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Items: 1 to 20 of 59

1.
Atypical inflammatory kinase IKBKE phosphorylates and inactivates FoxA1 to promote liver tumorigenesis
Bing Gao, Xueji Wu, Lang Bu, Qiwei Jiang, Lei Wang, Haining Liu, Xiaomei Zhang, Yuanzhong Wu, Xiaoxing Li, Jingting Li, Ying Liang, Lixia Xu, Wei Xie, Jianping Guo
Sci Adv. 2024 Feb 9; 10(6): eadk2285. Published online 2024 Feb 7. doi: 10.1126/sciadv.adk2285
PMCID:
PMC10849599
AbstractArticlePDF–5.3M
2.
IKKε and TBK1 prevent RIPK1 dependent and independent inflammation
Remzi Onur Eren, Göksu Gökberk Kaya, Robin Schwarzer, Manolis Pasparakis
Nat Commun. 2024; 15: 130. Published online 2024 Jan 2. doi: 10.1038/s41467-023-44372-y
PMCID:
PMC10761900
AbstractArticlePDF–6.9M
3.
Mitochondria-associated membrane collapse impairs TBK1-mediated proteostatic stress response in ALS
Seiji Watanabe, Yuri Murata, Yasuyoshi Oka, Kotaro Oiwa, Mai Horiuchi, Yohei Iguchi, Okiru Komine, Akira Sobue, Masahisa Katsuno, Tomoo Ogi, Koji Yamanaka
Proc Natl Acad Sci U S A. 2023 Nov 21; 120(47): e2315347120. Published online 2023 Nov 15. doi: 10.1073/pnas.2315347120
PMCID:
PMC10666035
AbstractArticlePDF–8.9M
4.
The RNA helicase DHX16 recognizes specific viral RNA to trigger RIG-I-dependent innate antiviral immunity
Adam Hage, Preeti Bharaj, Sarah van Tol, Maria I. Giraldo, Maria Gonzalez-Orozco, Karl M. Valerdi, Abbey N. Warren, Leopoldo Aguilera-Aguirre, Xuping Xie, Steven G. Widen, Hong M. Moulton, Benhur Lee, Jeffrey R. Johnson, Nevan J. Krogan, Adolfo García-Sastre, Pei-Yong Shi, Alexander N. Freiberg, Ricardo Rajsbaum
Cell Rep. 2022 Mar 8; 38(10): 110434. Published online 2022 Mar 8. doi: 10.1016/j.celrep.2022.110434
PMCID:
PMC8903195
AbstractArticlePDF–5.7M
5.
TBK1 and IKKε act like an OFF switch to limit NLRP3 inflammasome pathway activation
Fabian A. Fischer, Linda F. M. Mies, Sohaib Nizami, Eirini Pantazi, Sara Danielli, Benjamin Demarco, Michael Ohlmeyer, Michelle Sue Jann Lee, Cevayir Coban, Jonathan C. Kagan, Elena Di Daniel, Jelena S. Bezbradica
Proc Natl Acad Sci U S A. 2021 Sep 21; 118(38): e2009309118. Published online 2021 Sep 13. doi: 10.1073/pnas.2009309118
PMCID:
PMC8463895
AbstractArticlePDF–1.5M
6.
FGF21 is required for the metabolic benefits of IKKε/TBK1 inhibition
Shannon M. Reilly, Mohammad Abu-Odeh, Magdalene Ameka, Julia H. DeLuca, Meghan C. Naber, Benyamin Dadpey, Nima Ebadat, Andrew V. Gomez, Xiaoling Peng, BreAnne Poirier, Elyse Walk, Matthew J. Potthoff, Alan R. Saltiel
J Clin Invest. 2021 May 17; 131(10): e145546. Published online 2021 May 17. doi: 10.1172/JCI145546
PMCID:
PMC8121507
AbstractArticlePDF–2.6M
7.
I-κB Kinase-ε Deficiency Attenuates the Development of Angiotensin II-Induced Myocardial Hypertrophy in Mice
Yide Cao, Liangpeng Li, Yafeng Liu, Ganyi Chen, Zhonghao Tao, Rui Wang, Wen Chen
Oxid Med Cell Longev. 2021; 2021: 6429197. Published online 2021 Feb 8. doi: 10.1155/2021/6429197
PMCID:
PMC7886514
AbstractArticlePDF–2.1M
8.
IKKε deficiency inhibits acute lung injury following renal ischemia reperfusion injury
Chao Meng, Yi Qian, Cui Zhang, Han Liu, Xinwei Mu, Aiping Zhang
Mol Med Rep. 2020 Nov; 22(5): 4213–4220. Published online 2020 Sep 22. doi: 10.3892/mmr.2020.11532
PMCID:
PMC7533469
AbstractArticlePDF–770K
9.
A Novel Molecular Mechanism of IKKε-Mediated Akt/mTOR Inhibition in the Cardiomyocyte Autophagy after Myocardial Infarction
Shuai He, Jian Shen, Liangpeng Li, Yueyue Xu, Yide Cao, Li Yin, Zhonghao Tao, Zhibing Qiu, Wen Chen, Xin Chen
Oxid Med Cell Longev. 2020; 2020: 7046923. Published online 2020 Jul 16. doi: 10.1155/2020/7046923
PMCID:
PMC7382748
AbstractArticlePDF–3.4M
10.
IKK Epsilon Deficiency Attenuates Angiotensin II-Induced Abdominal Aortic Aneurysm Formation in Mice by Inhibiting Inflammation, Oxidative Stress, and Apoptosis
Hao Chai, ZhongHao Tao, YongChao Qi, HaoYu Qi, Wen Chen, YueYue Xu, LeiYang Zhang, HongWei Chen, Xin Chen
Oxid Med Cell Longev. 2020; 2020: 3602824. Published online 2020 Jan 22. doi: 10.1155/2020/3602824
PMCID:
PMC6998751
AbstractArticlePDF–2.8M
11.
Hepatic IKKε expression is dispensable for high-fat feeding-induced increases in liver lipid content and alterations in glucose tolerance
J. Jason Collier, Heidi M. Batdorf, Tamra M. Mendoza, David H. Burk, Thomas M. Martin, Jingying Zhang, Randall L. Mynatt, Susan J. Burke
Am J Physiol Endocrinol Metab. 2020 Jan 1; 318(1): E11–E21. Published online 2019 Oct 29. doi: 10.1152/ajpendo.00309.2019
PMCID:
PMC6985790
AbstractArticle
12.
Innate Immune Signaling Organelles Display Natural and Programmable Signaling Flexibility
Yunhao Tan, Jonathan C. Kagan
Cell. Author manuscript; available in PMC 2020 Apr 4.
Published in final edited form as: Cell. 2019 Apr 4; 177(2): 384–398.e11. Published online 2019 Mar 7. doi: 10.1016/j.cell.2019.01.039
PMCID:
PMC6710629
AbstractArticlePDF–1.2M
13.
Microbial recognition by GEF-H1 controls IKKε mediated activation of IRF5
Yun Zhao, Rachid Zagani, Sung-Moo Park, Naohiro Yoshida, Pankaj Shah, Hans-Christian Reinecker
Nat Commun. 2019; 10: 1349. Published online 2019 Mar 22. doi: 10.1038/s41467-019-09283-x
PMCID:
PMC6430831
AbstractArticlePDF–3.4M
14.
Reciprocal regulation of STING and TCR signaling by mTORC1 for T-cell activation and function
Takayuki Imanishi, Midori Unno, Wakana Kobayashi, Natsumi Yoneda, Satoshi Matsuda, Kazutaka Ikeda, Takayuki Hoshii, Atsushi Hirao, Kensuke Miyake, Glen N Barber, Makoto Arita, Ken J Ishii, Shizuo Akira, Takashi Saito
Life Sci Alliance. 2019 Feb; 2(1): e201800282. Published online 2019 Jan 25. doi: 10.26508/lsa.201800282
PMCID:
PMC6348487
AbstractArticlePDF–2.2M
15.
TBK1 and IKKε prevent TNF-induced cell death by RIPK1 phosphorylation
Elodie Lafont, Peter Draber, Eva Rieser, Matthias Reichert, Sebastian Kupka, Diego de Miguel, Helena Draberova, Anne von Mässenhausen, Amandeep Bhamra, Stephen Henderson, Katarzyna Wojdyla, Avigayil Chalk, Silvia Surinova, Andreas Linkermann, Henning Walczak
Nat Cell Biol. Author manuscript; available in PMC 2019 May 12.
Published in final edited form as: Nat Cell Biol. 2018 Dec; 20(12): 1389–1399. Published online 2018 Nov 12. doi: 10.1038/s41556-018-0229-6
PMCID:
PMC6268100
AbstractArticlePDF–2.8M
16.
Eda-activated RelB recruits an SWI/SNF (BAF) chromatin-remodeling complex and initiates gene transcription in skin appendage formation
Jian Sima, Zhijiang Yan, Yaohui Chen, Elin Lehrmann, Yongqing Zhang, Ramaiah Nagaraja, Weidong Wang, Zhong Wang, David Schlessinger
Proc Natl Acad Sci U S A. 2018 Aug 7; 115(32): 8173–8178. Published online 2018 Jul 23. doi: 10.1073/pnas.1800930115
PMCID:
PMC6094125
AbstractArticlePDF–1.5M
17.
IL-17 receptor-associated adaptor Act1 directly stabilizes mRNAs to mediate IL-17 inflammatory signaling
Tomasz Herjan, Lingzi Hong, Jodi Bubenik, Katarzyna Bulek, Wen Qian, Caini Liu, Xiao Li, Xing Chen, Hui Yang, Suidong Ouyang, Hao Zhou, Junjie Zhao, Vasu Komireddy, Eric Cockman, Mark Aronica, Kewal Asosingh, Donny D. Licatalosi, Jun Qin, Paul L. Fox, Thomas A. Hamilton, Donna Driscoll, Xiaoxia Li
Nat Immunol. Author manuscript; available in PMC 2018 Sep 21.
Published in final edited form as: Nat Immunol. 2018 Apr; 19(4): 354–365. Published online 2018 Mar 21. doi: 10.1038/s41590-018-0071-9
PMCID:
PMC6082628
AbstractArticlePDF–1.5M
18.
The role of TBK1 and IKKε in the expression and activation of Pellino 1
Hilary Smith, Xin-Yu Liu, Liang Dai, Eddy T. H. Goh, Aye-Thu Chan, Jiajia Xi, Cheah-Chen Seh, Insaf A. Qureshi, Julien Lescar, Christiane Ruedl, Robert Gourlay, Simon Morton, Joanne Hough, Edward G. Mciver, Philip Cohen, Peter C. F. Cheung
Biochem J. Author manuscript; available in PMC 2018 Jan 31.
Published in final edited form as: Biochem J. 2011 Mar 15; 434(3): 537–548. doi: 10.1042/BJ20101421
PMCID:
PMC5791887
AbstractArticlePDF–2.6M
19.
IκB Kinase ε Is an NFATc1 Kinase that Inhibits T Cell Immune Response
Junjie Zhang, Hao Feng, Jun Zhao, Emily R. Feldman, Si-Yi Chen, Weiming Yuan, Canhua Huang, Omid Akbari, Scott A. Tibbetts, Pinghui Feng
Cell Rep. Author manuscript; available in PMC 2017 Feb 6.
Published in final edited form as: Cell Rep. 2016 Jul 12; 16(2): 405–418. Published online 2016 Jun 23. doi: 10.1016/j.celrep.2016.05.083
PMCID:
PMC5293007
AbstractArticlePDF–1.1M
20.
IKBKE is required during KRAS-induced pancreatic tumorigenesis
Mihir Rajurkar, Kyvan Dang, Maite G. Fernandez-Barrena, Xiangfan Liu, Martin E. Fernandez-Zapico, Brian C Lewis, Junhao Mao
Cancer Res. Author manuscript; available in PMC 2018 Jan 15.
Published in final edited form as: Cancer Res. 2017 Jan 15; 77(2): 320–329. Published online 2017 Jan 9. doi: 10.1158/0008-5472.CAN-15-1684
PMCID:
PMC5243176
AbstractArticlePDF–1.3M

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