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Select item 106539061.

Human OTUD6B positively regulates type I IFN antiviral innate immune responses by deubiquitinating and stabilizing IRF3

Jian Wang, Hui Zheng, Chunsheng Dong, Sidong Xiong

mBio. 2023 Sep-Oct; 14(5): e00332-23. Published online 2023 Aug 31. doi: 10.1128/mbio.00332-23

PMCID:: PMC10653906

Abstract Article PDF–13M

Select item 102374222.

TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing

Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan

Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233

PMCID:: PMC10237422

Abstract Article PDF–23M

Select item 97419673.

DDX24 promotes metastasis by regulating RPL5 in non‐small cell lung cancer

Xinyan Hu, Fangfang Li, Yulan Zhou, Hairun Gan, Tiancheng Wang, Luting Li, Haoyu Long, Bing Li, Pengfei Pang

Cancer Med. 2022 Dec; 11(23): 4513–4525. Published online 2022 Jul 21. doi: 10.1002/cam4.4835

PMCID:: PMC9741967

Abstract Article PDF–25M

Select item 95747524.

The OTUD6B‐LIN28B‐MYC axis determines the proliferative state in multiple myeloma

Carmen Paulmann, Ria Spallek, Oleksandra Karpiuk, Michael Heider, Isabell Schäffer, Jana Zecha, Susan Klaeger, Michaela Walzik, Rupert Öllinger, Thomas Engleitner, Matthias Wirth, Ulrich Keller, Jan Krönke, Martina Rudelius, Susanne Kossatz, Roland Rad, Bernhard Kuster, Florian Bassermann

EMBO J. 2022 Oct; 41(20): e110871. Published online 2022 Sep 5. doi: 10.15252/embj.2022110871

PMCID:: PMC9574752

Abstract Article PDF–4.3M

Select item 94488935.

Novel biallelic variants affecting the OTU domain of the gene OTUD6B associate with severe intellectual disability syndrome and molecular dynamics simulations

Sultan Cingoz, Didem Soydemir, Tülay Oncü Oner, Ezgi Karaca, Burcu Ozden, Semra Hız Kurul, Erhan Bayram, University of Washington Center for Mendelian Genomics, Bradley P. Coe, Deborah A. Nickerson, Evan E. Eichler

Eur J Med Genet. Author manuscript; available in PMC 2023 Jun 1.

Published in final edited form as: Eur J Med Genet. 2022 Jun; 65(6): 104497. Published online 2022 Apr 14. doi: 10.1016/j.ejmg.2022.104497

PMCID:: PMC9448893

Abstract Article PDF–1.4M

Select item 92792856.

Scalable multiplex co-fractionation/mass spectrometry platform for accelerated protein interactome discovery

Pierre C. Havugimana, Raghuveera Kumar Goel, Sadhna Phanse, Ahmed Youssef, Dzmitry Padhorny, Sergei Kotelnikov, Dima Kozakov, Andrew Emili

Nat Commun. 2022; 13: 4043. Published online 2022 Jul 13. doi: 10.1038/s41467-022-31809-z

PMCID:: PMC9279285

Abstract Article PDF–2.5M

Select item 88570497.

Tau interactome maps synaptic and mitochondrial processes associated with neurodegeneration

Tara E. Tracy, Jesus Madero-Pérez, Danielle L. Swaney, Timothy S. Chang, Michelle Moritz, Csaba Konrad, Michael E. Ward, Erica Stevenson, Ruth Hüttenhain, Grant Kauwe, Maria Mercedes, Lauren Sweetland-Martin, Xu Chen, Sue-Ann Mok, Man Ying Wong, Maria Telpoukhovskaia, Sang-Won Min, Chao Wang, Peter Dongmin Sohn, Jordie Martin, Yungui Zhou, Wenjie Luo, John Q. Trojanowski, Virginia M.Y. Lee, Shiaoching Gong, Giovanni Manfredi, Giovanni Coppola, Nevan J. Krogan, Daniel H. Geschwind, Li Gan

Cell. Author manuscript; available in PMC 2022 Feb 19.

Published in final edited form as: Cell. 2022 Feb 17; 185(4): 712–728.e14. Published online 2022 Jan 20. doi: 10.1016/j.cell.2021.12.041

PMCID:: PMC8857049

Abstract Article PDF–3.6M

Select item 88108598.

Deubiquitylase OTUD6B stabilizes the mutated pVHL and suppresses cell migration in clear cell renal cell carcinoma

Kai Guo, Yinghua Wei, Ze Wang, Xiaoli Zhang, Xin Zhang, Xinxin Liu, Wenyong Wu, Zhengsheng Wu, Lingqiang Zhang, Chun-Ping Cui

Cell Death Dis. 2022 Feb; 13(2): 97. Published online 2022 Feb 2. doi: 10.1038/s41419-021-04135-3

Correction in:: Cell Death Dis. 2022 Jun; 13(6): 515.

PMCID:: PMC8810859

Abstract Article PDF–5.5M

Select item 86666659.

CD95/Fas suppresses NF-κB activation through recruitment of KPC2 in a CD95L/FasL-independent mechanism

Jean-Philippe Guégan, Justine Pollet, Christophe Ginestier, Emmanuelle Charafe-Jauffret, Marcus E. Peter, Patrick Legembre

iScience. 2021 Dec 17; 24(12): 103538. Published online 2021 Dec 1. doi: 10.1016/j.isci.2021.103538

PMCID:: PMC8666665

Abstract Article PDF–3.2M

Select item 853574510.

Compound Heterozygote of Point Mutation and Chromosomal Microdeletion Involving OTUD6B Coinciding with ZMIZ1 Variant in Syndromic Intellectual Disability

Tim Phetthong, Arthaporn Khongkrapan, Natini Jinawath, Go-Hun Seo, Duangrurdee Wattanasirichaigoon

Genes (Basel) 2021 Oct; 12(10): 1583. Published online 2021 Oct 7. doi: 10.3390/genes12101583

PMCID:: PMC8535745

Abstract Article PDF–4.4M

Select item 846297411.

Photocaged Cell-Permeable Ubiquitin Probe for Temporal Profiling of Deubiquitinating Enzymes

Weijun Gui, Siqi Shen, Zhihao Zhuang

J Am Chem Soc. Author manuscript; available in PMC 2021 Nov 18.

Published in final edited form as: J Am Chem Soc. 2020 Nov 18; 142(46): 19493–19501. Published online 2020 Nov 3. doi: 10.1021/jacs.9b12426

PMCID:: PMC8462974

Abstract Article PDF–975K

Select item 829290912.

SPOP and OTUD7A Control EWS–FLI1 Protein Stability to Govern Ewing Sarcoma Growth

Siyuan Su, Jianfeng Chen, Yao Jiang, Ying Wang, Tamara Vital, Jiaming Zhang, Christian Laggner, Kong T. Nguyen, Zhichuan Zhu, Alex W. Prevatte, Natalie K. Barker, Laura E. Herring, Ian J. Davis, Pengda Liu

Adv Sci (Weinh) 2021 Jul; 8(14): 2004846. Published online 2021 Jun 1. doi: 10.1002/advs.202004846

PMCID:: PMC8292909

Abstract Article PDF–4.0M

Select item 816503013.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 790335114.

Stress-induced NEDDylation promotes cytosolic protein aggregation through HDAC6 in a p62-dependent manner

Soyeon Kim, Mira Kwon, Yiseul Hwang, Junghyun Yoon, Sangwook Park, Ho Chul Kang

iScience. 2021 Mar 19; 24(3): 102146. Published online 2021 Feb 6. doi: 10.1016/j.isci.2021.102146

PMCID:: PMC7903351

Abstract Article PDF–49M

Select item 760600815.

BCAR1 promotes proliferation and cell growth in lung adenocarcinoma via upregulation of POLR2A

Chun‐guo Mao, Sha‐sha Jiang, Cheng Shen, Tan Long, Hua Jin, Qun‐You Tan, Bo Deng

Thorac Cancer. 2020 Nov; 11(11): 3326–3336. Published online 2020 Oct 1. doi: 10.1111/1759-7714.13676

PMCID:: PMC7606008

Abstract Article PDF–2.5M

Select item 738152516.

DUB-independent regulation of pVHL by OTUD6B suppresses hepatocellular carcinoma

Xiaoming Dai, Jing Liu, Wenyi Wei

Protein Cell. 2020 Aug; 11(8): 546–548. Published online 2020 Apr 22. doi: 10.1007/s13238-020-00721-x

PMCID:: PMC7381525

Article PDF–236K

Select item 734672617.

Wnt regulation: exploring Axin-Disheveled interactions and defining mechanisms by which the SCF E3 ubiquitin ligase is recruited to the destruction complex

Kristina N. Schaefer, Mira I. Pronobis, Clara E. Williams, Shiping Zhang, Lauren Bauer, Dennis Goldfarb, Feng Yan, M. Ben Major, Mark Peifer

Mol Biol Cell. 2020 May 1; 31(10): 992–1014. doi: 10.1091/mbc.E19-11-0647

PMCID:: PMC7346726

Abstract Article PDF–5.5M

Select item 717524918.

Deubiquitylase OTUD6B Governs pVHL Stability in an Enzyme‐Independent Manner and Suppresses Hepatocellular Carcinoma Metastasis

Xinxin Liu, Xiaoli Zhang, Zhiqiang Peng, Chunnan Li, Ze Wang, Chanjuan Wang, Zhikang Deng, Bo Wu, Yu Cui, Zhanxin Wang, Chun‐Ping Cui, Min Zheng, Lingqiang Zhang

Adv Sci (Weinh) 2020 Apr; 7(8): 1902040. Published online 2020 Mar 8. doi: 10.1002/advs.201902040

PMCID:: PMC7175249

Abstract Article PDF–4.0M

Select item 653385419.

OTUD6B-AS1 Might Be a Novel Regulator of Apoptosis in Systemic Sclerosis

Miki Takata, Elena Pachera, Mojca Frank-Bertoncelj, Anastasiia Kozlova, Astrid Jüngel, Michael L. Whitfield, Shervin Assassi, Maurizio Calcagni, Jeska de Vries-Bouwstra, Tom W. Huizinga, Fina Kurreeman, Gabriela Kania, Oliver Distler

Front Immunol. 2019; 10: 1100. Published online 2019 May 17. doi: 10.3389/fimmu.2019.01100

PMCID:: PMC6533854

Abstract Article PDF–2.9M

Select item 616668220.

Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei

Domenico Fasci, Hugo van Ingen, Richard A. Scheltema, Albert J. R. Heck

Mol Cell Proteomics. 2018 Oct; 17(10): 2018–2033. Published online 2018 Jul 18. doi: 10.1074/mcp.RA118.000924

PMCID:: PMC6166682

Abstract Article PDF–3.8M

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