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Select item 107115561.

Guanine-containing ssDNA and RNA induce dimeric and tetrameric structural forms of SAMHD1

Benjamin Orris, Min Woo Sung, Shridhar Bhat, Yingrong Xu, Kevin W Huynh, Seungil Han, Darren C Johnson, Benedikt Bosbach, David J Shields, James T Stivers

Nucleic Acids Res. 2023 Dec 11; 51(22): 12443–12458. Published online 2023 Nov 1. doi: 10.1093/nar/gkad971

PMCID:: PMC10711556

Abstract Article PDF–2.4M

Select item 106537932.

Gene editing of SAMHD1 in macrophage-like cells reveals complex relationships between SAMHD1 phospho-regulation, HIV-1 restriction, and cellular dNTP levels

Moritz Schüssler, Kerstin Schott, Nina Verena Fuchs, Adrian Oo, Morssal Zahadi, Paula Rauch, Baek Kim, Renate König

mBio. 2023 Sep-Oct; 14(5): e02252-23. Published online 2023 Oct 6. doi: 10.1128/mbio.02252-23

PMCID:: PMC10653793

Abstract Article PDF–2.5M

Select item 105658763.

Pulse-SILAC and Interactomics Reveal Distinct DDB1-CUL4–Associated Factors, Cellular Functions, and Protein Substrates

Jennifer Raisch, Marie-Line Dubois, Marika Groleau, Dominique Lévesque, Thomas Burger, Carla-Marie Jurkovic, Romain Brailly, Gwendoline Marbach, Alyson McKenna, Catherine Barrette, Pierre-Étienne Jacques, François-Michel Boisvert

Mol Cell Proteomics. 2023 Oct; 22(10): 100644. Published online 2023 Sep 7. doi: 10.1016/j.mcpro.2023.100644

PMCID:: PMC10565876

Abstract Article PDF–3.7M

Select item 105356964.

Activation of STING by SAMHD1 Deficiency Promotes PANoptosis and Enhances Efficacy of PD-L1 Blockade in Diffuse Large B-cell Lymphoma

Yiqing Cai, Xiaomin Chen, Tiange Lu, Xiaosheng Fang, Mengfei Ding, Zhuoya Yu, Shunfeng Hu, Jiarui Liu, Xiangxiang Zhou, Xin Wang

Int J Biol Sci. 2023; 19(14): 4627–4643. Published online 2023 Aug 28. doi: 10.7150/ijbs.85236

PMCID:: PMC10535696

Abstract Article PDF–7.5M

Select item 104046995.

SAMHD1 impairs type I interferon induction through the MAVS, IKKε, and IRF7 signaling axis during viral infection

Constanza E. Espada, Levent Sari, Michael P. Cahill, Hua Yang, Stacia Phillips, Nicholas Martinez, Adam D. Kenney, Jacob S. Yount, Yong Xiong, Milo M. Lin, Li Wu

J Biol Chem. 2023 Jul; 299(7): 104925. Published online 2023 Jun 14. doi: 10.1016/j.jbc.2023.104925

PMCID:: PMC10404699

Abstract Article PDF–3.3M

Select item 103595946.

Protein oxidation increases SAMHD1 binding ssDNA via its regulatory site

Theresa L Simermeyer, Stephanie Batalis, LeAnn C Rogers, Owen J Zalesak, Thomas Hollis

Nucleic Acids Res. 2023 Jul 21; 51(13): 7014–7024. Published online 2023 May 29. doi: 10.1093/nar/gkad447

PMCID:: PMC10359594

Abstract Article PDF–1.2M

Select item 103184687.

The host antiviral protein SAMHD1 suppresses NF-κB activation by interacting with the IKK complex during inflammatory responses and viral infection

Hua Yang, Constanza E. Espada, Stacia Phillips, Nicholas Martinez, Adam D. Kenney, Jacob S. Yount, Yong Xiong, Li Wu

J Biol Chem. 2023 Jun; 299(6): 104750. Published online 2023 Apr 24. doi: 10.1016/j.jbc.2023.104750

PMCID:: PMC10318468

Abstract Article PDF–4.9M

Select item 102426428.

SAMHD1 single nucleotide polymorphisms impact outcome in children with newly diagnosed acute myeloid leukemia

Richard J. Marrero, Xueyuan Cao, Huiyun Wu, Abdelrahman H. Elsayed, Jeffery M. Klco, Raul C. Ribeiro, Jeffrey E. Rubnitz, Xiaotu Ma, Soheil Meshinchi, Richard Aplenc, E. Anders Kolb, Rhonda E. Ries, Todd A. Alonzo, Stanley B. Pounds, Jatinder K. Lamba

Blood Adv. 2023 Jun 13; 7(11): 2538–2550. Published online 2023 Jan 24. doi: 10.1182/bloodadvances.2022009088

PMCID:: PMC10242642

Abstract Article PDF–708K

Select item 102382709.

De-ubiquitination of SAMHD1 by USP7 promotes DNA damage repair to overcome oncogenic stress and affect chemotherapy sensitivity

Jingwei Liu, Tingting Zhou, Xiang Dong, Qiqiang Guo, Lixia Zheng, Xiaoxun Wang, Naijin Zhang, Danni Li, Ling Ren, Fei Yi, Ying Zhang, Ziwei Li, Xiwen Wang, Chengsi Deng, Chunlu Li, Hongde Xu, Yi Guan, Xiaoman Li, Yang Yu, Wendong Guo, Zhuo Wang, Bo Jiang, Xuan Wu, Ning Bai, Yanling Feng, Mengtao Ma, Qingquan Kong, Jiayi Wei, Zhenshuang Wang, Hao Li, Songming Lu, Liangzi Cao, Yutong Xiao, Xiaoyu Song, Zhenning Wang, Chengzhong Xing, Liu Cao

Oncogene. 2023; 42(22): 1843–1856. Published online 2023 Apr 20. doi: 10.1038/s41388-023-02667-w

PMCID:: PMC10238270

Abstract Article PDF–6.2M

Select item 1023742210.

TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing

Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan

Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233

PMCID:: PMC10237422

Abstract Article PDF–23M

Select item 1019814711.

Recombinant Klotho attenuates IFNγ receptor signaling and SAMHD1 expression through blocking NF-κB translocation in glomerular mesangial cells

Kuen-Daw Tsai, Yi-Chao Lee, Bo-Yu Chen, Li-Syuan Wu, Shan-Yuan Liang, Ming-Yuan Liu, Yu-Wen Hung, Hui-Ling Hsu, Pei-Qi Chen, Jia-Ching Shieh, Yi-Ju Lee, Ting-Hui Lin

Int J Med Sci. 2023; 20(6): 810–817. Published online 2023 Apr 29. doi: 10.7150/ijms.78279

PMCID:: PMC10198147

Abstract Article PDF–1.5M

Select item 1016736912.

SAMHD1-induced endosomal FAK signaling promotes human renal clear cell carcinoma metastasis by activating Rac1-mediated lamellipodia protrusion

Sunho An, Tam Thuy Lu Vo, Taekwon Son, Hoon Choi, Jinyoung Kim, Juyeon Lee, Byung Hoon Kim, Misun Choe, Eunyoung Ha, Young-Joon Surh, Kyu-Won Kim, Ji Hae Seo

Exp Mol Med. 2023 Apr; 55(4): 779–793. Published online 2023 Apr 3. doi: 10.1038/s12276-023-00961-x

PMCID:: PMC10167369

Abstract Article PDF–4.7M

Select item 994839713.

SAMHD1 expression modulates innate immune activation and correlates with ovarian cancer prognosis

Lucía Gutiérrez-Chamorro, Eudald Felip, Adrià Bernat-Peguera, Ifeanyi Jude Ezeonwumelu, Iris Teruel, Anna Martínez-Cardús, Bonaventura Clotet, Eva Riveira-Muñoz, Margarita Romeo, Mireia Margelí, Ester Ballana

Front Immunol. 2023; 14: 1112761. Published online 2023 Feb 9. doi: 10.3389/fimmu.2023.1112761

PMCID:: PMC9948397

Abstract Article PDF–3.7M

Select item 979869914.

SAMHD1 silencing cooperates with radiotherapy to enhance anti-tumor immunity through IFI16-STING pathway in lung adenocarcinoma

Yangyi Li, Yuke Gao, Xueping Jiang, Yajie Cheng, Jianguo Zhang, Liexi Xu, Xinyu Liu, Zhengrong Huang, Conghua Xie, Yan Gong

J Transl Med. 2022; 20: 628. Published online 2022 Dec 29. doi: 10.1186/s12967-022-03844-3

PMCID:: PMC9798699

Abstract Article PDF–13M

Select item 977255815.

HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation

Jingsheng Yuan, Tao Lv, Jian Yang, Zhenru Wu, Lvnan Yan, Jiayin Yang, Yujun Shi, Li Jiang

Cell Mol Gastroenterol Hepatol. 2023; 15(2): 307–325. Published online 2022 Oct 14. doi: 10.1016/j.jcmgh.2022.10.005

PMCID:: PMC9772558

Abstract Article PDF–8.2M

Select item 976969816.

A whole genome CRISPR screen identifies AHR loss as a mechanism of resistance to a PARP7 inhibitor

Huadong Chen, Morgan E. Diolaiti, Patrick C. O’Leary, Ajda Rojc, Nevan J. Krogan, Minkyu Kim, Alan Ashworth

Mol Cancer Ther. Author manuscript; available in PMC 2023 Jan 5.

Published in final edited form as: Mol Cancer Ther. 2022 Jul 5; 21(7): 1076–1089. doi: 10.1158/1535-7163.MCT-21-0841

PMCID:: PMC9769698

Abstract Article PDF–2.7M

Select item 975583717.

Interferon-inducible SAMHD1 restricts viral replication through downregulation of lipid synthesis

Ni An, Qinghua Ge, Huihan Shao, Quanjie Li, Fei Guo, Chen Liang, Xiaoyu Li, Dongrong Yi, Long Yang, Shan Cen

Front Immunol. 2022; 13: 1007718. Published online 2022 Nov 30. doi: 10.3389/fimmu.2022.1007718

PMCID:: PMC9755837

Abstract Article PDF–9.0M

Select item 974947518.

Sulforaphane Reduces SAMHD1 Phosphorylation To Protect Macrophages from HIV-1 Infection

H. John Sharifi, Dakota N. Paine, Vincent A. Fazzari, Alexandria F. Tipple, Emilee Patterson, Carlos M. C. de Noronha

J Virol. 2022 Dec; 96(23): e01187-22. Published online 2022 Nov 15. doi: 10.1128/jvi.01187-22

PMCID:: PMC9749475

Abstract Article PDF–1.7M

Select item 952570319.

Disease-associated KBTBD4 mutations in medulloblastoma elicit neomorphic ubiquitylation activity to promote CoREST degradation

Zhuoyao Chen, Rafael M. Ioris, Stacey Richardson, Ava N. Van Ess, Iolanda Vendrell, Benedikt M. Kessler, Francesca M. Buffa, Luca Busino, Steven C. Clifford, Alex N. Bullock, Vincenzo D’Angiolella

Cell Death Differ. 2022 Oct; 29(10): 1955–1969. Published online 2022 Apr 4. doi: 10.1038/s41418-022-00983-4

PMCID:: PMC9525703

Abstract Article PDF–4.4M

Select item 948193320.

ALS-linked loss of Cyclin-F function affects HSP90

Alexander Siebert, Vanessa Gattringer, Jochen H Weishaupt, Christian Behrends

Life Sci Alliance. 2022 Dec; 5(12): e202101359. Published online 2022 Sep 16. doi: 10.26508/lsa.202101359

PMCID:: PMC9481933

Abstract Article PDF–3.5M

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