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Select item 116126431.

miR-373-3p promotes aerobic glycolysis in colon cancer cells by targeting MFN2: MiR-373-3p promotes glycolysis through MFN2

Yu Wang, Jie Lun, Yuying Zhang, Mengchao Yu, Xingqian Liu, Jing Guo, Hongwei Zhang, Wensheng Qiu, Jing Fang

Acta Biochim Biophys Sin (Shanghai) 2024 Oct 25; 56(10): 1498–1508. Published online 2024 Jun 27. doi: 10.3724/abbs.2024090

PMCID:: PMC11612643

Abstract Article PDF–2.5M

Select item 112625842.

Homozygous Mutations in GDAP1 and MFN2 Genes Resulted in Autosomal Recessive Forms of Charcot–Marie–Tooth Disease in Consanguineous Pakistani Families

Muhammad Asif, Chien-Chun Chiou, Malik Fiaz Hussain, Manzoor Hussain, Zureesha Sajid, Muhammad Gulsher, Afifa Raheem, Adil Khan, Nasreen Nasreen, Andrzej Kloczkowski, Mubashir Hassan, Furhan Iqbal, Chien-Chin Chen

DNA Cell Biol. 2023 Nov; 42(11): 697–708. Published online 2023 Nov 10. doi: 10.1089/dna.2023.0169

PMCID:: PMC11262584

Abstract Article PDF–598K

Select item 112099353.

Antagonistic roles of canonical and alternative-RPA in disease-associated tandem CAG repeat instability

Terence Gall-Duncan, Jennifer Luo, Carla-Marie Jurkovic, Laura A. Fischer, Kyota Fujita, Amit L. Deshmukh, Rachel J. Harding, Stephanie Tran, Mustafa Mehkary, Vanessa Li, David E. Leib, Ran Chen, Hikari Tanaka, Amanda G. Mason, Dominique Lévesque, Mahreen Khan, Mortezaali Razzaghi, Tanya Prasolava, Stella Lanni, Nozomu Sato, Marie-Christine Caron, Gagan B. Panigrahi, Peixiang Wang, Rachel Lau, Arturo López Castel, Jean-Yves Masson, Lynette Tippett, Clinton Turner, Maria Spies, Albert R. La Spada, Eric I. Campos, Maurice A. Curtis, François-Michel Boisvert, Richard L.M. Faull, Beverly L. Davidson, Masayuki Nakamori, Hitoshi Okazawa, Marc S. Wold, Christopher E. Pearson

Cell. Author manuscript; available in PMC 2024 Oct 26.

Published in final edited form as: Cell. 2023 Oct 26; 186(22): 4898–4919.e25. Published online 2023 Oct 11. doi: 10.1016/j.cell.2023.09.008

PMCID:: PMC11209935

Abstract Article PDF–3.0M

Select item 111451414.

MFN2 suppresses the accumulation of lipid droplets and the progression of clear cell renal cell carcinoma

Zhiduan Cai, Wenjun Luo, Haoran Wang, Rui Zhu, Yaoji Yuan, Xiangyu Zhan, Mengyuan Xie, Haoquan Zhuang, Haoyu Chen, Yuyu Xu, Xiezhao Li, Leyuan Liu, Guibin Xu

Cancer Sci. 2024 Jun; 115(6): 1791–1807. Published online 2024 Mar 13. doi: 10.1111/cas.16151

PMCID:: PMC11145141

Abstract Article PDF–36M

Select item 110583605.

Mitofusin-2 enhances cervical cancer progression through Wnt/β-catenin signaling

Sung Yong Ahn

BMB Rep. 2024 Apr 30; 57(4): 194–199. Published online 2024 Mar 21. doi: 10.5483/BMBRep.2023-0205

PMCID:: PMC11058360

Abstract Article PDF–4.5M

Select item 108974906.

MTCH2 cooperates with MFN2 and lysophosphatidic acid synthesis to sustain mitochondrial fusion

Andres Goldman, Michael Mullokandov, Yehudit Zaltsman, Limor Regev, Smadar Levin-Zaidman, Atan Gross

EMBO Rep. 2024 Jan; 25(1): 45–67. Published online 2023 Dec 14. doi: 10.1038/s44319-023-00009-1

PMCID:: PMC10897490

Abstract Article PDF–9.2M

Select item 107341947.

Clinicopathologic features of two unrelated autopsied patients with Charcot-Marie-Tooth disease carrying MFN2 gene mutation

Hideki Hayashi, Rie Saito, Hidetomo Tanaka, Norikazu Hara, Shin Koide, Yosuke Yonemochi, Tetsuo Ozawa, Mariko Hokari, Yasuko Toyoshima, Akinori Miyashita, Osamu Onodera, Kouichirou Okamoto, Takeshi Ikeuchi, Takashi Nakajima, Akiyoshi Kakita

Acta Neuropathol Commun. 2023; 11: 207. Published online 2023 Dec 20. doi: 10.1186/s40478-023-01692-w

PMCID:: PMC10734194

Article PDF–1.6M

Select item 107265948.

Role of mitochondrial fusion proteins MFN2 and OPA1 on lung cellular senescence in chronic obstructive pulmonary disease

Chenfei Li, Qi Liu, Qing Chang, Meiqin Xie, Jiali Weng, Xiaohui Wang, Mengnan Li, Jiani Chen, Yan Huang, Xiaohua Yang, Kai Wang, Na Zhang, Kian Fan Chung, Ian M. Adcock, Hai Zhang, Feng Li

Respir Res. 2023; 24: 319. Published online 2023 Dec 18. doi: 10.1186/s12931-023-02634-9

PMCID:: PMC10726594

Abstract Article PDF–9.6M

Select item 106199789.

A human mitofusin 2 mutation can cause mitophagic cardiomyopathy

Antonietta Franco, Jiajia Li, Daniel P Kelly, Ray E Hershberger, Ali J Marian, Renate M Lewis, Moshi Song, Xiawei Dang, Alina D Schmidt, Mary E Mathyer, John R Edwards, Cristina de Guzman Strong, Gerald W Dorn

eLife. 2023; 12: e84235. Published online 2023 Nov 1. doi: 10.7554/eLife.84235

PMCID:: PMC10619978

Abstract Article PDF–15M

Select item 1061621110.

DIAPH1-MFN2 interaction regulates mitochondria-SR/ER contact and modulates ischemic/hypoxic stress

Gautham Yepuri, Lisa M. Ramirez, Gregory G. Theophall, Sergei V. Reverdatto, Nosirudeen Quadri, Syed Nurul Hasan, Lei Bu, Devi Thiagarajan, Robin Wilson, Raquel López Díez, Paul F. Gugger, Kaamashri Mangar, Navneet Narula, Stuart D. Katz, Boyan Zhou, Huilin Li, Aleksandr B. Stotland, Roberta A. Gottlieb, Ann Marie Schmidt, Alexander Shekhtman, Ravichandran Ramasamy

Nat Commun. 2023; 14: 6900. Published online 2023 Oct 30. doi: 10.1038/s41467-023-42521-x

PMCID:: PMC10616211

Abstract Article PDF–12M

Select item 1047042011.

LRRK2 aggravates kidney injury through promoting MFN2 degradation and abnormal mitochondrial integrity

Shun Zhang, Subo Qian, Hailong Liu, Ding Xu, Weimin Xia, Huangqi Duan, Chen Wang, Shenggen Yu, Yingying Chen, Ping Ji, Shujun Wang, Xingang Cui, Ying Wang, Haibo Shen

Redox Biol. 2023 Oct; 66: 102860. Published online 2023 Aug 22. doi: 10.1016/j.redox.2023.102860

PMCID:: PMC10470420

Abstract Article PDF–24M

Select item 1039866012.

C9orf72 protein quality control by UBR5‐mediated heterotypic ubiquitin chains

Julia Jülg, Dieter Edbauer, Christian Behrends

EMBO Rep. 2023 Aug; 24(8): e55895. Published online 2023 Jun 15. doi: 10.15252/embr.202255895

PMCID:: PMC10398660

Abstract Article PDF–2.4M

Select item 1037865613.

The Role of Mitochondrial Dynamics and Mitotic Fission in Regulating the Cell Cycle in Cancer and Pulmonary Arterial Hypertension: Implications for Dynamin-Related Protein 1 and Mitofusin2 in Hyperproliferative Diseases

Pierce Colpman, Asish Dasgupta, Stephen L. Archer

Cells. 2023 Jul; 12(14): 1897. Published online 2023 Jul 20. doi: 10.3390/cells12141897

PMCID:: PMC10378656

Abstract Article PDF–4.9M

Select item 1024034814.

MFN2 deficiency affects calcium homeostasis in lung adenocarcinoma cells via downregulation of UCP4

Jingjing Zhang, Lifang Pan, Qiang Zhang, Yanyan Zhao, Wenwen Wang, Nengming Lin, Shirong Zhang, Qiong Wu

FEBS Open Bio. 2023 Jun; 13(6): 1107–1124. Published online 2023 Mar 14. doi: 10.1002/2211-5463.13591

PMCID:: PMC10240348

Abstract Article PDF–4.8M

Select item 1023742215.

TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing

Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan

Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233

PMCID:: PMC10237422

Abstract Article PDF–23M

Select item 971188316.

A mitofusin 2/HIF1α axis sets a maturation checkpoint in regenerating skeletal muscle

Xun Wang, Yuemeng Jia, Jiawei Zhao, Nicholas P. Lesner, Cameron J. Menezes, Spencer D. Shelton, Siva Sai Krishna Venigalla, Jian Xu, Chunyu Cai, Prashant Mishra

J Clin Invest. 2022 Dec 1; 132(23): e161638. Published online 2022 Dec 1. doi: 10.1172/JCI161638

PMCID:: PMC9711883

Abstract Article PDF–56M

Select item 967372117.

Disruption of Sarcoplasmic Reticulum‐Mitochondrial Contacts Underlies Contractile Dysfunction in Experimental and Human Atrial Fibrillation: A Key Role of Mitofusin 2

Jin Li, Xi Qi, Kennedy S. Ramos, Eva Lanters, Jaap Keijer, Natasja de Groot, Bianca Brundel, Deli Zhang

J Am Heart Assoc. 2022 Oct 4; 11(19): e024478. Published online 2022 Sep 29. doi: 10.1161/JAHA.121.024478

PMCID:: PMC9673721

Abstract Article PDF–4.1M

Select item 926261418.

A dual-activity topoisomerase complex regulates mRNA translation and turnover

Shuaikun Su, Yutong Xue, Alexei Sharov, Yongqing Zhang, Seung Kyu Lee, Jennifer L Martindale, Wen Li, Wai Lim Ku, Keji Zhao, Supriyo De, Weiping Shen, Payel Sen, Myriam Gorospe, Dongyi Xu, Weidong Wang

Nucleic Acids Res. 2022 Jul 8; 50(12): 7013–7033. Published online 2022 Jun 24. doi: 10.1093/nar/gkac538

PMCID:: PMC9262614

Abstract Article PDF–3.6M

Select item 911973619.

OpenCell: proteome-scale endogenous tagging enables the cartography of human cellular organization

Nathan H. Cho, Keith C. Cheveralls, Andreas-David Brunner, Kibeom Kim, André C. Michaelis, Preethi Raghavan, Hirofumi Kobayashi, Laura Savy, Jason Y. Li, Hera Canaj, James Y.S. Kim, Edna M. Stewart, Christian Gnann, Frank McCarthy, Joana P. Cabrera, Rachel M. Brunetti, Bryant B. Chhun, Greg Dingle, Marco Y. Hein, Bo Huang, Shalin B. Mehta, Jonathan S. Weissman, Rafael Gómez-Sjöberg, Daniel N. Itzhak, Loic A. Royer, Matthias Mann, Manuel D. Leonetti

Science. Author manuscript; available in PMC 2022 Sep 11.

Published in final edited form as: Science. 2022 Mar 11; 375(6585): eabi6983. Published online 2022 Mar 11. doi: 10.1126/science.abi6983

PMCID:: PMC9119736

Abstract Article PDF–3.3M

Select item 905883620.

The involvement of Parkin-dependent mitophagy in the anti-cancer activity of Ginsenoside

Xin Sun, Yeting Hong, Yuhan Shu, Caixia Wu, Guiqin Ye, Hanxiao Chen, Hongying Zhou, Ruilan Gao, Jianbin Zhang

J Ginseng Res. 2022 Mar; 46(2): 266–274. Published online 2021 Jul 8. doi: 10.1016/j.jgr.2021.06.009

PMCID:: PMC9058836

Abstract Article PDF–2.9M

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