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Items: 1 to 20 of 1079

1.
HIF1α-regulated glycolysis promotes activation-induced cell death and IFN-γ induction in hypoxic T cells
Hongxing Shen, Oluwagbemiga A. Ojo, Haitao Ding, Logan J. Mullen, Chuan Xing, M. Iqbal Hossain, Abdelrahman Yassin, Vivian Y. Shi, Zach Lewis, Ewa Podgorska, Shaida A. Andrabi, Maciek R. Antoniewicz, James A. Bonner, Lewis Zhichang Shi
Nat Commun. 2024; 15: 9394. Published online 2024 Oct 30. doi: 10.1038/s41467-024-53593-8
PMCID:
PMC11526104
AbstractArticlePDF–3.4M
2.
Olig2+/NG2+/BLBP+ astrocyte progenitors: a novel component of the neurovascular unit in the developing mouse hippocampus
Shoichiro Omura, Rina Ogawa, Tomomi Kawachi, Aya Ogawa, Yuuki Arai, Natsumi Takayama, Aki Masui, Kumiko Kondo, Hiroki Sugimoto, Hiroshi M. Shinohara, Tokiharu Takahashi, Hideyuki Maeda, Kyoji Ohyama
Front Cell Neurosci. 2024; 18: 1464402. Published online 2024 Oct 17. doi: 10.3389/fncel.2024.1464402
PMCID:
PMC11524929
AbstractArticlePDF–2.8M
3.
m6A-modified exosome-derived circHIF1α binding to KH domain of IGF2BP3 mediates DNA damage and arrests G1/S transition phase to resists bacterial infection in bacteremia
Jiang Yu, Yidan Gao, Fei Liu, Yuyu Zhang, Jianda Li, Luogang Ding, Sufang Ren, Jie Yang, Jian Jiao, Gong Feng, Zhi Chen, Wenbo Sun, Jiaqiang Wu
J Nanobiotechnology. 2024; 22: 654. Published online 2024 Oct 24. doi: 10.1186/s12951-024-02932-4
PMCID:
PMC11515445
AbstractArticlePDF–9.4M
4.
HIF1 activation safeguards cortical bone formation against impaired oxidative phosphorylation
Mohd P. Khan, Elena Sabini, Katherine Beigel, Giulia Lanzolla, Brittany Laslow, Dian Wang, Christophe Merceron, Amato Giaccia, Fanxin Long, Deanne Taylor, Ernestina Schipani
JCI Insight. 2024 Sep 24; 9(18): e182330. Published online 2024 Aug 1. doi: 10.1172/jci.insight.182330
PMCID:
PMC11457864
AbstractArticlePDF–14M
5.
ER Stress and Mitochondrial Perturbations Regulate Cell Death in Retinal Detachment: Exploring the Role of HIF1α
Bhavneet Kaur, Bruna Miglioranza Scavuzzi, Mengling Yang, Jingyu Yao, Lin Jia, Steven F. Abcouwer, David N. Zacks
Invest Ophthalmol Vis Sci. 2024 Sep; 65(11): 39. Published online 2024 Sep 26. doi: 10.1167/iovs.65.11.39
PMCID:
PMC11437674
AbstractArticlePDF–5.4M
6.
TRPA1 Influences Staphylococcus aureus Skin Infection in Mice and Associates with HIF-1a and MAPK Pathway Modulation
Manoj Yadav, Prem Prashant Chaudhary, Grace Ratley, Brandon D’Souza, Mahaldeep Kaur, Sundar Ganesan, Juraj Kabat, Ian A. Myles
Int J Mol Sci. 2024 Sep; 25(18): 9933. Published online 2024 Sep 14. doi: 10.3390/ijms25189933
PMCID:
PMC11432213
AbstractArticlePDF–4.3M
7.
PHD2 safeguards modest mesendoderm development
Meng Li, Huaizhang Jin, Yun Zhao, Guoping Zhu, Yu Liu, Hongan Long, Xiaopeng Shen
Commun Biol. 2024; 7: 1100. Published online 2024 Sep 7. doi: 10.1038/s42003-024-06824-z
PMCID:
PMC11380689
AbstractArticlePDF–4.1M
8.
Therapeutic efficacy of ECs Foxp1 targeting Hif1α-Hk2 glycolysis signal to restrict angiogenesis
Jingjiang Pi, Jie Liu, Huan Chang, Xiaoli Chen, Wenqi Pan, Qi Zhang, Tao Zhuang, Jiwen Liu, Haikun Wang, Brian Tomlinson, Paul Chan, Yu Cheng, Zuoren Yu, Lin Zhang, Zhenlin Zhao, Zhongmin Liu, Jie Liu, Yuzhen Zhang
Redox Biol. 2024 Sep; 75: 103281. Published online 2024 Jul 26. doi: 10.1016/j.redox.2024.103281
PMCID:
PMC11342203
AbstractArticlePDF–14M
9.
Expression of HIF1α in intestinal epithelium restricts arthritis inflammation by inhibiting RIPK3-induced cell death machinery
Pang Lyu, Jinming Wen, Wenshuo Zhang, Ning Liu, Iris Stolzer, Andreas Gießl, Yewei Jia, Daniele Mauro, Fulin Zhang, Francesco Ciccia, Didier Soulat, Claudia Günther, Georg Schett, Aline Bozec
Ann Rheum Dis. 2024 Aug; 83(8): 984–997. Published online 2024 Mar 19. doi: 10.1136/ard-2023-224491
PMCID:
PMC11287550
AbstractArticlePDF–4.1M
10.
Differential but complementary roles of HIF-1α and HIF-2α in the regulation of bone homeostasis
Sun Young Lee, Su-Jin Kim, Ka Hyon Park, Gyuseok Lee, Youngsoo Oh, Je-Hwang Ryu, Yun Hyun Huh
Commun Biol. 2024; 7: 892. Published online 2024 Jul 23. doi: 10.1038/s42003-024-06581-z
PMCID:
PMC11263705
AbstractArticlePDF–3.3M
11.
Vhl safeguards thymic epithelial cell identity and thymopoietic capacity by constraining Hif1a activity during development
Christiane Grammer, Julia A. Komorowska, Jeremy B. Swann
iScience. 2024 Jul 19; 27(7): 110258. Published online 2024 Jun 13. doi: 10.1016/j.isci.2024.110258
PMCID:
PMC11261450
AbstractArticlePDF–11M
12.
Multiple roles for hypoxia inducible factor 1-alpha in airway epithelial cells during mucormycosis
Povilas Kavaliauskas, Yiyou Gu, Naushaba Hasin, Karen T. Graf, Abdullah Alqarihi, Amol C. Shetty, Carrie McCracken, Thomas J. Walsh, Ashraf S. Ibrahim, Vincent M. Bruno
Nat Commun. 2024; 15: 5282. Published online 2024 Jun 20. doi: 10.1038/s41467-024-49637-8
PMCID:
PMC11190229
AbstractArticlePDF–3.7M
13.
Iron deficiency affects oxygen transport and activates HIF1 signaling pathway to regulate phenotypic transformation of VSMC in aortic dissection
Yuanyang Chen, Xu Li, Zhiwei Wang, Shun Yuan, Xiaoyan Shen, Xiaoping Xie, Kai Xing, Qingyi Zhu
Mol Med. 2024; 30: 90. Published online 2024 Jun 17. doi: 10.1186/s10020-024-00859-y
PMCID:
PMC11184844
AbstractArticlePDF–6.9M
14.
UCHL1-dependent control of hypoxia-inducible factor transcriptional activity during liver fibrosis
Amy Collins, Rebecca Scott, Caroline L. Wilson, Giuseppe Abbate, Gabrielle B. Ecclestone, Adam G. Albanese, Demi Biddles, Steven White, Jeremy French, John Moir, Wasfi Alrawashdeh, Colin Wilson, Sanjay Pandanaboyana, John S. Hammond, Rohan Thakkar, Fiona Oakley, Jelena Mann, Derek A. Mann, Niall S. Kenneth
Biosci Rep. 2024 Jun 26; 44(6): BSR20232147. Published online 2024 Jun 14. doi: 10.1042/BSR20232147
PMCID:
PMC11182734
AbstractArticlePDF–3.0M
15.
MiR-18a affects hypoxia induced glucose metabolism transition in HT22 hippocampal neuronal cell line through the Hif1a gene
Chuncheng Liu, Gehui Liu, Xinyang Zuo, Donghui Qu, Yefeng Sun, Linan Liu, Xiujuan Zhao, Jun Li, Lu Cai
BMC Neurol. 2024; 24: 204. Published online 2024 Jun 15. doi: 10.1186/s12883-024-03717-w
PMCID:
PMC11179257
AbstractArticlePDF–3.0M
16.
The transcription factor HIF-1α in NKp46+ ILCs limits chronic intestinal inflammation and fibrosis
Eric Nelius, Zheng Fan, Michal Sobecki, Ewelina Krzywinska, Shunmugam Nagarajan, Irina Ferapontova, Dagmar Gotthardt, Norihiko Takeda, Veronika Sexl, Christian Stockmann
Life Sci Alliance. 2024 Sep; 7(9): e202402593. Published online 2024 Jun 14. doi: 10.26508/lsa.202402593
PMCID:
PMC11178940
AbstractArticlePDF–3.1M
17.
Alternative splicing of CEACAM1 by Hypoxia-Inducible Factor–1α enhances tolerance to hepatic ischemia in mice and humans
Kenneth J. Dery, Hidenobu Kojima, Shoichi Kageyama, Kentaro Kadono, Hirofumi Hirao, Brian Cheng, Yuan Zhai, Douglas G. Farmer, Fady M. Kaldas, Xiaoyi Yuan, Holger K. Eltzschiasg, Jerzy W. Kupiec-Weglinski
Sci Transl Med. Author manuscript; available in PMC 2024 Jun 10.
Published in final edited form as: Sci Transl Med. 2023 Aug 2; 15(707): eadf2059. Published online 2023 Aug 2. doi: 10.1126/scitranslmed.adf2059
PMCID:
PMC11164245
AbstractArticlePDF–2.9M
18.
HIF-1 is involved in high glucose-induced paracellular permeability of brain endothelial cells
Jingqi Yan, Ziyan Zhang, Honglian Shi
Cell Mol Life Sci. 2012 Jan; 69(1): 115–128. Published online 2011 May 27. doi: 10.1007/s00018-011-0731-5
PMCID:
PMC11115066
AbstractArticlePDF–904K
19.
The HIF-1 transcription complex is essential for translational control of myeloid hematopoietic cell function by maintaining mTOR phosphorylation
Inna M. Yasinska, Bernhard F. Gibbs, Gurprit S. Lall, Vadim V. Sumbayev
Cell Mol Life Sci. 2014 Feb; 71(4): 699–710. Published online 2013 Jul 20. doi: 10.1007/s00018-013-1421-2
PMCID:
PMC11113144
AbstractArticlePDF–886K
20.
Ambient oxygen levels regulate intestinal dysbiosis and GVHD severity after allogeneic stem cell transplantation
Keisuke Seike, Anders Kiledal, Hideaki Fujiwara, Israel Henig, Marina Burgos da Silva, Marcel R.M. van den Brink, Robert Hein, Matthew Hoostal, Chen Liu, Katherine Oravecz-Wilson, Emma Lauder, Lu Li, Yaping Sun, Thomas M. Schmidt, Yatrik M. Shah, Robert R. Jenq, Gregory Dick, Pavan Reddy
Immunity. Author manuscript; available in PMC 2024 May 16.
Published in final edited form as: Immunity. 2023 Feb 14; 56(2): 353–368.e6. Published online 2023 Feb 2. doi: 10.1016/j.immuni.2023.01.007
PMCID:
PMC11098523
AbstractArticlePDF–3.0M

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