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Select item 108733431.

Protein phosphatase 1 regulatory subunit 15 A promotes translation initiation and induces G2M phase arrest during cuproptosis in cancers

Chunyu Liu, Liang Chen, Yukun Cong, Lulin Cheng, Yujun Shuai, Fang Lv, Kang Chen, Yarong Song, Yifei Xing

Cell Death Dis. 2024 Feb; 15(2): 149. Published online 2024 Feb 16. doi: 10.1038/s41419-024-06489-w

PMCID:: PMC10873343

Abstract Article PDF–7.6M

Select item 108525792.

Induction of GADD34 Regulates the Neurotoxicity of Amyloid β

Niangui Xu, Zhijie Xiao, Ting Zou, Zhiling Huang

Am J Alzheimers Dis Other Demen. 2015 May; 30(3): 313–319. Published online 2014 Sep 9. doi: 10.1177/1533317514545616

PMCID:: PMC10852579

Abstract Article PDF–596K

Select item 107438593.

The PPP1R15 Family of eIF2-alpha Phosphatase Targeting Subunits (GADD34 and CReP)

Danielle Hicks, Krithika Giresh, Lisa A. Wrischnik, Douglas C. Weiser

Int J Mol Sci. 2023 Dec; 24(24): 17321. Published online 2023 Dec 10. doi: 10.3390/ijms242417321

PMCID:: PMC10743859

Abstract Article PDF–1.9M

Select item 102374224.

TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing

Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan

Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233

PMCID:: PMC10237422

Abstract Article PDF–23M

Select item 102032275.

GADD34 activates p53 and may have utility as a marker of atherosclerosis

Go Tomiyoshi, Rika Nakamura, Natsuko Shinmen, Yoichi Yoshida, Seiichiro Mine, Toshio Machida, Katsuro Iwase, Yasuo Iwadate, Takaki Hiwasa, Hideyuki Kuroda

Front Med (Lausanne) 2023; 10: 1128921. Published online 2023 May 9. doi: 10.3389/fmed.2023.1128921

PMCID:: PMC10203227

Abstract Article PDF–3.5M

Select item 87297666.

Enterovirus 71 Activates GADD34 via Precursor 3CD to Promote IRES-Mediated Viral Translation

Hui Li, Wenqian Li, Shuangling Zhang, Manman Qiu, Zhuoran Li, Yongquan Lin, Juan Tan, Wentao Qiao

Microbiol Spectr. 2022 Jan-Feb; 10(1): e01388-21. Published online 2022 Jan 5. doi: 10.1128/spectrum.01388-21

PMCID:: PMC8729766

Abstract Article PDF–3.5M

Select item 86338037.

Substrate recognition determinants of human eIF2α phosphatases

George Hodgson, Antonina Andreeva, Anne Bertolotti

Open Biol. 2021 Dec; 11(12): 210205. Published online December 1, 2021. doi: 10.1098/rsob.210205

PMCID:: PMC8633803

Abstract Article PDF–988K

Select item 85665888.

Sensitization of the UPR by loss of PPP1R15A promotes fibrosis and senescence in IPF

Susan Monkley, Catherine Overed-Sayer, Helen Parfrey, Doris Rassl, Damian Crowther, Leire Escudero-Ibarz, Nicola Davis, Alan Carruthers, Richard Berks, Marisa Coetzee, Ewa Kolosionek, Maria Karlsson, Leia R. Griffin, Maryam Clausen, Graham Belfield, Cory M. Hogaboam, Lynne A. Murray

Sci Rep. 2021; 11: 21584. Published online 2021 Nov 3. doi: 10.1038/s41598-021-00769-7

PMCID:: PMC8566588

Abstract Article PDF–2.7M

Select item 85008389.

Higher-order phosphatase–substrate contacts terminate the integrated stress response

Yahui Yan, Heather P. Harding, David Ron

Nat Struct Mol Biol. 2021; 28(10): 835–846. Published online 2021 Oct 8. doi: 10.1038/s41594-021-00666-7

PMCID:: PMC8500838

Abstract Article PDF–11M

Select item 816503010.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 775805011.

In silico APC/C substrate discovery reveals cell cycle-dependent degradation of UHRF1 and other chromatin regulators

Jennifer L. Franks, Raquel C. Martinez-Chacin, Xianxi Wang, Rochelle L. Tiedemann, Thomas Bonacci, Rajarshi Choudhury, Derek L. Bolhuis, Taylor P. Enrico, Ryan D. Mouery, Jeffrey S. Damrauer, Feng Yan, Joseph S. Harrison, M. Ben Major, Katherine A. Hoadley, Aussie Suzuki, Scott B. Rothbart, Nicholas G. Brown, Michael J. Emanuele

PLoS Biol. 2020 Dec; 18(12): e3000975. Published online 2020 Dec 11. doi: 10.1371/journal.pbio.3000975

PMCID:: PMC7758050

Abstract Article PDF–4.2M

Select item 751887312.

GADD34 is a modulator of autophagy during starvation

Gennaro Gambardella, Leopoldo Staiano, Maria Nicoletta Moretti, Rossella De Cegli, Luca Fagnocchi, Giuseppe Di Tullio, Sara Polletti, Clarissa Braccia, Andrea Armirotti, Alessio Zippo, Andrea Ballabio, Maria Antonietta De Matteis, Diego di Bernardo

Sci Adv. 2020 Sep; 6(39): eabb0205. Published online 2020 Sep 25. doi: 10.1126/sciadv.abb0205

PMCID:: PMC7518873

Abstract Article PDF–1016K

Select item 732206713.

RIG-I regulates myeloid differentiation by promoting TRIM25-mediated ISGylation

Song-Fang Wu, Li Xia, Xiao-Dong Shi, Yu-Jun Dai, Wei-Na Zhang, Jun-Mei Zhao, Wu Zhang, Xiang-Qin Weng, Jing Lu, Huang-Ying Le, Sheng-ce Tao, Jiang Zhu, Zhu Chen, Yue-Ying Wang, Saijuan Chen

Proc Natl Acad Sci U S A. 2020 Jun 23; 117(25): 14395–14404. Published online 2020 Jun 8. doi: 10.1073/pnas.1918596117

PMCID:: PMC7322067

Abstract Article PDF–2.7M

Select item 646369814.

The regulatory protein GADD34 inhibits TRAIL-induced apoptosis via TRAF6/ERK-dependent stabilization of myeloid cell leukemia 1 in liver cancer cells

Peiying Song, Songpeng Yang, Hui Hua, Hongying Zhang, Qingbin Kong, Jiao Wang, Ting Luo, Yangfu Jiang

J Biol Chem. 2019 Apr 12; 294(15): 5945–5955. Published online 2019 Feb 19. doi: 10.1074/jbc.RA118.006029

PMCID:: PMC6463698

Abstract Article PDF–2.5M

Select item 616668215.

Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei

Domenico Fasci, Hugo van Ingen, Richard A. Scheltema, Albert J. R. Heck

Mol Cell Proteomics. 2018 Oct; 17(10): 2018–2033. Published online 2018 Jul 18. doi: 10.1074/mcp.RA118.000924

PMCID:: PMC6166682

Abstract Article PDF–3.8M

Select item 595925216.

EIF2B2 mutations in vanishing white matter disease hypersuppress translation and delay recovery during the integrated stress response

Stephanie L. Moon, Roy Parker

RNA. 2018 Jun; 24(6): 841–852. doi: 10.1261/rna.066563.118

PMCID:: PMC5959252

Abstract Article PDF–4.8M

Select item 591245917.

Hairy and enhancer of split 1 (HES1) protects cells from endoplasmic reticulum stress–induced apoptosis through repression of GADD34

Ji Eun Lee, William Morrison, Julie Hollien

J Biol Chem. 2018 Apr 20; 293(16): 5947–5955. Published online 2018 Feb 28. doi: 10.1074/jbc.RA118.002124

PMCID:: PMC5912459

Abstract Article PDF–1.7M

Select item 576691418.

Chronic oxidative stress promotes GADD34-mediated phosphorylation of the TAR DNA-binding protein TDP-43, a modification linked to neurodegeneration

Catherine Wenhui Goh, Irene Chengjie Lee, Jeyapriya Rajameenakshi Sundaram, Simi Elizabeth George, Permeen Yusoff, Matthew Hayden Brush, Newman Siu Kwan Sze, Shirish Shenolikar

J Biol Chem. 2018 Jan 5; 293(1): 163–176. Published online 2017 Nov 6. doi: 10.1074/jbc.M117.814111

PMCID:: PMC5766914

Abstract Article PDF–2.5M

Select item 576284119.

Oxidative stress promotes SIRT1 recruitment to the GADD34/PP1α complex to activate its deacetylase function

Irene Chengjie Lee, Xue Yan Ho, Simi Elizabeth George, Catherine Wenhui Goh, Jeyapriya Rajameenakshi Sundaram, Karen Ka Lam Pang, Weiwei Luo, Permeen Yusoff, Newman Siu Kwan Sze, Shirish Shenolikar

Cell Death Differ. 2018 Feb; 25(2): 255–267. Published online 2017 Oct 6. doi: 10.1038/cdd.2017.152

PMCID:: PMC5762841

Abstract Article PDF–3.9M

Select item 553161120.

Architecture of the human interactome defines protein communities and disease networks

Edward L. Huttlin, Raphael J. Bruckner, Joao A. Paulo, Joe R. Cannon, Lily Ting, Kurt Baltier, Greg Colby, Fana Gebreab, Melanie P. Gygi, Hannah Parzen, John Szpyt, Stanley Tam, Gabriela Zarraga, Laura Pontano-Vaites, Sharan Swarup, Anne E. White, Devin K. Schweppe, Ramin Rad, Brian K. Erickson, Robert A. Obar, K.G. Guruharsha, Kejie Li, Spyros Artavanis-Tsakonas, Steven P. Gygi, J. Wade Harper

Nature. Author manuscript; available in PMC 2017 Nov 17.

Published in final edited form as: Nature. 2017 May 25; 545(7655): 505–509. Published online 2017 May 17. doi: 10.1038/nature22366

PMCID:: PMC5531611

Abstract Article PDF–2.7M

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