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Select item 111724741.

Transcriptional Up-Regulation of FBXW7 by K_Ca1.1 K⁺ Channel Inhibition through the Nrf2 Signaling Pathway in Human Prostate Cancer LNCaP Cell Spheroid Model

Susumu Ohya, Hiroaki Kito, Junko Kajikuri, Yohei Yamaguchi, Miki Matsui

Int J Mol Sci. 2024 Jun; 25(11): 6019. Published online 2024 May 30. doi: 10.3390/ijms25116019

PMCID:: PMC11172474

Abstract Article PDF–3.0M

Select item 111594952.

Fbxw7 contributes to tumor suppression by targeting multiple proteins for ubiquitin‐dependent degradation

Yo Fujii, Masayoshi Yada, Masaaki Nishiyama, Takumi Kamura, Hidehisa Takahashi, Ryosuke Tsunematsu, Etsuo Susaki, Tadashi Nakagawa, Akinobu Matsumoto, Keiichi I. Nakayama

Cancer Sci. 2006 Aug; 97(8): 729–736. Published online 2006 Jul 4. doi: 10.1111/j.1349-7006.2006.00239.x

PMCID:: PMC11159495

Abstract Article PDF–359K

Select item 110720943.

AUF1 protects against ferroptosis to alleviate sepsis-induced acute lung injury by regulating NRF2 and ATF3

Yichun Wang, Diyu Chen, Han Xie, Mingwang Jia, Xiaofang Sun, Fang Peng, Feifei Guo, Daolin Tang

Cell Mol Life Sci. 2022 May; 79(5): 228. Published online 2022 Apr 7. doi: 10.1007/s00018-022-04248-8

PMCID:: PMC11072094

Abstract Article PDF–11M

Select item 110720124.

E3-ubiquitin ligase, FBXW7 regulates mitotic progression by targeting BubR1 for ubiquitin-mediated degradation

Vishnu M. Nair, Amit Santhu Sabu, Ahmed Hussain, Delvin P. Kombarakkaran, R. Bhagya Lakshmi, Tapas K. Manna

Cell Mol Life Sci. 2023 Dec; 80(12): 374. Published online 2023 Nov 26. doi: 10.1007/s00018-023-05019-9

PMCID:: PMC11072012

Abstract Article PDF–11M

Select item 110267295.

The SCF-FBW7β E3 ligase mediates ubiquitination and degradation of the serine/threonine protein kinase PINK1

Seo Jeong Jeon, Kwang Chul Chung

J Biol Chem. 2024 Apr; 300(4): 107198. Published online 2024 Mar 18. doi: 10.1016/j.jbc.2024.107198

PMCID:: PMC11026729

Abstract Article PDF–4.8M

Select item 109629676.

Epidermal growth factor receptor (EGFR) is a target of the tumor-suppressor E3 ligase FBXW7

Matteo Boretto, Maarten H. Geurts, Shashank Gandhi, Ziliang Ma, Nadzeya Staliarova, Martina Celotti, Sangho Lim, Gui-Wei He, Rosemary Millen, Else Driehuis, Harry Begthel, Lidwien Smabers, Jeanine Roodhart, Johan van Es, Wei Wu, Hans Clevers

Proc Natl Acad Sci U S A. 2024 Mar 19; 121(12): e2309902121. Published online 2024 Mar 14. doi: 10.1073/pnas.2309902121

PMCID:: PMC10962967

Abstract Article PDF–5.5M

Select item 109200867.

ASPM stabilizes the NOTCH intracellular domain 1 and promotes oncogenesis by blocking FBXW7 binding in hepatocellular carcinoma cells

Tze‐Sian Chan, Li‐Hsin Cheng, Chung‐Chi Hsu, Pei‐Ming Yang, Tai‐Yan Liao, Hsiao‐Yen Hsieh, Pei‐Chun Lin, Wei‐Chun HuangFu, Chih‐Pin Chuu, Kelvin K. Tsai

Mol Oncol. 2024 Mar; 18(3): 562–579. Published online 2024 Jan 26. doi: 10.1002/1878-0261.13589

PMCID:: PMC10920086

Abstract Article PDF–6.1M

Select item 108508188.

Cancer‐associated FBXW7 loss is synthetic lethal with pharmacological targeting of CDC7

Joseph S. Baxter, Rachel Brough, Dragomir B. Krastev, Feifei Song, Sandhya Sridhar, Aditi Gulati, John Alexander, Theodoros I. Roumeliotis, Zuza Kozik, Jyoti S. Choudhary, Syed Haider, Stephen J. Pettitt, Andrew N. J. Tutt, Christopher J. Lord

Mol Oncol. 2024 Feb; 18(2): 369–385. Published online 2023 Oct 22. doi: 10.1002/1878-0261.13537

PMCID:: PMC10850818

Abstract Article PDF–2.7M

Select item 108097689.

Fbxw7 suppresses carcinogenesis and stemness in triple-negative breast cancer through CHD4 degradation and Wnt/β-catenin pathway inhibition

Guodong Xiao, Weiping Lu, Jing Yuan, Zuyue Liu, Peili Wang, Huijie Fan

J Transl Med. 2024; 22: 99. Published online 2024 Jan 24. doi: 10.1186/s12967-024-04897-2

PMCID:: PMC10809768

Abstract Article PDF–6.6M

Select item 1073438910.

FBXW7-loss Sensitizes Cells to ATR Inhibition Through Induced Mitotic Catastrophe

Siobhan O'Brien, Tajinder Ubhi, Lucie Wolf, Krishna Gandhi, Sichun Lin, Naz Chaudary, Neesha C. Dhani, Michael Milosevic, Grant W. Brown, Stephane Angers

Cancer Res Commun. 2023 Dec; 3(12): 2596–2607. Published online 2023 Dec 21. doi: 10.1158/2767-9764.CRC-23-0306

PMCID:: PMC10734389

Abstract Article PDF–11M

Select item 1050940611.

FBXW7 Enhances Cisplatin-Induced Apoptosis in Oral Cancer Cell Lines

Qi Yang, Yang Sun, Bo Qiu, Huanhuan Zhao

Int Dent J. 2023 Oct; 73(5): 620–627. Published online 2022 Dec 5. doi: 10.1016/j.identj.2022.11.008

PMCID:: PMC10509406

Abstract Article PDF–1.4M

Select item 1049589912.

Epigenetic Status of FBXW7 Gene and Its Role in Ovarian Cancer Pathogenesis

Meerah Al Hinai, Shika Hanif Malgundkar, Ishita Gupta, Ritu Lakhtakia, Moza Al Kalbani, Ikram Burney, Mansour Al Moundhri, Aikou Okamoto, Yahya Tamimi

Asian Pac J Cancer Prev. 2023; 24(5): 1583–1590. doi: 10.31557/APJCP.2023.24.5.1583

PMCID:: PMC10495899

Abstract Article PDF–1.2M

Select item 1048680313.

The Highs and Lows of FBXW7: New Insights into Substrate Affinity in Disease and Development

Claire C. de la Cova

Cells. 2023 Sep; 12(17): 2141. Published online 2023 Aug 24. doi: 10.3390/cells12172141

PMCID:: PMC10486803

Abstract Article PDF–1.7M

Select item 1047466614.

FBXW7 in breast cancer: mechanism of action and therapeutic potential

Siyu Chen, Ping Leng, Jinlin Guo, Hao Zhou

J Exp Clin Cancer Res. 2023; 42: 226. Published online 2023 Sep 2. doi: 10.1186/s13046-023-02767-1

PMCID:: PMC10474666

Abstract Article PDF–2.6M

Select item 1031451915.

Enhancement of TKI sensitivity in lung adenocarcinoma through m6A-dependent translational repression of Wnt signaling by circ-FBXW7

Kai Li, Zi-Yang Peng, Rui Wang, Xiang Li, Ning Du, Da-Peng Liu, Jia Zhang, Yun-Feng Zhang, Lei Ma, Ye Sun, Shou-Ching Tang, Hong Ren, Yi-Ping Yang, Xin Sun

Mol Cancer. 2023; 22: 103. Published online 2023 Jul 1. doi: 10.1186/s12943-023-01811-0

PMCID:: PMC10314519

Abstract Article PDF–8.4M

Select item 1021667216.

The Role of FBXW7 in Gynecologic Malignancies

Riccardo Di Fiore, Sherif Suleiman, Rosa Drago-Ferrante, Yashwanth Subbannayya, Sarah Suleiman, Mariela Vasileva-Slaveva, Angel Yordanov, Francesca Pentimalli, Antonio Giordano, Jean Calleja-Agius

Cells. 2023 May; 12(10): 1415. Published online 2023 May 17. doi: 10.3390/cells12101415

PMCID:: PMC10216672

Abstract Article PDF–1.6M

Select item 1019579417.

FBXW7β loss-of-function enhances FASN-mediated lipogenesis and promotes colorectal cancer growth

Wenxia Wei, Baifu Qin, Weijie Wen, Boyu Zhang, Haidan Luo, Yuzhi Wang, Hui Xu, Xiaoshan Xie, Sicheng Liu, Xin Jiang, Mengan Wang, Qin Tang, Jiayu Zhang, Runxiang Yang, Zongmin Fan, Haiwen Lyu, Junzhong Lin, Kai Li, Mong-Hong Lee

Signal Transduct Target Ther. 2023; 8: 187. Published online 2023 May 19. doi: 10.1038/s41392-023-01405-8