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Items: 1 to 20 of 88

1.
Large-scale mutational analysis identifies UNC93B1 variants that drive TLR-mediated autoimmunity in mice and humans
Victoria E. Rael, Julian A. Yano, John P. Huizar, Leianna C. Slayden, Madeleine A. Weiss, Elizabeth A. Turcotte, Jacob M. Terry, Wenqi Zuo, Isabelle Thiffault, Tomi Pastinen, Emily G. Farrow, Janda L. Jenkins, Mara L. Becker, Stephen C. Wong, Anne M. Stevens, Catherine Otten, Eric J. Allenspach, Devon E. Bonner, Jonathan A. Bernstein, Matthew T. Wheeler, Robert A. Saxton, Undiagnosed Diseases Network, Bo Liu, Olivia Majer, Gregory M. Barton
J Exp Med. 2024 Aug 5; 221(8): e20232005. Published online 2024 May 23. doi: 10.1084/jem.20232005
PMCID:
PMC11116816
AbstractArticlePDF–6.9M
2.
Cyclical palmitoylation regulates TLR9 signalling and systemic autoimmunity in mice
Hai Ni, Yinuo Wang, Kai Yao, Ling Wang, Jiancheng Huang, Yongfang Xiao, Hongyao Chen, Bo Liu, Cliff Y. Yang, Jijun Zhao
Nat Commun. 2024; 15: 1. Published online 2024 Jan 2. doi: 10.1038/s41467-023-43650-z
PMCID:
PMC10762000
AbstractArticlePDF–2.7M
3.
Early cellular mechanisms of type I interferon-driven susceptibility to tuberculosis
Dmitri I. Kotov, Ophelia V. Lee, Stefan A. Fattinger, Charlotte A. Langner, Jaresley V. Guillen, Joshua M. Peters, Andres Moon, Eileen M. Burd, Kristen C. Witt, Daniel B. Stetson, David L. Jaye, Bryan D. Bryson, Russell E. Vance
Cell. Author manuscript; available in PMC 2023 Dec 30.
Published in final edited form as: Cell. 2023 Dec 7; 186(25): 5536–5553.e22. Published online 2023 Nov 28. doi: 10.1016/j.cell.2023.11.002
PMCID:
PMC10757650
AbstractArticlePDF–3.3M
4.
Macrophage Mitochondrial Biogenesis and Metabolic Reprogramming Induced by Leishmania donovani Require Lipophosphoglycan and Type I Interferon Signaling
Hamlet Acevedo Ospina, Marie-Michèle Guay-Vincent, Albert Descoteaux
mBio. 2022 Nov-Dec; 13(6): e02578-22. Published online 2022 Oct 12. doi: 10.1128/mbio.02578-22
PMCID:
PMC9764995
AbstractArticlePDF–4.3M
5.
Differences in neuroinvasion and protective innate immune pathways between encephalitic California Serogroup orthobunyaviruses
Alyssa B. Evans, Clayton W. Winkler, Karin E. Peterson
PLoS Pathog. 2022 Mar; 18(3): e1010384. Published online 2022 Mar 4. doi: 10.1371/journal.ppat.1010384
PMCID:
PMC8926202
AbstractArticlePDF–4.0M
6.
UNC93B1 Is Widely Expressed in the Murine CNS and Is Required for Neuroinflammation and Neuronal Injury Induced by MicroRNA let-7b
Markus G. Klammer, Omar Dzaye, Thomas Wallach, Christina Krüger, Dorothea Gaessler, Alice Buonfiglioli, Katja Derkow, Helmut Kettenmann, Melanie M. Brinkmann, Seija Lehnardt
Front Immunol. 2021; 12: 715774. Published online 2021 Sep 13. doi: 10.3389/fimmu.2021.715774
PMCID:
PMC8475950
AbstractArticlePDF–5.7M
7.
BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING)
Kou Motani, Hidetaka Kosako
J Biol Chem. 2020 Aug 7; 295(32): 11174–11183. Published online 2020 Jun 17. doi: 10.1074/jbc.RA120.014323
PMCID:
PMC7415991
AbstractArticlePDF–2.0M
8.
Requirements for the differentiation of innate T-bethigh memory-phenotype CD4+ T lymphocytes under steady state
Takeshi Kawabe, Jaeu Yi, Akihisa Kawajiri, Kerry Hilligan, Difeng Fang, Naoto Ishii, Hidehiro Yamane, Jinfang Zhu, Dragana Jankovic, Kwang Soon Kim, Giorgio Trinchieri, Alan Sher
Nat Commun. 2020; 11: 3366. Published online 2020 Jul 6. doi: 10.1038/s41467-020-17136-1
Correction in:
Nat Commun. 2020; 11: 4624.
PMCID:
PMC7338451
AbstractArticlePDF–3.5M
9.
Nucleic Acid-Sensing Toll-Like Receptors Play a Dominant Role in Innate Immune Recognition of Pneumococci
Agata Famà, Angelina Midiri, Giuseppe Mancuso, Carmelo Biondo, Germana Lentini, Roberta Galbo, Maria Miriam Giardina, Giuseppe Valerio De Gaetano, Letizia Romeo, Giuseppe Teti, Concetta Beninati
mBio. 2020 Mar-Apr; 11(2): e00415-20. Published online 2020 Mar 24. doi: 10.1128/mBio.00415-20
PMCID:
PMC7157524
AbstractArticlePDF–2.9M
10.
Cross-reactive antigen expressed by B6 splenocytes drives receptor editing and MZ differentiation of IgG2a-reactive AM14 Vκ8 B cells
Kerstin Nündel, Purvi Mande, Stephanie L. Moses, Patricia Busto, Jaime L. Cullen, Madelyn R. Schmidt, Mark J. Shlomchik, Robert T. Woodland, Ann Marshak-Rothstein
J Immunol. Author manuscript; available in PMC 2021 Mar 18.
Published in final edited form as: J Immunol. 2019 Oct 15; 203(8): 2055–2062. doi: 10.4049/jimmunol.1900499
PMCID:
PMC7078032
AbstractArticlePDF–2.1M
11.
Neutrophil extracellular trap-associated RNA and LL37 enable self-amplifying inflammation in psoriasis
Franziska Herster, Zsofia Bittner, Nathan K. Archer, Sabine Dickhöfer, David Eisel, Tatjana Eigenbrod, Thomas Knorpp, Nicole Schneiderhan-Marra, Markus W. Löffler, Hubert Kalbacher, Tim Vierbuchen, Holger Heine, Lloyd S. Miller, Dominik Hartl, Lukas Freund, Knut Schäkel, Martin Heister, Kamran Ghoreschi, Alexander N. R. Weber
Nat Commun. 2020; 11: 105. Published online 2020 Jan 8. doi: 10.1038/s41467-019-13756-4
PMCID:
PMC6949246
AbstractArticlePDF–2.7M
12.
Bone marrow CX3CR1+ mononuclear cells relay a systemic microbiota signal to control hematopoietic progenitors in mice
Seungwon Lee, Hyekang Kim, Gihoon You, Young-Min Kim, Seunghun Lee, Viet-Hoan Le, Ohseop Kwon, Sin-Hyeog Im, You-Me Kim, Kwang Soon Kim, Young Chul Sung, Ki Hean Kim, Charles D. Surh, Yunji Park, Seung-Woo Lee
Blood. 2019 Oct 17; 134(16): 1312–1322. Prepublished online 2019 Aug 6. doi: 10.1182/blood.2019000495
PMCID:
PMC6888141
AbstractArticle
13.
Unc93b1 recruits Syntenin-1 to dampen TLR7 signaling and prevent autoimmunity
Olivia Majer, Bo Liu, Lieselotte SM Kreuk, Nevan Krogan, Gregory M. Barton
Nature. Author manuscript; available in PMC 2020 Mar 23.
Published in final edited form as: Nature. 2019 Nov; 575(7782): 366–370. Published online 2019 Sep 23. doi: 10.1038/s41586-019-1612-6
PMCID:
PMC6856441
AbstractArticlePDF–3.8M
14.
Release from Unc93b1 reinforces the compartmentalized activation of select TLRs
Olivia Majer, Bo Liu, Brian J Woo, Lieselotte SM Kreuk, Erik Van Dis, Gregory M Barton
Nature. Author manuscript; available in PMC 2020 Mar 23.
Published in final edited form as: Nature. 2019 Nov; 575(7782): 371–374. Published online 2019 Sep 23. doi: 10.1038/s41586-019-1611-7
PMCID:
PMC6856438
AbstractArticlePDF–3.5M
15.
Unc93b1-Dependent Endosomal Toll-Like Receptor Signaling Regulates Inflammation and Mortality during Coxsackievirus B3 Infection
Erin I. Lafferty, Sean A. Wiltshire, Isabelle Angers, Silvia M. Vidal, Salman T. Qureshi
J Innate Immun. 2015 Apr; 7(3): 315–330. Published online 2015 Feb 11. doi: 10.1159/000369342
PMCID:
PMC6738833
AbstractArticlePDF–603K
16.
B cell receptor and Toll-like receptor signaling coordinate to control distinct B-1 responses to both self and the microbiota
Lieselotte SM Kreuk, Meghan A Koch, Leianna C Slayden, Nicholas A Lind, Sophia Chu, Hannah P Savage, Aaron B Kantor, Nicole Baumgarth, Gregory M Barton
eLife. 2019; 8: e47015. Published online 2019 Aug 21. doi: 10.7554/eLife.47015
PMCID:
PMC6703855
AbstractArticlePDF–1.9M
17.
TLR induces reorganization of the IgM-BCR complex regulating murine B-1 cell responses to infections
Hannah P Savage, Kathrin Kläsener, Fauna L Smith, Zheng Luo, Michael Reth, Nicole Baumgarth
eLife. 2019; 8: e46997. Published online 2019 Aug 21. doi: 10.7554/eLife.46997
PMCID:
PMC6703853
AbstractArticlePDF–4.5M
18.
Enhanced susceptibility to chemically induced colitis caused by excessive endosomal TLR signaling in LRBA-deficient mice
Kuan-wen Wang, Xiaoming Zhan, William McAlpine, Zhao Zhang, Jin Huk Choi, Hexin Shi, Takuma Misawa, Tao Yue, Duanwu Zhang, Ying Wang, Sara Ludwig, Jamie Russell, Miao Tang, Xiaohong Li, Anne R. Murray, Eva Marie Y. Moresco, Emre E. Turer, Bruce Beutler
Proc Natl Acad Sci U S A. 2019 Jun 4; 116(23): 11380–11389. Published online 2019 May 16. doi: 10.1073/pnas.1901407116
PMCID:
PMC6561264
AbstractArticlePDF–1.4M
19.
The chaperone UNC93B1 regulates toll-like receptor stability independent of endosomal TLR transport
Karin Pelka, Damien Bertheloot, Elisa Reimer, Kshiti Phulphagar, Susanne V. Schmidt, Anette Christ, Rainer Stahl, Nicki Watson, Kensuke Miyake, Nir Hacohen, Albert Haas, Melanie M. Brinkmann, Ann Marshak-Rothstein, Felix Meissner, Eicke Latz
Immunity. Author manuscript; available in PMC 2019 May 15.
Published in final edited form as: Immunity. 2018 May 15; 48(5): 911–922.e7. doi: 10.1016/j.immuni.2018.04.011
PMCID:
PMC6482051
AbstractArticlePDF–2.6M
20.
Endosomal Toll-Like Receptors 7 and 9 Cooperate in Detection of Murine Gammaherpesvirus 68 Infection
Kendra A. Bussey, Sripriya Murthy, Elisa Reimer, Baca Chan, Bastian Hatesuer, Klaus Schughart, Britt Glaunsinger, Heiko Adler, Melanie M. Brinkmann
J Virol. 2019 Feb 1; 93(3): e01173-18. Prepublished online 2018 Nov 14. Published online 2019 Jan 17. doi: 10.1128/JVI.01173-18
PMCID:
PMC6340039
AbstractArticlePDF–2.2M

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