeleine F. Hardy, Nishka Kishore, Jennifer J. Knapp, István A. Kovács, Irma Lemmens, Miles W. Mee, Joseph C. Mellor, Carl Pollis, Carles Pons, Aaron D. Richardson, Sadie Schlabach, Bridget Teeking, Anupama Yadav, Mariana Babor, Dawit Balcha, Omer Basha, Christian Bowman-Colin, Suet-Feung Chin, Soon Gang Choi, Claudia Colabella, Georges Coppin, Cassandra D’Amata, David De Ridder, Steffi De Rouck, Miquel Duran-Frigola, Hanane Ennajdaoui, Florian Goebels, Liana Goehring, Anjali Gopal, Ghazal Haddad, Elodie Hatchi, Mohamed Helmy, Yves Jacob, Yoseph Kassa, Serena Landini, Roujia Li, Natascha van Lieshout, Andrew MacWilliams, Dylan Markey, Joseph N. Paulson, Sudharshan Rangarajan, John Rasla, Ashyad Rayhan, Thomas Rolland, Adriana San-Miguel, Yun Shen, Dayag Sheykhkarimli, Gloria M. Sheynkman, Eyal Simonovsky, Murat Taşan, Alexander Tejeda, Vincent Tropepe, Jean-Claude Twizere, Yang Wang, Robert J. Weatheritt, Jochen Weile, Yu Xia, Xinping Yang, Esti Yeger-Lotem, Quan Zhong, Patrick Aloy, Gary D. Bader, Javier De Las Rivas, Suzanne Gaudet, Tong Hao, Janusz Rak, Jan Tavernier, David E. Hill, Marc Vidal, Frederick P. Roth, Michael A. Calderwood

Nature. Author manuscript; available in PMC 2020 Oct 8.

Published in final edited form as: Nature. 2020 Apr; 580(7803): 402–408. Published online 2020 Apr 8. doi: 10.1038/s41586-020-2188-x

PMCID:: PMC7169983

Abstract Article PDF–5.4M

Select item 69812068.

Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRAS^G13D

Susan A. Kennedy, Mohamed-Ali Jarboui, Sriganesh Srihari, Cinzia Raso, Kenneth Bryan, Layal Dernayka, Theodosia Charitou, Manuel Bernal-Llinares, Carlos Herrera-Montavez, Aleksandar Krstic, David Matallanas, Max Kotlyar, Igor Jurisica, Jasna Curak, Victoria Wong, Igor Stagljar, Thierry LeBihan, Lisa Imrie, Priyanka Pillai, Miriam A. Lynn, Erik Fasterius, Cristina Al-Khalili Szigyarto, James Breen, Christina Kiel, Luis Serrano, Nora Rauch, Oleksii Rukhlenko, Boris N. Kholodenko, Luis F. Iglesias-Martinez, Colm J. Ryan, Ruth Pilkington, Patrizia Cammareri, Owen Sansom, Steven Shave, Manfred Auer, Nicola Horn, Franziska Klose, Marius Ueffing, Karsten Boldt, David J. Lynn, Walter Kolch

Nat Commun. 2020; 11: 499. Published online 2020 Jan 24. doi: 10.1038/s41467-019-14224-9

PMCID:: PMC6981206

Abstract Article PDF–3.7M

Select item 67426469.

Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations

Robert Fragoza, Jishnu Das, Shayne D. Wierbowski, Jin Liang, Tina N. Tran, Siqi Liang, Juan F. Beltran, Christen A. Rivera-Erick, Kaixiong Ye, Ting-Yi Wang, Li Yao, Matthew Mort, Peter D. Stenson, David N. Cooper, Xiaomu Wei, Alon Keinan, John C. Schimenti, Andrew G. Clark, Haiyuan Yu

Nat Commun. 2019; 10: 4141. Published online 2019 Sep 12. doi: 10.1038/s41467-019-11959-3

PMCID:: PMC6742646

Abstract Article PDF–1.2M

Select item 671971810.

Identification of phagocytosis regulators using magnetic genome-wide CRISPR screens

Michael S. Haney, Christopher J. Bohlen, David W Morgens, James A. Ousey, Amira A. Barkal, C. Kimberly Tsui, Braeden Ego, Roni Levin, Roarke Kamber, Hannah Collins, Andrew Tucker, Amy Li, Daan Vorselen, Lorenzo Labitigan, Emily Crane, Evan Boyle, Lihua Jiang, Joanne Chan, Esther Rincón, William J. Greenleaf, Billy Li, Michael P. Snyder, Irving L. Weissman, Julie A. Theriot, Sean R. Collins, Ben A. Barres, Michael C. Bassik

Nat Genet. Author manuscript; available in PMC 2019 Sep 3.

Published in final edited form as: Nat Genet. 2018 Dec; 50(12): 1716–1727. Published online 2018 Nov 5. doi: 10.1038/s41588-018-0254-1

PMCID:: PMC6719718

Abstract Article PDF–1.3M

Select item 671572511.

Maximizing binary interactome mapping with a minimal number of assays

Soon Gang Choi, Julien Olivet, Patricia Cassonnet, Pierre-Olivier Vidalain, Katja Luck, Luke Lambourne, Kerstin Spirohn, Irma Lemmens, Mélanie Dos Santos, Caroline Demeret, Louis Jones, Sudharshan Rangarajan, Wenting Bian, Eloi P. Coutant, Yves L. Janin, Sylvie van der Werf, Philipp Trepte, Erich E. Wanker, Javier De Las Rivas, Jan Tavernier, Jean-Claude Twizere, Tong Hao, David E. Hill, Marc Vidal, Michael A. Calderwood, Yves Jacob

Nat Commun. 2019; 10: 3907. Published online 2019 Aug 29. doi: 10.1038/s41467-019-11809-2

PMCID:: PMC6715725

Abstract Article PDF–1.7M

Select item 624030012.

ADAP is an upstream regulator that precedes SLP-76 at sites of TCR engagement and stabilizes signaling microclusters

Juliana B. Lewis, Frank A. Scangarello, Joanne M. Murphy, Keith P. Eidell, Michelle O. Sodipo, Michael J. Ophir, Ryan Sargeant, Maria-Cristina Seminario, Stephen C. Bunnell

J Cell Sci. 2018 Nov 1; 131(21): jcs215517. Published online 2018 Nov 8. doi: 10.1242/jcs.215517

PMCID:: PMC6240300

Abstract Article

Select item 616668213.

Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei

Domenico Fasci, Hugo van Ingen, Richard A. Scheltema, Albert J. R. Heck

Mol Cell Proteomics. 2018 Oct; 17(10): 2018–2033. Published online 2018 Jul 18. doi: 10.1074/mcp.RA118.000924

PMCID:: PMC6166682

Abstract Article PDF–3.8M

Select item 603987014.

LuTHy: a double‐readout bioluminescence‐based two‐hybrid technology for quantitative mapping of protein–protein interactions in mammalian cells

Philipp Trepte, Sabrina Kruse, Simona Kostova, Sheila Hoffmann, Alexander Buntru, Anne Tempelmeier, Christopher Secker, Lisa Diez, Aline Schulz, Konrad Klockmeier, Martina Zenkner, Sabrina Golusik, Kirstin Rau, Sigrid Schnoegl, Craig C Garner, Erich E Wanker

Mol Syst Biol. 2018 Jul; 14(7): e8071. Published online 2018 Jul 11. doi: 10.15252/msb.20178071

PMCID:: PMC6039870

Abstract Article PDF–2.1M

Select item 554962615.

A PLC-γ1 Feedback Pathway Regulates Lck Substrate Phosphorylation at the T Cell Receptor and SLP-76 Complex

Judson Belmont, Tao Gu, Ashley Mudd, Arthur R. Salomon

J Proteome Res. Author manuscript; available in PMC 2018 Aug 4.

Published in final edited form as: J Proteome Res. 2017 Aug 4; 16(8): 2729–2742. Published online 2017 Jul 6. doi: 10.1021/acs.jproteome.6b01026

PMCID:: PMC5549626

Abstract Article PDF–3.0M

Select item 547960716.

SLP76 integrates into the B-cell receptor signaling cascade in chronic lymphocytic leukemia cells and is associated with an aggressive disease course

Nili Dezorella, Ben-Zion Katz, Mika Shapiro, Aaron Polliack, Chava Perry, Yair Herishanu

Haematologica. 2016 Dec; 101(12): 1553–1562. doi: 10.3324/haematol.2015.139154

PMCID:: PMC5479607

Abstract Article PDF–1.1M

Select item 544064617.

T Cell Costimulation by CD6 Is Dependent on Bivalent Binding of a GADS/SLP-76 Complex

Johannes Breuning, Marion H. Brown

Mol Cell Biol. 2017 Jun 1; 37(11): e00071-17. Prepublished online 2017 Mar 13. Published online 2017 May 16. doi: 10.1128/MCB.00071-17

PMCID:: PMC5440646

Abstract Article PDF–530K

Select item 539175718.

Activated Cdc42-associated kinase 1 (ACK1) binds the sterile α motif (SAM) domain of the adaptor SLP-76 and phosphorylates proximal tyrosines

Youg R. Thaker, Asha Recino, Monika Raab, Asma Jabeen, Maja Wallberg, Nelson Fernandez, Christopher E. Rudd

J Biol Chem. 2017 Apr 14; 292(15): 6281–6290. Published online 2017 Feb 10. doi: 10.1074/jbc.M116.759555

PMCID:: PMC5391757

Abstract Article PDF–2.0M

Select item 520102119.

Development of nanoscale structure in LAT-based signaling complexes

Valarie A. Barr, Eilon Sherman, Jason Yi, Itoro Akpan, Alexandre K. Rouquette-Jazdanian, Lawrence E. Samelson

J Cell Sci. 2016 Dec 15; 129(24): 4548–4562. doi: 10.1242/jcs.194886

PMCID:: PMC5201021

Abstract Article

Select item 488219020.

Widespread expansion of protein interaction capabilities by alternative splicing

Xinping Yang, Jasmin Coulombe-Huntington, Shuli Kang, Gloria M. Sheynkman, Tong Hao, Aaron Richardson, Song Sun, Fan Yang, Yun A. Shen, Ryan R. Murray, Kerstin Spirohn, Bridget E. Begg, Miquel Duran-Frigola, Andrew MacWilliams, Samuel J. Pevzner, Quan Zhong, Shelly A. Wanamaker, Stanley Tam, Lila Ghamsari, Nidhi Sahni, Song Yi, Maria D. Rodriguez, Dawit Balcha, Guihong Tan, Michael Costanzo, Brenda Andrews, Charles Boone, Xianghong J. Zhou, Kourosh Salehi-Ashtiani, Benoit Charloteaux, Alyce A. Chen, Michael A. Calderwood, Patrick Aloy, Frederick P. Roth, David E. Hill, Lilia M. Iakoucheva, Yu Xia, Marc Vidal

Cell. Author manuscript; available in PMC 2017 Feb 11.

Published in final edited form as: Cell. 2016 Feb 11; 164(4): 805–817. doi: 10.1016/j.cell.2016.01.029

PMCID:: PMC4882190

Abstract Article PDF–1.9M

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