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Select item 111442681.

PGC-1α repression dysregulates lipid metabolism and induces lipid droplet accumulation in the retinal pigment epithelium

Shuyan Zhou, Kaan Taskintuna, Jacob Hum, Jasmine Gulati, Stephanie Olaya, Jeremy Steinman, Nady Golestaneh

Cell Death Dis. 2024 Jun; 15(6): 385. Published online 2024 Jun 1. doi: 10.1038/s41419-024-06762-y

PMCID:: PMC11144268

Abstract Article PDF–13M

Select item 111427382.

Intermittent glucocorticoid treatment improves muscle metabolism via the PGC1α/Lipin1 axis in an aging-related sarcopenia model

Ashok D. Prabakaran, Kevin McFarland, Karen Miz, Hima Bindu Durumutla, Kevin Piczer, Fadoua El Abdellaoui Soussi, Hannah Latimer, Cole Werbrich, Hyun-Jy Chung, N. Scott Blair, Douglas P. Millay, Andrew J. Morris, Brendan Prideaux, Brian N. Finck, Mattia Quattrocelli

J Clin Invest. 2024 Jun 3; 134(11): e177427. Published online 2024 May 3. doi: 10.1172/JCI177427

PMCID:: PMC11142738

Abstract Article PDF–5.6M

Select item 111148583.

Transgenic expression and activation of PGC-1α protect dopaminergic neurons in the MPTP mouse model of Parkinson’s disease

Giuseppa Mudò, Johanna Mäkelä, Valentina Di Liberto, Timofey V. Tselykh, Melania Olivieri, Petteri Piepponen, Ove Eriksson, Annika Mälkiä, Alessandra Bonomo, Minna Kairisalo, Jose A. Aguirre, Laura Korhonen, Natale Belluardo, Dan Lindholm

Cell Mol Life Sci. 2012 Apr; 69(7): 1153–1165. Published online 2011 Oct 8. doi: 10.1007/s00018-011-0850-z

PMCID:: PMC11114858

Abstract Article PDF–745K

Select item 111055534.

PGC-1α induced browning promotes involution and inhibits lactation in mammary glands

Elena Piccinin, Annalisa Morgano, Claudia Peres, Annalisa Contursi, Justine Bertrand-Michel, Maria Arconzo, Hervé Guillou, Gaetano Villani, Antonio Moschetta

Cell Mol Life Sci. 2019 Dec; 76(24): 5011–5025. Published online 2019 Jun 1. doi: 10.1007/s00018-019-03160-y

PMCID:: PMC11105553

Abstract Article PDF–8.3M

Select item 110740135.

PGC-1α activation boosts exercise-dependent cellular response in the skeletal muscle

Soroosh Mozaffaritabar, Erika Koltai, Lei Zhou, Zoltan Bori, Attila Kolonics, Sylwester Kujach, Yaodong Gu, Atsuko Koike, Anita Boros, Zsolt Radák

J Physiol Biochem. 2024; 80(2): 329–335. Published online 2024 Jan 23. doi: 10.1007/s13105-024-01006-1

PMCID:: PMC11074013

Abstract Article PDF–872K

Select item 109535656.

Cfp1 Controls Cardiomyocyte Maturation by Modifying Histone H3K4me3 of Structural, Metabolic, and Contractile Related Genes

Changzhu Li, Yang Zhang, Jingling Shen, Hairong Bao, Yue Zhao, Desheng Li, Sijia Li, Yining Liu, Jiming Yang, Zhiwen Zhou, Kangyi Gao, Lexin Zhao, Yao Pei, Yanjie Lu, Zhenwei Pan, Benzhi Cai

Adv Sci (Weinh) 2024 Mar; 11(11): 2305992. Published online 2024 Jan 9. doi: 10.1002/advs.202305992

PMCID:: PMC10953565

Abstract Article PDF–5.8M

Select item 109176607.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 109044938.

Skeletal muscle TET3 promotes insulin resistance through destabilisation of PGC-1α

Beibei Liu, Di Xie, Xinmei Huang, Sungho Jin, Yangyang Dai, Xiaoli Sun, Da Li, Anton M. Bennett, Sabrina Diano, Yingqun Huang

Diabetologia. 2024; 67(4): 724–737. Published online 2024 Jan 13. doi: 10.1007/s00125-023-06073-5

PMCID:: PMC10904493

Abstract Article PDF–1.4M

Select item 108664289.

An enriched environment ameliorates maternal sleep deprivation-induced cognitive impairment in aged mice by improving mitochondrial function via the Sirt1/PGC-1α pathway

Ru-Meng Wei, Yue-Ming Zhang, Kai-Xuan Zhang, Gao-Xia Liu, Xue-Yan Li, Jing-Ya Zhang, Wei-Zhong Lun, Xue-Chun Liu, Gui-Hai Chen

Aging (Albany NY) 2024 Jan 31; 16(2): 1128–1144. Published online 2024 Jan 16. doi: 10.18632/aging.205385

PMCID:: PMC10866428

Abstract Article PDF–2.1M

Select item 1086598210.

Bicuculline Restores Frequency-Dependent Hippocampal I/E Ratio and Circuit Function in PGC-1ɑ Null Mice

Dwipayan Bhattacharya, Aundrea F. Bartley, Qin Li, Lynn E. Dobrunz

Neurosci Res. Author manuscript; available in PMC 2024 Feb 14.

Published in final edited form as: Neurosci Res. 2022 Nov; 184: 9–18. Published online 2022 Jul 14. doi: 10.1016/j.neures.2022.07.003

PMCID:: PMC10865982

Abstract Article PDF–1.9M

Select item 1079988011.

Peroxisome proliferator-activated receptor γ coactivator 1α regulates downstream of tyrosine kinase-7 (Dok-7) expression important for neuromuscular junction formation

Takumi Sugimoto, Chihiro Sakamaki, Tokushi Kimura, Takahiro Eguchi, Shinji Miura, Yasutomi Kamei

Sci Rep. 2024; 14: 1780. Published online 2024 Jan 20. doi: 10.1038/s41598-024-52198-x

PMCID:: PMC10799880

Abstract Article PDF–1.6M

Select item 1071786312.

Endurance exercise increases the protein levels of PGC-1α and respiratory chain complexes in mouse skeletal muscle during atorvastatin administration

Koji Nonaka, Yutaka Ozaki, Kenichi Ito, Masahiro Sakita, Satsuki Une, Junichi Akiyama

J Physiol Sci. 2019 Mar; 69(2): 327–333. Published online 2018 Dec 8. doi: 10.1007/s12576-018-0649-x

PMCID:: PMC10717863

Abstract Article PDF–1.0M

Select item 1071769413.

Chronic voluntary wheel running exercise ameliorates metabolic dysfunction via PGC-1α expression independently of FNDC5/irisin pathway in high fat diet-induced obese mice

Chaeeun Cho, Minje Ji, Eunhee Cho, Seon Yi, Jae Geun Kim, Sewon Lee

J Physiol Sci. 2023; 73: 6. Published online 2023 Apr 11. doi: 10.1186/s12576-023-00864-6

PMCID:: PMC10717694

Abstract Article PDF–1.6M

Select item 1059218714.

Ncoa2 promotes CD8⁺ T cell-mediated anti-tumor immunity by stimulating T-cell activation via upregulation of PGC-1α critical for mitochondrial function: Noca2 in CD8+ T-cell activation and antitumor response

Xiancai Zhong, Hongmin Wu, Ching Ouyang, Wencan Zhang, Yun Shi, Yi-Chang Wang, David K. Ann, Yousang Gwack, Weirong Shang, Zuoming Sun

Cancer Immunol Res. Author manuscript; available in PMC 2024 Apr 4.

Published in final edited form as: Cancer Immunol Res. 2023 Oct 4; 11(10): 1414–1431. doi: 10.1158/2326-6066.CIR-23-0092

PMCID:: PMC10592187

Abstract Article PDF–2.4M

Select item 1056351415.

PGC-1α regulates critical period onset/closure, mediating cortical plasticity

Wei-Jun Zhang, Hou-Zhen Shi, Mei-Na Guo, Long-Fei Xu, Hong-Ru Zhai, Zi-Zhong Liu, Yong-Qiang Zhu, Wei-Ning Zhang, Jia Wang

Front Mol Neurosci. 2023; 16: 1149906. Published online 2023 Sep 25. doi: 10.3389/fnmol.2023.1149906

PMCID:: PMC10563514

Abstract Article PDF–3.5M

Select item 1054420616.

PGC-1α–mediated angiogenesis prevents pulmonary hypertension in mice

Takayuki Fujiwara, Norifumi Takeda, Hironori Hara, Satoshi Ishii, Genri Numata, Hiroyuki Tokiwa, Manami Katoh, Sonoko Maemura, Takaaki Suzuki, Hiroshi Takiguchi, Tomonobu Yanase, Yoshiaki Kubota, Seitaro Nomura, Masaru Hatano, Kazutaka Ueda, Mutsuo Harada, Haruhiro Toko, Eiki Takimoto, Hiroshi Akazawa, Hiroyuki Morita, Satoshi Nishimura, Issei Komuro

JCI Insight. 2023 Sep 8; 8(17): e162632. Published online 2023 Sep 8. doi: 10.1172/jci.insight.162632

PMCID:: PMC10544206

Abstract Article PDF–2.5M

Select item 1051295617.

Epithelial NAD⁺ depletion drives mitochondrial dysfunction and contributes to intestinal inflammation

Elizabeth A. Novak, Erin C. Crawford, Heather L. Mentrup, Brian D. Griffith, David M. Fletcher, Meredith R. Flanagan, Corinne Schneider, Brian Firek, Matthew B. Rogers, Michael J. Morowitz, Jon D. Piganelli, Qian Wang, Kevin P. Mollen

Front Immunol. 2023; 14: 1231700. Published online 2023 Sep 7. doi: 10.3389/fimmu.2023.1231700

PMCID:: PMC10512956

Abstract Article PDF–8.9M

Select item 1048366618.

Impaired age-associated mitochondrial translation is mitigated by exercise and PGC-1α

Laura M. de Smalen, Anastasiya Börsch, Aurel B. Leuchtmann, Jonathan F. Gill, Danilo Ritz, Mihaela Zavolan, Christoph Handschin

Proc Natl Acad Sci U S A. 2023 Sep 5; 120(36): e2302360120. Published online 2023 Aug 28. doi: 10.1073/pnas.2302360120

PMCID:: PMC10483666

Abstract Article PDF–1.5M

Select item 1041912419.

Reciprocal Regulation of Peroxisome Biogenesis and Myogenic Factors Is Critical for Myogenesis

Chuan-Che Wu, Wei-Cheng Chen, Wen-Po Hsiao, Kai-Fan Huang, Yi-Shiuan Liao, Huang-Bin Lin, Yi-Ju Wu, Chien-Han Kao, Shen-Liang Chen

Int J Mol Sci. 2023 Aug; 24(15): 12262. Published online 2023 Jul 31. doi: 10.3390/ijms241512262

PMCID:: PMC10419124

Abstract Article PDF–4.9M

Select item 1040350520.

Myonectin protects against skeletal muscle dysfunction in male mice through activation of AMPK/PGC1α pathway

Yuta Ozaki, Koji Ohashi, Naoya Otaka, Hiroshi Kawanishi, Tomonobu Takikawa, Lixin Fang, Kunihiko Takahara, Minako Tatsumi, Sohta Ishihama, Mikito Takefuji, Katsuhiro Kato, Yuuki Shimizu, Yasuko K. Bando, Aiko Inoue, Masafumi Kuzuya, Shinji Miura, Toyoaki Murohara, Noriyuki Ouchi

Nat Commun. 2023; 14: 4675. Published online 2023 Aug 4. doi: 10.1038/s41467-023-40435-2

PMCID:: PMC10403505

Abstract Article PDF–2.8M

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