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Items: 1 to 20 of 65

1.
cGAS activation in classical dendritic cells causes autoimmunity in TREX1-deficient mice
Tong Li, Seoyun Yum, Junjiao Wu, Minghao Li, Yafang Deng, Lijun Sun, Xiaoxia Zuo, Zhijian J. Chen
Proc Natl Acad Sci U S A. 2024 Sep 17; 121(38): e2411747121. Published online 2024 Sep 10. doi: 10.1073/pnas.2411747121
PMCID:
PMC11420187
AbstractArticlePDF–2.9M
2.
Intratumoral TREX1 Induction Promotes Immune Evasion by Limiting Type I IFN
Eléonore Toufektchan, Alexandra Dananberg, Josefine Striepen, James H. Hickling, Abraham Shim, Yanyang Chen, Ashley Nichols, Mercedes A. Duran Paez, Lisa Mohr, Samuel F. Bakhoum, John Maciejowski
Cancer Immunol Res. 2024 Jun 4; 12(6): 673–686. Published online 2024 Feb 26. doi: 10.1158/2326-6066.CIR-23-1093
PMCID:
PMC11148545
AbstractArticlePDF–1.1M
3.
The Exonuclease TREX1 Constitutes an Innate Immune Checkpoint Limiting cGAS/STING-Mediated Antitumor Immunity
Junghyun Lim, Ryan Rodriguez, Katherine Williams, John Silva, Alan G. Gutierrez, Paul Tyler, Faezzah Baharom, Tao Sun, Eva Lin, Scott Martin, Brandon D. Kayser, Robert J. Johnston, Ira Mellman, Lélia Delamarre, Nathaniel R. West, Sören Müller, Yan Qu, Klaus Heger
Cancer Immunol Res. 2024 Jun 4; 12(6): 663–672. Published online 2024 Mar 15. doi: 10.1158/2326-6066.CIR-23-1078
PMCID:
PMC11148535
AbstractArticlePDF–6.5M
4.
Inherited C-terminal TREX1 variants disrupt homology-directed repair to cause senescence and DNA damage phenotypes in Drosophila, mice, and humans
Samuel D. Chauvin, Shoichiro Ando, Joe A. Holley, Atsushi Sugie, Fang R. Zhao, Subhajit Poddar, Rei Kato, Cathrine A. Miner, Yohei Nitta, Siddharth R. Krishnamurthy, Rie Saito, Yue Ning, Yuya Hatano, Sho Kitahara, Shin Koide, W. Alexander Stinson, Jiayuan Fu, Nehalee Surve, Lindsay Kumble, Wei Qian, Oleksiy Polishchuk, Prabhakar S. Andhey, Cindy Chiang, Guanqun Liu, Ludovic Colombeau, Raphaël Rodriguez, Nicolas Manel, Akiyoshi Kakita, Maxim N. Artyomov, David C. Schultz, P. Toby Coates, Elisha D. O. Roberson, Yasmine Belkaid, Roger A. Greenberg, Sara Cherry, Michaela U. Gack, Tristan Hardy, Osamu Onodera, Taisuke Kato, Jonathan J. Miner
Nat Commun. 2024; 15: 4696. Published online 2024 Jun 1. doi: 10.1038/s41467-024-49066-7
PMCID:
PMC11144269
AbstractArticlePDF–4.7M
5.
Genetic determinants of micronucleus formation in vivo
D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus
Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0
PMCID:
PMC10917660
AbstractArticlePDF–4.8M
6.
Aberrant RNA sensing in regulatory T cells causes systemic autoimmunity
Domnica Luca, Sumin Lee, Keiji Hirota, Yasutaka Okabe, Junji Uehori, Kazushi Izawa, Anna-Lisa Lanz, Verena Schütte, Burcu Sivri, Yuta Tsukamoto, Fabian Hauck, Rayk Behrendt, Axel Roers, Takashi Fujita, Ryuta Nishikomori, Min Ae Lee-Kirsch, Hiroki Kato
Sci Adv. 2024 Mar 1; 10(9): eadk0820. Published online 2024 Mar 1. doi: 10.1126/sciadv.adk0820
PMCID:
PMC10906915
AbstractArticlePDF–4.5M
7.
Molecular insight into the specific enzymatic properties of TREX1 revealing the diverse functions in processing RNA and DNA/RNA hybrids
Kuan-Wei Huang, Chia-Yun Wu, Shu-Ing Toh, Tung-Chang Liu, Chun-I Tu, Yin-Hsin Lin, An-Ju Cheng, Ya-Ting Kao, Jhih-Wei Chu, Yu-Yuan Hsiao
Nucleic Acids Res. 2023 Nov 27; 51(21): 11927–11940. Published online 2023 Oct 23. doi: 10.1093/nar/gkad910
PMCID:
PMC10681709
AbstractArticlePDF–1.6M
8.
Pharmacological inhibition of TBK1/IKKε blunts immunopathology in a murine model of SARS-CoV-2 infection
Tomalika R. Ullah, Matt D. Johansen, Katherine R. Balka, Rebecca L. Ambrose, Linden J. Gearing, James Roest, Julian P. Vivian, Sunil Sapkota, W. Samantha N. Jayasekara, Daniel S. Wenholz, Vina R. Aldilla, Jun Zeng, Stefan Miemczyk, Duc H. Nguyen, Nicole G. Hansbro, Rajan Venkatraman, Jung Hee Kang, Ee Shan Pang, Belinda J. Thomas, Arwaf S. Alharbi, Refaya Rezwan, Meredith O’Keeffe, William A. Donald, Julia I. Ellyard, Wilson Wong, Naresh Kumar, Benjamin T. Kile, Carola G. Vinuesa, Graham E. Kelly, Olivier F. Laczka, Philip M. Hansbro, Dominic De Nardo, Michael P. Gantier
Nat Commun. 2023; 14: 5666. Published online 2023 Sep 18. doi: 10.1038/s41467-023-41381-9
PMCID:
PMC10507085
AbstractArticlePDF–2.4M
9.
Suppression of TREX1 deficiency-induced cellular senescence and interferonopathies by inhibition of DNA damage response
Hekang Du, Nanyang Xiao, Sitong Zhang, Xueyuan Zhou, Yangfan Zhang, Zengzeng Lu, Yuqian Fu, Miaohui Huang, Shan Xu, Qi Chen
iScience. 2023 Jul 21; 26(7): 107090. Published online 2023 Jun 10. doi: 10.1016/j.isci.2023.107090
PMCID:
PMC10320204
AbstractArticlePDF–7.5M
10.
ABCC1 transporter exports the immunostimulatory cyclic dinucleotide cGAMP
Joanna H. Maltbaek, Stephanie Cambier, Jessica M. Snyder, Daniel B. Stetson
Immunity. Author manuscript; available in PMC 2023 Oct 11.
Published in final edited form as: Immunity. 2022 Oct 11; 55(10): 1799–1812.e4. Published online 2022 Sep 6. doi: 10.1016/j.immuni.2022.08.006
PMCID:
PMC9561016
AbstractArticlePDF–2.8M
11.
The E3 ubiquitin ligase ARIH1 promotes antiviral immunity and autoimmunity by inducing mono-ISGylation and oligomerization of cGAS
Tian-Chen Xiong, Ming-Cong Wei, Fang-Xu Li, Miao Shi, Hu Gan, Zhen Tang, Hong-Peng Dong, Tianzi Liuyu, Pu Gao, Bo Zhong, Zhi-Dong Zhang, Dandan Lin
Nat Commun. 2022; 13: 5973. Published online 2022 Oct 10. doi: 10.1038/s41467-022-33671-5
PMCID:
PMC9551088
AbstractArticlePDF–4.0M
12.
Deficiency of the bZIP transcription factors Mafg and Mafk causes misexpression of genes in distinct pathways and results in lens embryonic developmental defects
Shaili D. Patel, Deepti Anand, Hozumi Motohashi, Fumiki Katsuoka, Masayuki Yamamoto, Salil A. Lachke
Front Cell Dev Biol. 2022; 10: 981893. Published online 2022 Aug 26. doi: 10.3389/fcell.2022.981893
PMCID:
PMC9459095
AbstractArticlePDF–5.1M
13.
ADAR1 mutation causes ZBP1-dependent immunopathology
Nicholas W. Hubbard, Joshua M. Ames, Megan Maurano, Lan H. Chu, Kim Y. Somfleth, Nandan S Gokhale, Margo Werner, Jessica M. Snyder, Katrina Lichauco, Ram Savan, Daniel B. Stetson, Andrew Oberst
Nature. Author manuscript; available in PMC 2023 Jan 20.
Published in final edited form as: Nature. 2022 Jul; 607(7920): 769–775. Published online 2022 Jul 20. doi: 10.1038/s41586-022-04896-7
PMCID:
PMC9339495
AbstractArticlePDF–5.3M
14.
ADAR1 averts fatal type I interferon induction by ZBP1
Huipeng Jiao, Laurens Wachsmuth, Simone Wolf, Juliane Lohmann, Masahiro Nagata, Göksu Gökberk Kaya, Nikos Oikonomou, Vangelis Kondylis, Manuel Rogg, Martin Diebold, Simon E. Tröder, Branko Zevnik, Marco Prinz, Christoph Schell, George R. Young, George Kassiotis, Manolis Pasparakis
Nature. 2022; 607(7920): 776–783. Published online 2022 Jul 20. doi: 10.1038/s41586-022-04878-9
PMCID:
PMC9329096
AbstractArticlePDF–19M
15.
Genome Replication Is Associated With Release of Immunogenic DNA Waste
Nadja Schubert, Tina Schumann, Elena Daum, Karolin Flade, Yan Ge, Lara Hagedorn, Winfried Edelmann, Luise Müller, Marc Schmitz, Gunnar Kuut, Veit Hornung, Rayk Behrendt, Axel Roers
Front Immunol. 2022; 13: 880413. Published online 2022 May 11. doi: 10.3389/fimmu.2022.880413
PMCID:
PMC9130835
AbstractArticlePDF–6.8M
16.
Targeting Bcl6 in the TREX1 D18N murine model ameliorates autoimmunity by modulating T‐follicular helper cells and germinal center B cells
Rajkumar Venkatadri, Vikram Sabapathy, Murat Dogan, Saleh Mohammad, Scott E. Harvey, Sean R. Simpson, Jason M. Grayson, Nan Yan, Fred W. Perrino, Rahul Sharma
Eur J Immunol. 2022 May; 52(5): 825–834. Published online 2022 Feb 15. doi: 10.1002/eji.202149324
PMCID:
PMC9089306
AbstractArticlePDF–2.4M
17.
Intercellular cGAMP transmission induces innate immune activation and tissue inflammation in Trex1 deficiency
Bianca B. Jütte, Calvin Krollmann, Kevin Cieslak, Ruth-Miriam Koerber, Peter Boor, Claus M. Graef, Eva Bartok, Mirko Wagner, Thomas Carell, Jennifer Landsberg, Pia Aymans, Jörg Wenzel, Peter Brossart, Lino L. Teichmann
iScience. 2021 Aug 20; 24(8): 102833. Published online 2021 Jul 9. doi: 10.1016/j.isci.2021.102833
PMCID:
PMC8326191
AbstractArticlePDF–4.8M
18.
G3BP1 promotes DNA binding and activation of cGAS
Zhao-Shan Liu, Hong Cai, Wen Xue, Miao Wang, Tian Xia, Wan-Jin Li, Jia-Qing Xing, Ming Zhao, Yi-Jiao Huang, Shuai Chen, Sheng-Ming Wu, Xinzheng Wang, Xin Liu, Xue Pang, Zi-Yu Zhang, Tingting Li, Jiang Dai, Fangting Dong, Qing Xia, Ai-Ling Li, Tao Zhou, Zheng-gang Liu, Xue-Min Zhang, Tao Li
Nat Immunol. Author manuscript; available in PMC 2021 Jul 13.
Published in final edited form as: Nat Immunol. 2019 Jan; 20(1): 18–28. Published online 2018 Dec 3. doi: 10.1038/s41590-018-0262-4
PMCID:
PMC8276115
AbstractArticlePDF–2.6M
19.
USP29 maintains the stability of cGAS and promotes cellular antiviral responses and autoimmunity
Qiang Zhang, Zhen Tang, Ran An, Liya Ye, Bo Zhong
Cell Res. 2020 Oct; 30(10): 914–927. Published online 2020 May 26. doi: 10.1038/s41422-020-0341-6
Correction in:
Cell Res. 2020 Sep; 30(9): 821–822.
PMCID:
PMC7608407
AbstractArticlePDF–4.4M
20.
Absence of cGAS-mediated type I IFN responses in HIV-1–infected T cells
Carina Elsner, Aparna Ponnurangam, Julia Kazmierski, Thomas Zillinger, Jenny Jansen, Daniel Todt, Katinka Döhner, Shuting Xu, Aurélie Ducroux, Nils Kriedemann, Angelina Malassa, Pia-Katharina Larsen, Gunther Hartmann, Winfried Barchet, Eike Steinmann, Ulrich Kalinke, Beate Sodeik, Christine Goffinet
Proc Natl Acad Sci U S A. 2020 Aug 11; 117(32): 19475–19486. Published online 2020 Jul 24. doi: 10.1073/pnas.2002481117
PMCID:
PMC7431009
AbstractArticlePDF–2.3M

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