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Select item 109176601.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 105893352.

Sympathetic activity regulates epithelial proliferation and wound healing via adrenergic receptor α_2A

Anne S. ten Hove, Shilpashree Mallesh, Konstantina Zafeiropoulou, Janna W. M. de Kleer, Patricia H. P. van Hamersveld, Olaf Welting, Theodorus B. M. Hakvoort, Sven Wehner, Jurgen Seppen, Wouter J. de Jonge

Sci Rep. 2023; 13: 17990. Published online 2023 Oct 20. doi: 10.1038/s41598-023-45160-w

PMCID:: PMC10589335

Abstract Article PDF–3.0M

Select item 105684353.

Targeting adrenergic receptors to mitigate invariant natural killer T cells-induced acute liver injury

Michelangelo Bauwelz Gonzatti, Beatriz Marton Freire, Maísa Mota Antunes, Gustavo Batista de Menezes, Jhimmy Talbot, Jean Pierre Schatzmann Peron, Alexandre Salgado Basso, Alexandre Castro Keller

iScience. 2023 Oct 20; 26(10): 107947. Published online 2023 Sep 16. doi: 10.1016/j.isci.2023.107947

PMCID:: PMC10568435

Abstract Article PDF–5.4M

Select item 105338654.

Celf4 controls mRNA translation underlying synaptic development in the prenatal mammalian neocortex

Iva Salamon, Yongkyu Park, Terezija Miškić, Janja Kopić, Paul Matteson, Nicholas F. Page, Alfonso Roque, Geoffrey W. McAuliffe, John Favate, Marta Garcia-Forn, Premal Shah, Miloš Judaš, James H. Millonig, Ivica Kostović, Silvia De Rubeis, Ronald P. Hart, Željka Krsnik, Mladen-Roko Rasin

Nat Commun. 2023; 14: 6025. Published online 2023 Sep 27. doi: 10.1038/s41467-023-41730-8

PMCID:: PMC10533865

Abstract Article PDF–4.9M

Select item 104407265.

DRG afferents that mediate physiologic and pathologic mechanosensation from the distal colon

Rachel L. Wolfson, Amira Abdelaziz, Genelle Rankin, Sarah Kushner, Lijun Qi, Ofer Mazor, Seungwon Choi, Nikhil Sharma, David D. Ginty

Cell. Author manuscript; available in PMC 2024 Aug 3.

Published in final edited form as: Cell. 2023 Aug 3; 186(16): 3368–3385.e18. doi: 10.1016/j.cell.2023.07.007

PMCID:: PMC10440726

Abstract Article PDF–4.0M

Select item 104054316.

FOXO1 orchestrates the intestinal homeostasis via neuronal signaling in group 3 innate lymphoid cells

Fei Shao, Zhen Liu, Qinglin Wei, Dou Yu, Min Zhao, Xusheng Zhang, Xintong Gao, Zusen Fan, Shuo Wang

J Exp Med. 2023 Oct 2; 220(10): e20230133. Published online 2023 Aug 7. doi: 10.1084/jem.20230133

PMCID:: PMC10405431

Abstract Article PDF–6.3M

Select item 101129317.

MafB-dependent neurotransmitter signaling promotes β cell migration in the developing pancreas

Sara Bsharat, Emanuela Monni, Tania Singh, Jenny K. Johansson, Kavya Achanta, Ludivine Bertonnier-Brouty, Anja Schmidt-Christensen, Dan Holmberg, Zaal Kokaia, Rashmi B. Prasad, Isabella Artner

Development. 2023 Mar 15; 150(6): dev201009. Published online 2023 Mar 27. doi: 10.1242/dev.201009

PMCID:: PMC10112931

Abstract Article

Select item 98858608.

Heteromerization between α_2A adrenoceptors and different polymorphic variants of the dopamine D₄ receptor determines pharmacological and functional differences. Implications for impulsive-control disorders

Verònica Casadó-Anguera, Estefanía Moreno, Marta Sánchez-Soto, Ning Sheng Cai, Jordi Bonaventura, Patricia Homar-Ruano, Marcelo Rubinstein, Antoni Cortés, Enric I. Canela, Sergi Ferré, Vicent Casadó

Pharmacol Res. Author manuscript; available in PMC 2023 Jan 30.

Published in final edited form as: Pharmacol Res. 2021 Aug; 170: 105745. Published online 2021 Jun 26. doi: 10.1016/j.phrs.2021.105745

PMCID:: PMC9885860

Abstract Article PDF–1.2M

Select item 86575019.

Dexmedetomidine Promotes Lipopolysaccharide-Induced Differentiation of Cardiac Fibroblasts and Collagen I/III Synthesis through α_2A Adrenoreceptor-Mediated Activation of the PKC-p38-Smad2/3 Signaling Pathway in Mice

Jia Liao, Kaiying Li, Xingyu Su, Yihua Chen, Yingwei Wang, Xiangxu Tang, Yun Xing, Yaqian Xu, Xiaomeng Dai, Jiashuo Teng, Hongmei Li, Huadong Wang, Xiuxiu Lv, Yiyang Wang

Int J Mol Sci. 2021 Dec; 22(23): 12749. Published online 2021 Nov 25. doi: 10.3390/ijms222312749

PMCID:: PMC8657501

Abstract Article PDF–3.6M

Select item 807275110.

Role of α2-Adrenoceptor Subtypes in Suppression of L-Type Ca²⁺ Current in Mouse Cardiac Myocytes

Edward V. Evdokimovskii, Ryounghoon Jeon, Sungjo Park, Oleg Y. Pimenov, Alexey E. Alekseev

Int J Mol Sci. 2021 Apr; 22(8): 4135. Published online 2021 Apr 16. doi: 10.3390/ijms22084135

PMCID:: PMC8072751

Abstract Article PDF–2.0M

Select item 722429311.

Chronic Sympathetic Hyperactivity Triggers Electrophysiological Remodeling and Disrupts Excitation-Contraction Coupling in Heart

Humberto C. Joca, Artur Santos‐Miranda, Julliane V. Joviano-Santos, Rebeca P. M. Maia-Joca, Patricia C. Brum, George S. B. Williams, Jader S. Cruz

Sci Rep. 2020; 10: 8001. Published online 2020 May 14. doi: 10.1038/s41598-020-64949-7

PMCID:: PMC7224293

Abstract Article PDF–4.2M

Select item 684242712.

Molecular patterning of the embryonic cranial mesenchyme revealed by genome-wide transcriptional profiling

Krishnakali Dasgupta, Jong Uk Chung, Kesava Asam, Juhee Jeong

Dev Biol. Author manuscript; available in PMC 2020 Nov 15.

Published in final edited form as: Dev Biol. 2019 Nov 15; 455(2): 434–448. Published online 2019 Jul 24. doi: 10.1016/j.ydbio.2019.07.015

PMCID:: PMC6842427

Abstract Article PDF–6.1M

Select item 679293213.

A Point Mutation (D79N) of the α2A Adrenergic Receptor Abolishes the Antiepileptogenic Action of Endogenous Norepinephrine

Sridevi Janumpalli, Linda S. Butler, Leigh B. MacMillan, Lee E. Limbird, James O. McNamara

J Neurosci. 1998 Mar 15; 18(6): 2004–2008. doi: 10.1523/JNEUROSCI.18-06-02004.1998

PMCID:: PMC6792932

Abstract Article PDF–107K

Select item 677300614.

Antinociceptive Action of Nitrous Oxide Is Mediated by Stimulation of Noradrenergic Neurons in the Brainstem and Activation of α_2B Adrenoceptors

Shigehito Sawamura, Wade S. Kingery, M. Frances Davies, Geeta S. Agashe, J. David Clark, Brian K. Kobilka, Toshizaku Hashimoto, Mervyn Maze

J Neurosci. 2000 Dec 15; 20(24): 9242–9251. doi: 10.1523/JNEUROSCI.20-24-09242.2000

PMCID:: PMC6773006

Abstract Article PDF–1.3M

Select item 676234915.

The α_2A-Adrenergic Receptor Plays a Protective Role in Mouse Behavioral Models of Depression and Anxiety

Nicole L. Schramm, Michael P. McDonald, Lee E. Limbird

J Neurosci. 2001 Jul 1; 21(13): 4875–4882. doi: 10.1523/JNEUROSCI.21-13-04875.2001

PMCID:: PMC6762349

Abstract Article PDF–142K

Select item 675778116.

Mutation of the α_2A-Adrenoceptor Impairs Working Memory Performance and Annuls Cognitive Enhancement by Guanfacine

Jenna S. Franowicz, Lynn E. Kessler, Catherine M. Dailey Borja, Brian K. Kobilka, Lee E. Limbird, Amy F. T. Arnsten

J Neurosci. 2002 Oct 1; 22(19): 8771–8777. doi: 10.1523/JNEUROSCI.22-19-08771.2002

PMCID:: PMC6757781

Abstract Article PDF–132K

Select item 670838417.

Molecular codes and in vitro generation of hypocretin and melanin concentrating hormone neurons

Ali Seifinejad, Sha Li, Cyril Mikhail, Anne Vassalli, Sylvain Pradervand, Yoan Arribat, Hassan Pezeshgi Modarres, Bridget Allen, Rosalind M. John, Francesca Amati, Mehdi Tafti

Proc Natl Acad Sci U S A. 2019 Aug 20; 116(34): 17061–17070. Published online 2019 Aug 2. doi: 10.1073/pnas.1902148116

PMCID:: PMC6708384

Abstract Article PDF–2.4M

Select item 636862718.

The in vivo specificity of synaptic Gβ and Gγ subunits to the α_2a adrenergic receptor at CNS synapses

Yun Young Yim, Katherine M. Betke, W. Hayes McDonald, Ralf Gilsbach, Yunjia Chen, Karren Hyde, Qin Wang, Lutz Hein, Heidi Hamm

Sci Rep. 2019; 9: 1718. Published online 2019 Feb 8. doi: 10.1038/s41598-018-37222-1

Correction in:: Sci Rep. 2020; 10: 2966.

PMCID:: PMC6368627

Abstract Article PDF–2.4M

Select item 619152419.

Dorsal BNST α_2A-Adrenergic Receptors Produce HCN-Dependent Excitatory Actions That Initiate Anxiogenic Behaviors

Nicholas A. Harris, Austin T. Isaac, Anne Günther, Kevin Merkel, James Melchior, Michelle Xu, Eghosa Eguakun, Rafael Perez, Brett P. Nabit, Stephanie Flavin, Ralf Gilsbach, Brian Shonesy, Lutz Hein, Ted Abel, Arnd Baumann, Robert Matthews, Samuel W. Centanni, Danny G. Winder

J Neurosci. 2018 Oct 17; 38(42): 8922–8942. doi: 10.1523/JNEUROSCI.0963-18.2018

PMCID:: PMC6191524

Abstract Article PDF–7.0M

Select item 612761620.

Global Disruption of α2A Adrenoceptor Barely Affects Bone Tissue but Minimizes the Detrimental Effects of Thyrotoxicosis on Cortical Bone

Gisele M. Martins, Marília B. C. G. Teixeira, Marcos V. Silva, Bianca Neofiti-Papi, Manuela Miranda-Rodrigues, Patricia C. Brum, Cecilia H. A. Gouveia

Front Endocrinol (Lausanne) 2018; 9: 486. Published online 2018 Aug 28. doi: 10.3389/fendo.2018.00486

PMCID:: PMC6127616

Abstract Article PDF–6.6M

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