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Items: 1 to 20 of 63

1.
ZFYVE19 deficiency: a ciliopathy involving failure of cell division, with cell death
Jing Yang, Ya-Nan Zhang, Ren-Xue Wang, Chen-Zhi Hao, Yiling Qiu, Hao Chi, Wei-Sha Luan, HongYi Tang, Xiu-Juan Zhang, XuXu Sun, Jonathan A Sheps, Victor Ling, Muqing Cao, Jian-she Wang
J Med Genet. 2024 Aug; 61(8): 750–758. Published online 2024 May 30. doi: 10.1136/jmg-2023-109779
PMCID:
PMC11287636
AbstractArticlePDF–6.1M
2.
The GARP/Latent TGF-β1 complex on Treg cells modulates the induction of peripherally derived Treg cells during oral tolerance
Justin P. Edwards, Timothy W. Hand, Denise Morais da Fonseca, Deborah D. Glass, Yasmine Belkaid, Ethan M. Shevach
Eur J Immunol. Author manuscript; available in PMC 2024 Apr 17.
Published in final edited form as: Eur J Immunol. 2016 Jun; 46(6): 1480–1489. Published online 2016 Apr 23. doi: 10.1002/eji.201546204
PMCID:
PMC11022272
AbstractArticlePDF–1.9M
3.
Genetic determinants of micronucleus formation in vivo
D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus
Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0
PMCID:
PMC10917660
AbstractArticlePDF–4.8M
4.
APOE4 impairs the microglial response in Alzheimer’s disease by inducing TGFβ-mediated checkpoints
Zhuoran Yin, Neta Rosenzweig, Kilian L. Kleemann, Xiaoming Zhang, Wesley Brandão, Milica A. Margeta, Caitlin Schroeder, Kisha N. Sivanathan, Sebastian Silveira, Christian Gauthier, Dania Mallah, Kristen M. Pitts, Ana Durao, Shawn Herron, Hannah Shorey, Yiran Cheng, Jen-Li Barry, Rajesh K. Krishnan, Sam Wakelin, Jared Rhee, Anthony Yung, Michael Aronchik, Chao Wang, Nimansha Jain, Xin Bao, Emma Gerrits, Nieske Brouwer, Amy Deik, Daniel G. Tenen, Tsuneya Ikezu, Nicolas G. Santander, Gabriel L. McKinsey, Caroline Baufeld, Dean Sheppard, Susanne Krasemann, Roni Nowarski, Bart J.L. Eggen, Clary Clish, Rudolph E. Tanzi, Charlotte Madore, Thomas D. Arnold, David M. Holtzman, Oleg Butovsky
Nat Immunol. Author manuscript; available in PMC 2024 Nov 1.
Published in final edited form as: Nat Immunol. 2023 Nov; 24(11): 1839–1853. Published online 2023 Sep 25. doi: 10.1038/s41590-023-01627-6
PMCID:
PMC10863749
AbstractArticlePDF–8.5M
5.
Novel antigen-presenting cell imparts Treg-dependent tolerance to gut microbiota
Blossom Akagbosu, Zakieh Tayyebi, Gayathri Shibu, Yoselin A. Paucar Iza, Deeksha Deep, Yollanda Franco Parisotto, Logan Fisher, H. Amalia Pasolli, Valentin Thevin, Rasa Elmentaite, Maximilian Knott, Saskia Hemmers, Lorenz Jahn, Christin Friedrich, Jacob Verter, Zhong-Min Wang, Marcel van den Brink, Georg Gasteiger, Thomas G. P. Grünewald, Julien C. Marie, Christina Leslie, Alexander Y. Rudensky, Chrysothemis C. Brown
Nature. 2022; 610(7933): 752–760. Published online 2022 Sep 7. doi: 10.1038/s41586-022-05309-5
PMCID:
PMC9605865
AbstractArticlePDF–14M
6.
The β8 integrin cytoplasmic domain activates extracellular matrix adhesion to promote brain neurovascular development
Arpan De, John E. Morales, Zhihua Chen, Sumod Sebastian, Joseph H. McCarty
Development. 2022 Mar 15; 149(6): dev200472. Published online 2022 Mar 18. doi: 10.1242/dev.200472
PMCID:
PMC8977100
AbstractArticle
7.
Regulatory T cells promote innate inflammation following skin barrier breach via TGF-β activation
Joshua M. Moreau, Miqdad O. Dhariwala, Victoire Gouirand, Devi P. Boda, Ian C. Boothby, Margaret M. Lowe, Jarish N Cohen, Courtney E. Macon, John M. Leech, Lokesh A. Kalekar, Tiffany C. Scharschmidt, Michael D. Rosenblum
Sci Immunol. Author manuscript; available in PMC 2022 Mar 27.
Published in final edited form as: Sci Immunol. 2021 Aug 27; 6(62): eabg2329. doi: 10.1126/sciimmunol.abg2329
PMCID:
PMC8958044
AbstractArticlePDF–2.1M
8.
αVβ8 integrin targeting to prevent posterior capsular opacification
Mahbubul H. Shihan, Samuel G. Novo, Yan Wang, Dean Sheppard, Amha Atakilit, Thomas D. Arnold, Nicole M. Rossi, Adam P. Faranda, Melinda K. Duncan
JCI Insight. 2021 Nov 8; 6(21): e145715. Published online 2021 Nov 8. doi: 10.1172/jci.insight.145715
PMCID:
PMC8663568
AbstractArticlePDF–4.5M
9.
Regulatory T cells promote cancer immune-escape through integrin αvβ8-mediated TGF-β activation
Alexandra Lainé, Ossama Labiad, Hector Hernandez-Vargas, Sébastien This, Amélien Sanlaville, Sophie Léon, Stéphane Dalle, Dean Sheppard, Mark A. Travis, Helena Paidassi, Julien C. Marie
Nat Commun. 2021; 12: 6228. Published online 2021 Oct 28. doi: 10.1038/s41467-021-26352-2
PMCID:
PMC8553942
AbstractArticlePDF–3.2M
10.
Integrin αvβ8 on T cells suppresses anti-tumor immunity in multiple models and is a promising target for tumor immunotherapy
Eswari Dodagatta-Marri, Hsiao-Yen Ma, Benjia Liang, John Li, Dominique S. Meyer, Szu-Ying Chen, Kai-Hui Sun, Xin Ren, Bahar Zivak, Michael D. Rosenblum, Mark B. Headley, Lauren Pinzas, Nilgun I. Reed, Joselyn S. Del Cid, Byron C. Hann, Sharon Yang, Anand Giddabasappa, Kavon Noorbehesht, Bing Yang, Joseph Dal Porto, Tatsuya Tsukui, Kyle Niessen, Amha Atakilit, Rosemary J. Akhurst, Dean Sheppard
Cell Rep. Author manuscript; available in PMC 2021 Jul 29.
Published in final edited form as: Cell Rep. 2021 Jul 6; 36(1): 109309. doi: 10.1016/j.celrep.2021.109309
PMCID:
PMC8321414
AbstractArticlePDF–2.3M
11.
Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development
Francesco Bedogni, Robert F. Hevner
Front Mol Neurosci. 2021; 14: 686034. Published online 2021 Jul 12. doi: 10.3389/fnmol.2021.686034
PMCID:
PMC8313239
AbstractArticlePDF–1.6M
12.
Nonpeptidergic neurons suppress mast cells via glutamate to maintain skin homeostasis
Shiqun Zhang, Tara N. Edwards, Virendra K. Chaudhri, Jianing Wu, Jonathan A. Cohen, Toshiro Hirai, Natalie Rittenhouse, Elizabeth G. Schmitz, Paul Yifan Zhou, Benjamin D. McNeil, Yi Yang, H. Richard Koerber, Tina L. Sumpter, Amanda C. Poholek, Brian M. Davis, Kathryn M. Albers, Harinder Singh, Daniel H. Kaplan
Cell. Author manuscript; available in PMC 2022 Apr 15.
Published in final edited form as: Cell. 2021 Mar 18 : S0092-8674(21)00287-7. Published online 2021 Mar 18. doi: 10.1016/j.cell.2021.03.002
PMCID:
PMC8052305
AbstractArticlePDF–1.2M
13.
Competition for active TGFβ cytokine allows for selective retention of antigen-specific tissue resident memory T cells in the epidermal niche
Toshiro Hirai, Yi Yang, Yukari Zenke, Haiyue Li, Virendra K. Chaudhri, Jacinto S. De La Cruz Diaz, Paul Yifan Zhou, Breanna Anh-Thu Nguyen, Laurent Bartholin, Creg J. Workman, David W. Griggs, Dario A. A. Vignali, Harinder Singh, David Masopust, Daniel H. Kaplan
Immunity. Author manuscript; available in PMC 2022 Jan 12.
Published in final edited form as: Immunity. 2021 Jan 12; 54(1): 84–98.e5. Published online 2020 Nov 18. doi: 10.1016/j.immuni.2020.10.022
PMCID:
PMC7856016
AbstractArticlePDF–2.6M
14.
miR-222 regulates brain injury and inflammation following intracerebral hemorrhage by targeting ITGB8
Yan-Yan Bai, Jun-Zhi Niu
Mol Med Rep. 2020 Mar; 21(3): 1145–1153. Published online 2019 Dec 23. doi: 10.3892/mmr.2019.10903
PMCID:
PMC7003054
AbstractArticlePDF–1.2M
15.
Migratory DCs activate TGF-β to precondition naive CD8+ T cells for tissue-resident memory fate
Vinidhra Mani, Shannon K. Bromley, Tarmo Äijö, Rut Mora-Buch, Esteban Carrizosa, Ross D. Warner, Moustafa Hamze, Debattama R. Sen, Alexandra Y. Chasse, Alina Lorant, Jason W. Griffith, Rod A. Rahimi, Craig P. McEntee, Kate L. Jeffrey, Francesco Marangoni, Mark A. Travis, Adam Lacy-Hulbert, Andrew D. Luster, Thorsten R. Mempel
Science. Author manuscript; available in PMC 2020 Apr 11.
Published in final edited form as: Science. 2019 Oct 11; 366(6462): eaav5728. doi: 10.1126/science.aav5728
PMCID:
PMC6939608
AbstractArticlePDF–2.7M
16.
Keratinocyte-derived TGFβ is not required to maintain skin immune homeostasis
Yi Yang, Yukari Zenke, Toshiro Hirai, Daniel H. Kaplan
J Dermatol Sci. Author manuscript; available in PMC 2020 May 7.
Published in final edited form as: J Dermatol Sci. 2019 May; 94(2): 290–297. Published online 2019 May 7. doi: 10.1016/j.jdermsci.2019.04.008
Correction in:
J Dermatol Sci. 2019 Sep; 95(3): 134.
PMCID:
PMC6602918
AbstractArticlePDF–1.2M
17.
Keratinocyte-mediated activation of the cytokine TGFβ maintains skin-recirculating memory CD8+ T cells
Toshiro Hirai, Yukari Zenke, Yi Yang, Laurent Bartholin, Lalit K. Beura, David Masopust, Daniel H. Kaplan
Immunity. Author manuscript; available in PMC 2020 May 21.
Published in final edited form as: Immunity. 2019 May 21; 50(5): 1249–1261.e5. Published online 2019 Apr 2. doi: 10.1016/j.immuni.2019.03.002
PMCID:
PMC6531326
AbstractArticlePDF–1.8M
18.
Impaired αVβ8 and TGFβ signaling lead to microglial dysmaturation and neuromotor dysfunction
Thomas D. Arnold, Carlos O. Lizama, Kelly M. Cautivo, Nicolas Santander, Lucia Lin, Haiyan Qiu, Eric J. Huang, Chang Liu, Yoh-suke Mukouyama, Louis F. Reichardt, Ann C. Zovein, Dean Sheppard
J Exp Med. 2019 Apr 1; 216(4): 900–915. Published online 2019 Mar 7. doi: 10.1084/jem.20181290
PMCID:
PMC6446869
AbstractArticlePDF–5.1M
19.
Loss of Integrin αvβ8 in Murine Hepatocytes Accelerates Liver Regeneration
Stephen N. Greenhalgh, Kylie P. Matchett, Richard S. Taylor, Katherine Huang, John T. Li, Koy Saeteurn, Mhairi C. Donnelly, Eilidh E.M. Simpson, Joshua L. Pollack, Amha Atakilit, Kenneth J. Simpson, Jacquelyn J. Maher, John P. Iredale, Dean Sheppard, Neil C. Henderson
Am J Pathol. 2019 Feb; 189(2): 258–271. doi: 10.1016/j.ajpath.2018.10.007
PMCID:
PMC6360354
AbstractArticle
20.
Expression of metanephric nephron-patterning genes in differentiating mesonephric tubules.
K.M. Georgas, H.S. Chiu, E. Lesieur, B.A. Rumballe, M.H Little
Dev Dyn. Author manuscript; available in PMC 2018 Nov 8.
Published in final edited form as: Dev Dyn. 2011 Jun; 240(6): 1600–1612. Published online 2011 Apr 12. doi: 10.1002/dvdy.22640
PMCID:
PMC6224224
AbstractArticlePDF–947K

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