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Items: 1 to 20 of 38

1.
Genetic determinants of micronucleus formation in vivo
D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus
Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0
PMCID:
PMC10917660
AbstractArticlePDF–4.8M
2.
A narrow T cell receptor repertoire instructs thymic differentiation of MHC class Ib–restricted CD8+ regulatory T cells
Hye-Jung Kim, Hidetoshi Nakagawa, John Y. Choi, Xuchun Che, Andrew Divris, Qingshi Liu, Andrew E. Wight, Hengcheng Zhang, Anis Saad, Zhabiz Solhjou, Christa Deban, Jamil R. Azzi, Harvey Cantor
J Clin Invest. 2024 Jan 2; 134(1): e170512. Published online 2024 Jan 2. doi: 10.1172/JCI170512
PMCID:
PMC10760956
AbstractArticlePDF–2.1M
3.
Murine cytomegalovirus downregulates ERAAP and induces an unconventional T cell response to self
Kristina M. Geiger, Michael Manoharan, Rachel Coombs, Kathya Arana, Chan-Su Park, Angus Y. Lee, Nilabh Shastri, Ellen A. Robey, Laurent Coscoy
Cell Rep. Author manuscript; available in PMC 2023 Oct 23.
Published in final edited form as: Cell Rep. 2023 Apr 25; 42(4): 112317. Published online 2023 Mar 29. doi: 10.1016/j.celrep.2023.112317
PMCID:
PMC10539480
AbstractArticlePDF–1.2M
4.
ALS-linked loss of Cyclin-F function affects HSP90
Alexander Siebert, Vanessa Gattringer, Jochen H Weishaupt, Christian Behrends
Life Sci Alliance. 2022 Dec; 5(12): e202101359. Published online 2022 Sep 16. doi: 10.26508/lsa.202101359
PMCID:
PMC9481933
AbstractArticlePDF–3.5M
5.
Functional genomic landscape of cancer-intrinsic evasion of killing by T cells
Keith A. Lawson, Cristovão M. Sousa, Xiaoyu Zhang, Eiru Kim, Rummy Akthar, Joseph J. Caumanns, Yuxi Yao, Nicholas Mikolajewicz, Catherine Ross, Kevin R. Brown, Abdelrahman Abou Zid, Zi Peng Fan, Shirley Hui, Jordan A. Krall, Donald M. Simons, Chloe J. Slater, Victor De Jesus, Lujia Tang, Richa Singh, Joshua E. Goldford, Sarah Martin, Qian Huang, Elizabeth A. Francis, Andrea Habsid, Ryan Climie, David Tieu, Jiarun Wei, Ren Li, Amy Hin Yan Tong, Michael Aregger, Katherine S. Chan, Hong Han, Xiaowei Wang, Patricia Mero, John H. Brumell, Antonio Finelli, Laurie Ailles, Gary Bader, Gromoslaw A. Smolen, Gillian A. Kingsbury, Traver Hart, Charles Kung, Jason Moffat
Nature. Author manuscript; available in PMC 2022 Apr 18.
Published in final edited form as: Nature. 2020 Oct; 586(7827): 120–126. Published online 2020 Sep 23. doi: 10.1038/s41586-020-2746-2
PMCID:
PMC9014559
AbstractArticlePDF–6.6M
6.
ERAP1 is a critical regulator of inflammasome-mediated proinflammatory and ER stress responses
Maja K. Blake, Patrick O’Connell, Yuliya Pepelyayeva, Sarah Godbehere, Yasser A. Aldhamen, Andrea Amalfitano
BMC Immunol. 2022; 23: 9. Published online 2022 Mar 4. doi: 10.1186/s12865-022-00481-9
PMCID:
PMC8895631
AbstractArticlePDF–1.3M
7.
BraInMap elucidates the macromolecular connectivity landscape of mammalian brain
Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili
Cell Syst. Author manuscript; available in PMC 2021 Apr 22.
Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003
Correction in:
Cell Syst. 2020 Aug 26; 11(2): 208.
PMCID:
PMC7938770
AbstractArticlePDF–2.0M
8.
Sex-specific differences in endoplasmic reticulum aminopeptidase 1 modulation influence blood pressure and renin-angiotensin system responses
Sanjay Ranjit, Jian Yao Wong, Jia W. Tan, Chee Sin Tay, Jessica M. Lee, Kelly Yin Han Wong, Luminita H. Pojoga, Danielle L. Brooks, Amanda E. Garza, Stephen A. Maris, Isis Akemi Katayama, Jonathan S. Williams, Alicia Rivera, Gail K. Adler, Gordon H. Williams, Jose R. Romero
JCI Insight. 2019 Nov 1; 4(21): e129615. Published online 2019 Nov 1. doi: 10.1172/jci.insight.129615
PMCID:
PMC6948756
AbstractArticlePDF–2.8M
9.
ERAP1 promotes Hedgehog-dependent tumorigenesis by controlling USP47-mediated degradation of βTrCP
Francesca Bufalieri, Paola Infante, Flavia Bernardi, Miriam Caimano, Paolo Romania, Marta Moretti, Ludovica Lospinoso Severini, Julie Talbot, Ombretta Melaiu, Mirella Tanori, Laura Di Magno, Diana Bellavia, Carlo Capalbo, Stéphanie Puget, Enrico De Smaele, Gianluca Canettieri, Daniele Guardavaccaro, Luca Busino, Angelo Peschiaroli, Simonetta Pazzaglia, Giuseppe Giannini, Gerry Melino, Franco Locatelli, Alberto Gulino, Olivier Ayrault, Doriana Fruci, Lucia Di Marcotullio
Nat Commun. 2019; 10: 3304. Published online 2019 Jul 24. doi: 10.1038/s41467-019-11093-0
PMCID:
PMC6656771
AbstractArticlePDF–4.6M
10.
Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors
Hyeonwoo Kim, Christiane D. Wrann, Mark Jedrychowski, Sara Vidoni, Yukiko Kitase, Kenichi Nagano, Chenhe Zhou, Joshua Chou, Virginia-Jeni A. Parkman, Scott J. Novick, Timothy S. Strutzenberg, Bruce D. Pascal, Phuong T. Le, Daniel J. Brooks, Alexander M. Roche, Kaitlyn K. Gerber, Laura Mattheis, Wenjing Chen, Hua Tu, Mary L. Bouxsein, Patrick R. Griffin, Roland Baron, Clifford J. Rosen, Lynda F. Bonewald, Bruce M. Spiegelman
Cell. Author manuscript; available in PMC 2019 Dec 13.
Published in final edited form as: Cell. 2018 Dec 13; 175(7): 1756–1768.e17. doi: 10.1016/j.cell.2018.10.025
Correction in:
Cell. 2019 Jul 11; 178(2): 507–508.
PMCID:
PMC6298040
AbstractArticlePDF–1.2M
11.
ERAP1 deficient mice have reduced Type 1 regulatory T cells and develop skeletal and intestinal features of Ankylosing Spondylitis
Yuliya Pepelyayeva, David P. W. Rastall, Yasser A. Aldhamen, Patrick O’Connell, Sandra Raehtz, Fadel S. Alyaqoub, Maja K. Blake, Ashley M. Raedy, Ariana M. Angarita, Abdulraouf M. Abbas, Cristiane N. Pereira-Hicks, Sarah G. Roosa, Laura McCabe, Andrea Amalfitano
Sci Rep. 2018; 8: 12464. Published online 2018 Aug 20. doi: 10.1038/s41598-018-30159-5
PMCID:
PMC6102283
AbstractArticlePDF–2.5M
12.
Mice expressing human ERAP1 variants associated with ankylosing spondylitis have altered T-cell repertoires and NK cell functions, as well as increased in utero and perinatal mortality
David P W Rastall, Fadel S Alyaquob, Patrick O’Connell, Yuliya Pepelyayeva, Douglas Peters, Sarah Godbehere-Roosa, Cristiane Pereira-Hicks, Yasser A Aldhamen, Andrea Amalfitano
Int Immunol. 2017 Jun; 29(6): 277–289. Published online 2017 Jul 10. doi: 10.1093/intimm/dxx035
PMCID:
PMC5890900
AbstractArticlePDF–1.9M
13.
Fancd2 in vivo interaction network reveals a non-canonical role in mitochondrial function
Tingting Zhang, Wei Du, Andrew F. Wilson, Satoshi H. Namekawa, Paul R. Andreassen, Amom Ruhikanta Meetei, Qishen Pang
Sci Rep. 2017; 7: 45626. Published online 2017 Apr 5. doi: 10.1038/srep45626
PMCID:
PMC5381226
AbstractArticlePDF–1.4M
14.
Antigen processing in the ER is monitored by semi-invariant αβ TCRs specific for a conserved peptide-Qa-1b MHC Ib ligand
Jian Guan, Soo Jung Yang, Federico Gonzalez, Yuxin Yin, Nilabh Shastri
J Immunol. Author manuscript; available in PMC 2018 Mar 1.
Published in final edited form as: J Immunol. 2017 Mar 1; 198(5): 2017–2027. Published online 2017 Jan 20. doi: 10.4049/jimmunol.1600764
PMCID:
PMC5321846
AbstractArticlePDF–1.5M
15.
Immunodominant, protective response to the parasite Toxoplasma gondii requires antigen processing in the endoplasmic reticulum
Nicolas Blanchard, Federico Gonzalez, Marie Schaeffer, Nathalie T Joncker, Tiffany Cheng, Anjali J Shastri, Ellen A Robey, Nilabh Shastri
Nat Immunol. Author manuscript; available in PMC 2016 Aug 8.
Published in final edited form as: Nat Immunol. 2008 Aug; 9(8): 937–944. Published online 2008 Jun 29. doi: 10.1038/ni.1629
PMCID:
PMC4976627
AbstractArticlePDF–489K
16.
ERAAP shapes the peptidome associated with classical and non-classical MHC class I molecules
Niranjana A. Nagarajan, Danielle A. de Verteuil, Dev Sriranganadane, Wafaa Yahyaoui, Pierre Thibault, Claude Perreault, Nilabh Shastri
J Immunol. Author manuscript; available in PMC 2017 Aug 15.
Published in final edited form as: J Immunol. 2016 Aug 15; 197(4): 1035–1043. Published online 2016 Jul 1. doi: 10.4049/jimmunol.1500654
PMCID:
PMC4976029
AbstractArticlePDF–1.3M
17.
ERAP1 functions override the intrinsic selection of specific antigens as immunodominant peptides, thereby altering the potency of antigen-specific cytolytic and effector memory T-cell responses
David P. W. Rastall, Yasser A. Aldhamen, Sergey S. Seregin, Sarah Godbehere, Andrea Amalfitano
Int Immunol. 2014 Dec; 26(12): 685–695. Published online 2014 Aug 2. doi: 10.1093/intimm/dxu078
PMCID:
PMC4574741
AbstractArticlePDF–2.1M
18.
Functionally distinct ERAP1 allotype combinations distinguish individuals with Ankylosing Spondylitis
Emma Reeves, Alexandra Colebatch-Bourn, Tim Elliott, Christopher J. Edwards, Edward James
Proc Natl Acad Sci U S A. 2014 Dec 9; 111(49): 17594–17599. Published online 2014 Nov 24. doi: 10.1073/pnas.1408882111
PMCID:
PMC4267330
AbstractArticlePDF–1017K
19.
Impact of regulated secretion on anti-parasitic CD8 T cell responses
Harshita Satija Grover, H. Hamlet Chu, Felice D. Kelly, Soo Jung Yang, Michael L. Reese, Nicolas Blanchard, Federico Gonzalez, Shiao Wei Chan, John C. Boothroyd, Nilabh Shastri, Ellen A. Robey
Cell Rep. Author manuscript; available in PMC 2015 Jun 12.
Published in final edited form as: Cell Rep. 2014 Jun 12; 7(5): 1716–1728. Published online 2014 May 22. doi: 10.1016/j.celrep.2014.04.031
PMCID:
PMC4057976
AbstractArticlePDF–2.4M
20.
Rationally designed inhibitor targeting antigen-trimming aminopeptidases enhances antigen presentation and cytotoxic T-cell responses
Efthalia Zervoudi, Emmanuel Saridakis, James R. Birtley, Sergey S. Seregin, Emma Reeves, Paraskevi Kokkala, Yasser A. Aldhamen, Andrea Amalfitano, Irene M. Mavridis, Edward James, Dimitris Georgiadis, Efstratios Stratikos
Proc Natl Acad Sci U S A. 2013 Dec 3; 110(49): 19890–19895. Published online 2013 Nov 18. doi: 10.1073/pnas.1309781110
PMCID:
PMC3856834
AbstractArticlePDF–899K

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