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Select item 109176601.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 107016172.

Allelic effects on uromodulin aggregates drive autosomal dominant tubulointerstitial kidney disease

Guglielmo Schiano, Jennifer Lake, Marta Mariniello, Céline Schaeffer, Marianne Harvent, Luca Rampoldi, Eric Olinger, Olivier Devuyst

EMBO Mol Med. 2023 Dec; 15(12): e18242. Published online 2023 Oct 26. doi: 10.15252/emmm.202318242

PMCID:: PMC10701617

Abstract Article PDF–5.8M

Select item 105768023.

MANF stimulates autophagy and restores mitochondrial homeostasis to treat autosomal dominant tubulointerstitial kidney disease in mice

Yeawon Kim, Chuang Li, Chenjian Gu, Yili Fang, Eric Tycksen, Anuradhika Puri, Terri A. Pietka, Jothilingam Sivapackiam, Kendrah Kidd, Sun-Ji Park, Bryce G. Johnson, Stanislav Kmoch, Jeremy S. Duffield, Anthony J. Bleyer, Meredith E. Jackrel, Fumihiko Urano, Vijay Sharma, Maria Lindahl, Ying Maggie Chen

Nat Commun. 2023; 14: 6493. Published online 2023 Oct 14. doi: 10.1038/s41467-023-42154-0

PMCID:: PMC10576802

Abstract Article PDF–6.7M

Select item 105064134.

Smarca4 deficiency induces Pttg1 oncogene upregulation and hyperproliferation of tubular and interstitial cells during kidney development

Jinshu Xu, Xianxiao Zhou, Ting Zhang, Bin Zhang, Pin-Xian Xu

Front Cell Dev Biol. 2023; 11: 1233317. Published online 2023 Sep 4. doi: 10.3389/fcell.2023.1233317

PMCID:: PMC10506413

Abstract Article PDF–7.2M

Select item 101032625.

Tet2- and Tet3-Mediated Cytosine Hydroxymethylation in Six2 Progenitor Cells in Mice Is Critical for Nephron Progenitor Differentiation and Nephron Endowment

Xiujie Liang, Tamas Aranyi, Jianfu Zhou, Yuting Guan, Hailong Hu, Hongbo Liu, Katalin Susztak

J Am Soc Nephrol. 2023 Apr; 34(4): 572–589. Published online 2022 Dec 15. doi: 10.1681/ASN.2022040460

PMCID:: PMC10103262

Abstract Article

Select item 98700896.

ZEB2 controls kidney stromal progenitor differentiation and inhibits abnormal myofibroblast expansion and kidney fibrosis

Sudhir Kumar, Xueping Fan, Hila Milo Rasouly, Richa Sharma, David J. Salant, Weining Lu

JCI Insight. 2023 Jan 10; 8(1): e158418. Published online 2023 Jan 10. doi: 10.1172/jci.insight.158418

PMCID:: PMC9870089

Abstract Article PDF–8.1M

Select item 94088837.

Uromodulin Regulates Murine Aquaporin−2 Activity via Thick Ascending Limb–Collecting Duct Cross−Talk during Water Deprivation

Tomoaki Takata, Shintaro Hamada, Yukari Mae, Takuji Iyama, Ryohei Ogihara, Misako Seno, Kazuomi Nakamura, Miki Takata, Takaaki Sugihara, Hajime Isomoto

Int J Mol Sci. 2022 Aug; 23(16): 9410. Published online 2022 Aug 20. doi: 10.3390/ijms23169410

PMCID:: PMC9408883

Abstract Article PDF–3.1M

Select item 93067928.

NHE3 in the thick ascending limb is required for sustained but not acute furosemide-induced urinary acidification

Jianxiang Xue, Linto Thomas, Jessica A. Dominguez Rieg, Robert A. Fenton, Timo Rieg

Am J Physiol Renal Physiol. 2022 Aug 1; 323(2): F141–F155. Published online 2022 May 30. doi: 10.1152/ajprenal.00013.2022

PMCID:: PMC9306792

Abstract Article

Select item 92329759.

Disruption of mitochondrial complex III in cap mesenchyme but not in ureteric progenitors results in defective nephrogenesis associated with amino acid deficiency

Nan Guan, Hanako Kobayashi, Ken Ishii, Olena Davidoff, Feng Sha, Talat A. Ikizler, Chuan-Ming Hao, Navdeep S. Chandel, Volker H. Haase

Kidney Int. Author manuscript; available in PMC 2022 Jul 1.

Published in final edited form as: Kidney Int. 2022 Jul; 102(1): 108–120. Published online 2022 Mar 24. doi: 10.1016/j.kint.2022.02.030

PMCID:: PMC9232975

Abstract Article PDF–1.7M

Select item 897193910.

High-resolution Slide-seqV2 spatial transcriptomics enables discovery of disease-specific cell neighborhoods and pathways

Jamie L. Marshall, Teia Noel, Qingbo S. Wang, Haiqi Chen, Evan Murray, Ayshwarya Subramanian, Katherine A. Vernon, Silvana Bazua-Valenti, Katie Liguori, Keith Keller, Robert R. Stickels, Breanna McBean, Rowan M. Heneghan, Astrid Weins, Evan Z. Macosko, Fei Chen, Anna Greka

iScience. 2022 Apr 15; 25(4): 104097. Published online 2022 Mar 16. doi: 10.1016/j.isci.2022.104097

PMCID:: PMC8971939

Abstract Article PDF–7.1M

Select item 876504011.

Cell stress response impairs de novo NAD⁺ biosynthesis in the kidney

Yohan Bignon, Anna Rinaldi, Zahia Nadour, Virginie Poindessous, Ivan Nemazanyy, Olivia Lenoir, Baptiste Fohlen, Pierre Weill-Raynal, Alexandre Hertig, Alexandre Karras, Pierre Galichon, Maarten Naesens, Dany Anglicheau, Pietro E. Cippà, Nicolas Pallet

JCI Insight. 2022 Jan 11; 7(1): e153019. Published online 2022 Jan 11. doi: 10.1172/jci.insight.153019

PMCID:: PMC8765040

Abstract Article PDF–4.8M

Select item 863839012.

Generation of Distal Renal Segments Involves a Unique Population of Aqp2⁺ Progenitor Cells

Chao Gao, Lihe Chen, Enuo Chen, Akaki Tsilosani, Yang Xia, Wenzheng Zhang

J Am Soc Nephrol. 2021 Dec; 32(12): 3035–3049. Published online 2021 Dec. doi: 10.1681/ASN.2021030399

PMCID:: PMC8638390

Abstract Article

Select item 812647913.

Hnf1b haploinsufficiency differentially affects developmental target genes in a new renal cysts and diabetes mouse model

Leticia L. Niborski, Mélanie Paces-Fessy, Pierbruno Ricci, Adeline Bourgeois, Pedro Magalhães, Maria Kuzma-Kuzniarska, Celine Lesaulnier, Martin Reczko, Edwige Declercq, Petra Zürbig, Alain Doucet, Muriel Umbhauer, Silvia Cereghini

Dis Model Mech. 2021 May 1; 14(5): dmm047498. Published online 2021 May 4. doi: 10.1242/dmm.047498

PMCID:: PMC8126479

Abstract Article

Select item 754025014.

A mutation affecting laminin alpha 5 polymerisation gives rise to a syndromic developmental disorder

Lynelle K. Jones, Rachel Lam, Karen K. McKee, Maya Aleksandrova, John Dowling, Stephen I. Alexander, Amali Mallawaarachchi, Denny L. Cottle, Kieran M. Short, Lynn Pais, Jeffery H. Miner, Andrew J. Mallett, Cas Simons, Hugh McCarthy, Peter D. Yurchenco, Ian M. Smyth

Development. 2020 Nov 1; 147(21): dev189183. Published online 2020 Jun 22. doi: 10.1242/dev.189183

PMCID:: PMC7540250

Abstract Article

Select item 743801115.

Identification and characterization of cellular heterogeneity within the developing renal interstitium

Alicia R. England, Christopher P. Chaney, Amrita Das, Mohita Patel, Alicia Malewska, Daniel Armendariz, Gary C. Hon, Douglas W. Strand, Keri A. Drake, Thomas J. Carroll

Development. 2020 Aug 1; 147(15): dev190108. Published online 2020 Aug 14. doi: 10.1242/dev.190108

PMCID:: PMC7438011

Abstract Article

Select item 670730516.

Hepsin-mediated Processing of Uromodulin is Crucial for Salt-sensitivity and Thick Ascending Limb Homeostasis

Eric Olinger, Jennifer Lake, Susan Sheehan, Guglielmo Schiano, Tomoaki Takata, Natsuko Tokonami, Huguette Debaix, Francesco Consolato, Luca Rampoldi, Ron Korstanje, Olivier Devuyst

Sci Rep. 2019; 9: 12287. Published online 2019 Aug 23. doi: 10.1038/s41598-019-48300-3

PMCID:: PMC6707305

Abstract Article PDF–5.8M

Select item 629311317.

Salt stress in the renal tubules is linked to TAL-specific expression of uromodulin and an upregulation of heat shock genes

Lesley A. Graham, Alisha Aman, Desmond D. Campbell, Julian Augley, Delyth Graham, Martin W. McBride, Niall J. Fraser, Nicholas R. Ferreri, Anna F. Dominiczak, Sandosh Padmanabhan

Physiol Genomics. 2018 Nov 1; 50(11): 964–972. Published online 2018 Sep 14. doi: 10.1152/physiolgenomics.00057.2018

PMCID:: PMC6293113

Abstract Article

Select item 628786618.

Transcription Factor 21 Is Required for Branching Morphogenesis and Regulates the Gdnf-Axis in Kidney Development

Shintaro Ide, Gal Finer, Yoshiro Maezawa, Tuncer Onay, Tomokazu Souma, Rizaldy Scott, Kana Ide, Yoshihiro Akimoto, Chengjin Li, Minghao Ye, Xiangmin Zhao, Yusuke Baba, Takuya Minamizuka, Jing Jin, Minoru Takemoto, Koutaro Yokote, Susan E. Quaggin

J Am Soc Nephrol. 2018 Dec; 29(12): 2795–2808. Published online 2018 Oct 30. doi: 10.1681/ASN.2017121278

PMCID:: PMC6287866

Abstract Article

Select item 624691319.

Tamm-Horsfall Protein Protects the Urinary Tract against Candida albicans

Alison Coady, Anissa R. Ramos, Joshua Olson, Victor Nizet, Kathryn A. Patras

Infect Immun. 2018 Dec; 86(12): e00451-18. Prepublished online 2018 Oct 8. Published online 2018 Nov 20. doi: 10.1128/IAI.00451-18

PMCID:: PMC6246913

Abstract Article PDF–814K

Select item 620095320.

Uromodulin regulates renal magnesium homeostasis through the ion channel transient receptor potential melastatin 6 (TRPM6)

Mingzhu Nie, Manjot S. Bal, Jie Liu, Zhufeng Yang, Carolina Rivera, Xue-Ru Wu, Joost G. J. Hoenderop, René J. M. Bindels, Denise K. Marciano, Matthias T. F. Wolf

J Biol Chem. 2018 Oct 19; 293(42): 16488–16502. Published online 2018 Aug 23. doi: 10.1074/jbc.RA118.003950

PMCID:: PMC6200953

Abstract Article PDF–2.2M

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