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Select item 111132641.

Ercc1 DNA repair deficiency results in vascular aging characterized by VSMC phenotype switching, ECM remodeling, and an increased stress response

Janette van der Linden, Sanne J. M. Stefens, José María Heredia‐Genestar, Yanto Ridwan, Renata M. C. Brandt, Nicole van Vliet, Isa de Beer, Bibi S. van Thiel, Herman Steen, Caroline Cheng, Anton J. M. Roks, A. H. Jan Danser, Jeroen Essers, Ingrid van der Pluijm

Aging Cell. 2024 May; 23(5): e14126. Published online 2024 Mar 7. doi: 10.1111/acel.14126

PMCID:: PMC11113264

Abstract Article PDF–49M

Select item 105846892.

Fanconi anemia DNA crosslink repair factors protect against LINE-1 retrotransposition during mouse development

Nazareno Bona, Gerry P. Crossan

Nat Struct Mol Biol. 2023; 30(10): 1434–1445. Published online 2023 Aug 14. doi: 10.1038/s41594-023-01067-8

PMCID:: PMC10584689

Abstract Article PDF–9.2M

Select item 102049553.

Hypoxia extends lifespan and neurological function in a mouse model of aging

Robert S. Rogers, Hong Wang, Timothy J. Durham, Jonathan A. Stefely, Norah A. Owiti, Andrew L. Markhard, Lev Sandler, Tsz-Leung To, Vamsi K. Mootha

PLoS Biol. 2023 May; 21(5): e3002117. Published online 2023 May 23. doi: 10.1371/journal.pbio.3002117

PMCID:: PMC10204955

Abstract Article PDF–1.3M

Select item 99253834.

Genome-wide RNA polymerase stalling shapes the transcriptome during aging

Akos Gyenis, Jiang Chang, Joris J. P. G. Demmers, Serena T. Bruens, Sander Barnhoorn, Renata M. C. Brandt, Marjolein P. Baar, Marko Raseta, Kasper W. J. Derks, Jan H. J. Hoeijmakers, Joris Pothof

Nat Genet. 2023; 55(2): 268–279. Published online 2023 Jan 19. doi: 10.1038/s41588-022-01279-6

PMCID:: PMC9925383

Abstract Article PDF–10M

Select item 99025925.

Purkinje-cell-specific DNA repair-deficient mice reveal that dietary restriction protects neurons by cell-intrinsic preservation of genomic health

María Björk Birkisdóttir, Lisanne J. Van’t Sant, Renata M. C. Brandt, Sander Barnhoorn, Jan H. J. Hoeijmakers, Wilbert P. Vermeij, Dick Jaarsma

Front Aging Neurosci. 2022; 14: 1095801. Published online 2023 Jan 24. doi: 10.3389/fnagi.2022.1095801

PMCID:: PMC9902592

Abstract Article PDF–2.3M

Select item 86727816.

Novel small molecule inhibition of IKK/NF‐κB activation reduces markers of senescence and improves healthspan in mouse models of aging

Lei Zhang, Jing Zhao, Xiaodong Mu, Sara J. McGowan, Luise Angelini, Ryan D. O'Kelly, Matthew J. Yousefzadeh, Ayumi Sakamoto, Zaira Aversa, Nathan K. LeBrasseur, Yousin Suh, Johnny Huard, Theodore M. Kamenecka, Laura J. Niedernhofer, Paul D. Robbins

Aging Cell. 2021 Dec; 20(12): e13486. Published online 2021 Nov 3. doi: 10.1111/acel.13486

PMCID:: PMC8672781

Abstract Article PDF–2.2M

Select item 86255167.

Increased insulin sensitivity and diminished pancreatic beta-cell function in DNA repair deficient Ercc1^d/− mice

Ana P. Huerta Guevara, Sara J. McGowan, Melissa Kazantzis, Tania Rozgaja Stallons, Tokio Sano, Niels L. Mulder, Angelika Jurdzinski, Theo H. van Dijk, Bart J.L. Eggen, Johan W. Jonker, Laura J. Niedernhofer, Janine K. Kruit

Metabolism. Author manuscript; available in PMC 2021 Nov 26.

Published in final edited form as: Metabolism. 2021 Apr; 117: 154711. Published online 2021 Jan 23. doi: 10.1016/j.metabol.2021.154711

PMCID:: PMC8625516

Abstract Article PDF–1.6M

Select item 86195498.

In Vivo Renin Activity Imaging in the Kidney of Progeroid Ercc1 Mutant Mice

Bibi S. van Thiel, Janette van der Linden, Yanto Ridwan, Ingrid M. Garrelds, Marcel Vermeij, Marian C. Clahsen-van Groningen, Fatimunnisa Qadri, Natalia Alenina, Michael Bader, Anton J. M. Roks, A. H. Jan Danser, Jeroen Essers, Ingrid van der Pluijm

Int J Mol Sci. 2021 Nov; 22(22): 12433. Published online 2021 Nov 18. doi: 10.3390/ijms222212433

PMCID:: PMC8619549

Abstract Article PDF–2.0M

Select item 84235759.

Vascular Ageing Features Caused by Selective DNA Damage in Smooth Muscle Cell

Ehsan Ataei Ataabadi, Keivan Golshiri, Janette van der Linden, Martine de Boer, Dirk J. Duncker, Annika Jüttner, René de Vries, Richard Van Veghel, Ingrid van der Pluijm, Sophie Dutheil, Suman Chalgeri, Lei Zhang, Amy Lin, Robert E. Davis, Gretchen L. Snyder, A. H. Jan Danser, Anton J. M. Roks

Oxid Med Cell Longev. 2021; 2021: 2308317. Published online 2021 Aug 31. doi: 10.1155/2021/2308317

PMCID:: PMC8423575

Abstract Article PDF–2.2M

Select item 813900110.

In vivo 5-ethynyluridine (EU) labelling detects reduced transcription in Purkinje cell degeneration mouse mutants, but can itself induce neurodegeneration

Lisanne J. van’t Sant, Joshua J. White, Jan H. J. Hoeijmakers, Wilbert P. Vermeij, Dick Jaarsma

Acta Neuropathol Commun. 2021; 9: 94. Published online 2021 May 21. doi: 10.1186/s40478-021-01200-y

PMCID:: PMC8139001

Abstract Article PDF–6.1M

Select item 782130111.

Intrinsic DNA damage repair deficiency results in progressive microglia loss and replacement

Xiaoming Zhang, Yang Heng, Susanne M. Kooistra, Hilmar R. J. van Weering, Maaike L. Brummer, Emma Gerrits, Evelyn M. Wesseling, Nieske Brouwer, Tjalling W. Nijboer, Marissa L. Dubbelaar, Erik W. G. M. Boddeke, Bart J. L. Eggen

Glia. 2021 Mar; 69(3): 729–745. Published online 2020 Oct 17. doi: 10.1002/glia.23925

PMCID:: PMC7821301

Abstract Article PDF–9.9M

Select item 740696912.

Attenuation of ataxia telangiectasia mutated signalling mitigates age‐associated intervertebral disc degeneration

Yingchao Han, Chao‐Ming Zhou, Hongxing Shen, Jun Tan, Qing Dong, Lei Zhang, Sara J. McGowan, Jing Zhao, Gwendolyn A. Sowa, James D. Kang, Laura J. Niedernhofer, Paul D. Robbins, Nam N. Vo

Aging Cell. 2020 Jul; 19(7): e13162. Published online 2020 Jun 21. doi: 10.1111/acel.13162

PMCID:: PMC7406969

Abstract Article PDF–23M

Select item 723500713.

Dichotomy between the transcriptomic landscape of naturally versus accelerated aged murine hearts

Federica De Majo, Jana-Charlotte Hegenbarth, Frank Rühle, Christian Bär, Thomas Thum, Martine de Boer, Dirk J. Duncker, Blanche Schroen, Anne-Sophie Armand, Monika Stoll, Leon J. De Windt

Sci Rep. 2020; 10: 8136. Published online 2020 May 18. doi: 10.1038/s41598-020-65115-9

PMCID:: PMC7235007

Abstract Article PDF–5.4M

Select item 722702814.

Mouse Models of Inherited Retinal Degeneration with Photoreceptor Cell Loss

Gayle B. Collin, Navdeep Gogna, Bo Chang, Nattaya Damkham, Jai Pinkney, Lillian F. Hyde, Lisa Stone, Jürgen K. Naggert, Patsy M. Nishina, Mark P. Krebs

Cells. 2020 Apr; 9(4): 931. Published online 2020 Apr 10. doi: 10.3390/cells9040931

PMCID:: PMC7227028

Abstract Article PDF–5.4M

Select item 714496315.

XPF-ERCC1 protects liver, kidney and blood homeostasis outside the canonical excision repair pathways

Lee Mulderrig, Juan I. Garaycoechea

PLoS Genet. 2020 Apr; 16(4): e1008555. Published online 2020 Apr 9. doi: 10.1371/journal.pgen.1008555

PMCID:: PMC7144963

Abstract Article PDF–3.1M

Select item 705916716.

Deficiency in the DNA repair protein ERCC1 triggers a link between senescence and apoptosis in human fibroblasts and mouse skin

Dong Eun Kim, Martijn E. T. Dollé, Wilbert P. Vermeij, Akos Gyenis, Katharina Vogel, Jan H. J. Hoeijmakers, Christopher D. Wiley, Albert R. Davalos, Paul Hasty, Pierre‐Yves Desprez, Judith Campisi

Aging Cell. 2020 Mar; 19(3): e13072. Published online 2019 Nov 18. doi: 10.1111/acel.13072

PMCID:: PMC7059167

Abstract Article PDF–1.9M

Select item 705916517.

Tissue specificity of senescent cell accumulation during physiologic and accelerated aging of mice

Matthew J. Yousefzadeh, Jing Zhao, Christina Bukata, Erin A. Wade, Sara J. McGowan, Luise A. Angelini, Michael P. Bank, Aditi U. Gurkar, Collin A. McGuckian, Mariah F. Calubag, Jonathan I. Kato, Christin E. Burd, Paul D. Robbins, Laura J. Niedernhofer

Aging Cell. 2020 Mar; 19(3): e13094. Published online 2020 Jan 25. doi: 10.1111/acel.13094

PMCID:: PMC7059165

Abstract Article PDF–1.3M

Select item 694036218.

Tissue-infiltrating macrophages mediate an exosome-based metabolic reprogramming upon DNA damage

Evi Goulielmaki, Anna Ioannidou, Maria Tsekrekou, Kalliopi Stratigi, Ioanna K. Poutakidou, Katerina Gkirtzimanaki, Michalis Aivaliotis, Konstantinos Evangelou, Pantelis Topalis, Janine Altmüller, Vassilis G. Gorgoulis, Georgia Chatzinikolaou, George A. Garinis

Nat Commun. 2020; 11: 42. Published online 2020 Jan 2. doi: 10.1038/s41467-019-13894-9

PMCID:: PMC6940362

Abstract Article PDF–7.1M

Select item 681473719.

DNA damage and transcription stress cause ATP-mediated redesign of metabolism and potentiation of anti-oxidant buffering

Chiara Milanese, Cíntia R. Bombardieri, Sara Sepe, Sander Barnhoorn, César Payán-Goméz, Donatella Caruso, Matteo Audano, Silvia Pedretti, Wilbert P. Vermeij, Renata M. C. Brandt, Akos Gyenis, Mirjam M. Wamelink, Annelieke S. de Wit, Roel C. Janssens, René Leen, André B. P. van Kuilenburg, Nico Mitro, Jan H. J. Hoeijmakers, Pier G. Mastroberardino

Nat Commun. 2019; 10: 4887. Published online 2019 Oct 25. doi: 10.1038/s41467-019-12640-5

PMCID:: PMC6814737

Abstract Article PDF–2.7M

Select item 670327120.

Accelerated Age-Related Cognitive Decline and Neurodegeneration, Caused by Deficient DNA Repair

Nils Z. Borgesius, Monique C. de Waard, Ingrid van der Pluijm, Azar Omrani, Gerben C. M. Zondag, Gijsbertus T. J. van der Horst, David W. Melton, Jan H. J. Hoeijmakers, Dick Jaarsma, Ype Elgersma

J Neurosci. 2011 Aug 31; 31(35): 12543–12553. doi: 10.1523/JNEUROSCI.1589-11.2011

PMCID:: PMC6703271

Abstract Article PDF–3.1M

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