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Select item 111313171.

Ferredoxin 1: a gatekeeper in halting lung adenocarcinoma progression through activation of the GPRIN2 signaling pathway

Ming Liu, Shaoxian Wu, Haoyu Wu, You Zhou, Xinyu Zhang, Dawei Zhu, Jingting Jiang

J Transl Med. 2024; 22: 510. Published online 2024 May 27. doi: 10.1186/s12967-024-05277-6

PMCID:: PMC11131317

Abstract Article PDF–8.7M

Select item 108738092.

Functional spectrum and structural specificity of mitochondrial ferredoxins FDX1 and FDX2

Vinzent Schulz, Somsuvro Basu, Sven-A. Freibert, Holger Webert, Linda Boß, Ulrich Mühlenhoff, Fabien Pierrel, Lars-O. Essen, Douglas M. Warui, Squire Booker, Oliver Stehling, Roland Lill

Nat Chem Biol. Author manuscript; available in PMC 2024 Feb 17.

Published in final edited form as: Nat Chem Biol. 2023 Feb; 19(2): 206–217. Published online 2022 Oct 24. doi: 10.1038/s41589-022-01159-4

PMCID:: PMC10873809

Abstract Article PDF–6.3M

Select item 107981383.

Interactions of human mitochondrial Ferredoxin 1 (Adrenodoxin) by NMR; modulation by Cytochrome P450 substrate and by truncation of the C-terminal tail

Natalie Jay, Janie E. McGlohon, D. Fernando Estrada

J Inorg Biochem. Author manuscript; available in PMC 2024 Jan 19.

Published in final edited form as: J Inorg Biochem. 2023 Dec; 249: 112370. Published online 2023 Sep 12. doi: 10.1016/j.jinorgbio.2023.112370

PMCID:: PMC10798138

Abstract Article PDF–1.5M

Select item 107317584.

Systematic analysis based on the cuproptosis-related genes identifies ferredoxin 1 as an immune regulator and therapeutic target for glioblastoma

Lirui Dai, Peizhi Zhou, Liang Lyu, Shu Jiang

BMC Cancer. 2023; 23: 1249. Published online 2023 Dec 19. doi: 10.1186/s12885-023-11727-z

PMCID:: PMC10731758

Abstract Article PDF–12M

Select item 104700095.

Lipoylation is dependent on the ferredoxin FDX1 and dispensable under hypoxia in human cells

Pallavi R. Joshi, Shayan Sadre, Xiaoyan A. Guo, Jason G. McCoy, Vamsi K. Mootha

J Biol Chem. 2023 Sep; 299(9): 105075. Published online 2023 Jul 20. doi: 10.1016/j.jbc.2023.105075

PMCID:: PMC10470009

Abstract Article PDF–2.3M

Select item 104628416.

FDX1 regulates cellular protein lipoylation through direct binding to LIAS

Margaret B. Dreishpoon, Nolan R. Bick, Boryana Petrova, Douglas M. Warui, Alison Cameron, Squire J. Booker, Naama Kanarek, Todd R. Golub, Peter Tsvetkov

J Biol Chem. 2023 Sep; 299(9): 105046. Published online 2023 Jul 13. doi: 10.1016/j.jbc.2023.105046

PMCID:: PMC10462841

Abstract Article PDF–1.6M

Select item 101967137.

Expression of Ferredoxin1 in cisplatin‑resistant ovarian cancer cells confers their resistance against ferroptosis induced by cisplatin

Ryosuke Takahashi, Koki Kamizaki, Keitaro Yamanaka, Yoshito Terai, Yasuhiro Minami

Oncol Rep. 2023 Jun; 49(6): 124. Published online 2023 May 5. doi: 10.3892/or.2023.8561

PMCID:: PMC10196713

Abstract Article PDF–4.1M

Select item 101885278.

Prognostic and immunological role of FDX1 in pan-cancer: an in-silico analysis

Ziqiang Liu, Jinfeng Miao

Sci Rep. 2023; 13: 7926. Published online 2023 May 16. doi: 10.1038/s41598-023-34752-1

PMCID:: PMC10188527

Abstract Article PDF–12M

Select item 99136489.

Copper Death Inducer, FDX1, as a Prognostic Biomarker Reshaping Tumor Immunity in Clear Cell Renal Cell Carcinoma

Aimin Jiang, Juelan Ye, Ye Zhou, Baohua Zhu, Juan Lu, Silun Ge, Le Qu, Jianru Xiao, Linhui Wang, Chen Cai

Cells. 2023 Feb; 12(3): 349. Published online 2023 Jan 17. doi: 10.3390/cells12030349

PMCID:: PMC9913648

Abstract Article PDF–42M

Select item 988945610.

High expression of cuproptosis-related gene FDX1 in relation to good prognosis and immune cells infiltration in colon adenocarcinoma (COAD)

Lizong Wang, Yi Cao, Wei Guo, Jingyun Xu

J Cancer Res Clin Oncol. 2023; 149(1): 15–24. Published online 2022 Sep 29. doi: 10.1007/s00432-022-04382-7

PMCID:: PMC9889456

Abstract Article PDF–5.2M

Select item 981026211.

Multi-omics pan-cancer study of cuproptosis core gene FDX1 and its role in kidney renal clear cell carcinoma

Jiahao Xu, Zhengang Hu, Hui Cao, Hao Zhang, Peng Luo, Jian Zhang, Xiaoyan Wang, Quan Cheng, Jingbo Li

Front Immunol. 2022; 13: 981764. Published online 2022 Dec 20. doi: 10.3389/fimmu.2022.981764

PMCID:: PMC9810262

Abstract Article PDF–8.7M

Select item 954978112.

Tao Wang, Yufeng Liu, Qing Li, Yang Luo, Dawei Liu, Bin Li

Front Immunol. 2022; 13: 999823. Published online 2022 Sep 26. doi: 10.3389/fimmu.2022.999823

PMCID:: PMC9549781

Abstract Article PDF–9.7M

Select item 910630313.

Genome-wide CRISPR screens using isogenic cells reveal vulnerabilities conferred by loss of tumor suppressors

Xu Feng, Mengfan Tang, Merve Dede, Dan Su, Guangsheng Pei, Dadi Jiang, Chao Wang, Zhen Chen, Mi Li, Litong Nie, Yun Xiong, Siting Li, Jeong-Min Park, Huimin Zhang, Min Huang, Klaudia Szymonowicz, Zhongming Zhao, Traver Hart, Junjie Chen

Sci Adv. 2022 May; 8(19): eabm6638. Published online 2022 May 13. doi: 10.1126/sciadv.abm6638

PMCID:: PMC9106303

Abstract Article PDF–918K

Select item 862494914.

Molecular recognition in mitochondrial cytochromes P450 that catalyze the terminal steps of corticosteroid biosynthesis

Hwei-Ming Peng, Richard J. Auchus

Biochemistry. Author manuscript; available in PMC 2021 Nov 26.

Published in final edited form as: Biochemistry. 2017 May 2; 56(17): 2282–2293. Published online 2017 Apr 17. doi: 10.1021/acs.biochem.7b00034

PMCID:: PMC8624949

Abstract Article PDF–1.4M

Select item 835296415.

Integrative oncogene-dependency mapping identifies RIT1 vulnerabilities and synergies in lung cancer

Athea Vichas, Amanda K. Riley, Naomi T. Nkinsi, Shriya Kamlapurkar, Phoebe C. R. Parrish, April Lo, Fujiko Duke, Jennifer Chen, Iris Fung, Jacqueline Watson, Matthew Rees, Austin M. Gabel, James D. Thomas, Robert K. Bradley, John K. Lee, Emily M. Hatch, Marina K. Baine, Natasha Rekhtman, Marc Ladanyi, Federica Piccioni, Alice H. Berger

Nat Commun. 2021; 12: 4789. Published online 2021 Aug 9. doi: 10.1038/s41467-021-24841-y

PMCID:: PMC8352964

Abstract Article PDF–4.5M

Select item 821529316.

Structural and functional insights into aldosterone synthase interaction with its redox partner protein adrenodoxin

Simoné Brixius-Anderko, Emily E. Scott

J Biol Chem. 2021 Jan-Jun; 296: 100794. Published online 2021 May 18. doi: 10.1016/j.jbc.2021.100794

PMCID:: PMC8215293

Abstract Article PDF–2.7M

Select item 820766417.

The role of FDX1 in granulosa cell of Polycystic ovary syndrome (PCOS)

Zhi Wang, Hui Dong, Li Yang, Ping Yi, Qing Wang, Dongmei Huang

BMC Endocr Disord. 2021; 21: 119. Published online 2021 Jun 15. doi: 10.1186/s12902-021-00775-w

PMCID:: PMC8207664

Abstract Article PDF–1.6M

Select item 683185118.

Rewiring of the Human Mitochondrial Interactome during Neuronal Reprogramming Reveals Regulators of the Respirasome and Neurogenesis

Mohamed Taha Moutaoufik, Ramy Malty, Shahreen Amin, Qingzhou Zhang, Sadhna Phanse, Alla Gagarinova, Mara Zilocchi, Larissa Hoell, Zoran Minic, Maria Gagarinova, Hiroyuki Aoki, Jocelyn Stockwell, Matthew Jessulat, Florian Goebels, Kirsten Broderick, Nichollas E. Scott, James Vlasblom, Gabriel Musso, Bhanu Prasad, Eleonora Lamantea, Barbara Garavaglia, Alex Rajput, Kei Murayama, Yasushi Okazaki, Leonard J. Foster, Gary D. Bader, Francisco S. Cayabyab, Mohan Babu

iScience. 2019 Sep 27; 19: 1114–1132. Published online 2019 Sep 4. doi: 10.1016/j.isci.2019.08.057

PMCID:: PMC6831851

Abstract Article PDF–9.8M

Select item 654192619.

Active site structures of CYP11A1 in the presence of its physiological substrates and alterations upon binding of Adrenodoxin

Qianhong Zhu, Piotr J. Mak, Robert C. Tuckey, James R. Kincaid

Biochemistry. Author manuscript; available in PMC 2019 May 30.

Published in final edited form as: Biochemistry. 2017 Oct 31; 56(43): 5786–5797. Published online 2017 Oct 20. doi: 10.1021/acs.biochem.7b00766

PMCID:: PMC6541926

Abstract Article PDF–864K

Select item 526733820.

Human Mitochondrial Ferredoxin 1 (FDX1) and Ferredoxin 2 (FDX2) Both Bind Cysteine Desulfurase and Donate Electrons for Iron–Sulfur Cluster Biosynthesis

Kai Cai, Marco Tonelli, Ronnie O. Frederick, John L. Markley

Biochemistry. 2017 Jan 24; 56(3): 487–499. Published online 2016 Dec 21. doi: 10.1021/acs.biochem.6b00447

PMCID:: PMC5267338

Abstract Article PDF–5.1M

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