U.S. flag

An official website of the United States government

Display Settings:

Format
Items per page
Sort by

Send to:

Choose Destination

Links from GEO Profiles

Items: 1 to 20 of 56

1.
Genetic determinants of micronucleus formation in vivo
D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus
Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0
PMCID:
PMC10917660
AbstractArticlePDF–4.8M
2.
KRIT1-mediated regulation of neutrophil adhesion and motility
Nicholas Nobiletti, Jing Liu, Angela J. Glading
FEBS J. Author manuscript; available in PMC 2024 Feb 1.
Published in final edited form as: FEBS J. 2023 Feb; 290(4): 1078–1095. Published online 2022 Sep 20. doi: 10.1111/febs.16627
PMCID:
PMC9957810
AbstractArticlePDF–1.7M
3.
Circulating plasma miRNA homologs in mice and humans reflect familial cerebral cavernous malformation disease
Sharbel G. Romanos, Abhinav Srinath, Ying Li, Bingqing Xie, Chang Chen, Yan Li, Thomas Moore, Dehua Bi, Je Yeong Sone, Rhonda Lightle, Nick Hobson, Dongdong Zhang, Janne Koskimäki, Le Shen, Sara McCurdy, Catherine Chinhchu Lai, Agnieszka Stadnik, Kristina Piedad, Julián Carrión-Penagos, Abdallah Shkoukani, Daniel Snellings, Robert Shenkar, Dinanath Sulakhe, Yuan Ji, Miguel A. Lopez-Ramirez, Mark L. Kahn, Douglas A. Marchuk, Mark H. Ginsberg, Romuald Girard, Issam A. Awad
Transl Stroke Res. Author manuscript; available in PMC 2024 Aug 1.
Published in final edited form as: Transl Stroke Res. 2023 Aug; 14(4): 513–529. Published online 2022 Jun 17. doi: 10.1007/s12975-022-01050-3
PMCID:
PMC9758276
AbstractArticlePDF–1.3M
4.
Role of pericytes in the development of cerebral cavernous malformations
Zifeng Dai, Jingwei Li, Ying Li, Rui Wang, Huili Yan, Ziyu Xiong, Shiting Wu, Xi Yang, Dongbo Lu, Dongdong Zhang, Guofu Li, Yuwen Wang, Chunyang Men, Wenzhong Du, Xiangjian Zheng, Changbin Shi
iScience. 2022 Dec 22; 25(12): 105642. Published online 2022 Nov 19. doi: 10.1016/j.isci.2022.105642
PMCID:
PMC9713377
AbstractArticlePDF–8.5M
5.
β1 Integrin Monoclonal Antibody Treatment Ameliorates Cerebral Cavernous Malformations
Sara McCurdy, Jenny Lin, Robert Shenkar, Thomas Moore, Rhonda Lightle, Eva Faurobert, Miguel-Alejandro Lopez-Ramirez, Issam Awad, Mark H. Ginsberg
FASEB J. Author manuscript; available in PMC 2023 Dec 1.
Published in final edited form as: FASEB J. 2022 Dec; 36(12): e22629. doi: 10.1096/fj.202200907RR
PMCID:
PMC9674378
AbstractArticlePDF–2.6M
6.
Heterozygous Loss of KRIT1 in Mice Affects Metabolic Functions of the Liver, Promoting Hepatic Oxidative and Glycative Stress
Raffaella Mastrocola, Eleonora Aimaretti, Gustavo Ferreira Alves, Alessia Sofia Cento, Claudia Fornelli, Federica Dal Bello, Chiara Ferraris, Luca Goitre, Andrea Perrelli, Saverio Francesco Retta
Int J Mol Sci. 2022 Oct; 23(19): 11151. Published online 2022 Sep 22. doi: 10.3390/ijms231911151
PMCID:
PMC9570113
AbstractArticlePDF–4.3M
7.
PIK3CA and CCM mutations fuel cavernomas through a cancer-like mechanism
Aileen A. Ren, Daniel A. Snellings, Sophie Y. Su, Courtney C. Hong, Marco Castro, Alan T. Tang, Matthew R. Detter, Nicholas Hobson, Romuald Girard, Sharbel Romanos, Rhonda Lightle, Thomas Moore, Robert Shenkar, Christian Benavides, M. Makenzie Beaman, Helge Mueller-Fielitz, Mei Chen, Patricia Mericko, Jisheng Yang, Derek C. Sung, Michael T. Lawton, Michael Ruppert, Markus Schwaninger, Jakob Körbelin, Michael Potente, Issam A. Awad, Douglas A. Marchuk, Mark L. Kahn
Nature. Author manuscript; available in PMC 2021 Nov 26.
Published in final edited form as: Nature. 2021 Jun; 594(7862): 271–276. Published online 2021 Apr 28. doi: 10.1038/s41586-021-03562-8
PMCID:
PMC8626098
AbstractArticlePDF–6.4M
8.
Pdcd10-Stk24/25 complex controls kidney water reabsorption by regulating Aqp2 membrane targeting
Rui Wang, Shi-Ting Wu, Xi Yang, Yude Qian, Jaesung P. Choi, Rui Gao, Siliang Song, Yixuan Wang, Tao Zhuang, Justin J.L. Wong, Yuzhen Zhang, Zhiming Han, Hua A. Lu, Stephen I. Alexander, Renjing Liu, Yin Xia, Xiangjian Zheng
JCI Insight. 2021 Jun 22; 6(12): e142838. Published online 2021 Jun 22. doi: 10.1172/jci.insight.142838
PMCID:
PMC8262504
AbstractArticlePDF–6.9M
9.
Cerebral cavernous malformations are driven by ADAMTS5 proteolysis of versican
Courtney C. Hong, Alan T. Tang, Matthew R. Detter, Jaesung P. Choi, Rui Wang, Xi Yang, Andrea A. Guerrero, Carl F. Wittig, Nicholas Hobson, Romuald Girard, Rhonda Lightle, Thomas Moore, Robert Shenkar, Sean P. Polster, Lauren M. Goddard, Aileen A. Ren, N. Adrian Leu, Stephanie Sterling, Jisheng Yang, Li Li, Mei Chen, Patricia Mericko-Ishizuka, Lukas E. Dow, Hideto Watanabe, Markus Schwaninger, Wang Min, Douglas A. Marchuk, Xiangjian Zheng, Issam A. Awad, Mark L. Kahn
J Exp Med. 2020 Oct 5; 217(10): e20200140. Published online 2020 Jul 10. doi: 10.1084/jem.20200140
PMCID:
PMC7537394
AbstractArticlePDF–7.2M
10.
Targeting miR-27a/VE-cadherin interactions rescues cerebral cavernous malformations in mice
Jia Li, Yang Zhao, Jaesung Choi, Ka Ka Ting, Paul Coleman, Jinbiao Chen, Victoria C. Cogger, Li Wan, Zhongsong Shi, Thorleif Moller, Xiangjian Zheng, Mathew A. Vadas, Jennifer R. Gamble
PLoS Biol. 2020 Jun; 18(6): e3000734. Published online 2020 Jun 5. doi: 10.1371/journal.pbio.3000734
PMCID:
PMC7299406
AbstractArticlePDF–3.1M
11.
Distinct cellular roles for PDCD10 define a gut-brain axis in cerebral cavernous malformation
Alan T. Tang, Katie R. Sullivan, Courtney C. Hong, Lauren M. Goddard, Aparna Mahadevan, Aileen Ren, Heidy Pardo, Amy Peiper, Erin Griffin, Ceylan Tanes, Lisa M. Mattei, Jisheng Yang, Li Li, Patricia Mericko-Ishizuka, Le Shen, Nicholas Hobson, Romuald Girard, Rhonda Lightle, Thomas Moore, Robert Shenkar, Sean P. Polster, Claudia J. Roedel, Ning Li, Qin Zhu, Kevin J. Whitehead, Xiangjian Zheng, Amy Akers, Leslie Morrison, Helen Kim, Kyle Bittinger, Christopher J. Lengner, Markus Schwaninger, Anna Velcich, Leonard Augenlicht, Salim Abdelilah-Seyfried, Wang Min, Douglas A. Marchuk, Issam A. Awad, Mark L. Kahn
Sci Transl Med. Author manuscript; available in PMC 2019 Dec 31.
Published in final edited form as: Sci Transl Med. 2019 Nov 27; 11(520): eaaw3521. doi: 10.1126/scitranslmed.aaw3521
PMCID:
PMC6937779
AbstractArticlePDF–3.6M
12.
VEGF signalling enhances lesion burden in KRIT1 deficient mice
Peter V. DiStefano, Angela J. Glading
J Cell Mol Med. 2020 Jan; 24(1): 632–639. Published online 2019 Nov 20. doi: 10.1111/jcmm.14773
PMCID:
PMC6933401
AbstractArticlePDF–902K
13.
KRIT1 Deficiency Promotes Aortic Endothelial Dysfunction
Francesco Vieceli Dalla Sega, Raffaella Mastrocola, Giorgio Aquila, Francesca Fortini, Claudia Fornelli, Alessia Zotta, Alessia S. Cento, Andrea Perrelli, Enrica Boda, Antonio Pannuti, Saverio Marchi, Paolo Pinton, Roberto Ferrari, Paola Rizzo, Saverio Francesco Retta
Int J Mol Sci. 2019 Oct; 20(19): 4930. Published online 2019 Oct 5. doi: 10.3390/ijms20194930
PMCID:
PMC6801783
AbstractArticlePDF–2.4M
14.
Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics
Joel D. Federspiel, Todd M. Greco, Krystal K. Lum, Ileana M. Cristea
Mol Cell Proteomics. 2019 Aug 9; 18(8 Suppl 1): S92–S113. Published online 2019 Apr 30. doi: 10.1074/mcp.RA118.001253
PMCID:
PMC6692770
AbstractArticlePDF–7.7M
15.
Comprehensive transcriptome analysis of cerebral cavernous malformation across multiple species and genotypes
Janne Koskimäki, Romuald Girard, Yan Li, Laleh Saadat, Hussein A. Zeineddine, Rhonda Lightle, Thomas Moore, Seán Lyne, Kenneth Avner, Robert Shenkar, Ying Cao, Changbin Shi, Sean P. Polster, Dongdong Zhang, Julián Carrión-Penagos, Sharbel Romanos, Gregory Fonseca, Miguel A. Lopez-Ramirez, Eric M. Chapman, Evelyn Popiel, Alan T. Tang, Amy Akers, Pieter Faber, Jorge Andrade, Mark Ginsberg, W. Brent Derry, Mark L. Kahn, Douglas A. Marchuk, Issam A. Awad
JCI Insight. 2019 Feb 7; 4(3): e126167. Published online 2019 Feb 7. doi: 10.1172/jci.insight.126167
PMCID:
PMC6413775
AbstractArticlePDF–4.6M
16.
Cerebral cavernous malformations form an anticoagulant vascular domain in humans and mice
Miguel Alejandro Lopez-Ramirez, Angela Pham, Romuald Girard, Tine Wyseure, Preston Hale, Atsuki Yamashita, Janne Koskimäki, Sean Polster, Laleh Saadat, Ignacio A. Romero, Charles T. Esmon, Frederic Lagarrigue, Issam A. Awad, Laurent O. Mosnier, Mark H. Ginsberg
Blood. 2019 Jan 17; 133(3): 193–204. Prepublished online 2018 Nov 15. doi: 10.1182/blood-2018-06-856062
PMCID:
PMC6337879
AbstractArticle
17.
KRIT1 loss-of-function induces a chronic Nrf2-mediated adaptive homeostasis that sensitizes cells to oxidative stress: Implication for Cerebral Cavernous Malformation disease
Cinzia Antognelli, Eliana Trapani, Simona Delle Monache, Andrea Perrelli, Martina Daga, Stefania Pizzimenti, Giuseppina Barrera, Paola Cassoni, Adriano Angelucci, Lorenza Trabalzini, Vincenzo Nicola Talesa, Luca Goitre, Saverio Francesco Retta
Free Radic Biol Med. 2018 Feb 1; 115: 202–218. doi: 10.1016/j.freeradbiomed.2017.11.014
PMCID:
PMC5806631
AbstractArticle
18.
Endothelial TLR4 and the microbiome drive cerebral cavernous malformations
Alan T. Tang, Jaesung P. Choi, Jonathan J. Kotzin, Yiqing Yang, Courtney C. Hong, Nicholas Hobson, Romuald Girard, Hussein A. Zeineddine, Rhonda Lightle, Thomas Moore, Ying Cao, Robert Shenkar, Mei Chen, Patricia Mericko, Jisheng Yang, Li Li, Ceylan Tanes, Dmytro Kobuley, Urmo Võsa, Kevin J. Whitehead, Dean Y. Li, Lude Franke, Blaine Hart, Markus Schwaninger, Jorge Henao-Mejia, Leslie Morrison, Helen Kim, Issam A. Awad, Xiangjian Zheng, Mark L. Kahn
Nature. Author manuscript; available in PMC 2018 Jan 8.
Published in final edited form as: Nature. 2017 May 18; 545(7654): 305–310. Published online 2017 May 10. doi: 10.1038/nature22075
PMCID:
PMC5757866
AbstractArticlePDF–5.1M
19.
Thrombospondin1 (TSP1) replacement prevents cerebral cavernous malformations
Miguel Alejandro Lopez-Ramirez, Gregory Fonseca, Hussein A. Zeineddine, Romuald Girard, Thomas Moore, Angela Pham, Ying Cao, Robert Shenkar, Bart-Jan de Kreuk, Frederic Lagarrigue, Jack Lawler, Christopher K. Glass, Issam A. Awad, Mark H. Ginsberg
J Exp Med. 2017 Nov 6; 214(11): 3331–3346. doi: 10.1084/jem.20171178
PMCID:
PMC5679163
AbstractArticlePDF–2.5M
20.
Up-regulation of NADPH oxidase-mediated redox signaling contributes to the loss of barrier function in KRIT1 deficient endothelium
Luca Goitre, Peter V. DiStefano, Andrea Moglia, Nicholas Nobiletti, Eva Baldini, Lorenza Trabalzini, Julie Keubel, Eliana Trapani, Vladimir V. Shuvaev, Vladimir R. Muzykantov, Ingrid H. Sarelius, Saverio Francesco Retta, Angela J. Glading
Sci Rep. 2017; 7: 8296. Published online 2017 Aug 15. doi: 10.1038/s41598-017-08373-4
PMCID:
PMC5558000
AbstractArticlePDF–2.8M

Display Settings:

Format
Items per page
Sort by

Send to:

Choose Destination

Supplemental Content

Filter your results:

Find related data

Recent activity

You are here: NCBI > Literature > PubMed Central (PMC)
Support Center