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Select item 111552641.

Lineage-specific intolerance to oncogenic drivers restricts histological transformation

Eric E. Gardner, Ethan M. Earlie, Kate Li, Jerin Thomas, Melissa J. Hubisz, Benjamin D. Stein, Chen Zhang, Lewis C. Cantley, Ashley M. Laughney, Harold Varmus

Science. Author manuscript; available in PMC 2024 Jun 6.

Published in final edited form as: Science. 2024 Feb 9; 383(6683): eadj1415. Published online 2024 Feb 9. doi: 10.1126/science.adj1415

PMCID:: PMC11155264

Abstract Article PDF–2.7M

Select item 111268282.

Autophagy Contributes to Homeostasis in Esophageal Epithelium Where High Autophagic Vesicle Level Marks Basal Cells With Limited Proliferation and Enhanced Self-Renewal Potential

Alena Klochkova, Adam L. Karami, Annie D. Fuller, Louis R. Parham, Surali R. Panchani, Shruthi Natarajan, Jazmyne L. Jackson, Anbin Mu, Yinfei Tan, Kathy Q. Cai, Andres J. Klein-Szanto, Amanda B. Muir, Marie-Pier Tétreault, Xavier Graña, Kathryn E. Hamilton, Kelly A. Whelan

Cell Mol Gastroenterol Hepatol. 2024; 18(1): 15–40. Published online 2024 Mar 5. doi: 10.1016/j.jcmgh.2024.02.018

PMCID:: PMC11126828

Abstract Article PDF–8.9M

Select item 110943713.

Insulin receptor signaling engages bladder urothelial defenses that limit urinary tract infection

Laura Schwartz, Kristin Salamon, Aaron Simoni, Tad Eichler, Ashley R. Jackson, Matthew Murtha, Brian Becknell, Andrew Kauffman, Sarah Linn-Peirano, Natalie Holdsworth, Vidhi Tyagi, Hancong Tang, Steve Rust, Hanna Cortado, Irina Zabbarova, Anthony Kanai, John David Spencer

Cell Rep. Author manuscript; available in PMC 2024 May 15.

Published in final edited form as: Cell Rep. 2024 Apr 23; 43(4): 114007. Published online 2024 Mar 21. doi: 10.1016/j.celrep.2024.114007

PMCID:: PMC11094371

Abstract Article PDF–2.5M

Select item 110812244.

ΔNp63 regulates Sfrp1 expression to direct salivary gland branching morphogenesis

Theresa Wrynn, Sangwon Min, Erich Horeth, Jason Osinski, Satrajit Sinha, Rose-Anne Romano

PLoS One. 2024; 19(5): e0301082. Published online 2024 May 9. doi: 10.1371/journal.pone.0301082

PMCID:: PMC11081224

Abstract Article PDF–7.0M

Select item 110041805.

Decoding spatiotemporal transcriptional dynamics and epithelial fibroblast crosstalk during gastroesophageal junction development through single cell analysis

Naveen Kumar, Pon Ganish Prakash, Christian Wentland, Shilpa Mary Kurian, Gaurav Jethva, Volker Brinkmann, Hans-Joachim Mollenkopf, Tobias Krammer, Christophe Toussaint, Antoine-Emmanuel Saliba, Matthias Biebl, Christian Jürgensen, Bertram Wiedenmann, Thomas F. Meyer, Rajendra Kumar Gurumurthy, Cindrilla Chumduri

Nat Commun. 2024; 15: 3064. Published online 2024 Apr 9. doi: 10.1038/s41467-024-47173-z

PMCID:: PMC11004180

Abstract Article PDF–23M

Select item 109876626.

Metabolic rewiring of macrophages by epidermal-derived lactate promotes sterile inflammation in the murine skin

Uttkarsh Ayyangar, Aneesh Karkhanis, Heather Tay, Aliya Farissa Binte Afandi, Oindrila Bhattacharjee, Lalitha KS, Sze Han Lee, James Chan, Srikala Raghavan

EMBO J. 2024 Apr; 43(7): 1113–1134. Published online 2024 Feb 28. doi: 10.1038/s44318-024-00039-y

PMCID:: PMC10987662

Abstract Article PDF–12M

Select item 109524837.

Dysregulation of Grainyhead‐like 3 expression causes widespread developmental defects

Zihao Deng, Tariq Butt, Benedicta D. Arhatari, Charbel Darido, Alana Auden, Dijina Swaroop, Darren D. Partridge, Katharina Haigh, Thao Nguyen, Jody J. Haigh, Marina R. Carpinelli, Stephen M. Jane

Dev Dyn. 2023 May; 252(5): 647–667. Published online 2023 Jan 19. doi: 10.1002/dvdy.565

PMCID:: PMC10952483

Abstract Article PDF–23M

Select item 109176608.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 108811549.

LGN loss randomizes spindle orientation and accelerates tumorigenesis in PTEN-deficient epidermis

Sophie Viala, Charlotte Hadjadj, Vandana Nathan, Marie-Christine Guiot, Luke McCaffrey, Katie Cockburn, Maxime Bouchard

Mol Biol Cell. 2024 Feb 1; 35(2): br5. Published online 2024 Jan 12. doi: 10.1091/mbc.E23-03-0111

PMCID:: PMC10881154

Abstract Article PDF–5.9M

Select item 1086666210.

KCTD1/KCTD15 complexes control ectodermal and neural crest cell functions, and their impairment causes aplasia cutis

Jackelyn R. Raymundo, Hui Zhang, Giovanni Smaldone, Wenjuan Zhu, Kathleen E. Daly, Benjamin J. Glennon, Giovanni Pecoraro, Marco Salvatore, William A. Devine, Cecilia W. Lo, Luigi Vitagliano, Alexander G. Marneros

J Clin Invest. 2024 Feb 15; 134(4): e174138. Published online 2023 Dec 19. doi: 10.1172/JCI174138

PMCID:: PMC10866662

Abstract Article PDF–143M

Select item 1068293411.

Functional redundancy of frizzled 3 and frizzled 6 in planar cell polarity control of mouse hair follicles

Bo Dong, Samantha Vold, Cristina Olvera-Jaramillo, Hao Chang

Development. 2018 Oct 1; 145(19): dev168468. Published online 2018 Oct 8. doi: 10.1242/dev.168468

PMCID:: PMC10682934

Abstract Article

Select item 1067966112.

Polycomb repressive complex 2 regulates basal cell fate during adult olfactory neurogenesis

Tiffany Ko, Rhea Choi, Khalil Issa, Rupali Gupta, Edward Llinas, Lluis Morey, John B. Finlay, Bradley J. Goldstein

Stem Cell Reports. 2023 Nov 14; 18(11): 2283–2296. Published online 2023 Oct 12. doi: 10.1016/j.stemcr.2023.09.008

PMCID:: PMC10679661

Abstract Article PDF–3.6M

Select item 1065642713.

GATA6 is a crucial factor for Myocd expression in the visceral smooth muscle cell differentiation program of the murine ureter

Jennifer Kurz, Anna-Carina Weiss, Timo H.-W. Lüdtke, Lena Deuper, Mark-Oliver Trowe, Hauke Thiesler, Herbert Hildebrandt, Joerg Heineke, Stephen A. Duncan, Andreas Kispert

Development. 2022 Aug 1; 149(15): dev200522. Published online 2022 Jul 29. doi: 10.1242/dev.200522

PMCID:: PMC10656427

Abstract Article

Select item 1059167214.

Distinct mechanisms for sebaceous gland self-renewal and regeneration provide durability in response to injury

Natalia A. Veniaminova, Yunlong Y. Jia, Adrien M. Hartigan, Thomas J. Huyge, Shih-Ying Tsai, Marina Grachtchouk, Seitaro Nakagawa, Andrzej A. Dlugosz, Scott X. Atwood, Sunny Y. Wong

Cell Rep. Author manuscript; available in PMC 2023 Oct 23.

Published in final edited form as: Cell Rep. 2023 Sep 26; 42(9): 113121. Published online 2023 Sep 19. doi: 10.1016/j.celrep.2023.113121

PMCID:: PMC10591672

Abstract Article PDF–3.4M

Select item 1057681115.

FGFR2 is essential for salivary gland duct homeostasis and MAPK-dependent seromucous acinar cell differentiation

Marit H. Aure, Jennifer M. Symonds, Carlos U. Villapudua, Joshua T. Dodge, Sabine Werner, Wendy M. Knosp, Matthew P. Hoffman

Nat Commun. 2023; 14: 6485. Published online 2023 Oct 14. doi: 10.1038/s41467-023-42243-0

PMCID:: PMC10576811

Abstract Article PDF–17M

Select item 1050917716.

Epithelial plasticity and innate immune activation promote lung tissue remodeling following respiratory viral infection

Andrew K. Beppu, Juanjuan Zhao, Changfu Yao, Gianni Carraro, Edo Israely, Anna Lucia Coelho, Katherine Drake, Cory M. Hogaboam, William C. Parks, Jay K. Kolls, Barry R. Stripp

Nat Commun. 2023; 14: 5814. Published online 2023 Sep 19. doi: 10.1038/s41467-023-41387-3

PMCID:: PMC10509177

Abstract Article PDF–7.1M

Select item 1039213717.

Prmt5 promotes ciliated cell specification of airway epithelial progenitors via transcriptional inhibition of Tp63

Qiuling Li, Jie Jiao, Ya Heng, Qingshuang Lu, Yu Zheng, Huijun Li, Jun Cai, Mei Mei, Shilai Bao

J Biol Chem. 2023 Aug; 299(8): 104964. Published online 2023 Jun 24. doi: 10.1016/j.jbc.2023.104964

PMCID:: PMC10392137

Abstract Article PDF–4.2M

Select item 1036206218.

MOF-mediated histone H4 Lysine 16 acetylation governs mitochondrial and ciliary functions by controlling gene promoters

Dongmei Wang, Haimin Li, Navdeep S. Chandel, Yali Dou, Rui Yi

Nat Commun. 2023; 14: 4404. Published online 2023 Jul 21. doi: 10.1038/s41467-023-40108-0

PMCID:: PMC10362062

Abstract Article PDF–9.3M

Select item 1030631019.

Skin γδ T cell inflammatory responses are hardwired in the thymus by oxysterol sensing via GPR183 and calibrated by dietary cholesterol

Michela Frascoli, Enxhi Ferraj, Bing Miu, Justin Malin, Nicholas Spidale, Jennifer Cowan, Susannah C. Shissler, Robert Brink, Ying Xu, Jason G. Cyster, Avinash Bhandoola, Joonsoo Kang, Andrea Reboldi

Immunity. Author manuscript; available in PMC 2024 Mar 14.

Published in final edited form as: Immunity. 2023 Mar 14; 56(3): 562–575.e6. Published online 2023 Feb 25. doi: 10.1016/j.immuni.2023.01.025

PMCID:: PMC10306310

Abstract Article PDF–1.8M

Select item 1028107620.

T helper 1 effector memory CD4⁺ T cells protect the skin from poxvirus infection

Jake C. Harbour, Mahmoud Abdelbary, John B. Schell, Samantha P. Fancher, Jack J. McLean, Taylen J. Nappi, Susan Liu, Timothy J. Nice, Zheng Xia, Klaus Früh, Jeffrey C. Nolz

Cell Rep. Author manuscript; available in PMC 2023 Jun 20.

Published in final edited form as: Cell Rep. 2023 May 30; 42(5): 112407. Published online 2023 Apr 21. doi: 10.1016/j.celrep.2023.112407

PMCID:: PMC10281076

Abstract Article PDF–3.6M

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