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Items: 1 to 20 of 140

1.
Reduced intestinal lipid absorption improves glucose metabolism in aged G2-Terc knockout mice
Xue Liu, Ahmed Elagamy Mohamed Mahmoud Khalil, Uthayakumar Muthukumarasamy, Yasuhiro Onogi, Xiaocheng Yan, Inderjeet Singh, Elena Lopez-Gonzales, Andreas Israel, Alberto Cebrian Serrano, Till Strowig, Siegfried Ussar
BMC Biol. 2023; 21: 150. Published online 2023 Jul 4. doi: 10.1186/s12915-023-01629-8
PMCID:
PMC10320900
AbstractArticlePDF–2.3M
2.
Senescence-related impairment of autophagy induces toxic intraneuronal amyloid-β accumulation in a mouse model of amyloid pathology
Nuria Suelves, Shirine Saleki, Tasha Ibrahim, Debora Palomares, Sebastiaan Moonen, Marta J. Koper, Céline Vrancx, Devkee M. Vadukul, Nicolas Papadopoulos, Nikenza Viceconte, Eloïse Claude, Rik Vandenberghe, Christine A. F. von Arnim, Stefan N. Constantinescu, Dietmar Rudolf Thal, Anabelle Decottignies, Pascal Kienlen-Campard
Acta Neuropathol Commun. 2023; 11: 82. Published online 2023 May 17. doi: 10.1186/s40478-023-01578-x
PMCID:
PMC10189946
AbstractArticlePDF–16M
3.
Long-term male-specific chronic pain via telomere- and p53‑mediated spinal cord cellular senescence
Arjun Muralidharan, Susana G. Sotocinal, Noosha Yousefpour, Nur Akkurt, Lucas V. Lima, Shannon Tansley, Marc Parisien, Chengyang Wang, Jean-Sebastien Austin, Boram Ham, Gabrielle M.G.S. Dutra, Philippe Rousseau, Sioui Maldonado-Bouchard, Teleri Clark, Sarah F. Rosen, Mariam R. Majeed, Olivia Silva, Rachel Nejade, Xinyu Li, Stephania Donayre Pimentel, Christopher S. Nielsen, G. Gregory Neely, Chantal Autexier, Luda Diatchenko, Alfredo Ribeiro-da-Silva, Jeffrey S. Mogil
J Clin Invest. 2022 Apr 15; 132(8): e151817. Published online 2022 Apr 15. doi: 10.1172/JCI151817
PMCID:
PMC9012275
AbstractArticlePDF–5.2M
4.
Dysfunctional telomeres through mitostress‐induced cGAS/STING activation to aggravate immune senescence and viral pneumonia
Nianyin Lv, Yufang Zhao, Xiaoyi Liu, Lusha Ye, Zihao Liang, Yanhua Kang, Yeping Dong, Wei Wang, Narasaiah Kolliputi, Liyun Shi
Aging Cell. 2022 Apr; 21(4): e13594. Published online 2022 Mar 21. doi: 10.1111/acel.13594
PMCID:
PMC9009109
AbstractArticlePDF–2.8M
5.
DNA damage response at telomeres boosts the transcription of SARS‐CoV‐2 receptor ACE2 during aging
Sara Sepe, Francesca Rossiello, Valeria Cancila, Fabio Iannelli, Valentina Matti, Giada Cicio, Matteo Cabrini, Eugenia Marinelli, Busola R Alabi, Alessia di Lillo, Arianna Di Napoli, Jerry W Shay, Claudio Tripodo, Fabrizio d’Adda di Fagagna
EMBO Rep. 2022 Feb 3; 23(2): e53658. Published online 2021 Dec 2. doi: 10.15252/embr.202153658
PMCID:
PMC8811650
AbstractArticlePDF–2.8M
6.
Pulmonary Alveolar Stem Cell Senescence, Apoptosis, and Differentiation by p53-Dependent and -Independent Mechanisms in Telomerase-Deficient Mice
Kexiong Zhang, Lihui Wang, Xiaojing Hong, Hao Chen, Yao Shi, Yingying Liu, Jun Liu, Jun-Ping Liu
Cells. 2021 Nov; 10(11): 2892. Published online 2021 Oct 26. doi: 10.3390/cells10112892
PMCID:
PMC8616483
AbstractArticlePDF–2.8M
7.
DNA-RNA Hybrid (R-Loop): From a Unified Picture of the Mammalian Telomere to the Genome-Wide Profile
Minoo Rassoulzadegan, Ali Sharifi-Zarchi, Leila Kianmehr
Cells. 2021 Jun; 10(6): 1556. Published online 2021 Jun 19. doi: 10.3390/cells10061556
PMCID:
PMC8233970
AbstractArticlePDF–3.3M
8.
Network-based screen in iPSC-derived cells reveals therapeutic candidate for heart valve disease
Christina V. Theodoris, Ping Zhou, Lei Liu, Yu Zhang, Tomohiro Nishino, Yu Huang, Aleksandra Kostina, Sanjeev S. Ranade, Casey A. Gifford, Vladimir Uspensky, Anna Malaschicheva, Sheng Ding, Deepak Srivastava
Science. Author manuscript; available in PMC 2021 Aug 12.
Published in final edited form as: Science. 2021 Feb 12; 371(6530): eabd0724. Published online 2020 Dec 10. doi: 10.1126/science.abd0724
PMCID:
PMC7880903
AbstractArticlePDF–2.0M
9.
The mTOR pathway is necessary for survival of mice with short telomeres
Iole Ferrara-Romeo, Paula Martinez, Sarita Saraswati, Kurt Whittemore, Osvaldo Graña-Castro, Lydia Thelma Poluha, Rosa Serrano, Elena Hernandez-Encinas, Carmen Blanco-Aparicio, Juana Maria Flores, Maria A. Blasco
Nat Commun. 2020; 11: 1168. Published online 2020 Mar 3. doi: 10.1038/s41467-020-14962-1
PMCID:
PMC7054554
AbstractArticlePDF–3.0M
10.
Muscle Stem Cells Give Rise to Rhabdomyosarcomas in a Severe Mouse Model of Duchenne Muscular Dystrophy
Francesca Boscolo Sesillo, David Fox, Alessandra Sacco
Cell Rep. Author manuscript; available in PMC 2019 Nov 13.
Published in final edited form as: Cell Rep. 2019 Jan 15; 26(3): 689–701.e6. doi: 10.1016/j.celrep.2018.12.089
PMCID:
PMC6853774
AbstractArticlePDF–2.2M
11.
ZCCHC8, the nuclear exosome targeting component, is mutated in familial pulmonary fibrosis and is required for telomerase RNA maturation
Dustin L. Gable, Valeriya Gaysinskaya, Christine C. Atik, C. Conover Talbot, Jr., Byunghak Kang, Susan E. Stanley, Elizabeth W. Pugh, Nuria Amat-Codina, Kara M. Schenk, Murat O. Arcasoy, Cory Brayton, Liliana Florea, Mary Armanios
Genes Dev. 2019 Oct 1; 33(19-20): 1381–1396. doi: 10.1101/gad.326785.119
PMCID:
PMC6771387
AbstractArticlePDF–12M
12.
Telomere dysfunction impairs epidermal stem cell specification and differentiation by disrupting BMP/pSmad/P63 signaling
Na Liu, Yu Yin, Haiying Wang, Zhongcheng Zhou, Xiaoyan Sheng, Haifeng Fu, Renpeng Guo, Hua Wang, Jiao Yang, Peng Gong, Wen Ning, Zhenyu Ju, Yifei Liu, Lin Liu
PLoS Genet. 2019 Sep; 15(9): e1008368. Published online 2019 Sep 13. doi: 10.1371/journal.pgen.1008368
PMCID:
PMC6760834
AbstractArticlePDF–4.4M
13.
Targeting Cardiac Fibrosis with Engineered T cells
Haig Aghajanian, Toru Kimura, Joel G. Rurik, Aidan S. Hancock, Michael S. Leibowitz, Li Li, John Scholler, James Monslow, Albert Lo, Wei Han, Tao Wang, Kenneth Bedi, Michael P. Morley, Ricardo A. Linares Saldana, Nikhita A. Bolar, Kendra McDaid, Charles-Antoine Assenmacher, Cheryl L. Smith, Dagmar Wirth, Carl H. June, Kenneth B. Margulies, Rajan Jain, Ellen Puré, Steven M. Albelda, Jonathan A. Epstein
Nature. Author manuscript; available in PMC 2020 Mar 11.
Published in final edited form as: Nature. 2019 Sep; 573(7774): 430–433. Published online 2019 Sep 11. doi: 10.1038/s41586-019-1546-z
PMCID:
PMC6752964
AbstractArticlePDF–6.8M
14.
Mitochondrion-processed TERC regulates senescence without affecting telomerase activities
Qian Zheng, Peipei Liu, Ge Gao, Jiapei Yuan, Pengfeng Wang, Jinliang Huang, Leiming Xie, Xinping Lu, Fan Di, Tanjun Tong, Jun Chen, Zhi Lu, Jisong Guan, Geng Wang
Protein Cell. 2019 Sep; 10(9): 631–648. Published online 2019 Feb 20. doi: 10.1007/s13238-019-0612-5
PMCID:
PMC6711880
AbstractArticlePDF–3.3M
15.
Telomere Shortening in Neural Stem Cells Disrupts Neuronal Differentiation and Neuritogenesis
Sacri R. Ferrón, M. Ángeles Marqués-Torrejón, Helena Mira, Ignacio Flores, Kerrie Taylor, María A. Blasco, Isabel Fariñas
J Neurosci. 2009 Nov 18; 29(46): 14394–14407. doi: 10.1523/JNEUROSCI.3836-09.2009
PMCID:
PMC6665809
AbstractArticlePDF–1.6M
16.
Compromised Chondrocyte Differentiation Capacity in TERC Knockout Mouse Embryonic Stem Cells Derived by Somatic Cell Nuclear Transfer
Wei-Fang Chang, Yun-Hsin Wu, Jie Xu, Li-Ying Sung
Int J Mol Sci. 2019 Mar; 20(5): 1236. Published online 2019 Mar 12. doi: 10.3390/ijms20051236
PMCID:
PMC6429130
AbstractArticlePDF–2.1M
17.
Length‐independent telomere damage drives post‐mitotic cardiomyocyte senescence
Rhys Anderson, Anthony Lagnado, Damien Maggiorani, Anna Walaszczyk, Emily Dookun, James Chapman, Jodie Birch, Hanna Salmonowicz, Mikolaj Ogrodnik, Diana Jurk, Carole Proctor, Clara Correia‐Melo, Stella Victorelli, Edward Fielder, Rolando Berlinguer‐Palmini, Andrew Owens, Laura C Greaves, Kathy L Kolsky, Angelo Parini, Victorine Douin‐Echinard, Nathan K LeBrasseur, Helen M Arthur, Simon Tual‐Chalot, Marissa J Schafer, Carolyn M Roos, Jordan D Miller, Neil Robertson, Jelena Mann, Peter D Adams, Tamara Tchkonia, James L Kirkland, Jeanne Mialet‐Perez, Gavin D Richardson, João F Passos
EMBO J. 2019 Mar 1; 38(5): e100492. Published online 2019 Feb 8. doi: 10.15252/embj.2018100492
PMCID:
PMC6396144
AbstractArticlePDF–2.1M
18.
Short telomere syndromes cause a primary T cell immunodeficiency
Christa L. Wagner, Vidya Sagar Hanumanthu, C. Conover Talbot, Jr., Roshini S. Abraham, David Hamm, Dustin L. Gable, Christopher G. Kanakry, Carolyn D. Applegate, Janet Siliciano, J. Brooks Jackson, Stephen Desiderio, Jonathan K. Alder, Leo Luznik, Mary Armanios
J Clin Invest. 2018 Dec 3; 128(12): 5222–5234. Published online 2018 Oct 22. doi: 10.1172/JCI120216
PMCID:
PMC6264634
AbstractArticlePDF–5.7M
19.
Telomeric epigenetic response mediated by Gadd45a regulates stem cell aging and lifespan
Daojun Diao, Hu Wang, Tangliang Li, Zhencan Shi, Xiaoqing Jin, Tobias Sperka, Xudong Zhu, Meimei Zhang, Fan Yang, Yusheng Cong, Li Shen, Qimin Zhan, Jing Yan, Zhangfa Song, Zhenyu Ju
EMBO Rep. 2018 Oct; 19(10): e45494. Published online 2018 Aug 20. doi: 10.15252/embr.201745494
PMCID:
PMC6172461
AbstractArticlePDF–2.5M
20.
Telomerase reverse transcriptase protects against angiotensin II-induced microvascular endothelial dysfunction
Karima Ait-Aissa, Andrew O. Kadlec, Joseph Hockenberry, David D. Gutterman, Andreas M. Beyer
Am J Physiol Heart Circ Physiol. 2018 May 1; 314(5): H1053–H1060. Published online 2017 Dec 22. doi: 10.1152/ajpheart.00472.2017
PMCID:
PMC6008150
AbstractArticle

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