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Select item 107242751.

MYOD-SKP2 axis boosts tumorigenesis in fusion negative rhabdomyosarcoma by preventing differentiation through p57^Kip2 targeting

Silvia Pomella, Matteo Cassandri, Lucrezia D’Archivio, Antonella Porrazzo, Cristina Cossetti, Doris Phelps, Clara Perrone, Michele Pezzella, Antonella Cardinale, Marco Wachtel, Sara Aloisi, David Milewski, Marta Colletti, Prethish Sreenivas, Zoë S. Walters, Giovanni Barillari, Angela Di Giannatale, Giuseppe Maria Milano, Cristiano De Stefanis, Rita Alaggio, Sonia Rodriguez-Rodriguez, Nadia Carlesso, Christopher R. Vakoc, Enrico Velardi, Beat W. Schafer, Ernesto Guccione, Susanne A. Gatz, Ajla Wasti, Marielle Yohe, Myron Ignatius, Concetta Quintarelli, Janet Shipley, Lucio Miele, Javed Khan, Peter J. Houghton, Francesco Marampon, Berkley E. Gryder, Biagio De Angelis, Franco Locatelli, Rossella Rota

Nat Commun. 2023; 14: 8373. Published online 2023 Dec 15. doi: 10.1038/s41467-023-44130-0

PMCID:: PMC10724275

Abstract Article PDF–8.9M

Select item 105391702.

Exploiting the fibroblast growth factor receptor-1 vulnerability to therapeutically restrict the MYC-EZH2-CDKN1C axis-driven proliferation in Mantle cell lymphoma

Anuvrat Sircar, Satishkumar Singh, Zijun Y. Xu-Monette, Krysta Mila Coyle, Laura K. Hilton, Evangelia Chavdoula, Parvathi Ranganathan, Neeraj Jain, Walter Hanel, Philip Tsichlis, Lapo Alinari, Blake R. Peterson, Jianguo Tao, Natarajan Muthusamy, Robert Baiocchi, Narendranath Epperla, Ken H. Young, Ryan Morin, Lalit Sehgal

Leukemia. 2023; 37(10): 2094–2106. Published online 2023 Aug 19. doi: 10.1038/s41375-023-02006-8

PMCID:: PMC10539170

Abstract Article PDF–5.3M

Select item 103582143.

PIK3R3 is upregulated in liver cancer and activates Akt signaling to control cancer growth by regulation of CDKN1C and SMC1A

Weidong Lin, Kunpeng Wang, Jinggang Mo, Liezhi Wang, Zhenshun Song, Hao Jiang, Cong Wang, Chong Jin

Cancer Med. 2023 Jul; 12(13): 14413–14425. Published online 2023 May 22. doi: 10.1002/cam4.6068

PMCID:: PMC10358214

Abstract Article PDF–19M

Select item 95808814.

Identification and targeting of a HES1‐YAP1‐CDKN1C functional interaction in fusion‐negative rhabdomyosarcoma

Alexander R. Kovach, Kristianne M. Oristian, David G. Kirsch, Rex C. Bentley, Changde Cheng, Xiang Chen, Po‐Han Chen, Jen‐Tsan Ashley Chi, Corinne M. Linardic

Mol Oncol. 2022 Oct; 16(20): 3587–3605. Published online 2022 Aug 29. doi: 10.1002/1878-0261.13304

PMCID:: PMC9580881

Abstract Article PDF–2.3M

Select item 94897705.

Fbxo22 promotes cervical cancer progression via targeting p57^Kip2 for ubiquitination and degradation

Min Lin, Jianan Zhang, Hakim Bouamar, Zhiwei Wang, Lu-Zhe Sun, Xueqiong Zhu

Cell Death Dis. 2022 Sep; 13(9): 805. Published online 2022 Sep 20. doi: 10.1038/s41419-022-05248-z

PMCID:: PMC9489770

Abstract Article PDF–7.7M

Select item 91715516.

Loss of p57 Expression in Conceptions Other Than Complete Hydatidiform Mole: A Case Series With Emphasis on the Etiology, Genetics, and Clinical Significance

Deyin Xing, Karin Miller, Katie Beierl, Brigitte M. Ronnett

Am J Surg Pathol. Author manuscript; available in PMC 2022 Jun 7.

Published in final edited form as: Am J Surg Pathol. 2022 Jan 1; 46(1): 18–32. doi: 10.1097/PAS.0000000000001749

PMCID:: PMC9171551

Abstract Article PDF–1.4M

Select item 90405567.

A protein interaction landscape of breast cancer

Minkyu Kim, Jisoo Park, Mehdi Bouhaddou, Kyumin Kim, Ajda Rojc, Maya Modak, Margaret Soucheray, Michael J. McGregor, Patrick O’Leary, Denise Wolf, Erica Stevenson, Tzeh Keong Foo, Dominique Mitchell, Kari A. Herrington, Denise P. Muñoz, Beril Tutuncuoglu, Kuei-Ho Chen, Fan Zheng, Jason F. Kreisberg, Morgan E. Diolaiti, John D. Gordan, Jean-Philippe Coppé, Danielle L. Swaney, Bing Xia, Laura van ’t Veer, Alan Ashworth, Trey Ideker, Nevan Krogan

Science. Author manuscript; available in PMC 2022 Apr 26.

Published in final edited form as: Science. 2021 Oct; 374(6563): eabf3066. Published online 2021 Oct 1. doi: 10.1126/science.abf3066

PMCID:: PMC9040556

Abstract Article PDF–2.2M

Select item 89071028.

High Maternal Serum Estradiol in First Trimester of Multiple Pregnancy Contributes to Small for Gestational Age via DNMT1-Mediated CDKN1C Upregulation

Xiao-Ling Hu, Shuai Shi, Ning-Ning Hou, Ye Meng, Miao Li, Ai-Xia Liu, Yong-Chao Lu, Jing-Yi Li, Jian-Zhong Sheng, Yi-Min Zhu, He-Feng Huang

Reprod Sci. 2022 Apr; 29(4): 1368–1378. Published online 2021 Sep 27. doi: 10.1007/s43032-021-00735-8

PMCID:: PMC8907102

Abstract Article PDF–2.5M

Select item 85009709.

CDKN1C as a prognostic biomarker correlated with immune infiltrates and therapeutic responses in breast cancer patients

Jianguo Lai, Xiaoyi Lin, Fangrong Cao, Hsiaopei Mok, Bo Chen, Ning Liao

J Cell Mol Med. 2021 Oct; 25(19): 9390–9401. Published online 2021 Aug 31. doi: 10.1111/jcmm.16880

PMCID:: PMC8500970

Abstract Article PDF–1.7M

Select item 830544510.

A Beckwith–Wiedemann-Associated CDKN1C Mutation Allows the Identification of a Novel Nuclear Localization Signal in Human p57^Kip2

Emanuela Stampone, Debora Bencivenga, Clementina Barone, Marilena Di Finizio, Fulvio Della Ragione, Adriana Borriello

Int J Mol Sci. 2021 Jul; 22(14): 7428. Published online 2021 Jul 11. doi: 10.3390/ijms22147428

PMCID:: PMC8305445

Abstract Article PDF–2.8M

Select item 828547911.

Glucocorticoid receptor triggers a reversible drug-tolerant dormancy state with acquired therapeutic vulnerabilities in lung cancer

Stefan Prekovic, Karianne Schuurman, Isabel Mayayo-Peralta, Anna G. Manjón, Mark Buijs, Selçuk Yavuz, Max D. Wellenstein, Alejandro Barrera, Kim Monkhorst, Anne Huber, Ben Morris, Cor Lieftink, Theofilos Chalkiadakis, Ferhat Alkan, Joana Silva, Balázs Győrffy, Liesbeth Hoekman, Bram van den Broek, Hans Teunissen, Donna O. Debets, Tesa Severson, Jos Jonkers, Timothy Reddy, Karin E. de Visser, William Faller, Roderick Beijersbergen, Maarten Altelaar, Elzo de Wit, Rene Medema, Wilbert Zwart

Nat Commun. 2021; 12: 4360. Published online 2021 Jul 16. doi: 10.1038/s41467-021-24537-3

PMCID:: PMC8285479

Abstract Article PDF–16M

Select item 817778712.

CDKN1C‐mediated growth inhibition by an EZH1/2 dual inhibitor overcomes resistance of mantle cell lymphoma to ibrutinib

Yuki Kagiyama, Shuhei Fujita, Yutaka Shima, Kazutsune Yamagata, Takuo Katsumoto, Makoto Nakagawa, Daisuke Honma, Nobuaki Adachi, Kazushi Araki, Ayako Kato, Koichiro Inaki, Yoshimasa Ono, Suguru Fukuhara, Yukio Kobayashi, Kensei Tobinai, Issay Kitabayashi

Cancer Sci. 2021 Jun; 112(6): 2314–2324. Published online 2021 May 1. doi: 10.1111/cas.14905

PMCID:: PMC8177787

Abstract Article PDF–1.5M

Select item 816503013.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 815183814.

Variable Expressivity of the Beckwith-Wiedemann Syndrome in Four Pedigrees Segregating Loss-of-Function Variants of CDKN1C

Angela Sparago, Flavia Cerrato, Laura Pignata, Francisco Cammarata-Scalisi, Livia Garavelli, Carmelo Piscopo, Alessandra Vancini, Andrea Riccio

Genes (Basel) 2021 May; 12(5): 706. Published online 2021 May 9. doi: 10.3390/genes12050706

PMCID:: PMC8151838

Abstract Article PDF–809K

Select item 795916315.

Improved molecular detection of mosaicism in Beckwith-Wiedemann Syndrome

Samuel W Baker, Kelly A Duffy, Jennifer Richards-Yutz, Matthew A Deardorff, Jennifer M Kalish, Arupa Ganguly

J Med Genet. Author manuscript; available in PMC 2022 Mar 1.

Published in final edited form as: J Med Genet. 2021 Mar; 58(3): 178–184. Published online 2020 May 19. doi: 10.1136/jmedgenet-2019-106498

PMCID:: PMC7959163

Abstract Article PDF–717K

Select item 784468016.

MicroRNA-103 Promotes Proliferation and Inhibits Apoptosis in Spinal Osteosarcoma Cells by Targeting p57

Xuesong Wang, Yong Lin, Lei Peng, Ruifu Sun, Xiaojin Gong, Jinlong Du, Xiugong Zhang

Oncol Res. 2018; 26(6): 933–940. Published online 2018 Jul 5. doi: 10.3727/096504017X15144741233346

Retraction in:: Oncol Res. 2024; 32(10): 1673–1674.

PMCID:: PMC7844680

Abstract Article

Select item 761460317.

Dephosphorylation of the proneural transcription factor ASCL1 re-engages a latent post-mitotic differentiation programme in neuroblastoma

Fahad R. Ali, Daniel Marcos, Igor Chernukhin, Laura M. Woods, Lydia M. Parkinson, Luke A. Wylie, Tatiana D. Papkovskaia, John D. Davies, Jason S. Carroll, Anna Philpott

Mol Cancer Res. Author manuscript; available in PMC 2023 Jun 1.

Published in final edited form as: Mol Cancer Res. 2020 Dec 1; 18(12): 1759–1766. Published online 2020 Oct 12. doi: 10.1158/1541-7786.MCR-20-0693