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Items: 1 to 20 of 48

1.
Transcriptional repression by a secondary DNA binding surface of DNA topoisomerase I safeguards against hypertranscription
Mei Sheng Lau, Zhenhua Hu, Xiaodan Zhao, Yaw Sing Tan, Jinyue Liu, Hua Huang, Clarisse Jingyi Yeo, Hwei Fen Leong, Oleg V. Grinchuk, Justin Kaixuan Chan, Jie Yan, Wee-Wei Tee
Nat Commun. 2023; 14: 6464. Published online 2023 Oct 13. doi: 10.1038/s41467-023-42078-9
PMCID:
PMC10576097
AbstractArticlePDF–1.9M
2.
Ago2 and a miRNA reduce Topoisomerase 1 for enhancing DNA cleavage in antibody diversification by activation-induced cytidine deaminase
Maki Kobayashi, Hiroyuki Wakaguri, Masakazu Shimizu, Koichiro Higasa, Fumihiko Matsuda, Tasuku Honjo
Proc Natl Acad Sci U S A. 2023 May 2; 120(18): e2216918120. Published online 2023 Apr 24. doi: 10.1073/pnas.2216918120
PMCID:
PMC10161001
AbstractArticlePDF–4.1M
3.
Signatures of TOP1 transcription-associated mutagenesis in cancer and germline
Martin A. M. Reijns, David A. Parry, Thomas C. Williams, Ferran Nadeu, Rebecca L. Hindshaw, Diana O. Rios Szwed, Michael D. Nicholson, Paula Carroll, Shelagh Boyle, Romina Royo, Alex J. Cornish, Hang Xiang, Kate Ridout, The Genomics England Research Consortium, Colorectal Cancer Domain UK 100,000 Genomes Project, Anna Schuh, Konrad Aden, Claire Palles, Elias Campo, Tatjana Stankovic, Martin S. Taylor, Andrew P. Jackson
Nature. 2022; 602(7898): 623–631. Published online 2022 Feb 9. doi: 10.1038/s41586-022-04403-y
Correction in:
Nature. 2022; 605(7910): E7.
PMCID:
PMC8866115
AbstractArticlePDF–6.9M
4.
NuMorph: Tools for cortical cellular phenotyping in tissue-cleared whole-brain images
Oleh Krupa, Giulia Fragola, Ellie Hadden-Ford, Jessica T. Mory, Tianyi Liu, Zachary Humphrey, Benjamin W. Rees, Ashok Krishnamurthy, William D. Snider, Mark J. Zylka, Guorong Wu, Lei Xing, Jason L. Stein
Cell Rep. Author manuscript; available in PMC 2021 Oct 21.
Published in final edited form as: Cell Rep. 2021 Oct 12; 37(2): 109802. doi: 10.1016/j.celrep.2021.109802
PMCID:
PMC8530274
AbstractArticlePDF–4.0M
5.
Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development
Francesco Bedogni, Robert F. Hevner
Front Mol Neurosci. 2021; 14: 686034. Published online 2021 Jul 12. doi: 10.3389/fnmol.2021.686034
PMCID:
PMC8313239
AbstractArticlePDF–1.6M
6.
BraInMap elucidates the macromolecular connectivity landscape of mammalian brain
Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili
Cell Syst. Author manuscript; available in PMC 2021 Apr 22.
Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003
Correction in:
Cell Syst. 2020 Aug 26; 11(2): 208.
PMCID:
PMC7938770
AbstractArticlePDF–2.0M
7.
The E3 ubiquitin ligase Cul4b promotes CD4+ T cell expansion by aiding the repair of damaged DNA
Asif A. Dar, Keisuke Sawada, Joseph M. Dybas, Emily K. Moser, Emma L. Lewis, Eddie Park, Hossein Fazelinia, Lynn A. Spruce, Hua Ding, Steven H. Seeholzer, Paula M. Oliver
PLoS Biol. 2021 Feb; 19(2): e3001041. Published online 2021 Feb 1. doi: 10.1371/journal.pbio.3001041
PMCID:
PMC7888682
AbstractArticlePDF–4.5M
8.
Deletion of Topoisomerase 1 in excitatory neurons causes genomic instability and early onset neurodegeneration
Giulia Fragola, Angela M. Mabb, Bonnie Taylor-Blake, Jesse K. Niehaus, William D. Chronister, Hanqian Mao, Jeremy M. Simon, Hong Yuan, Zibo Li, Michael J. McConnell, Mark J. Zylka
Nat Commun. 2020; 11: 1962. Published online 2020 Apr 23. doi: 10.1038/s41467-020-15794-9
PMCID:
PMC7181881
AbstractArticlePDF–4.2M
9.
Telencephalic Embryonic Subtractive Sequences: A Unique Collection of Neurodevelopmental Genes
Alessandro Bulfone, Pietro Carotenuto, Andrea Faedo, Veruska Aglio, Livia Garzia, Anna Maria Bello, Andrea Basile, Alessandra Andrè, Massimo Cocchia, Ombretta Guardiola, Andrea Ballabio, John L. R. Rubenstein, Massimo Zollo
J Neurosci. 2005 Aug 17; 25(33): 7586–7600. doi: 10.1523/JNEUROSCI.0522-05.2005
PMCID:
PMC6725394
AbstractArticlePDF–682K
10.
Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics
Joel D. Federspiel, Todd M. Greco, Krystal K. Lum, Ileana M. Cristea
Mol Cell Proteomics. 2019 Aug 9; 18(8 Suppl 1): S92–S113. Published online 2019 Apr 30. doi: 10.1074/mcp.RA118.001253
PMCID:
PMC6692770
AbstractArticlePDF–7.7M
11.
ATG5 is required for B cell polarization and presentation of particulate antigens
Florent Arbogast, Johan Arnold, Philippe Hammann, Lauriane Kuhn, Johana Chicher, Diane Murera, Justine Weishaar, Sylviane Muller, Jean-Daniel Fauny, Frédéric Gros
Autophagy. 2019; 15(2): 280–294. Published online 2018 Sep 22. doi: 10.1080/15548627.2018.1516327
PMCID:
PMC6333460
AbstractArticlePDF–2.7M
12.
Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors
Hyeonwoo Kim, Christiane D. Wrann, Mark Jedrychowski, Sara Vidoni, Yukiko Kitase, Kenichi Nagano, Chenhe Zhou, Joshua Chou, Virginia-Jeni A. Parkman, Scott J. Novick, Timothy S. Strutzenberg, Bruce D. Pascal, Phuong T. Le, Daniel J. Brooks, Alexander M. Roche, Kaitlyn K. Gerber, Laura Mattheis, Wenjing Chen, Hua Tu, Mary L. Bouxsein, Patrick R. Griffin, Roland Baron, Clifford J. Rosen, Lynda F. Bonewald, Bruce M. Spiegelman
Cell. Author manuscript; available in PMC 2019 Dec 13.
Published in final edited form as: Cell. 2018 Dec 13; 175(7): 1756–1768.e17. doi: 10.1016/j.cell.2018.10.025
Correction in:
Cell. 2019 Jul 11; 178(2): 507–508.
PMCID:
PMC6298040
AbstractArticlePDF–1.2M
13.
Spartan deficiency causes accumulation of Topoisomerase 1 cleavage complexes and tumorigenesis
Reeja S. Maskey, Karen S. Flatten, Cynthia J. Sieben, Kevin L. Peterson, Darren J. Baker, Hyun-Ja Nam, Myoung Shin Kim, Thomas C. Smyrk, Yusuke Kojima, Yuka Machida, Annyoceli Santiago, Jan M. van Deursen, Scott H. Kaufmann, Yuichi J. Machida
Nucleic Acids Res. 2017 May 5; 45(8): 4564–4576. Published online 2017 Feb 13. doi: 10.1093/nar/gkx107
PMCID:
PMC5416836
AbstractArticlePDF–6.4M
14.
The transcriptional regulator Aire binds to and activates super-enhancers
Kushagra Bansal, Hideyuki Yoshida, Christophe Benoist, Diane Mathis
Nat Immunol. Author manuscript; available in PMC 2017 Jul 30.
Published in final edited form as: Nat Immunol. 2017 Mar; 18(3): 263–273. Published online 2017 Jan 30. doi: 10.1038/ni.3675
PMCID:
PMC5310976
AbstractArticlePDF–2.5M
15.
Jade-1S phosphorylation induced by CK1α contributes to cell cycle progression
Lori Borgal, Markus M. Rinschen, Claudia Dafinger, Valérie I. Liebrecht, Hinrich Abken, Thomas Benzing, Bernhard Schermer
Cell Cycle. 2016; 15(8): 1034–1045. Published online 2016 Feb 26. doi: 10.1080/15384101.2016.1152429
PMCID:
PMC4889251
AbstractArticlePDF–1.1M
16.
Topoisomerase 1 Regulates Gene Expression in Neurons through Cleavage Complex-Dependent and -Independent Mechanisms
Angela M. Mabb, Jeremy M. Simon, Ian F. King, Hyeong-Min Lee, Lin-Kun An, Benjamin D. Philpot, Mark J. Zylka
PLoS One. 2016; 11(5): e0156439. Published online 2016 May 27. doi: 10.1371/journal.pone.0156439
PMCID:
PMC4883752
AbstractArticlePDF–4.7M
17.
Elf5-centered transcription factor hub controls trophoblast stem cell self-renewal and differentiation through stoichiometry-sensitive shifts in target gene networks
Paulina A. Latos, Arnold R. Sienerth, Alexander Murray, Claire E. Senner, Masanaga Muto, Masahito Ikawa, David Oxley, Sarah Burge, Brian J. Cox, Myriam Hemberger
Genes Dev. 2015 Dec 1; 29(23): 2435–2448. doi: 10.1101/gad.268821.115
PMCID:
PMC4691948
AbstractArticlePDF–1.0M
18.
Lack of mitochondrial topoisomerase I (TOP1mt) impairs liver regeneration
Salim Khiati, Simone A. Baechler, Valentina M. Factor, Hongliang Zhang, Shar-yin N. Huang, Ilaria Dalla Rosa, Carole Sourbier, Leonard Neckers, Snorri S. Thorgeirsson, Yves Pommier
Proc Natl Acad Sci U S A. 2015 Sep 8; 112(36): 11282–11287. Published online 2015 Aug 24. doi: 10.1073/pnas.1511016112
PMCID:
PMC4568654
AbstractArticlePDF–1.2M
19.
Beads-free protein immunoprecipitation for a mass spectrometry-based interactome and posttranslational modifications analysis
Michal Mikula, Tymon Rubel, Jakub Karczmarski, Malgorzata Statkiewicz, Karol Bomsztyk, Jerzy Ostrowski
Proteome Sci. 2015; 13: 23. Published online 2015 Sep 2. doi: 10.1186/s12953-015-0079-0
PMCID:
PMC4557753
AbstractArticlePDF–1.5M
20.
Pharmacological targeting of the Wdr5-MLL interaction in C/EBPa N-terminal leukemia
Florian Grebien, Masoud Vedadi, Matthäus Getlik, Roberto Giambruno, Amit Grover, Roberto Avellino, Anna Skucha, Sarah Vittori, Ekaterina Kuznetsova, David Smil, Dalia Barsyte-Lovejoy, Fengling Li, Gennadiy Poda, Matthieu Schapira, Hong Wu, Aiping Dong, Guillermo Senisterra, Alexey Stukalov, Kilian V. M. Huber, Andreas Schönegger, Richard Marcellus, Martin Bilban, Christoph Bock, Peter J. Brown, Johannes Zuber, Keiryn L. Bennett, Rima Al-awar, Ruud Delwel, Claus Nerlov, Cheryl H. Arrowsmith, Giulio Superti-Furga
Nat Chem Biol. Author manuscript; available in PMC 2016 Feb 1.
Published in final edited form as: Nat Chem Biol. 2015 Aug; 11(8): 571–578. Published online 2015 Jul 13. doi: 10.1038/nchembio.1859
PMCID:
PMC4511833
AbstractArticlePDF–2.2M

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