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Select item 111788421.

Loss of connectin novex-3 leads to heart dysfunction associated with impaired cardiomyocyte proliferation and abnormal nuclear mechanics

Ken Hashimoto, Momoko Ohira, Aya Kodama, Misaki Kimoto, Mariko Inoue, Shigenobu Toné, Yuu Usui, Akira Hanashima, Takato Goto, Yuhei Ogura, Yoshihiro Ujihara, Satoshi Mohri

Sci Rep. 2024; 14: 13727. Published online 2024 Jun 14. doi: 10.1038/s41598-024-64608-1

PMCID:: PMC11178842

Abstract Article PDF–5.4M

Select item 93021922.

Deletion of obscurin immunoglobulin domains Ig58/59 leads to age-dependent cardiac remodeling and arrhythmia

Alyssa Grogan, Andrew Coleman, Humberto Joca, Henk Granzier, Mark W. Russel, Christopher W. Ward, Aikaterini Kontrogianni-Konstantopoulos

Basic Res Cardiol. Author manuscript; available in PMC 2022 Jul 21.

Published in final edited form as: Basic Res Cardiol. 2020 Sep 10; 115(6): 60. Published online 2020 Sep 10. doi: 10.1007/s00395-020-00818-8

PMCID:: PMC9302192

Abstract Article PDF–3.3M

Select item 88357213.

Impaired Intracellular Ca²⁺ Dynamics, M-Band and Sarcomere Fragility in Skeletal Muscles of Obscurin KO Mice

Enrico Pierantozzi, Péter Szentesi, Cecilia Paolini, Beatrix Dienes, János Fodor, Tamás Oláh, Barbara Colombini, Dilson E. Rassier, Egidio Maria Rubino, Stephan Lange, Daniela Rossi, László Csernoch, Maria Angela Bagni, Carlo Reggiani, Vincenzo Sorrentino

Int J Mol Sci. 2022 Feb; 23(3): 1319. Published online 2022 Jan 24. doi: 10.3390/ijms23031319

PMCID:: PMC8835721

Abstract Article PDF–2.3M

Select item 79387704.

BraInMap elucidates the macromolecular connectivity landscape of mammalian brain

Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili

Cell Syst. Author manuscript; available in PMC 2021 Apr 22.

Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003

Correction in:: Cell Syst. 2020 Aug 26; 11(2): 208.

PMCID:: PMC7938770

Abstract Article PDF–2.0M

Select item 72475465.

Proteomic Analysis of Myocardia Containing the Obscurin R4344Q Mutation Linked to Hypertrophic Cardiomyopathy

Li-Yen R. Hu, Aikaterini Kontrogianni-Konstantopoulos

Front Physiol. 2020; 11: 478. Published online 2020 May 18. doi: 10.3389/fphys.2020.00478

PMCID:: PMC7247546

Abstract Article PDF–1.0M

Select item 65091386.

Murine obscurin and Obsl1 have functionally redundant roles in sarcolemmal integrity, sarcoplasmic reticulum organization, and muscle metabolism

Jordan Blondelle, Valeria Marrocco, Madison Clark, Patrick Desmond, Stephanie Myers, Jim Nguyen, Matthew Wright, Shannon Bremner, Enrico Pierantozzi, Samuel Ward, Eric Estève, Vincenzo Sorrentino, Majid Ghassemian, Stephan Lange

Commun Biol. 2019; 2: 178. Published online 2019 May 9. doi: 10.1038/s42003-019-0405-7

PMCID:: PMC6509138

Abstract Article PDF–2.9M

Select item 59555407.

Genomic variants in an inbred mouse model predict mania-like behaviors

Michael C. Saul, Sharon A. Stevenson, Changjiu Zhao, Terri M. Driessen, Brian E. Eisinger, Stephen C. Gammie

PLoS One. 2018; 13(5): e0197624. Published online 2018 May 16. doi: 10.1371/journal.pone.0197624

PMCID:: PMC5955540

Abstract Article PDF–3.1M

Select item 57990238.

Chemical cross-linking mass spectrometry analysis of protein conformations and supercomplexes in heart tissue

Juan D. Chavez, Chi Fung Lee, Arianne Caudal, Andrew Keller, Rong Tian, James E. Bruce

Cell Syst. Author manuscript; available in PMC 2019 Jan 24.

Published in final edited form as: Cell Syst. 2018 Jan 24; 6(1): 136–141.e5. Published online 2017 Nov 29. doi: 10.1016/j.cels.2017.10.017

PMCID:: PMC5799023

Abstract Article PDF–730K

Select item 57953889.

The interactome of intact mitochondria by cross-linking mass spectrometry provides evidence for coexisting respiratory supercomplexes

Fan Liu, Philip Lössl, Beverley M. Rabbitts, Robert S. Balaban, Albert J. R. Heck

Mol Cell Proteomics. 2018 Feb; 17(2): 216–232. Published online 2017 Dec 8. doi: 10.1074/mcp.RA117.000470

PMCID:: PMC5795388

Abstract Article PDF–4.4M

Select item 569466710.

Novel obscurins mediate cardiomyocyte adhesion and size via the PI3K/AKT/mTOR signaling pathway

Maegen A. Ackermann, Brendan King, Nicole A.P. Lieberman, Prameela J. Bobbili, Michael Rudloff, Christopher E. Berndsen, Nathan T. Wright, Peter A. Hecker, Aikaterini Kontrogianni-Konstantopoulos

J Mol Cell Cardiol. Author manuscript; available in PMC 2017 Nov 19.

Published in final edited form as: J Mol Cell Cardiol. 2017 Oct; 111: 27–39. Published online 2017 Aug 4. doi: 10.1016/j.yjmcc.2017.08.004

PMCID:: PMC5694667

Abstract Article PDF–3.3M

Select item 546250211.

Deregulated Ca²⁺ cycling underlies the development of arrhythmia and heart disease due to mutant obscurin

Li-Yen R. Hu, Maegen A. Ackermann, Peter A. Hecker, Benjamin L. Prosser, Brendan King, Kelly A. O’Connell, Alyssa Grogan, Logan C. Meyer, Christopher E. Berndsen, Nathan T. Wright, W. Jonathan Lederer, Aikaterini Kontrogianni-Konstantopoulos

Sci Adv. 2017 Jun; 3(6): e1603081. Published online 2017 Jun 7. doi: 10.1126/sciadv.1603081

PMCID:: PMC5462502

Abstract Article PDF–4.4M

Select item 528389612.

Exercise-induced alterations and loss of sarcomeric M-line organization in the diaphragm muscle of obscurin knockout mice

D. Randazzo, B. Blaauw, C. Paolini, E. Pierantozzi, S. Spinozzi, S. Lange, J. Chen, F. Protasi, C. Reggiani, V. Sorrentino

Am J Physiol Cell Physiol. 2017 Jan 1; 312(1): C16–C28. Published online 2016 Oct 26. doi: 10.1152/ajpcell.00098.2016

PMCID:: PMC5283896

Abstract Article

Select item 438043813.

Expression of the Immunoglobulin Superfamily Cell Adhesion Molecules in the Developing Spinal Cord and Dorsal Root Ganglion

Zirong Gu, Fumiyasu Imai, In Jung Kim, Hiroko Fujita, Kei ichi Katayama, Kensaku Mori, Yoshihiro Yoshihara, Yutaka Yoshida

PLoS One. 2015; 10(3): e0121550. Published online 2015 Mar 31. doi: 10.1371/journal.pone.0121550

PMCID:: PMC4380438

Abstract Article PDF–36M

Select item 407349414.

The Central Role of EED in the Orchestration of Polycomb Group Complexes

Qi Cao, Xiaoju Wang, Meng Zhao, Rendong Yang, Rohit Malik, Yuanyuan Qiao, Anton Poliakov, Anastasia K. Yocum, Yong Li, Wei Chen, Xuhong Cao, Xia Jiang, Arun Dahiya, Clair Harris, Felix Y. Feng, Sundeep Kalantry, Zhaohui S. Qin, Saravana M. Dhanasekaran, Arul M. Chinnaiyan

Nat Commun. Author manuscript; available in PMC 2014 Jul 24.

Published in final edited form as: Nat Commun. 2014; 5: 3127. doi: 10.1038/ncomms4127

PMCID:: PMC4073494

Abstract Article PDF–2.1M

Select item 391644115.

Obscurins: Goliaths and Davids Take over Non-Muscle Tissues

Maegen A. Ackermann, Marey Shriver, Nicole A. Perry, Li-Yen R. Hu, Aikaterini Kontrogianni-Konstantopoulos

PLoS One. 2014; 9(2): e88162. Published online 2014 Feb 6. doi: 10.1371/journal.pone.0088162

Correction in:: PLoS One. 2018; 13(1): e0190842.

PMCID:: PMC3916441

Abstract Article PDF–37M

Select item 363381616.

The kinase domains of obscurin interact with intercellular adhesion proteins

Li-Yen R. Hu, Aikaterini Kontrogianni-Konstantopoulos

FASEB J. 2013 May; 27(5): 2001–2012. doi: 10.1096/fj.12-221317

Correction in:: FASEB J. 2024 Dec 15; 38(23): e70237.

PMCID:: PMC3633816

Abstract Article

Select item 357554017.

Obscurin is required for ankyrinB-dependent dystrophin localization and sarcolemma integrity

Davide Randazzo, Emiliana Giacomello, Stefania Lorenzini, Daniela Rossi, Enrico Pierantozzi, Bert Blaauw, Carlo Reggiani, Stephan Lange, Angela K. Peter, Ju Chen, Vincenzo Sorrentino

J Cell Biol. 2013 Feb 18; 200(4): 523–536. doi: 10.1083/jcb.201205118

PMCID:: PMC3575540

Abstract Article PDF–3.5M

Select item 338621318.

Obscurin and KCTD6 regulate cullin-dependent small ankyrin-1 (sAnk1.5) protein turnover

Stephan Lange, Sue Perera, Phildrich Teh, Ju Chen

Mol Biol Cell. 2012 Jul 1; 23(13): 2490–2504. doi: 10.1091/mbc.E12-01-0052

PMCID:: PMC3386213

Abstract Article PDF–4.8M

Select item 338306519.

Mapping the Nephronophthisis-Joubert-Meckel-Gruber Protein Network Reveals Ciliopathy Disease Genes and Pathways

Liyun Sang, Julie J. Miller, Kevin C. Corbit, Rachel H. Giles, Matthew J. Brauer, Edgar A. Otto, Lisa M. Baye, Xiaohui Wen, Suzie J. Scales, Mandy Kwong, Erik G. Huntzicker, Mindan K. Sfakianos, Wendy Sandoval, J. Fernando Bazan, Priya Kulkarni, Francesc R. Garcia-Gonzalo, Allen D. Seol, John F. O'Toole, Susanne Held, Heiko M. Reutter, William S. Lane, Muhammad Arshad Rafiq, Abdul Noor, Muhammad Ansar, Akella Radha Rama Devi, Val C. Sheffield, Diane C. Slusarski, John B. Vincent, Daniel A. Doherty, Friedhelm Hildebrandt, Jeremy F. Reiter, Peter K. Jackson

Cell. Author manuscript; available in PMC 2012 Jun 26.

Published in final edited form as: Cell. 2011 May 13; 145(4): 513–528. doi: 10.1016/j.cell.2011.04.019

PMCID:: PMC3383065

Abstract Article PDF–2.0M

Select item 317805920.

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas

Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042

PMCID:: PMC3178059

Abstract Article PDF–1.0M

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