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Select item 62423371.

A Single Mutation Traps a Half-sites Reactive Enzyme in Mid-stream, Explaining Asymmetry in Hydride Transfer^†

Janet S. Finer-Moore, Tom T. Lee, Robert M. Stroud

Biochemistry. Author manuscript; available in PMC 2018 Nov 19.

Published in final edited form as: Biochemistry. 2018 May 15; 57(19): 2786–2795. Published online 2018 May 2. doi: 10.1021/acs.biochem.8b00176

PMCID:: PMC6242337

Abstract Article PDF–2.4M

Select item 47653282.

QM/MM study of Thymidylate Synthase: Enzymatic motions and the temperature dependence of the rate limiting step

Natalia Kanaan, Sergio Martí, Vicent Moliner, Amnon Kohen

J Phys Chem A. Author manuscript; available in PMC 2016 Feb 24.

Published in final edited form as: J Phys Chem A. 2009 Mar 12; 113(10): 2176–2182. doi: 10.1021/jp810548d

PMCID:: PMC4765328

Abstract Article PDF–1.7M

Select item 46615673.

Conservation and Role of Electrostatics in Thymidylate Synthase

Divita Garg, Stephane Skouloubris, Julien Briffotaux, Hannu Myllykallio, Rebecca C. Wade

Sci Rep. 2015; 5: 17356. Published online 2015 Nov 27. doi: 10.1038/srep17356

PMCID:: PMC4661567

Abstract Article PDF–1.1M

Select item 38806494.

Development and Binding Mode Assessment of N-[4-[2-propyn-1-yl[(6S)-4,6,7,8-tetrahydro-2-(hydroxymethyl)-4-oxo-3H-cyclopenta[g]quinazolin-6-yl]amino]benzoyl]-L-γ-glutamyl-D-glutamic acid (BGC 945), a Novel Thymidylate Synthase Inhibitor that Targets Tumor Cells

Anna Tochowicz, Sean Dalziel, Oliv Eidam, Joseph D. O’Connell, 3rd, Sarah Griner, Janet S. Finer-Moore, Robert M. Stroud

J Med Chem. Author manuscript; available in PMC 2014 Jul 11.

Published in final edited form as: J Med Chem. 2013 Jul 11; 56(13): 10.1021/jm400490e. Published online 2013 Jun 21. doi: 10.1021/jm400490e

PMCID:: PMC3880649

Abstract Article PDF–1.6M

Select item 36741085.

Mg²⁺ binds to the surface of thymidylate synthase and affects hydride transfer at the interior active site

Zhen Wang, Paul J. Sapienza, Thelma Abeysinghe, Calvin Luzum, Andrew L. Lee, Janet S. Finer-Moore, Robert M. Stroud, Amnon Kohen

J Am Chem Soc. Author manuscript; available in PMC 2014 May 22.

Published in final edited form as: J Am Chem Soc. 2013 May 22; 135(20): 7583–7592. Published online 2013 May 10. doi: 10.1021/ja400761x

PMCID:: PMC3674108

Abstract Article PDF–2.2M

Select item 27866126.

Polyphosphate Accumulation in Escherichia coli in Response to Defects in DNA Metabolism

Luciana Amado, Andrei Kuzminov

J Bacteriol. 2009 Dec; 191(24): 7410–7416. Published online 2009 Oct 16. doi: 10.1128/JB.01138-09

PMCID:: PMC2786612

Abstract Article PDF–1.1M

Select item 25568927.

The role of protein dynamics in thymidylate synthase catalysis: Variants of conserved dUMP-binding Tyr-261

Zachary Newby, Tom T. Lee, Richard J. Morse, Lu Liu, Yaoquan Liu, Prasanna Venkatraman, Daniel V. Santi, Janet S. Finer-Moore, Robert M. Stroud

Biochemistry. Author manuscript; available in PMC 2008 Oct 1.

Published in final edited form as: Biochemistry. 2006 Jun 20; 45(24): 7415–7428. doi: 10.1021/bi060152s

PMCID:: PMC2556892

Abstract Article PDF–5.2M

Select item 25568678.

The Role of Y94 in Proton and Hydride Transfers Catalyzed by Thymidylate Synthase

Baoyu Hong, Frank Maley, Amnon Kohen

Biochemistry. Author manuscript; available in PMC 2008 Dec 11.

Published in final edited form as: Biochemistry. 2007 Dec 11; 46(49): 14188–14197. Published online 2007 Nov 14. doi: 10.1021/bi701363s

PMCID:: PMC2556867

Abstract Article PDF–2.3M

Select item 22921779.

Protein abundance profiling of the Escherichia coli cytosol

Yasushi Ishihama, Thorsten Schmidt, Juri Rappsilber, Matthias Mann, F Ulrich Hartl, Michael J Kerner, Dmitrij Frishman

BMC Genomics. 2008; 9: 102. Published online 2008 Feb 27. doi: 10.1186/1471-2164-9-102

PMCID:: PMC2292177

Abstract Article PDF–1.0M

Select item 224286310.

Structure of the Y94F mutant of Escherichia coli thymidylate synthase

Sue A. Roberts, David C. Hyatt, Jerry E. Honts, Liming Changchien, Gladys F. Maley, Frank Maley, William R. Montfort

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006 Sep 1; 62(Pt 9): 840–843. Published online 2006 Aug 18. doi: 10.1107/S1744309106029691

PMCID:: PMC2242863

Abstract Article PDF–519K

Select item 220669111.

Significance of mutations on the structural perturbation of thymidylate synthase: Implications for their involvement in subunit exchange

Ruth L. Saxl, Gladys F. Maley, Charles R. Hauer, Robert Maccoll, Liming Changchien, Frank Maley

Protein Sci. 2007 Jul; 16(7): 1439–1448. doi: 10.1110/ps.062509807

PMCID:: PMC2206691

Abstract Article PDF–492K

Select item 214362312.

Crystal structures of a marginally active thymidylate synthase mutant, Arg 126-->Glu.

P. Strop, L. Changchien, F. Maley, W. R. Montfort

Protein Sci. 1997 Dec; 6(12): 2504–2511. doi: 10.1002/pro.5560061203

PMCID:: PMC2143623

Summary PDF–2.1M

Select item 169820913.

Experimental and Computational Assessment of Conditionally Essential Genes in Escherichia coli

Andrew R. Joyce, Jennifer L. Reed, Aprilfawn White, Robert Edwards, Andrei Osterman, Tomoya Baba, Hirotada Mori, Scott A. Lesely, Bernhard Ø. Palsson, Sanjay Agarwalla

J Bacteriol. 2006 Dec; 188(23): 8259–8271. Published online 2006 Sep 29. doi: 10.1128/JB.00740-06

PMCID:: PMC1698209

Abstract Article PDF–779K

Select item 168148114.

Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110

Koji Hayashi, Naoki Morooka, Yoshihiro Yamamoto, Katsutoshi Fujita, Katsumi Isono, Sunju Choi, Eiichi Ohtsubo, Tomoya Baba, Barry L Wanner, Hirotada Mori, Takashi Horiuchi

Mol Syst Biol. 2006; 2: 2006.0007. Published online 2006 Feb 21. doi: 10.1038/msb4100049

PMCID:: PMC1681481

Abstract Article PDF–141K

Select item 132520015.

Escherichia coli K-12: a cooperatively developed annotation snapshot—2005

Monica Riley, Takashi Abe, Martha B. Arnaud, Mary K.B. Berlyn, Frederick R. Blattner, Roy R. Chaudhuri, Jeremy D. Glasner, Takashi Horiuchi, Ingrid M. Keseler, Takehide Kosuge, Hirotada Mori, Nicole T. Perna, Guy Plunkett, III, Kenneth E. Rudd, Margrethe H. Serres, Gavin H. Thomas, Nicholas R. Thomson, David Wishart, Barry L. Wanner

Nucleic Acids Res. 2006; 34(1): 1–9. Published online 2006 Jan 5. doi: 10.1093/nar/gkj405